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41. 发明授权

US6023659A Database system employing protein function hierarchies for viewing biomolecular sequence data 失效
标题翻译：数据库系统采用蛋白质功能层次来观察生物分子序列数据
公开(公告)号：US6023659A
公开(公告)日：2000-02-08
申请号：US812290
申请日：1997-03-06
申请人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
发明人： Jeffrey J. Seilhamer , Ingrid E. Akerblom , Christina M. Altus , Tod M. Klingler , Frank Russo , Janice Au-Young , Jennifer L. Hillman , Timothy J. Maslyn
IPC分类号： G06F17/30 , G06F19/18 , G06F19/22 , G06F19/28 , G06F7/08
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22
摘要： Disclosed is a relational database system for storing biomolecular sequence information in a manner that allows sequences to be catalogued and searched according to one or more protein function hierarchies. The hierarchies allow searches for sequences based upon a protein's biological function or molecular function. Also disclosed is a mechanism for automatically grouping new sequences into protein function hierarchies. This mechanism uses descriptive information obtained from "external hits" which are matches of stored sequences against gene sequences stored in an external database such as GenBank. The descriptive information provided with the external database is evaluated according to a specific algorithm and used to automatically group the external hits (or the sequences associated with the hits) in the categories. Ultimately, the biomolecular sequences stored in databases of this invention are provided with both descriptive information from the external hit and category information from a relevant hierarchy or hierarchies.
摘要翻译：公开了一种用于以允许根据一个或多个蛋白质功能层级对序列进行编目和搜索的方式存储生物分子序列信息的关系数据库系统。层次结构允许基于蛋白质的生物学功能或分子功能搜索序列。还公开了一种用于将新序列自动分组成蛋白质功能层级的机制。该机制使用从“外部命中”获得的描述性信息，其是存储在存储在诸如GenBank的外部数据库中的基因序列的存储序列的匹配。根据特定算法对外部数据库提供的描述性信息进行评估，并用于在类别中自动分组外部命中（或命中关联的序列）。最终，存储在本发明的数据库中的生物分子序列具有来自相关层级或等级的外部命中和类别信息的描述性信息。

42. 发明授权

US5972677A Mammalian phospholipase A.sub.2 nucleotide sequences low molecular weight amino acid sequences encoded thereby antisense sequences and nucleotide sequences having internal ribosome binding sites 失效
标题翻译：哺乳动物磷脂酶A2核苷酸序列由低分子量氨基酸序列编码，由此反义序列和具有内部核糖体结合位点的核苷酸序列
公开(公告)号：US5972677A
公开(公告)日：1999-10-26
申请号：US888497
申请日：1997-07-07
申请人： Jay A. Tischfield , Jeffrey J. Seilhamer
发明人： Jay A. Tischfield , Jeffrey J. Seilhamer
IPC分类号： C12N9/16 , C12N15/55 , C12N9/20
CPC分类号： C12N9/16 , C07K2319/00
摘要： Novel mammalian phospholipase (PLA.sub.2) nucleotide sequences and low molecular weight (about 14KD) amino acid sequences encoded thereby are disclosed. More particularly, a cloned human HPLA.sub.2 cDNA expressing HPLA.sub.2 -10 and its cloned rat RPLA.sub.2 cDNA counterpart, expressing RPLA.sub.2 -10, which are characterized as PLA.sub.2 Type IV, are disclosed. A second type of PLA.sub.2 cDNA, characterized as PLA.sub.2 Type III and exemplified by a rat PLA.sub.2 cDNA encoding RPLA.sub.2 -8 and a partial human PLA.sub.2 nucleotide sequence encoding HPLA.sub.2 -8, is disclosed. Expression of the cDNAs encode the two new types of PLA.sub.2 enzymes which have phospholipase activity. The novel PLA.sub.2 s do not include disulfide bridges between cysteine amino acids 11 and 77 or elapid loops. However, the novel PLA.sub.2 s may include amino acid COOH-terminal extensions which can vary in length. Seventeen of the eighteen absolutely conserved amino acids in all active 14KD PLA.sub.2 s are believed to be conserved in RPLA.sub.2 -8 and HPLA.sub.2 -8, whereas all eighteen are believed to be conserved in RPLA.sub.2 -10 and HPLA.sub.2 -10. Because the encoded sequences of RPLA.sub.2 -8 and HPLA.sub.2 -8 include only 16 cysteine amino acids, they have been designated as Type III. RPLA.sub.2 -10 and HPLA.sub.2 -10 are designated as Type IV since their encoded sequences include only 12 cysteine amino acids.
摘要翻译：公开了新型哺乳动物磷脂酶（PLA2）核苷酸序列和由此编码的低分子量（约14KD）氨基酸序列。更具体地，公开了表达为PLA2 IV型的克隆的表达HPLA2-10的人HPLA2 cDNA及其克隆的大鼠RPLA2 cDNA对应物，表达RPLA2-10。公开了第二种类型的PLA2，其特征为PLA2型III，并且由编码RPLA2-8的大鼠PLA2 cDNA和编码HPLA2-8的部分人PLA2核苷酸序列示例。 cDNA的表达编码了具有磷脂酶活性的两种新型PLA2酶。新型PLA2不包括半胱氨酸氨基酸11和77之间的二硫键或elapid环。然而，新颖的PLA2可以包括可以在长度上变化的氨基酸COOH-末端延伸。所有活性14KD PLA2中十八个绝对保守氨基酸中的17个被认为在RPLA2-8和HPLA2-8中保守，而所有十八个被认为在RPLA2-10和HPLA2-10中保守。由于RPLA2-8和HPLA2-8的编码序列仅包含16个半胱氨酸氨基酸，因此已被指定为III型。 RPLA2-10和HPLA2-10被命名为IV型，因为它们的编码序列仅包括12个半胱氨酸氨基酸。

