专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20060199815A1 NK1 antagonists 有权
标题翻译： NK1拮抗剂
公开(公告)号：US20060199815A1
公开(公告)日：2006-09-07
申请号：US11358827
申请日：2006-02-21
申请人： Sunil Paliwal , Gregory Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan Arredondo , Michelle Wrobleski , Anandan Palani
发明人： Sunil Paliwal , Gregory Reichard , Cheng Wang , Dong Xiao , Hon-Chung Tsui , Neng-Yang Shih , Juan Arredondo , Michelle Wrobleski , Anandan Palani
IPC分类号： A61K31/538 , A61K31/498 , A61K31/4747
CPC分类号： C07D498/10 , A61K31/166 , A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4375 , A61K31/438 , A61K31/451 , A61K31/454 , A61K31/4545 , A61K31/537 , A61K31/5377 , A61K31/573 , A61K45/06 , C07D207/14 , C07D207/50 , C07D211/28 , C07D211/32 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/72 , C07D211/76 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/10 , C07D413/12 , C07D471/10 , C07D487/10 , C07D491/10 , C07D513/10
摘要： A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 and R5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.
摘要翻译：具有式（I）的NK 1拮抗剂，其中Ar 1和Ar 2是任选取代的苯基或杂芳基，X 1 硫醚或亚氨基键，R 4和R 5不都是H或烷基，其余的变量如说明书中所定义，可用于治疗许多障碍，包括呕吐，抑郁，焦虑和咳嗽。药物组合物。还公开了治疗方法和与其它药剂的组合。

42. 发明授权

US07034057B2 Compounds for the treatment of inflammatory disorders 失效
公开(公告)号：US07034057B2
公开(公告)日：2006-04-25
申请号：US10716890
申请日：2003-11-19
申请人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
发明人： Zhaoning Zhu , Robert Mazzola , Zhuyan Guo , Brian J. Lavey , Lisa Sinning , Joseph Kozlowski , Brian McKittrick , Neng-Yang Shih
IPC分类号： A61K31/165 , A61K31/18 , A61K31/21 , A61K31/27
CPC分类号： C07D213/30 , C07C62/34 , C07C69/757 , C07C235/40 , C07C255/54 , C07C259/08 , C07C279/08 , C07C311/29 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/40 , C07D213/73 , C07D213/74 , C07D215/06 , C07D215/14 , C07D215/18 , C07D215/233 , C07D215/26 , C07D215/38 , C07D219/02 , C07D221/16 , C07D233/60 , C07D233/64 , C07D251/10 , C07D277/24 , C07D277/64 , C07D311/04 , C07D311/58 , C07D317/08 , C07D317/64 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.

43. 发明申请

US20060009528A1 Cannabinoid receptor ligands 有权
公开(公告)号：US20060009528A1
公开(公告)日：2006-01-12
申请号：US11203946
申请日：2005-08-15
申请人： Joseph Kozlowski , Neng-Yang Shih , Brian Lavey , Razia Rizvi , Bandarpalle Shankar , James Spitler , Ling Tong , Ronald Wolin , Michael Wong
发明人： Joseph Kozlowski , Neng-Yang Shih , Brian Lavey , Razia Rizvi , Bandarpalle Shankar , James Spitler , Ling Tong , Ronald Wolin , Michael Wong
IPC分类号： A61K31/18
CPC分类号： C07D213/70 , C07C31/24 , C07C317/22 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/41 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2603/74 , C07D213/71 , C07D213/74 , C07D213/89 , C07D215/36 , C07D233/42 , C07D233/84 , C07D239/38 , C07D307/64 , C07D333/20 , C07D333/34 , C07D333/38
摘要： There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.

