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41. 发明申请

US20130326405A1 Method and Apparatus Pertaining to Radiation Treatment Plan Optimization States 审中-公开
标题翻译：辐射治疗计划优化状态的方法和装置
公开(公告)号：US20130326405A1
公开(公告)日：2013-12-05
申请号：US13484946
申请日：2012-05-31
申请人： Janne Nord , Jarkko Peltola , Lauri Halko , Tao Sun
发明人： Janne Nord , Jarkko Peltola , Lauri Halko , Tao Sun
IPC分类号： G06F3/048
CPC分类号： A61N5/103
摘要： A control circuit stores a plurality of radiation treatment plan states as pertain to optimization of a given radiation treatment plan. The control circuit detects a user's selection of a particular one of the plurality of radiation treatment plan states and responsively displays dose distribution information as corresponds to that selected state. The control circuit can automatically store at least some of those states and/or can provide the user with an opportunity to selectively save a particular state. The control circuit can provide the user with an opportunity to modify optimization objectives such that at least two of the states correspond to different optimization objectives for the radiation treatment plan. The control circuit can also display a radiation treatment plan state selector to facilitate the user selecting the particular state. An individual selector for each state can provide a visual indication of merit as pertains to each such state.
摘要翻译：控制电路存储与给定辐射治疗计划的优化相关的多个辐射治疗计划状态。控制电路检测用户对多个放射治疗计划状态中的特定一个的选择，并且响应地显示与该选择状态对应的剂量分布信息。控制电路可以自动存储这些状态中的至少一些和/或可以向用户提供选择性地保存特定状态的机会。控制电路可以向用户提供修改优化目标的机会，使得至少两个状态对应于辐射治疗计划的不同优化目标。控制电路还可以显示放射治疗计划状态选择器以便于用户选择特定状态。每个状态的单独选择器可以提供与每个这样的状态相关的优点的视觉指示。

42. 发明申请

US20120143575A1 Method For Optimization With Gradient Information 有权
标题翻译：梯度信息优化方法
公开(公告)号：US20120143575A1
公开(公告)日：2012-06-07
申请号：US13390010
申请日：2010-07-27
申请人： Matthias Imhof , Kaveh Ghayour , Tao Sun
发明人： Matthias Imhof , Kaveh Ghayour , Tao Sun
IPC分类号： G06G7/48 , G06F17/10
CPC分类号： G01V11/00 , G01V1/282 , G01V1/30 , G01V2210/614 , G01V2210/66 , G01V2210/661 , G01V2210/665
摘要： A method of improving a geologic model of a subsurface region. One or more sets of parameter values are selected. Each parameter represents a geologic property. A cost and a gradient of the cost are obtained for each set. A geometric approximation of a parameter space defined by one or more formations is constructed. A response surface model is generated expressing the cost and gradient associated with each formation. When a finishing condition is not satisfied, at least one additional set is selected based at least in part on the response surface model associated with previously selected sets. Parts of the method are repeated using successively selected additional sets to update the approximation and the response surface model until the finishing condition is satisfied. Sets having a predetermined level of cost to a geologic model of the subsurface region and/or their associated predicted outcomes are outputted to update the geologic model.
摘要翻译：一种改善地下区域地质模型的方法。选择一组或多组参数值。每个参数代表地质属性。为每一组获得成本和成本梯度。构造由一个或多个地层定义的参数空间的几何近似。生成响应曲面模型，表示与每个组合相关联的成本和梯度。当不满足整理条件时，至少部分地基于与先前选择的组相关联的响应面模型选择至少一个附加集合。使用连续选择的附加集来重复该方法的部分以更新近似值和响应面模型，直到满足完成条件。输出具有对地下区域的地质模型和/或其相关联的预测结果的预定成本水平的集合以更新地质模型。

