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41. 发明申请

US20100143409A1 Generation of virus-like particles and use as panfilovirus vaccines 审中-公开
标题翻译：生成病毒样颗粒并用作泛病毒疫苗
公开(公告)号：US20100143409A1
公开(公告)日：2010-06-10
申请号：US12590368
申请日：2009-11-06
申请人： Sina Bavari , M. Javad Aman , Alan L. Schmaljohn , Kelly L. Warfield , Dana Swenson
发明人： Sina Bavari , M. Javad Aman , Alan L. Schmaljohn , Kelly L. Warfield , Dana Swenson
IPC分类号： A61K39/12 , C12Q1/70 , C12N7/00 , C12N7/04 , C12N5/00 , C12N5/02 , C07K14/00
CPC分类号： C12N7/00 , A61K31/365 , A61K31/7048 , A61K31/724 , A61K2039/525 , C12N2760/14123 , C12N2760/14223
摘要： In this application are described filovirus-like particles for both Ebola and Marburg and their use as a diagnostic and therapeutic agent as well as a filovirus vaccine. Also described is the association of Ebola and Marburg with lipid rafts during assembly and budding, and the requirement of functional rafts for entry of filoviruses into cells.
摘要翻译：在本申请中描述了用于埃博拉和马尔堡的类病毒颗粒，以及它们作为诊断和治疗剂以及粉状病毒疫苗的用途。还描述了埃博拉和马尔堡在组装和萌芽期间与脂筏的关系，以及功能性筏对于将细菌进入细胞的要求。

42. 发明授权

US07682618B2 Generation of virus-like particles and use as panfilovirus vaccine 失效
标题翻译：生成病毒样颗粒并用作泛病毒疫苗
公开(公告)号：US07682618B2
公开(公告)日：2010-03-23
申请号：US11105031
申请日：2005-04-13
申请人： Sina Bavari , M. Javad Aman , Alan L. Schmaljohn , Kelly L. Warfield , Dana Swenson
发明人： Sina Bavari , M. Javad Aman , Alan L. Schmaljohn , Kelly L. Warfield , Dana Swenson
IPC分类号： A61K39/12 , C12Q1/70 , C12N7/00 , C12N5/10
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , C12N7/00 , C12N2760/14122 , C12N2760/14123 , C12N2760/14134 , C12N2760/14145 , C12N2760/14222 , C12N2760/14223 , C12N2760/14234 , C12N2760/14245 , C12N2810/60
摘要： In this application are described filovirus-like particles for both Ebola and Marburg and their use as a diagnostic and therapeutic agent as well as a filovirus vaccine. Also described is the association of Ebola and Marburg with lipid rafts during assembly and budding, and the requirement of functional rafts for entry of filoviruses into cells.
摘要翻译：在本申请中描述了用于埃博拉和马尔堡的类病毒颗粒，以及它们作为诊断和治疗剂以及粉状病毒疫苗的用途。还描述了埃博拉和马尔堡在组装和萌芽期间与脂筏的关系，以及功能性筏对于将细菌进入细胞的要求。

43. 发明申请

US20090186849A1 ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING A FILOVIRUS INFECTION 有权
公开(公告)号：US20090186849A1
公开(公告)日：2009-07-23
申请号：US12402464
申请日：2009-03-11
申请人： David A. Stein , Patrick L. Iversen , Sina Bavari , Dwight D. Weller
发明人： David A. Stein , Patrick L. Iversen , Sina Bavari , Dwight D. Weller
IPC分类号： A61K31/7088
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/31 , C12N2310/32 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the Ebola virus AUG start site region of VP24; ii) the Ebola virus AUG start site region of VP35; iii) the Marburg virus AUG start site region of VP24; or iv) the Marburg virus AUG start site region of NP.

