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41. 发明授权

US08728149B2 Assembly for making a polymeric medical device 有权
标题翻译：用于制造聚合物医疗装置的组件
公开(公告)号：US08728149B2
公开(公告)日：2014-05-20
申请号：US13244225
申请日：2011-09-23
申请人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
发明人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
IPC分类号： A61F2/06 , B23Q1/00 , B29C35/08
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2240/001 , A61L31/04 , A61L31/14
摘要： A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The assembly and method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
摘要翻译：聚合物管定位在聚合物心轴上，然后激光切割以形成可植入的医疗装置，例如支架。组装和方法减少了支架内表面的污染，如果使用传统的玻璃或金属心轴，则同时由于聚合物心轴的屏蔽作用而同时降低对支架内表面的损伤。

42. 发明授权

US08568469B1 Stent locking element and a method of securing a stent on a delivery system 有权
标题翻译：支架锁定元件和将支架固定在输送系统上的方法
公开(公告)号：US08568469B1
公开(公告)日：2013-10-29
申请号：US10879328
申请日：2004-06-28
申请人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Bin Huang , Svava Maria Atladottir
发明人： David C. Gale , Klaus Kleine , Anthony J. Abbate , Bin Huang , Svava Maria Atladottir
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/91558 , A61F2002/91583 , A61F2002/91591 , A61F2002/9505 , A61F2220/0033
摘要： A stent with a stent locking element and a method of securing a stent on a delivery implement, such as a catheter are disclosed. The locking element can include coupling elements capable of being releasably coupled to one another. The coupling elements may be adapted to inhibit shifting of the stent on the delivery implement. In some embodiments, the releasably coupled elements may secure the stent on the delivery implement.
摘要翻译：公开了具有支架锁定元件的支架和将支架固定在诸如导管的递送工具上的方法。锁定元件可以包括能够可释放地彼此联接的联接元件。联接元件可适于阻止支架在输送工具上的移动。在一些实施例中，可释放地联接的元件可将支架固定在输送工具上。

43. 发明授权

US08241554B1 Method of forming a stent pattern on a tube 有权
标题翻译：在管上形成支架图案的方法
公开(公告)号：US08241554B1
公开(公告)日：2012-08-14
申请号：US10881554
申请日：2004-06-29
申请人： Anthony J. Abbate , David C. Gale , Klaus Kleine , Svava Maria Atladottir
发明人： Anthony J. Abbate , David C. Gale , Klaus Kleine , Svava Maria Atladottir
IPC分类号： B29D22/00
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2240/001 , A61F2250/0048 , B29L2023/007
摘要： Methods of fabricating an implantable medical device from a tube or a sheet in an expanded or stretched state, respectively, are disclosed herein. The implantable medical device may be an endoprosthesis such as a stent. In one embodiment, the method may include radially expanding a tube about a cylindrical axis of the tube from a first diameter to a second diameter. The method may further include forming a pattern on at least a portion of the expanded tube. Additional embodiments may include forming a stent pattern on a stretched sheet from which a stent may be formed. In addition, a stent pattern may be formed on a tube that is formed from a stretched sheet.
摘要翻译：本文公开了分别从扩张或拉伸状态的管或片制造可植入医疗装置的方法。可植入医疗装置可以是内置假体，例如支架。在一个实施例中，该方法可以包括将管围绕管的圆柱形轴线从第一直径径向扩张至第二直径。该方法还可以包括在扩张管的至少一部分上形成图案。另外的实施例可以包括在可从其形成支架的拉伸片材上形成支架图案。此外，可以在由拉伸片形成的管上形成支架图案。

44. 发明授权

US08191501B2 Apparatus for selectively coating a medical article 有权
标题翻译：用于选择性地涂敷医疗用品的装置
公开(公告)号：US08191501B2
公开(公告)日：2012-06-05
申请号：US12616651
申请日：2009-11-11
申请人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F. A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05B5/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译：用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。