43. 发明授权

US07662860B2 3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs 失效
标题翻译： SARS冠状病毒3CL蛋白酶和抗SARS药物的3D结构模型
公开(公告)号：US07662860B2
公开(公告)日：2010-02-16
申请号：US11293847
申请日：2005-12-02
申请人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
发明人： Jianhua Shen , Hualiang Jiang , Xu Shen , Jianping Zuo , Xiaomin Luo , Donglu Bai , Jingkang Shen , Kaixian Chen , Chunshan Gui , Lili Chen , Jing Chen , Yifu Yang , Xianhan Zhuang , Yiming Yang , Xuchang He , Hong Liu , Bing Xiong , Haibin Luo , Tao Sun , Fei Ye
IPC分类号： A61K31/165
CPC分类号： C12N9/506 , A61K31/167
摘要： The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.
摘要翻译：本发明公开了通过分子模拟获得的SARS-CoV病毒3CL蛋白酶的三维结构。使用3D结构作为筛选现有医学数据库CMC（Comprehensive Medicinal Chemistry，MDL Information System，Inc。）的药物靶点，并发现一组具有抑制SARS-CoV病毒3CL蛋白酶活性的化合物。在分子和病毒水平测试了Cinanserin，发现能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒。合成Cinanserin类似物并在分子和病毒水平进行测试，发现它们能够抑制SARS-CoV病毒3CL蛋白酶和SARS-CoV病毒，可用于治疗和/或预防SARS-CoV病毒感染。

44. 发明授权

US06896591B2 Mixed-abrasive polishing composition and method for using the same 有权
标题翻译：混合研磨抛光组合物及其使用方法
公开(公告)号：US06896591B2
公开(公告)日：2005-05-24
申请号：US10364243
申请日：2003-02-11
申请人： Atenafu N. Chaneyalew , Tao Sun
发明人： Atenafu N. Chaneyalew , Tao Sun
IPC分类号： C09G1/02 , C09K3/14 , B24B1/00
CPC分类号： C09G1/02 , C09K3/1463
摘要： The invention provides a polishing composition comprising (i) an abrasive comprising (a) about 5 to about 45 wt. % of first abrasive particles having a Mohs' hardness of about 8 or more, (b) about 1 to about 45 wt. % of second abrasive particles having a three-dimensional structure comprising aggregates of smaller primary particles, and (c) about 10 to about 90 wt. % of third abrasive particles comprising silica, and (ii) a liquid carrier. The invention also provides a method of polishing a substrate, which method comprises the steps of (i) providing the above-described polishing composition, (ii) providing a substrate having a surface, and (iii) abrading at least a portion of the substrate surface with the polishing composition to polish the substrate.
摘要翻译：本发明提供一种抛光组合物，其包含（i）研磨剂，其包含（a）约5至约45重量％％的摩尔硬度为约8或更高的第一磨料颗粒的百分比，（b）约1至约45重量％％的具有三维结构的第二磨料颗粒包括较小一次颗粒的聚集体，和（c）约10至约90wt。％的包含二氧化硅的第三磨料颗粒，和（ii）液体载体。本发明还提供一种抛光衬底的方法，该方法包括以下步骤：（i）提供上述抛光组合物，（ii）提供具有表面的衬底，和（iii）研磨衬底的至少一部分用抛光组合物表面抛光底物。

45. 发明授权

US06641630B1 CMP compositions containing iodine and an iodine vapor-trapping agent 失效
标题翻译：含有碘和碘蒸汽捕获剂的CMP组合物
公开(公告)号：US06641630B1
公开(公告)日：2003-11-04
申请号：US10165133
申请日：2002-06-06
申请人： Tao Sun
发明人： Tao Sun
IPC分类号： B24B100
CPC分类号： C09G1/02
摘要： The invention provides a chemical-mechanical polishing system, and a method of polishing using the system, comprising (a) an abrasive, a polishing pad, or both an abrasive and a polishing pad, (b) iodine, (c) an iodine vapor-trapping agent, and (d) a liquid carrier.
摘要翻译：本发明提供一种化学机械抛光系统和使用该系统的抛光方法，其包括（a）研磨剂，抛光垫或研磨剂和抛光垫两者，（b）碘，（c）碘蒸气吸收剂，和（d）液体载体。