44. 发明申请

US20060205693A1 Antisense antiviral compounds and methods for treating a filovirus infection 有权
标题翻译：反义抗病毒化合物和治疗病毒感染的方法
公开(公告)号：US20060205693A1
公开(公告)日：2006-09-14
申请号：US11264444
申请日：2005-10-31
申请人： David Stein , Patrick Iversen , Sina Bavari
发明人： David Stein , Patrick Iversen , Sina Bavari
IPC分类号： A61K48/00
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/31 , C12N2310/32 , C12N2310/3513
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Filoviridae family, and in the treatment of a viral infection. The compounds and methods relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having: a) a nuclease resistant backbone, b) 15-40 nucleotide bases, and c) a targeting sequence of at least 15 bases in length that hybridizes to a target region selected from the following: i) the AUG start site region of VP35, as exemplified by antisense compounds SEQ ID NO:21-26, ii) the AUG start site region of VP24, as exemplified by antisense compound SEQ ID NO:34, iii) the region 85 to 65 base pairs upstream of the AUG start site of VP24, as exemplified by SEQ ID NO:39, iv) the AUG start site region of polymerase L, as exemplified by antisense compound SEQ ID NO: 17, and v) combinations of (i), (ii), (iii), and/or (iv).
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制丝状病毒科病毒生长和用于病毒感染治疗中的用途和生产方法。该化合物和方法涉及哺乳动物中的病毒感染的治疗，包括埃博拉和马尔堡病毒的灵长类动物。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有：a）核酸酶抗性主链，b）15-40个核苷酸碱基，和c）长度为至少15个碱基的靶向序列与选自以下的靶区域杂交： i）VP35的AUG起始位点区域，如反义化合物SEQ ID NO：21-26所示，ii）VP24的AUG起始位点区域，如反义化合物SEQ ID NO：34所示，iii）区域85至 VP24的AUG起始位点上游65个碱基对，如SEQ ID NO：39所示，iv）聚合酶L的AUG起始位点区域，如反义化合物SEQ ID NO：17所示，v）（i ），（ii），（iii）和/或（iv）。

45. 发明授权

US06713284B2 Bacterial superantigen vaccines 失效
标题翻译：细菌超抗原疫苗
公开(公告)号：US06713284B2
公开(公告)日：2004-03-30
申请号：US08882431
申请日：1997-06-25
申请人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
发明人： Robert G. Ulrich , Mark A. Olson , Sina Bavari
IPC分类号： C12N1509
CPC分类号： C07K14/31
摘要： The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.
摘要翻译：本发明涉及遗传减毒的超抗原毒素疫苗改变，使得超抗原属性不存在，然而有效识别超抗原并产生适当的免疫应答。显示减毒的超抗原毒素保护动物免受野生型毒素的攻击。描述了生产和使用改变的超抗原毒素的方法。

46. 发明申请

US20170274063A1 THERMOSTABLE, CHROMATOGRAPHICALLY PURIFIED NANO-VLP VACCINE 审中-公开
公开(公告)号：US20170274063A1
公开(公告)日：2017-09-28
申请号：US15508719
申请日：2015-08-07
申请人： John Howard CARRA , Sina BAVARI , David HONE , U.S ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES DEPARTMENT OF THE ARMY
发明人： John Howard Carra , Sina Bavari , David Hone
IPC分类号： A61K39/12 , G01N30/86 , G01N30/02 , A61K9/51 , A61K39/295
CPC分类号： A61K39/12 , A61K9/5184 , A61K39/295 , A61K2039/55561 , C12N2760/14123 , C12N2760/14134 , G01N30/02 , G01N30/8617 , G01N2030/022
摘要： In this application is described a method for preparing nano-VLP composition, thereby permitting purification using chromatography and filtration. The nano-VLP composition has a more uniform size range of filovirus particles, roughly 230 nm diameter, allowing ease of manipulation of the composition, while retaining GP conformational integrity and the antigenic effectiveness of the vaccine. Additionally, the nano-VLP can be lyophilized without loss of nano-VLP structure, or GP immunogenicity. Lyophilized nano-VLP have greatly enhanced thermostability, allowing the creation of a filovirus nano-VLP vaccine without a cold chain requirement.

47. 发明授权

US09597326B2 Benzonapthyridine compositions and uses thereof 有权
公开(公告)号：US09597326B2
公开(公告)日：2017-03-21
申请号：US13640832
申请日：2011-04-13
申请人： Gillis Otten , Tom Yao-Hsiang Wu , Travis K. Warren , Sina Bavari
发明人： Gillis Otten , Tom Yao-Hsiang Wu , Travis K. Warren , Sina Bavari
IPC分类号： A61K31/4745 , A61K31/4375 , A61K33/06 , A61K38/16
CPC分类号： A61K31/4745 , A61K31/4375 , A61K33/06 , A61K38/162 , A61K2300/00
摘要： The present invention generally relates to compositions comprising benzonapthyridine small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject that has had pre- or post-exposure to a pathogen such as hemorrhagic fever virus. Also provided are methods of preparing and using the SMIP compositions of the invention.