43. 发明授权

US5605817A DNA encoding chemokine expressed in fetal spleen 失效
标题翻译：编码在胎儿脾中表达的趋化因子的DNA
公开(公告)号：US5605817A
公开(公告)日：1997-02-25
申请号：US375346
申请日：1995-01-19
申请人： Roger Coleman , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Roger Coleman , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： G01N33/50 , C07K14/52 , C12N1/21 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/523 , C07K2319/00 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to the protein.
摘要翻译：本发明提供鉴定和编码来自人胎儿脾细胞的新型表达趋化因子（FSEC）的核苷酸和氨基酸序列。本发明还提供编码FSEC的核苷酸序列的反义分子，用于产生纯化的FSEC的表达载体，能够特异性结合FSEC的抗体，用于检测编码FSEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达FSEC的细胞，基于编码FSEC的核酸分子和能够特异性结合蛋白质的抗体的趋化因子激活的诊断测试。

44. 发明授权

US5019508A Synovial phospholipases 失效
标题翻译：滑膜磷脂酶
公开(公告)号：US5019508A
公开(公告)日：1991-05-28
申请号：US215726
申请日：1988-07-06
申请人： Lorin K. Johnson , Jeffrey J. Seilhamer , Waldemar Pruzanski , Peter Vadas
发明人： Lorin K. Johnson , Jeffrey J. Seilhamer , Waldemar Pruzanski , Peter Vadas
IPC分类号： A61K38/00 , C07K16/40 , C12N9/18 , C12N15/55
CPC分类号： C12N9/18 , C07K16/40 , A61K38/00
摘要： Mammalian synovial phospholipase A.sub.2 (sPLA.sub.2) enzymes are provided, as well as DNA constructs encoding these enzymes, methods of producing the enzymes recombinantly, and antibodies thereto. Therapeutic methods employing anti-synovial phospholipase antibodies are also provided, in addition to diagnositc methods and other applications of sPLA.sub.2.
摘要翻译：提供哺乳动物滑膜磷脂酶A2（sPLA2）酶，以及编码这些酶的DNA构建体，重组产生酶的方法及其抗体。除了sPLA2的诊断方法和其他应用之外，还提供了使用抗滑膜磷脂酶抗体的治疗方法。

45. 发明授权

US06500938B1 Composition for the detection of signaling pathway gene expression 失效
标题翻译：用于检测信号通路基因表达的组成
公开(公告)号：US06500938B1
公开(公告)日：2002-12-31
申请号：US09016434
申请日：1998-01-30
申请人： Janice Au-Young , Jeffrey J. Seilhamer
发明人： Janice Au-Young , Jeffrey J. Seilhamer
IPC分类号： C07H2100
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/158
摘要： The present invention relates to a composition comprising a plurality of polynucleotide probes. The composition can be used as array elements in a microarray. The present invention also relates to a method for selecting polynucleotide probes of the composition.
摘要翻译：本发明涉及包含多个多核苷酸探针的组合物。该组合物可用作微阵列中的阵列元件。本发明还涉及选择组合物的多核苷酸探针的方法。

46. 发明授权

US06080548A Cyclic nucleotide phosphodiesterases 失效
标题翻译：环状核苷酸磷酸二酯酶
公开(公告)号：US06080548A
公开(公告)日：2000-06-27
申请号：US255748
申请日：1999-02-23
申请人： Janice Au-Young , Benjamin G. Cocks , Roger Coleman , Jeffrey J. Seilhamer , Douglas A. Fisher
发明人： Janice Au-Young , Benjamin G. Cocks , Roger Coleman , Jeffrey J. Seilhamer , Douglas A. Fisher
IPC分类号： C12N9/16 , C12N15/12 , C07K7/04 , C07K14/47
CPC分类号： C12N9/16
摘要： The invention provides human cyclic nucleotide phosphodiesterases (PDE8) and polynucleotides which identify and encode PDE8. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE8.
摘要翻译：本发明提供了人类环核苷酸磷酸二酯酶（PDE8）和识别和编码PDE8的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了治疗或预防与PDE8表达相关的疾病的方法。