45. 发明申请

US20110009948A1 Fiber Reinforced Composite Stents 有权
标题翻译：纤维增强复合支架
公开(公告)号：US20110009948A1
公开(公告)日：2011-01-13
申请号：US12878937
申请日：2010-09-09
申请人： Bin Huang , David C. Gale , Srinivasan Sridharan , Joseph R. Callol , Klaus Kleine , Syed F. A. Hossainy , Timothy A. Limon , Anthony J. Abbate
发明人： Bin Huang , David C. Gale , Srinivasan Sridharan , Joseph R. Callol , Klaus Kleine , Syed F. A. Hossainy , Timothy A. Limon , Anthony J. Abbate
IPC分类号： A61F2/82 , B05D1/02
CPC分类号： A61F2/915 , A61F2/04 , A61F2/06 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2002/91508 , A61F2002/91575 , A61F2210/0004 , A61F2210/0009 , A61F2210/0076 , A61F2220/005 , A61F2230/0013 , A61F2250/0098 , A61L31/129 , B23K26/402 , B23K26/50 , B23K2103/42 , B23K2103/50 , B29C43/02 , B29C45/0001 , B29C45/0005 , B29C45/0055 , B29C47/0004 , B29C47/0023 , B29C47/0026 , B29C47/0066 , B29C47/06 , B29C47/1045 , B29C53/566 , B29C53/583 , B29C59/02 , B29C59/021 , B29C2043/028 , B29K2101/00 , B29K2105/12 , B29K2267/043 , B29K2995/0056 , B29K2995/006 , B29L2023/003 , B29L2031/7546 , D03D3/02
摘要： Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.
摘要翻译：公开了用纤维增强的用于植入体腔的聚合复合支架。

46. 发明授权

US07622070B2 Method of manufacturing an implantable polymeric medical device 有权
标题翻译：制造可植入聚合物医疗装置的方法
公开(公告)号：US07622070B2
公开(公告)日：2009-11-24
申请号：US11157145
申请日：2005-06-20
申请人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
发明人： Svava Maria Atladottir , David C. Gale , Klaus Kleine
IPC分类号： B26D3/10 , B26D7/01 , A61F2/06
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2240/001 , A61L31/04 , A61L31/14
摘要： A polymeric tube is positioned on a polymeric mandrel and then laser cut to form an implantable medical device, such as a stent. The method reduces contamination of the inner surface of the stent, which would be caused if conventional glass or metal mandrels are used, while simultaneously reducing damage to the inner surface of the stent due to the shielding effect of the polymeric mandrel.
摘要翻译：聚合物管定位在聚合物心轴上，然后激光切割以形成可植入的医疗装置，例如支架。该方法减少了支架内表面的污染，如果使用传统的玻璃或金属心轴，则会由于聚合物心轴的屏蔽作用而同时减少对支架内表面的损伤。

47. 发明申请

US20070228023A1 Pulsed Synchronized Laser Cutting of Stents 审中-公开
标题翻译：脉冲同步激光切割支架
公开(公告)号：US20070228023A1
公开(公告)日：2007-10-04
申请号：US11278131
申请日：2006-03-30
申请人： Klaus Kleine , William Fox , Scott Palley
发明人： Klaus Kleine , William Fox , Scott Palley
IPC分类号： B23K26/38
CPC分类号： B23K26/0823 , A61F2/91 , B23K26/0626
摘要： A system for pulsed synchronized laser cutting of stents and/or other medical products includes a numerical controller and a machine for moving a tube of material during cutting. A pulsed fiber laser is configured to cut the tube into, for example, a stent, the numerical controller being in communication with the machine and configured to send movement control information to the machine. The numerical controller may also receive movement speed information from the machine. The numerical controller is also in communication with the pulsed fiber laser and is configured to send pulse control information to the pulsed fiber laser. The numerical controller is configured to cause average laser power to decrease by decreasing frequency of laser pulses as stent cutting speed decreases, and to cause average laser power to increase by increasing frequency of laser pulses as stent cutting speed increases.
摘要翻译：用于支架和/或其他医疗产品的脉冲同步激光切割的系统包括数字控制器和用于在切割期间移动材料管的机器。脉冲光纤激光器被配置为将管切割成例如支架，数字控制器与机器通信并被配置为向机器发送运动控制信息。数值控制器还可以从机器接收移动速度信息。数字控制器还与脉冲光纤激光器通信，并配置为向脉冲光纤激光器发送脉冲控制信息。数值控制器被配置为通过降低激光脉冲的频率来降低平均激光功率，因为支架切割速度降低，并且由于支架切割速度增加，激光脉冲的频率增加导致平均激光功率增加。