48. 发明授权

US09347951B2 Fusion protein comprising the extracellular domain of a filovirus glycoprotein fused to an immunoglobulin heavy chain constant region 有权
标题翻译：融合蛋白包含与免疫球蛋白重链恒定区融合的病毒糖蛋白的细胞外结构域
公开(公告)号：US09347951B2
公开(公告)日：2016-05-24
申请号：US13882041
申请日：2011-10-28
申请人： Gerardo Kaplan , Krishnamurthy Konduru , Jerome Jacques , Sina Bavari , Steven Bradfute
发明人： Gerardo Kaplan , Krishnamurthy Konduru , Jerome Jacques , Sina Bavari , Steven Bradfute
IPC分类号： G01N33/68 , A61K39/12 , G01N33/569 , C07K14/005 , A61K39/00
CPC分类号： G01N33/6854 , A61K39/12 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6056 , C07K14/005 , C07K2319/30 , C07K2319/43 , C12N2760/14122 , C12N2760/14134 , G01N33/56983 , G01N2333/08 , G01N2469/20 , G01N2800/26
摘要： This invention provides fusion proteins comprising a Filovirus glycoprotein segment and an immunoglobulin polypeptide segment. The fusion proteins are useful in immunogenic compositions to protect against infections by Filoviruses, such as Ebola virus, in both humans and non-human animals. The fusion proteins are also useful in diagnostic assays to detect Filovirus infections.
摘要翻译：本发明提供包含病毒糖蛋白片段和免疫球蛋白多肽片段的融合蛋白。融合蛋白可用于免疫原性组合物中，以防止人类和非人类动物中的诸如埃博拉病毒之类的病毒如伊洛韦病毒感染。融合蛋白也可用于诊断测定法以检测病毒感染。

49. 发明授权

US08936915B2 Cleavage sensitive antibodies and methods of use thereof 有权
标题翻译：切割敏感抗体及其使用方法
公开(公告)号：US08936915B2
公开(公告)日：2015-01-20
申请号：US13387124
申请日：2010-08-17
申请人： Sina Bavari , Jonathan E. Nuss
发明人： Sina Bavari , Jonathan E. Nuss
IPC分类号： G01N33/53 , C07K16/28 , C12Q1/37 , G01N33/68
CPC分类号： C07K16/28 , C07K2317/34 , C12Q1/37 , G01N33/6854 , G01N2333/33
摘要： We disclose cleavage-sensitive antibodies with epitopes spanning the scissile bond of the toxins molecular target protein, enabling toxin-associated proteolysis to be measured in a variety of assay formats.
摘要翻译：我们公开了具有跨毒素分子靶蛋白的剪切键的表位的切割敏感性抗体，能够以多种测定形式测量毒素相关的蛋白水解。

50. 发明申请

US20130122042A1 BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF 有权
标题翻译：苯并噻唑组合物及其用途
公开(公告)号：US20130122042A1
公开(公告)日：2013-05-16
申请号：US13640832
申请日：2011-04-13
申请人： Gillis Otten , Tom Yao-Hsiang Wu , Travis K. Warren , Sina Bavari
发明人： Gillis Otten , Tom Yao-Hsiang Wu , Travis K. Warren , Sina Bavari
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K31/4375 , A61K33/06 , A61K38/162 , A61K2300/00
摘要： The present invention generally relates to compositions comprising benzonapthyridine small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject that has had pre- or post-exposure to a pathogen such as hemorrhagic fever virus. Also provided are methods of preparing and using the SMIP compositions of the invention.
摘要翻译：本发明一般涉及能够刺激或调节暴露于病原体如出血热病毒之前或之后的受试者中的免疫应答的苯并萘啶小分子免疫增强剂（SMIP）的组合物。还提供了制备和使用本发明的SMIP组合物的方法。

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