47. 发明授权

US6066488A Cathepsin C homolog 失效
标题翻译：组织蛋白酶C同源物
公开(公告)号：US6066488A
公开(公告)日：2000-05-23
申请号：US871314
申请日：1997-06-09
申请人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
发明人： Roger Coleman , Scott Michael Braxton , Jeffrey J. Seilhamer
IPC分类号： G01N33/50 , C07K14/60 , C12N9/48 , C12N15/09 , C12N15/57 , C12Q1/34 , C12Q1/68 , G01N33/53 , G01N33/566 , C12N9/50 , C12N9/64 , C12N15/00
CPC分类号： C12N9/48
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new cathepsin C homolog (RCP) expressed in THP-1 cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode RCP, expression vectors for the production of purified RCP, antibodies capable of binding specifically to RCP, hybridization probes or oligonucleotides for the detection of RCP-encoding nucleotide sequences, genetically engineered host cells for the expression of RCP, diagnostic tests for activation of monocyte/macrophages based on RCP-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码在THP-1细胞中表达的新的组织蛋白酶C同系物（RCP）的核苷酸和氨基酸序列。本发明还提供编码RCP的核苷酸序列的反义分子，用于产生纯化的RCP的表达载体，能够特异性结合RCP的抗体，用于检测编码RCP的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达RCP的细胞，用于基于编码RCP的核酸分子激活单核细胞/巨噬细胞的诊断测试，以及使用该蛋白质产生能够特异性结合蛋白质的抗体和使用蛋白质筛选抑制剂。

48. 发明授权

US5932423A Cyclic nucleotide phosphodiesterases 失效
公开(公告)号：US5932423A
公开(公告)日：1999-08-03
申请号：US974565
申请日：1997-11-19
申请人： Janice Au-Young , Benjamin G. Cocks , Roger Coleman , Jeffrey J. Seilhamer , Douglas A. Fisher
发明人： Janice Au-Young , Benjamin G. Cocks , Roger Coleman , Jeffrey J. Seilhamer , Douglas A. Fisher
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , C07K16/40 , C12N9/16 , C12N15/12 , C12N15/55 , C12Q1/44 , C12Q1/68 , C12N5/06 , C12P21/02
CPC分类号： C12N9/16 , A61K38/00
摘要： The invention provides human cyclic nucleotide phosphodiesterases (PDE8) and polynucleotides which identify and encode PDE8. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE8.

49. 发明授权

US5869633A Thrombin receptor homolog polynucleotide 失效
标题翻译：凝血酶受体同系物多核苷酸
公开(公告)号：US5869633A
公开(公告)日：1999-02-09
申请号：US911320
申请日：1997-08-14
申请人： Roger Coleman , Janice Au-Young , Olga Bandman , Jeffrey J. Seilhamer
发明人： Roger Coleman , Janice Au-Young , Olga Bandman , Jeffrey J. Seilhamer
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K39/395 , A61K48/00 , A61P43/00 , C07K14/705 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel thrombin receptor homolog (TRH) expressed in human liver. The present invention also provides for antisense molecules to the nucleotide sequences which encode TRH, diagnostic tests based on TRH encoding nucleic acid molecules, expression vectors for the production of purified TRH, antibodies capable of binding specifically to TRH, hybridization probes or oligonucleotides for the detection of TRH-encoding nucleotide sequences, genetically engineered host cells for the expression of TRH, and antagonists, antibodies and inhibitors with specific binding activity for the polypeptide TRH.
摘要翻译：本发明提供鉴定和编码在人肝中表达的新型凝血酶受体同系物（TRH）的核苷酸和氨基酸序列。本发明还提供编码TRH的核苷酸序列的反义分子，基于编码核酸分子的TRH的诊断试验，用于产生纯化的TRH的表达载体，能够特异性结合TRH的抗体，用于检测的杂交探针或寡核苷酸的TRH编码核苷酸序列，用于表达TRH的遗传工程化宿主细胞，以及对多肽TRH具有特异性结合活性的拮抗剂，抗体和抑制剂。

50. 发明授权

US5866332A Human myeloid terminal differentiation response gene 失效
标题翻译：人骨髓末端分化反应基因
公开(公告)号：US5866332A
公开(公告)日：1999-02-02
申请号：US602208
申请日：1996-02-15
申请人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
发明人： Benjamin Graeme Cocks , Janice Au-Young , Jeffrey J. Seilhamer
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/12 , C12N15/19 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for myd118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 and MYD118 polypeptide. The invention specifically provides for use of the myd118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide sequences for myd118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供了myd118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118和MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供了myd118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于myd118的核苷酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

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