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41. 发明授权

US06872202B2 Laser slit lamp with laser radiation source 有权
标题翻译：激光裂隙灯带激光辐射源
公开(公告)号：US06872202B2
公开(公告)日：2005-03-29
申请号：US10043463
申请日：2002-01-10
申请人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diego Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
发明人： Mario Gerlach , Martin Wiechmann , Olaf Kittelmann , Diego Zimare , Michael Kempe , Dirk Muehlhoff , Alexander Kalies
IPC分类号： A61B18/20 , A61B3/135 , A61F9/007 , A61F9/008 , G02B21/06 , A61B18/18
CPC分类号： G02B21/06 , A61B3/135 , A61F9/008 , A61F9/00821 , A61F9/009 , A61F2009/00863 , A61F2009/00891
摘要： A laser slit lamp comprising a slit lamp base, a slit lamp head and a slit lamp microscope. The laser slit lamp is connected with an applicator. It comprises a device for uniting radiation from at least two radiation sources collinearly and for directing the radiation of a treatment beam or working beam onto the location to be treated in or on the eye of a patient, a device for generating a target beam or marking beam for targeting and observing the location to be treated in or on the eye, and an adjusting device in the applicator for changing the intensity and diameter of the working beam spot used for treatment. The radiation sources are laser radiation sources arranged in the slit lamp head, in the slit lamp base or in the slit lamp microscope for generating the working beam, illumination beam and/or target beam. Devices for control, regulation and monitoring are likewise arranged in the interior of the slit lamp.
摘要翻译：一种激光裂隙灯，包括狭缝灯座，裂隙灯头和裂隙灯显微镜。激光裂隙灯与施加器连接。它包括用于将来自至少两个辐射源的辐射并联并用于将治疗光束或工作光束的辐射引导到患者眼中或眼睛上待处理的位置的装置，用于产生目标光束或标记用于瞄准和观察在眼睛中或眼睛上待处理的位置的光束，以及用于改变用于治疗的作用光束斑点的强度和直径的施加器中的调节装置。辐射源是布置在裂隙灯头，裂隙灯底座或狭缝灯显微镜中用于产生工作光束，照明光束和/或目标光束的激光辐射源。用于控制，调节和监视的装置同样设置在裂隙灯的内部。

42. 发明授权

US08808279B2 Device and method for measuring an optical break-through in a tissue 有权
标题翻译：用于测量组织中光学穿透的装置和方法
公开(公告)号：US08808279B2
公开(公告)日：2014-08-19
申请号：US10525424
申请日：2003-08-22
申请人： Dirk Mühlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff , Dick Manfred , Michael Bergt
发明人： Dirk Mühlhoff , Michael Kempe , Markus Strehle , Mario Gerlach , Markus Sticker , Mark Bischoff , Dick Manfred , Michael Bergt
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/00814 , A61F9/00825 , A61F9/00827 , A61F9/0084 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00872 , A61F2009/00874
摘要： The invention relates to a device for measuring an optical penetration that is triggered in a tissue underneath the tissue surface by means of therapeutic laser radiation which a laser-surgical device concentrates in a treatment focus located in said tissue. The inventive device is provided with a detection beam path comprising a lens system which couples radiation emanating from the tissue underneath the tissue surface into the detection beam path. A detector device generating a detection signal which indicates the spatial dimension and/or position of the optical penetration in the issue is arranged downstream of the detection beam path.
摘要翻译：本发明涉及一种用于测量通过治疗激光辐射在组织表面下方的组织中触发的光学穿透的装置，激光手术装置集中在位于所述组织中的治疗焦点。本发明的装置设置有检测光束路径，该检测光束路径包括将从组织表面下方的组织发出的辐射耦合到检测光束路径中的透镜系统。产生检测信号的检测器装置被布置在检测光束路径的下游，该检测信号指示在问题中的光学穿透的空间维度和/或位置。

