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41. 发明申请

US20090155207A1 Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders 审中-公开
标题翻译：使用免疫调节化合物治疗横纹肌肉炎，多发性硬化症和其他疾病
公开(公告)号：US20090155207A1
公开(公告)日：2009-06-18
申请号：US12324728
申请日：2008-11-26
申请人： Robert J. Hariri , David I. Stirling , Herbert Faleck , Anthony D. Radice
发明人： Robert J. Hariri , David I. Stirling , Herbert Faleck , Anthony D. Radice
IPC分类号： A61K38/21 , A61K31/56 , A61K31/445 , A61K39/395
CPC分类号： A61K31/00 , A61K31/454 , A61K31/573 , A61K38/212 , A61K38/215 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Methods of treating, preventing or managing transverse myelitis, multiple sclerosis, and/or other disorders are disclosed. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with a second active agent. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
摘要翻译：公开了治疗，预防或治疗横贯性脊髓炎，多发性硬化症和/或其它病症的方法。所述方法包括给予本文提供的免疫调节化合物，例如3-（4-氨基-1-氧代-1,3-二氢 - 异吲哚-2-基 - 哌啶-2,6-二酮或1,3-二氧代 -2-（2,6-二氧代哌啶-3-基）-4-氨基异吲哚啉进一步描述了使用免疫调节化合物与第二活性剂组合的治疗方法。适用于该方法的药物组合物和单一单位剂型还公开了本文。

42. 发明授权

US07311905B2 Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells 有权
标题翻译：衍生自产后哺乳动物胎盘的胚胎样干细胞，以及使用所述细胞的用途和治疗方法
公开(公告)号：US07311905B2
公开(公告)日：2007-12-25
申请号：US10366671
申请日：2003-02-13
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N65/00
CPC分类号： A61K35/28 , A61K35/50 , A61K35/51 , A61K35/545 , A61K48/00 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N5/0605 , C12N5/0607 , C12N2500/90 , C12N2509/00 , C12N2533/90
摘要： The present invention provides compositions and methods of using embryonic-like stem cells that originate from a post-partum placenta with conventional cord blood compositions or other stem or progenitor cells. The embryonic-like stem cells can be used alone or in a mixture with other stem cell populations. In accordance with the present invention, the embryonic-like stem cells may be mixed with other stem cell populations, including but not limited to, umbilical cord blood, fetal and neonatal hematopoietic stem cells and progenitor cells, human stem cells and progenitor cells derived from bone marrow. The embryonic-like stem cells and the mixed populations of embryonic-like stem cells and stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses.
摘要翻译：本发明提供了使用源自产后胎盘的胚胎样干细胞与常规脐带血组合物或其它干细胞或祖细胞的组合物和方法。胚胎样干细胞可以单独使用或与其他干细胞群混合使用。根据本发明，胚胎样干细胞可以与其他干细胞群体混合，包括但不限于脐带血，胎儿和新生儿造血干细胞和祖细胞，人干细胞和源自骨髓。胚胎样干细胞和胚胎样干细胞和干细胞的混合群体具有多种用途和应用，包括但不限于用于移植和治疗和预防疾病以及诊断和研究用途的治疗用途。

43. 发明授权

US4970926A Apparatus for making angled hole ventricular catheter 失效
标题翻译：用于制作斜孔心室导管的装置
公开(公告)号：US4970926A
公开(公告)日：1990-11-20
申请号：US227397
申请日：1988-08-02
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali Ghahremani-Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali Ghahremani-Ghadjar
IPC分类号： A61M25/00
CPC分类号： A61M25/0015 , A61M25/007 , Y10T83/0596 , Y10T83/7673 , Y10T83/8831 , Y10T83/8857 , Y10T83/889 , Y10T83/944
摘要： An apparatus for making a hollow elongated member having a plurality of apertures therein comprising: a first component for supporting a hollow elongated member in a predetermined position and orientation for formation of a plurality of apertures therein; and a second component for forming a plurality of apertures at a predetermined position and orientation and of a predetermmined dimension thereof in the hollow elongated member; the second component being guidably received within the first component for alignment therewith. Alternatively, the apparatus includes an insert comprising rod means for forming a plurality of apertures of a predetermined size; and means for forming and supporting the hollow bore of the elongated member. The rod means is positioned at a predetermined orientation with respect to the bore forming means so that the hollow elongated member receives a plurality of apertures therein at a predetermined position, orientation and dimension. This embodiment includes a molding assembly comprising means for forming and supporting a hollow elongated member by substantially completely surrounding the member; a plurality of apertures located in the forming means for guidably receiving the rod means therein to properly orient the insert within a forming means; and means for introducing a polymerizable liquid into the molding assembly so as to form the catheter by polymerization of the liquid therein.
摘要翻译：一种用于制造具有多个孔的中空细长构件的装置，包括：用于将中空细长构件支撑在用于在其中形成多个孔的预定位置和取向的第一部件; 以及用于在所述中空细长构件中以预定位置和方向以及预定尺寸形成多个孔的第二部件; 所述第二部件被可引导地接纳在所述第一部件内用于与其对准。或者，该装置包括插入件，其包括用于形成预定尺寸的多个孔的杆装置; 以及用于形成和支撑细长构件的中空孔的装置。杆装置相对于孔形成装置定位在预定取向，使得中空细长构件在预定位置，取向和尺寸处容纳多个孔。该实施例包括一个模制组件，其包括用于通过基本上完全围绕该构件形成和支撑中空细长构件的装置; 位于所述成形装置中的多个孔，用于在其中引导地容纳所述杆装置，以将所述插入件适当地定位在成形装置内; 以及用于将可聚合液体引入到模制组件中以通过其中的液体聚合形成导管的装置。