44. 发明申请

US20050113383A1 Novel non-imidazole compounds 失效
标题翻译：新型非咪唑化合物
公开(公告)号：US20050113383A1
公开(公告)日：2005-05-26
申请号：US10974329
申请日：2004-10-27
申请人： Stuart Rosenblum , Qingbei Zeng , Mwangi Mutahi , Robert Aslanian , Pauline Ting , Neng-Yang Shih , Daniel Solomon , Jianhua Cao , Henry Vaccaro , Kevin McCormick , John Baldwin , Ge Li
发明人： Stuart Rosenblum , Qingbei Zeng , Mwangi Mutahi , Robert Aslanian , Pauline Ting , Neng-Yang Shih , Daniel Solomon , Jianhua Cao , Henry Vaccaro , Kevin McCormick , John Baldwin , Ge Li
IPC分类号： C07D211/34 , A61K31/496 , A61P1/00 , A61P1/04 , A61P3/04 , A61P9/00 , A61P9/04 , A61P11/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/28 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/38 , C07D211/62 , C07D211/96 , C07D243/08 , C07D401/06 , C07D401/14 , C07D405/14 , C07D407/12 , C07D407/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D487/06 , A61K31/4545 , C07D43/14 , C07D45/14
CPC分类号： C07D401/14 , C07D211/26 , C07D211/38 , C07D211/62 , C07D211/96 , C07D243/08 , C07D401/06 , C07D407/12 , C07D407/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D487/06
摘要： Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H1 receptor antagonist.
摘要翻译：公开的是式的新化合物还公开了包含式I化合物的药物组合物。还公开了治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻拥塞）。还公开了使用组合式I化合物来治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻塞）具有H 1受体拮抗剂。

45. 发明授权

US06849621B2 Piperidine compounds 失效
标题翻译：哌啶化合物
公开(公告)号：US06849621B2
公开(公告)日：2005-02-01
申请号：US10095134
申请日：2002-03-11
申请人： Stuart B. Rosenblum , Qingbei Zeng , Mwangi Wa Mutahi , Robert G. Aslanian , Pauline C. Ting , Neng-Yang Shih , Daniel M. Solomon , Jianhua Cao , Henry A. Vaccaro , Kevin D. McCormick , John J. Baldwin , Ge Li
发明人： Stuart B. Rosenblum , Qingbei Zeng , Mwangi Wa Mutahi , Robert G. Aslanian , Pauline C. Ting , Neng-Yang Shih , Daniel M. Solomon , Jianhua Cao , Henry A. Vaccaro , Kevin D. McCormick , John J. Baldwin , Ge Li
IPC分类号： C07D211/34 , A61K31/496 , A61P1/00 , A61P1/04 , A61P3/04 , A61P9/00 , A61P9/04 , A61P11/00 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/28 , A61P37/08 , A61P43/00 , C07D211/26 , C07D211/38 , C07D211/62 , C07D211/96 , C07D243/08 , C07D401/06 , C07D401/14 , C07D405/14 , C07D407/12 , C07D407/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D487/06 , A61K31/4545 , C07D403/06
CPC分类号： C07D401/14 , C07D211/26 , C07D211/38 , C07D211/62 , C07D211/96 , C07D243/08 , C07D401/06 , C07D407/12 , C07D407/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D487/06
摘要： Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I.Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H. receptor antagonist.
摘要翻译：所公开的新化合物还公开了包含式I化合物的药物组合物。还公开了治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻充血）。还公开了使用式I化合物与下列化合物组合治疗各种疾病或病症的方法，例如过敏，过敏诱发的气道反应和充血（例如，鼻塞） H.受体拮抗剂。