43. 发明申请

US20120319007A1 LUMINESCENCE MICROSCOPY 有权
标题翻译：荧光显微镜
公开(公告)号：US20120319007A1
公开(公告)日：2012-12-20
申请号：US13518115
申请日：2010-10-22
申请人： Michael Kempe , Ralf Netz , Gerhard Krampert
发明人： Michael Kempe , Ralf Netz , Gerhard Krampert
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G02B21/16
摘要： A luminescence microscopy method includes a sample being used, which comprises a certain substance, wherein the certain substance can be converted repeatedly from a first state, in which it can be excited into emitting luminescence radiation, into a second state, in which it cannot be excited into emitting luminescence radiation. The substance present in the sample can be brought into the first state by irradiating switch radiation. The certain substance can be excited into emitting luminescence radiation by irradiating excitation radiation. The sample emitting luminescence radiation can be displayed. A high-resolution selection of sample regions extending perpendicularly to a sample surface is carried out by irradiating either the switch radiation or the excitation radiation as structured illumination of the sample. A high-resolution selection of the sample surface is carried out by irradiating the switch radiation and/or the excitation radiation as TIRF illumination of the sample.
摘要翻译：发光显微镜方法包括使用的样品，其包含某种物质，其中某些物质可以从其可被激发发射发光辐射的第一状态重复地转换到第二状态，其中不能是激发发射发光辐射。存在于样品中的物质可以通过照射开关辐射而进入第一状态。可以通过照射激发辐射来激发某些物质发射发光辐射。可以显示发射发光辐射的样品。垂直于样品表面延伸的样品区域的高分辨率选择是通过照射样品的结构照明中的开关辐射或激发辐射来进行的。通过将开关辐射和/或激发辐射照射作为样品的TIRF照明来进行样品表面的高分辨率选择。

44. 发明申请

US20110182529A1 METHODS AND APPARATUSES FOR STRUCTURED ILLUMINATION MICROSCOPY 有权
标题翻译：用于结构化照明显微镜的方法和装置
公开(公告)号：US20110182529A1
公开(公告)日：2011-07-28
申请号：US13121466
申请日：2009-09-22
申请人： Michael Kempe , Gerhard Krampert , Ingo Kleppe , Ralf Wolleschensky
发明人： Michael Kempe , Gerhard Krampert , Ingo Kleppe , Ralf Wolleschensky
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： G02B21/0032 , G01N21/6458 , G02B21/0072 , G02B21/0076 , G02B21/008 , G02B21/367 , G02B27/58
摘要： In structured illumination microscopy, the multiple recording of images with different phase positions of the structuring requires a high stability in the optical arrangement and sample throughout the entire measuring process. Also, the structuring must be projected into the sample in a highly homogeneous manner. The current invention optimizes recording of individual images in order to achieve the best possible resolution in the result image even in problematic samples. An optimization of this kind can be carried out in different ways, for example, by determining an optimal adjustment for at least one illumination parameter or recording parameter or by pulsed illumination such that an excitation from a triplet state of the fluorescent dye to a higher triplet state is reduced, or by illuminating the sample with depletion light for depopulating a triplet state of the fluorescent dye, which reduces bleaching.
摘要翻译：在结构化照明显微镜中，具有结构化不同相位位置的图像的多次记录在整个测量过程中需要光学布置和样品中的高稳定性。此外，结构化必须以高度均匀的方式投射到样品中。本发明优化各个图像的记录，以便即使在有问题的样本中也能在结果图像中实现最佳分辨率。可以以不同的方式进行这种优化，例如通过确定至少一个照明参数或记录参数的最佳调整或通过脉冲照明使得从荧光染料的三重态到更高三重态的激发或通过用耗尽光照射样品来减少荧光染料的三线态，从而减少漂白。

45. 发明申请

US20100294749A1 LASER BEAM MACHINING 有权
标题翻译：激光加工
公开(公告)号：US20100294749A1
公开(公告)日：2010-11-25
申请号：US12744216
申请日：2008-11-20
申请人： Michael Kempe , Peter Westphal , Wolfgang Grau , Georg Von Freymann
发明人： Michael Kempe , Peter Westphal , Wolfgang Grau , Georg Von Freymann
IPC分类号： B23K26/06
CPC分类号： B23K26/046 , G02B7/32 , G02B21/244 , G02B21/245 , G03F7/70375 , G03F7/70383
摘要： A method for laser beam machining of a workpiece in which a laser beam is focused by an objective, into or onto the workpiece having a boundary surface, to produce a machining effect by a two-photon process, and the position of the focal point with respect to the workpiece is shifted. To obtain a reference for the position of the focal point, an image of a luminating modulation object is projected through the objective onto the workpiece into the focal plane or so as to intersect it. Reflections of the image occurring at the boundary surface are imaged into an autofocus image plane, and are detected by a camera. The camera image plane either intersects the autofocus image plane when the image of the illuminating modulation object lies in the focal plane, or lies in the autofocus image plane when the image of the modulation object intersects the focal plane.
摘要翻译：一种用于激光束加工的方法，其中激光束被物镜聚焦到具有边界表面的工件中或之上，以通过双光子过程产生加工效果，并且焦点的位置与相对于工件移动。为了获得焦点的位置的参考，发光调制对象的图像通过物镜投射到工件上进入焦平面或与之相交。在边界面发生的图像的反射被成像为自动聚焦图像平面，并且由相机检测。当照明调制对象的图像位于焦平面时，相机图像平面与自动聚焦图像平面相交，或者当调制对象的图像与焦平面相交时，相机图像平面位于自动聚焦图像平面中。