44. 发明授权

US4931056A Catheter guide apparatus for perpendicular insertion into a cranium orifice 失效
标题翻译：导管引导装置，用于垂直插入头颅孔
公开(公告)号：US4931056A
公开(公告)日：1990-06-05
申请号：US261063
申请日：1988-10-24
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61B17/16 , A61B19/00
CPC分类号： A61B17/1695 , A61B90/11
摘要： An apparatus and method for drilling an orifice in a human cranium at an angle of substantially 90.degree. to a plane defined by a tangent to the surface of the cranium at the orifice. The apparatus comprises a first tubular guide for directing a drill at the proper angle, the first guide being suppored upon the cranium by a plurality of leg members. The invention further comprises a hand-operated twist drill device, configured for insertion into the tubular guide. A second guide, of reduced diameter relative to the first tubular guide is insertable into the first guide upon completion of the burr hole to facilitate entry of a catheter into the ventricular portion of the patient's brain. The method of the invention comprises positioning the first drill guide upon the patient's cranium, inserting the twist drill therein so as to prepare a burr hole extending at an angle of substantially 90.degree. to a plane tangential to the surface, replacing the drill with a catheter guide insertable within the drill guide and inserting a catheter through the second guide, through the burr hole and into a ventricular portion of the patient's brain.
摘要翻译：一种用于在人类头颅中以与孔口表面的切线限定的平面大致90度的角度钻孔的装置和方法。该装置包括用于以适当角度引导钻头的第一管状引导件，第一引导件由多个腿部构件支撑在颅骨上。本发明还包括一种手动麻花钻装置，其构造成用于插入管状引导件中。相对于第一管状引导件直径减小的第二引导件在毛刺孔完成时可插入到第一引导件中，以便于将导管进入患者大脑的心室部分。本发明的方法包括将第一钻子引导件定位在患者的颅骨上，将麻花钻插入其中，以便制备一个与表面相切的平面以大致90度的角度延伸的钻孔，用导管引导件可插入到钻孔引导器内并将导管穿过第二引导件穿过钻孔并进入患者大脑的心室部分。

45. 发明授权

US4875482A Flexible grasping device 失效
标题翻译：柔性抓握装置
公开(公告)号：US4875482A
公开(公告)日：1989-10-24
申请号：US209434
申请日：1988-06-21
申请人： Robert J. Hariri , Jamshid B. G. Ghajar , Fathali Ghahremani-Ghadjar
发明人： Robert J. Hariri , Jamshid B. G. Ghajar , Fathali Ghahremani-Ghadjar
IPC分类号： A61B17/42
CPC分类号： A61B17/42
摘要： A device is disclosed comprising a stretchable cylindrical net-like structure and at least one guide ring for partial placement over a fetus. The cylindrical net-like structure is formed such that as force is applied along its longitudinal axis, the length of the cylindrical structure is increased while the diameter of such cylindrical structure is decreased. The guide ring is expandable for passage therethrough of the fetal head and has an at rest diameter between that of the fetal neck and the fetal head.
摘要翻译：公开了一种装置，其包括可伸缩的圆柱形网状结构和用于部分放置在胎儿上的至少一个引导环。圆柱形网状结构形成为当沿着其纵向轴线施加力时，圆柱形结构的长度增加，而这种圆柱形结构的直径减小。引导环可扩张以通过胎头部，并且具有在胎儿颈部和胎儿头部之间的静止直径。