47. 发明授权

US06635630B2 Selective neurokinin antagonists 失效
标题翻译：选择性神经激肽拮抗剂
公开(公告)号：US06635630B2
公开(公告)日：2003-10-21
申请号：US10163663
申请日：2002-06-06
申请人： Neng-Yang Shih , Ho-Jane Shue , Gregory A. Reichard , Sunil Paliwal , David J. Blythin , John J. Piwinski , Dong Xiao , Xiao Chen
发明人： Neng-Yang Shih , Ho-Jane Shue , Gregory A. Reichard , Sunil Paliwal , David J. Blythin , John J. Piwinski , Dong Xiao , Xiao Chen
IPC分类号： A61K31330
CPC分类号： C07D239/10 , C07C45/71 , C07C217/48 , C07D211/58 , C07D233/14 , C07D233/16 , C07D233/22 , C07D233/30 , C07D233/32 , C07D233/42 , C07D233/46 , C07D233/48 , C07D233/78 , C07D285/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07F9/6506 , C07C47/575
摘要： Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is —O—, —S—, —SO—, —SO2—, —NR12—, —NCOR12— or —NR12SO2R15; is selected from the group consisting of X2 is —O—, —S— or —NR5—; Y is ═O, ═S or ═NR11; Y1 is H, C1-C6 alkyl, —NR17R13, —SCH3, R19-aryl(CH2)n6—, R19-heteroaryl-(CH2)n6—, —(CH2)n6—heterocycloalkyl, —(C1-C3)alkyl-NH—C(O)O(C1-C6)alkyl or —NHC(O)R15; R5 is H or —(CH2)n1—G, wherein n1 is 0-5, G is H, —CF3, —CHF2, —CH2F, —OH, —O—(C1-C6 alkyl), —SO2R13, —O—(C3-C8 cycloalkyl), —NR13R14, —SO2NR13R14, —NR13SO2R15, —NR13COR12, —NR12(CONR13R14), —CONR13R14, —COOR12, C3-C8 cycloalkyl, R19-aryl, R19-heteroaryl, and provided when n1=0, G is not H; R1, R2, R3 and R7 are H, alkyl, cycloalkyl, —CHF2, —CH2F or —CF3; or R1 and R2, together with the carbon to which they are attached, form an alkylene ring; or R1 and R2 together are ═O; R6 is R7 or —OH; and the remaining variables are as defined in the specification, methods of treating diseases susceptible to treatment with neurokinin antagonists with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. Also disclosed are pharmaceutical compositions comprising an effective amount of a compound of claim 1, at least one pharmaceutically acceptable carrier, and in combination with an effective amount of a selective serotonin reuptake inhibitor.
摘要翻译：由结构式表示的化合物或其药学上可接受的盐，其中Ar 1和Ar 2是任选取代的杂芳基或任选取代的苯基; X 1是-O - ， - S - ， - SO-，-SO 2 - ，-NR 12 - ， - NR C 12 - 或-NR 12 SO 2 R 15选自X 2是-O - ， - S-或-NR 5 - ; Y是= O，= S或= NR 11; Y 1是H，C 1 -C 6烷基，-NR 17 R 13，-SCH 3，R 19 - 芳基（CH 2）n6 - （CH 2）n6 - ， - （CH 2）n 6-杂环烷基， - （C 1 -C 3）烷基-NH-C（O）O（C 1 -C 6）烷基或-NHC（O） R 15; R 5是H或 - （CH 2）n1-G，其中n1是0-5，G是H，-CF 3，-CHF 2，-CH 2 F，-OH，-O-（C 1 -C 6 烷基），-SO 2 R 13，-O-（C 3 -C 8环烷基），-NR 13 R 14，-SO 2 NR 13 R 14，-NR 13 SO 2 R 15， NR 13 R 12，-NR 12（CONR 13 R 14），-CONR 13 R 14，-COOR 12，C 3 -C 8环烷基，R 19 芳基，R 19 - 杂芳基，并且当n 1 = 0时，G不为H; R 1，R 2，R 3和R 7为H，烷基，环烷基，-CHF 2 ，-CH2F或-CF3; 或R 1和R 2与它们所连接的碳一起形成亚烷基环; 或R 1和R 2一起为= O; R 6为R 7或-OH;其余变量如本说明书中所定义，治疗易受神经激肽拮抗剂治疗的疾病的方法，所述化合物和包含所述化合物的药物组合物。还公开了药物组合物，其包含有效量的权利要求1的化合物，至少一种药学上可接受的载体，并与有效量的选择性5-羟色胺再摄取抑制剂组合。