46. 发明申请

US20100201784A1 METHOD FOR THE MICROSCOPIC THREE-DIMENSIONAL REPRODUCTION OF A SAMPLE 审中-公开
标题翻译：一种样品的微观三维再现方法
公开(公告)号：US20100201784A1
公开(公告)日：2010-08-12
申请号：US12680056
申请日：2008-09-16
申请人： Helmut Lippert , Benno Radt , Michael Kempe , Christian Dietrich
发明人： Helmut Lippert , Benno Radt , Michael Kempe , Christian Dietrich
IPC分类号： H04N13/02
CPC分类号： G06T7/97 , G02B21/002 , G02B21/244 , G02B21/367
摘要： A method for the three-dimensional imaging of a sample in which image information from different depth planes of the sample is stored in a spatially resolved manner, and the three-dimensional image of the sample is subsequently reconstructed from this stored image information is provided. A reference structure is applied to the illumination light, at least one fluorescing reference object is positioned next to or in the sample, images of the reference structure of the illumination light, of the reference object are recorded from at least one detection direction and evaluated. The light sheet is brought into an optimal position based on the results and image information of the reference object and of the sample from a plurality of detection directions is stored. Transformation operators are obtained on the basis of the stored image information and the reconstruction of the three-dimensional image of the is based on these transformation operators.
摘要翻译：提供了一种用于样本的三维成像的方法，其中以空间分辨的方式存储来自样本的不同深度平面的图像信息，并且随后从该存储的图像信息重建样本的三维图像。参考结构被应用于照明光，至少一个发荧光参考对象被放置在样本旁边或样本中，从至少一个检测方向记录参考物体的照明光的参考结构的图像并进行评估。基于结果使光照片进入最佳位置，存储参考对象的图像信息和来自多个检测方向的样本的图像信息。基于存储的图像信息和基于这些变换算子的三维图像的重建获得转换算子。

47. 发明授权

US07728270B2 Microscopy method and microscope including two detections 有权
标题翻译：显微镜方法和显微镜包括两个检测
公开(公告)号：US07728270B2
公开(公告)日：2010-06-01
申请号：US12088410
申请日：2006-09-14
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： H01L27/00
CPC分类号： G02B21/002
摘要： A microscopy method is provided for generating an image of an image field passing in a predetermined depth of a sample to be examined, comprising a plurality of illumination steps, in which a part of the image field is in each case illuminated with a focused illumination beam bundle, which effects the generation of sample radiation on account of an interaction with the sample, detection steps, in which the sample radiation generated is detected, and an evaluation step, in which the image is generated on the basis of the sample radiation detected, wherein a first and second detection step are carried out during each illumination step, wherein sample radiation generated at the focus and outside the focus is detected in the first detection step and a smaller proportion of the sample radiation generated at the focus than in the first detection step and also sample radiation generated outside the focus are detected in the second detection step, and wherein the sample radiation detected in the second detection step is used in the evaluation step to reduce the proportion outside the focus in the sample radiation detected in the first detection step.
摘要翻译：提供了一种显微镜方法，用于产生通过待检查样本的预定深度的图像场的图像，包括多个照明步骤，其中图像场的一部分在每种情况下被照射聚焦照明光束束，其由于与样品的相互作用而影响样品辐射的产生，其中检测到产生的样品辐射的检测步骤以及基于检测到的样品辐射而产生图像的评估步骤，其中在每个照明步骤期间执行第一和第二检测步骤，其中在第一检测步骤中检测在焦点处和在焦点外部产生的样品辐射，以及在焦点处产生的样品辐射比在第一检测中产生的较小比例在第二检测步骤中检测步骤，并且在焦点外产生的样本辐射被检测，并且其中在t中检测到的样本辐射在评估步骤中使用第二检测步骤来减少在第一检测步骤中检测到的样品辐射中焦点外的比例。