48. 发明申请

US20070045255A1 Laser induced plasma machining with an optimized process gas 审中-公开
标题翻译：用优化的工艺气体激光诱导等离子体加工
公开(公告)号：US20070045255A1
公开(公告)日：2007-03-01
申请号：US11210349
申请日：2005-08-23
申请人： Klaus Kleine , Scott Palley
发明人： Klaus Kleine , Scott Palley
IPC分类号： B23K10/00 , B23K26/38
CPC分类号： B23K26/38 , A61F2/91 , B23K26/0624 , B23K2103/42 , B23K2103/50
摘要： Embodiments of methods of laser machining that include inducing formation of a plasma plume from a process gas through interaction of the gas with a laser beam are disclosed. The methods may include removing material from the substrate by interaction of the induced plasma plume with the substrate. The process gas may be optimized to achieve a desired machining effect.
摘要翻译：公开了激光加工方法的实施例，其包括通过气体与激光束的相互作用从工艺气体引起等离子体羽流的形成。所述方法可以包括通过诱导的等离子体羽流与衬底的相互作用从衬底去除材料。可以优化处理气体以实现期望的加工效果。

49. 发明申请

US20070038290A1 Fiber reinforced composite stents 审中-公开
标题翻译：纤维增强复合支架
公开(公告)号：US20070038290A1
公开(公告)日：2007-02-15
申请号：US11205254
申请日：2005-08-15
申请人： Bin Huang , David Gale , Srinivasan Sridharan , Joseph Callol , Klaus Kleine , Syed Hossainy , Timothy Limon , Anthony Abbate
发明人： Bin Huang , David Gale , Srinivasan Sridharan , Joseph Callol , Klaus Kleine , Syed Hossainy , Timothy Limon , Anthony Abbate
IPC分类号： A61F2/88 , A61F2/90 , B29C47/20
CPC分类号： A61F2/915 , A61F2/04 , A61F2/06 , A61F2/90 , A61F2/91 , A61F2002/072 , A61F2002/91508 , A61F2002/91575 , A61F2210/0004 , A61F2210/0009 , A61F2210/0076 , A61F2220/005 , A61F2230/0013 , A61F2250/0098 , A61L31/129 , B23K26/402 , B23K26/50 , B23K2103/42 , B23K2103/50 , B29C43/02 , B29C45/0001 , B29C45/0005 , B29C45/0055 , B29C48/0022 , B29C48/022 , B29C48/09 , B29C48/10 , B29C48/18 , B29C48/2886 , B29C53/566 , B29C53/583 , B29C59/02 , B29C59/021 , B29C2043/028 , B29K2101/00 , B29K2105/12 , B29K2267/043 , B29K2995/0056 , B29K2995/006 , B29L2023/003 , B29L2031/7546 , D03D3/02
摘要： Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.
摘要翻译：公开了用纤维增强的用于植入体腔的聚合复合支架。

50. 发明申请

US20060224226A1 In-vivo radial orientation of a polymeric implantable medical device 审中-公开
标题翻译：聚合物可植入医疗装置的体内径向取向
公开(公告)号：US20060224226A1
公开(公告)日：2006-10-05
申请号：US11096342
申请日：2005-03-31
申请人： Bin Huang , Klaus Kleine , David Gale
发明人： Bin Huang , Klaus Kleine , David Gale
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/9155 , A61F2002/91575 , A61F2230/0013
摘要： A method and system for treating a bodily lumen with an implantable medical device, such as a stent, are disclosed. The device may be disposed within a bodily lumen and radially expanded by circumferentially deforming a tube-like section of the device. The deforming section may expand the lumen and the deformed section may support the lumen.
摘要翻译：公开了一种用可植入医疗装置（例如支架）治疗身体管腔的方法和系统。该装置可以设置在体腔中并且通过使装置的管状部分周向变形而径向扩张。变形部分可以扩张内腔，并且变形的部分可以支撑管腔。

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