48. 发明授权

US06436928B1 Selective neurokinin antagonists 失效
标题翻译：选择性神经激肽拮抗剂
公开(公告)号：US06436928B1
公开(公告)日：2002-08-20
申请号：US09737036
申请日：2000-12-14
申请人： Neng-Yang Shih , Ho-Jane Shue , Gregory A. Reichard , Sunil Paliwal , David J. Blythin , John J. Piwinski , Dong Xiao , Xiao Chen
发明人： Neng-Yang Shih , Ho-Jane Shue , Gregory A. Reichard , Sunil Paliwal , David J. Blythin , John J. Piwinski , Dong Xiao , Xiao Chen
IPC分类号： A61K314166
CPC分类号： C07D239/10 , C07C45/71 , C07C217/48 , C07D211/58 , C07D233/14 , C07D233/16 , C07D233/22 , C07D233/30 , C07D233/32 , C07D233/42 , C07D233/46 , C07D233/48 , C07D233/78 , C07D285/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D413/10 , C07F9/6506 , C07C47/575
摘要： A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar1 and Ar2 are optionally substituted heteroaryl or optionally substituted phenyl; X1 is —O—, —SO0-2—, —NR12—, —NCOR12— or —NR12SO2R15; is X2 is —O—, —S— or optionally substituted nitrogen; Y is ═O, ═S or ═NR11; Y1 is H, alkyl, —NR17R13, —SCH3, R19-aryl(CH2)n6—, R19-heteroaryl-(CH2)n6—, —(CH2)n6-heterocycloalkyl, -alkyl-NH—C(O)O-alkyl or —NHC(O)R15; R1, R2, R3 and R7 are H, alkyl, OH-alkyl, cycloalkyl, —CHF2, —CH2F or —CF3; or R1 and R2 form an alkylene ring; or R1 and R2 together are ═O; R6 is H, alkyl, —OR13 or —SR12; and the remaining variables are as defined in the specification, is disclosed, as well as a pharmaceutical compositions comprising said compound, methods of using said compound as a neurokinin antagonist, and the combination of said compounds with a selective serotonin reuptake inhibitor.
摘要翻译：由结构式表示的化合物或其药学上可接受的盐，其中Ar 1和Ar 2是任选取代的杂芳基或任选取代的苯基; X 1是-O-，-SOO 2 - ， - NR 12 - ， - NRCOR 12 - 或-NR 12 SO 2 R 15; isX2是-O - ， - S-或任选取代的氮; Y是= O，= S或= NR 11; Y 1是H，烷基，-NR 17 R 13，-SCH 3，R 19 - 芳基（CH 2）n6 - ，R 19 - （CH2）n6-， - （CH2）n6-杂环烷基， - 烷基-NH-C（O）O-烷基或-NHC（O）R15; R1，R2，R3和R7是H，烷基，环烷基，-CHF 2，-CH 2 F或-CF 3; 或R 1和R 2形成亚烷基环; 或R 1和R 2一起为= O; R 6为H，烷基，-OR 13或-SR 12;其余变量如本说明书中所定义，以及包含所述化合物的药物组合物，使用所述化合物的方法作为神经激肽拮抗剂，以及所述化合物与选择性5-羟色胺再摄取抑制剂的组合。

49. 发明授权

US6063926A Substituted oximes as neurokinin antagonists 失效
标题翻译：取代肟作为神经激肽拮抗剂
公开(公告)号：US6063926A
公开(公告)日：2000-05-16
申请号：US195429
申请日：1998-11-18
申请人： Gregory A. Reichard , Cheryl A. Alaimo , Neng-Yang Shih , Pauline C. Ting , Nicholas I. Carruthers , Brian J. Lavey
发明人： Gregory A. Reichard , Cheryl A. Alaimo , Neng-Yang Shih , Pauline C. Ting , Nicholas I. Carruthers , Brian J. Lavey
IPC分类号： C07D211/24 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/76 , C07D211/94 , C07D401/12 , C07D401/14 , C07D417/14 , C07D401/00 , C07D211/26 , C07D211/44 , C07D211/68
CPC分类号： C07D401/12 , C07D211/24 , C07D211/52 , C07D211/58 , C07D211/62 , C07D211/76 , C07D211/94 , C07D401/14 , C07D417/14
摘要： Compounds within the genus represented by the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; ##STR2## R.sup.4 is methyl or ethyl; and Z is substituted piperidinyl.
摘要翻译：由结构式I表示的属的化合物或其药学上可接受的盐，其中：T是取代的苯基或取代的吡啶基; R4是甲基或乙基; Z是取代的哌啶基。

50. 发明授权

US5892039A Piperazino derivatives as neurokinin antagonists 失效
标题翻译：哌嗪衍生物作为神经激肽拮抗剂
公开(公告)号：US5892039A
公开(公告)日：1999-04-06
申请号：US706016
申请日：1996-08-30
申请人： Ho-Jane Shue , Neng-Yang Shih , David J. Blythin , Xiao Chen , John J. Piwinski , Kevin D. McCormick
发明人： Ho-Jane Shue , Neng-Yang Shih , David J. Blythin , Xiao Chen , John J. Piwinski , Kevin D. McCormick
IPC分类号： C07D487/08 , A61K31/40 , A61K31/439 , A61K31/46 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4995 , A61K31/50 , A61K31/501 , A61K31/505 , A61P1/00 , A61P9/00 , A61P11/00 , A61P11/06 , A61P11/14 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/04 , C07D487/18 , C07D401/02
CPC分类号： C07D401/06 , C07D241/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D453/02 , C07D487/04
摘要： The invention relates to compounds of the formula ##STR1## These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
摘要翻译：本发明涉及下式的化合物这些化合物是神经激肽拮抗剂。这些化合物可用于治疗慢性气道疾病如哮喘。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式