46. 发明授权

US06376421B2 Ion exchanged aluminum-magnesium silicate or fluorinated magnesium silicate aerogels and catalyst supports therefrom 失效
标题翻译：离子交换的铝 - 硅酸镁或氟化硅酸镁气凝胶和催化剂载体
公开(公告)号：US06376421B2
公开(公告)日：2002-04-23
申请号：US09794526
申请日：2001-02-27
申请人： Tao Sun , David R. Wilson , Juan M. Garces
发明人： Tao Sun , David R. Wilson , Juan M. Garces
IPC分类号： B01J3100
CPC分类号： C08F10/00 , B01J21/10 , B01J21/14 , B01J27/12 , B01J37/036 , C08F4/65912 , C08F4/6592 , C08F4/65927 , C08F110/06 , C08F210/16 , C08F4/65916 , C08F4/76 , C08F4/025
摘要： Aluminum-magnesium silicate- or fluorinated magnesium silicate- aerogels which may be calcined, chemically modified, ion-exchanged, agglomerated, used as a component of a catalyst composition for an addition polymerization; supported versions thereof; and processes for polymerization are disclosed.
摘要翻译：可以煅烧，化学改性，离子交换，附聚的铝 - 硅酸镁 - 或氟化硅酸镁 - 气凝胶，用作加成聚合的催化剂组合物的组分; 支持版本; 并且公开了聚合方法。

47. 发明授权

US5958367A Methods for preparing porous metal oxides 失效
标题翻译：多孔金属氧化物的制备方法
公开(公告)号：US5958367A
公开(公告)日：1999-09-28
申请号：US729059
申请日：1996-10-10
申请人： Jackie Y. Ying , David M. Antonelli , Tao Sun
发明人： Jackie Y. Ying , David M. Antonelli , Tao Sun
IPC分类号： C01B13/32 , C01B37/00 , C01G33/00
CPC分类号： C01G33/00 , C01B13/32 , C01B37/00 , C01P2002/54 , C01P2002/72 , C01P2002/82 , C01P2004/04 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C01P2006/17
摘要： The present invention relates to a composition and a method for producing hexagonally-packed mesoporous metal oxides wherein the metal oxide is selected from transition metals and lanthanide metals. The composition includes hexagonally packed metal oxide mesostructures that are resistant to pore collapse upon removal of surfactant and are thermally stable. The composition can include a surfactant complexed with the metal. Also described are methods for producing the hexagonally-packed mesoporous metal oxides. The present invention also relates to compositions and methods for producing porous metal oxides. The compositions include microporous and mesoporous metal oxides that are resistant to pore collapse upon removal of surfactant and are thermally stable. Also described are methods for producing microporous metal oxides.
摘要翻译：本发明涉及一种制备六角填料介孔金属氧化物的组合物和方法，其中金属氧化物选自过渡金属和镧系金属。该组合物包括在去除表面活性剂时耐孔隙塌陷并且是热稳定的六边形填充金属氧化物介孔结构。组合物可以包括与金属络合的表面活性剂。还描述了生产六边形填充的中孔金属氧化物的方法。本发明还涉及用于制备多孔金属氧化物的组合物和方法。所述组合物包括微孔和介孔金属氧化物，其在除去表面活性剂后具有抵抗孔隙破裂并且是热稳定的。还描述了生产微孔金属氧化物的方法。

48. 发明授权

US10146393B2 Method and apparatus pertaining to radiation treatment plan optimization states 有权
公开(公告)号：US10146393B2
公开(公告)日：2018-12-04
申请号：US13484946
申请日：2012-05-31
申请人： Janne Nord , Jarkko Peltola , Lauri Halko , Tao Sun
发明人： Janne Nord , Jarkko Peltola , Lauri Halko , Tao Sun
IPC分类号： G06F3/048 , A61N5/10
摘要： A control circuit stores a plurality of radiation treatment plan states as pertain to optimization of a given radiation treatment plan. The control circuit detects a user's selection of a particular one of the plurality of radiation treatment plan states and responsively displays dose distribution information as corresponds to that selected state. The control circuit can automatically store at least some of those states and/or can provide the user with an opportunity to selectively save a particular state. The control circuit can provide the user with an opportunity to modify optimization objectives such that at least two of the states correspond to different optimization objectives for the radiation treatment plan. The control circuit can also display a radiation treatment plan state selector to facilitate the user selecting the particular state. An individual selector for each state can provide a visual indication of merit as pertains to each such state.

