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41. 发明申请

US20100261207A9 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 有权
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：US20100261207A9
公开(公告)日：2010-10-14
申请号：US12295572
申请日：2007-03-30
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K16/24 , A61K51/088 , A61K51/1021 , C07K14/525 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域Neutrokine-α和/或Neutrokine-αSV多肽的可溶形式，载体，宿主细胞和重组方法生产相同。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

42. 发明申请

US20090221008A1 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 有权
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：US20090221008A1
公开(公告)日：2009-09-03
申请号：US12295572
申请日：2007-03-30
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K16/24 , A61K51/088 , A61K51/1021 , C07K14/525 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域Neutrokine-α和/或Neutrokine-αSV多肽的可溶形式，载体，宿主细胞和重组方法生产相同。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

43. 发明授权

US06881401B1 Methods of treatment of immune system related disorders using Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α治疗免疫系统相关疾病的方法
公开(公告)号：US06881401B1
公开(公告)日：2005-04-19
申请号：US09589285
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K38/00 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/24 , C12P21/08 , A61K38/18 , A61K38/19 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , C07H21/04 , C07K14/52 , C07K14/715 , C07K2317/622
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

44. 发明授权

US06562579B1 Diagnostic methods using antibodies to Neutrokine-alpha 有权
标题翻译：使用Neutrokine-α抗体的诊断方法
公开(公告)号：US06562579B1
公开(公告)日：2003-05-13
申请号：US09588947
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： G01N3353
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

45. 发明申请

US20090068201A1 METHODS OF TREATMENT USING ANTIBODIES TO NEUTROKINE-ALPHA 有权
标题翻译：使用抗体治疗中耳炎的方法
公开(公告)号：US20090068201A1
公开(公告)日：2009-03-12
申请号：US12170333
申请日：2008-07-09
申请人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： A61K39/395 , A61K38/00 , C12N5/06 , A61P31/00
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

46. 发明授权

US06403770B1 Antibodies to neutrokine-alpha 有权
标题翻译：中性粒细胞α的抗体
公开(公告)号：US06403770B1
公开(公告)日：2002-06-11
申请号：US09589287
申请日：2000-06-08
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen
IPC分类号： C07K1600
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

47. 发明授权

US07335489B2 Polynucleotides encoding a protein kinase C inhibitor protein and methods of using these polynucleotides 失效
标题翻译：编码蛋白激酶C抑制蛋白的多核苷酸和使用这些多核苷酸的方法
公开(公告)号：US07335489B2
公开(公告)日：2008-02-26
申请号：US10453478
申请日：2003-06-04
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
IPC分类号： C07K14/35 , C12N15/00 , C12N5/00 , C12N1/20 , C07H21/04 , C07H21/02 , C07K14/435
CPC分类号： C07K14/47 , A61K38/00
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译：公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了将这些多肽用于治疗目的的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。还公开了用于检测利用序列和多肽的疾病的诊断方法。

48. 发明申请

US20090197278A9 Antibodies to hADA2 审中-公开
标题翻译： hADA2的抗体
公开(公告)号：US20090197278A9
公开(公告)日：2009-08-06
申请号：US12036846
申请日：2008-02-25
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
IPC分类号： G01N33/53 , C07H21/04 , C12N15/00 , C12N5/00 , C12P21/04 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译：公开了编码此类多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了将这些多肽用于治疗目的的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。还公开了用于检测利用序列和多肽的疾病的诊断方法。

49. 发明申请

US20080227110A1 Human Genes, Sequences and Expression Products 审中-公开
标题翻译：人类基因，序列和表达产物
公开(公告)号：US20080227110A1
公开(公告)日：2008-09-18
申请号：US12036846
申请日：2008-02-25
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
IPC分类号： G01N33/53 , C07H21/04 , C12N15/00 , C12N5/00 , C12P21/04 , C07K16/00
CPC分类号： C07K14/47 , A61K38/00
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译：公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了将这些多肽用于治疗目的的方法。还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。还公开了用于检测利用序列和多肽的疾病的诊断方法。

50. 发明授权

US07368244B2 Peptidoglycan recognition proteins 失效
标题翻译：肽聚糖识别蛋白
公开(公告)号：US07368244B2
公开(公告)日：2008-05-06
申请号：US11214796
申请日：2005-08-31
申请人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
发明人： Paul E. Young , Steven M. Ruben , Craig A. Rosen , Henrik S. Olsen
IPC分类号： C07H21/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention related to three novel peptidoglican recognition binding protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译：本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型肽基识别结合蛋白。更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。图1A-B，图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。还提供了PGRP-K，PGRP-W和PGRP-C多肽。进一步提供载体，宿主细胞和用于制备其的重组方法。本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。

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