46. 发明申请

US20150238566A1 METHOD OF OBTAINING EFFECTIVE AMOUNTS OF AVIAN FOLLISTATIN 审中-公开
标题翻译：获得AVIAN FOLLISTATIN有效成分的方法
公开(公告)号：US20150238566A1
公开(公告)日：2015-08-27
申请号：US14557419
申请日：2014-12-01
申请人： Neerav Padliya , Robert J. Hariri , Carlon Colker
发明人： Neerav Padliya , Robert J. Hariri , Carlon Colker
IPC分类号： A61K38/17
CPC分类号： A61K38/1703 , A23L15/00 , A23L33/17 , A23V2002/00 , A61K35/57 , A23V2250/542 , A23V2200/316 , A61K2300/00 , A61K38/1709
摘要： Embodiments of the present invention are generally related to methods of obtaining effective amount of avian follistatin. More specifically, embodiments of the present invention relate to products comprising avian follistatin, and methods of optimizing the same based on avian follistatin concentrations utilized during the manufacturing process. In one embodiment of the present invention, a method of creating a consumable product for treatment of a muscle degenerating disease having avian follistatin comprises selecting an avian egg based upon a desired threshold of avian follistatin concentration therein; extracting material from the avian egg, the material comprising avian follistatin; and processing the material with one or more excipients to yield the consumable product.
摘要翻译：本发明的实施方案通常涉及获得有效量的禽卵泡抑素的方法。更具体地，本发明的实施方案涉及包含禽类卵泡抑素的产品，以及基于在制造过程中使用的禽类卵泡抑素浓度的优化方法。在本发明的一个实施方案中，一种产生用于治疗具有鸟类卵泡抑素的肌肉退化疾病的消耗品的方法包括：根据所需的禽卵泡抑素浓度阈值选择禽卵; 从鸟类卵中提取物质，该材料包括鸟类卵泡抑素; 并用一种或多种赋形剂处理该材料以产生消耗品。

47. 发明授权

US08617535B2 Cytotherapeutics, cytotherapeutic units and methods for treatments using them 有权
标题翻译：细胞治疗剂，细胞治疗单位和使用它们的治疗方法
公开(公告)号：US08617535B2
公开(公告)日：2013-12-31
申请号：US11592544
申请日：2006-11-03
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00 , A61K35/28 , A61K35/50
CPC分类号： A61K35/51 , A61K35/50 , A61K35/54
摘要： The present invention provides cytotherapeutic units comprising predetermined numbers of selected types of potent cells. Assurance of the nature and identities of such cells is achieved through assay and certification of said numbers and identities. Therapeutic modalities are provided. Libraries of cell preparations with assayed and preferably certified populations are preferred and the preparation of cell preparations tailored to specific patients or disease states are provided.
摘要翻译：本发明提供了包含预定数量的选择类型的有效细胞的细胞治疗单元。通过对所述数字和身份的测定和认证来确保这些细胞的性质和身份的保证。提供治疗方式。具有测定和优选认证群体的细胞制备物库是优选的，并且提供了针对特定患者或疾病状态的细胞制剂的制备。

48. 发明授权

US08057789B2 Placental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells 有权
标题翻译：源自产后哺乳动物胎盘的胎盘干细胞，以及使用所述细胞的治疗方法和方法
公开(公告)号：US08057789B2
公开(公告)日：2011-11-15
申请号：US11982007
申请日：2007-10-31
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61K35/50 , A61K35/51 , A61K35/545 , A61K48/00 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12N5/0068 , C12N5/0605 , C12N5/0607 , C12N2500/90 , C12N2509/00 , C12N2533/90
摘要： The present invention provides compositions and methods of using placental stem cells that originate from a postpartum placenta with conventional cord blood compositions or other stem or progenitor cells. The placental stem cells can be used alone or in a mixture with other stem cell populations. In accordance with the present invention, the placental stem cells may be mixed with other stem cell populations, including but not limited to, umbilical cord blood, fetal and neonatal hematopoietic stem cells and progenitor cells, human stem cells and progenitor cells derived from bone marrow. The placental stem cells and the mixed populations of placental stem cells and stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses.
摘要翻译：本发明提供使用来自具有常规脐带血组合物或其它干细胞或祖细胞的产后胎盘的胎盘干细胞的组合物和方法。胎盘干细胞可以单独使用或与其他干细胞群混合使用。根据本发明，胎盘干细胞可以与其它干细胞群体混合，包括但不限于脐带血，胎儿和新生儿造血干细胞和祖细胞，源自骨髓的人干细胞和祖细胞。胎盘干细胞和胎盘干细胞和干细胞的混合种群具有多种用途和应用，包括但不限于用于移植和治疗和预防疾病的治疗用途以及诊断和研究用途。

49. 发明授权

US07976836B2 Treatment of stroke using placental stem cells 有权
标题翻译：使用胎盘干细胞治疗中风
公开(公告)号：US07976836B2
公开(公告)日：2011-07-12
申请号：US12341961
申请日：2008-12-22
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： A01N63/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

50. 发明申请

US20100297689A1 PLACENTAL STEM CELL POPULATIONS 有权
标题翻译：单位干细胞群体
公开(公告)号：US20100297689A1
公开(公告)日：2010-11-25
申请号：US12848007
申请日：2010-07-30
申请人： James Edinger , Qian Ye , Jai-Lun Wang , Robert J. Hariri
发明人： James Edinger , Qian Ye , Jai-Lun Wang , Robert J. Hariri
IPC分类号： C12Q1/02 , C12N5/02
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
摘要翻译：本发明提供胎盘干细胞和胎盘干细胞群体，以及培养，增殖和扩增胎盘干细胞的方法。本发明还提供了分离胎盘干细胞的方法。本发明还提供了在测定和移植中使用胎盘干细胞的方法。

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