49. 发明申请

US20160077237A1 Method of Stratigraphic Modeling of Faults 审中-公开
标题翻译：断层地层建模方法
公开(公告)号：US20160077237A1
公开(公告)日：2016-03-17
申请号：US14483371
申请日：2014-09-11
申请人： Tao Sun , Martin Perlmutter , Michael James Pyrcz , Morgan Sullivan , Ashley Harris
发明人： Tao Sun , Martin Perlmutter , Michael James Pyrcz , Morgan Sullivan , Ashley Harris
IPC分类号： G01V99/00
CPC分类号： G01V99/005 , G01V2210/642 , G06F17/5009
摘要： A new gridding method is disclosed for forward stratigraphic modeling that allows for syndepositional and/or postdepositional fault movement. The new gridding algorithm may represent both the lateral move of structure block, and provide efficiency that is comparable to the structured grid for forward stratigraphy model accessing previous deposited sediments stored in the grid. Embodiments of the disclosed methods allow for structural moves by performing a set of simple operations on the grid. The operations are generally simple, and do not change the overall topology of the grid. Therefore the operation can be easily repeated and the overall topological structure of the grid remains largely unchanged for simple access by the forward stratigraphic model. Further details and advantages of various embodiments of the method are described in more herein.
摘要翻译：公开了一种新的网格化方法，用于前向地层建模，允许综合沉积和/或后沉积故障运动。新的网格算法可以代表结构块的横向移动，并且提供与用于前向地层学模型访问先前沉积在网格中的沉积物的结构化网格相当的效率。所公开的方法的实施例允许通过在网格上执行一组简单的操作来进行结构移动。操作通常很简单，不要改变网格的整体拓扑。因此，通过前向地层模型的简单访问，可以容易地重复操作并且电网的整体拓扑结构基本上保持不变。该方法的各种实施例的更多细节和优点在本文中更详细地描述。

50. 发明申请

US20150219793A1 Conditional Process-Aided Multiple-Points Statistics Modeling 审中-公开
标题翻译：条件过程辅助多点统计建模
公开(公告)号：US20150219793A1
公开(公告)日：2015-08-06
申请号：US14421372
申请日：2013-08-23
申请人： Hongmei Li , Tao Sun
发明人： Hongmei Li , Tao Sun
IPC分类号： G01V99/00 , G06F17/18
摘要： A method of simulating a hydrocarbon reservoir is disclosed. A process-based model is generated that mimics a depositional process of the reservoir. The process-based model is analyzed to extract statistics of geometries of a body that forms part of the reservoir, and depositional rules of the body. An object-based modeling method is applied to construct multiple unconditional geologic models of the body using the statistics and the depositional rules. Training images are constructed using the multiple unconditional geologic models. Well data and gross thickness data are assigned into a simulation grid. A single multiple-point geostatistical simulation is performed using the training images. A three-dimensional (3D) reservoir model is constructed using results of the multiple-point geostatistical simulation.
摘要翻译：公开了一种模拟烃储层的方法。生成基于过程的模型，其模拟储层的沉积过程。分析基于过程的模型，以提取形成储层的一部分的身体的几何体的统计数据，以及身体的沉积规则。应用基于对象的建模方法，利用统计学和沉积规则构建身体的多个无条件地质模型。使用多个无条件地质模型构建训练图像。井数据和总厚度数据被分配到模拟网格中。使用训练图像执行单个多点地统计模拟。使用多点地统计模拟的结果构建三维（3D）储层模型。

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