48. 发明授权

US07612884B2 Method and arrangement for optical examination or processing of a sample 有权
标题翻译：用于光学检查或样品处理的方法和装置
公开(公告)号：US07612884B2
公开(公告)日：2009-11-03
申请号：US10539491
申请日：2003-11-29
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： G01N21/00
CPC分类号： G02B21/0076 , G02B21/0032
摘要： A method and an arrangement for the optical examination and/or processing of a sample comprise an element for generating an illumination light, an element arranged downstream of the latter for spectral splitting of the illumination light for generating spatially separated spectral components, an element for parallelizing the split illumination light, an element for focusing the illumination light on or in the sample, wherein the spectral components are superposed, and an element for detecting the sample light, advantageously comprising an element for generating a short-pulse illumination light, an element arranged downstream of the latter for spectral splitting of the illumination light for generating spatially separated spectral components with pulse lengths that are greater than the pulse length of the illumination light, wherein these spectral components are combined again in the sample.
摘要翻译：用于光学检查和/或处理样品的方法和装置包括用于产生照明光的元件，布置在其后面的元件，用于分光照明光以产生空间上分离的光谱分量，用于并行化的元件分割照明光，用于将照明光聚焦在样品上或样品中的元件，其中重叠光谱分量，以及用于检测样品光的元件，有利地包括用于产生短脉冲照明光的元件，布置成后者用于分光光束，用于产生具有大于照明光的脉冲长度的脉冲长度的空间分离的光谱分量，其中这些光谱分量再次组合在样本中。

49. 发明申请

US20090036880A1 Device and Method for Changing a Lens Implanted Into an Eye 审中-公开
标题翻译：用于改变植入眼睛的镜片的装置和方法
公开(公告)号：US20090036880A1
公开(公告)日：2009-02-05
申请号：US11988399
申请日：2006-07-05
申请人： Mark Bischoff , Michael Kempe , Markus Strehle , Walter Wrobel
发明人： Mark Bischoff , Michael Kempe , Markus Strehle , Walter Wrobel
IPC分类号： A61F9/011
CPC分类号： A61F9/008 , A61F2/1627 , A61F2/1635 , A61F9/00834 , A61F2009/00844 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088 , G02C2202/14
摘要： The invention relates to a device for altering an optical and/or mechanical property of a lens that is implanted in an eye, the device including a laser device, which has a laser beam source that provides a pulsed laser beam and an optical unit, which impinges on the implanted lens with the pulsed laser beam. The device also includes a control device, which controls the laser device such that the optical and/or mechanical property of the lens is altered on the basis of non-linear interaction between the laser beam and the lens material.
摘要翻译：本发明涉及一种用于改变植入眼睛中的透镜的光学和/或机械特性的装置，该装置包括具有提供脉冲激光束和光学单元的激光束源的激光装置，该激光装置用脉冲激光束撞击在植入的透镜上。该装置还包括控制装置，其控制激光装置，使得基于激光束和透镜材料之间的非线性相互作用来改变透镜的光学和/或机械特性。

50. 发明授权

US07463344B2 Arrangement for the optical detection of light radiation which is excited and/or backscattered in a specimen with a double-objective arrangement 失效
标题翻译：光学检测用于双目标布置的样品中被激发和/或反向散射的光辐射的布置
公开(公告)号：US07463344B2
公开(公告)日：2008-12-09
申请号：US10888896
申请日：2004-07-09
申请人： Ralf Wolleschensky , Michael Kempe
发明人： Ralf Wolleschensky , Michael Kempe
IPC分类号： G01N21/00
CPC分类号： G02B21/18 , G02B21/002
摘要： Arrangement and method for the optical detection of light radiation which is excited and/or backscattered in a specimen, wherein the illumination of the specimen and/or the detection of the specimen light is carried out by at least two objectives arranged on different sides of the specimen. The specimen illumination is focused in or in the vicinity of a pupil plane of the beam path between the specimen plane and the detection plane at least on one axis and an element for the spatial separation of the illumination light from the detection light are provided in this plane.
摘要翻译：在样本中被激发和/或反向散射的光辐射的光学检测的布置和方法，其中样本的照明和/或样本光的检测通过布置在样品的不同侧面上的至少两个物体进行标本。样本照明至少在一个轴上聚焦在样本平面和检测平面之间的光束路径的光瞳平面附近或附近，并且在该位置处提供用于照明光与检测光的空间分离的元件飞机

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