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41. 发明申请

US20150056232A1 RECOMBINANT BACTERIUM FOR INDUCTION OF CELLULAR IMMUNE RESPONSE 审中-公开
标题翻译：用于诱导细胞免疫应答的重组细菌
公开(公告)号：US20150056232A1
公开(公告)日：2015-02-26
申请号：US14390306
申请日：2013-03-14
申请人： Roy Curtiss, III
发明人： Roy Curtiss, III
IPC分类号： C12N15/74 , A61K39/145 , A61K39/04 , C12N15/70
CPC分类号： C12N15/74 , A61K39/00 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/522 , A61K2039/523 , A61K2039/542 , C12N15/09 , C12N15/70 , C12N15/746 , C12N2760/16134
摘要： The present invention provides a recombinant bacterium and methods of using the recombinant bacterium to induce a cellular immune response.
摘要翻译：本发明提供重组细菌和使用重组细菌诱导细胞免疫应答的方法。

42. 发明授权

US08445254B2 Regulated expression of antigen and/or regulated attentuation to enhance vaccine immunogenicity and/or safety 有权
标题翻译：抗原的调节表达和/或调节注意力以增强疫苗免疫原性和/或安全性
公开(公告)号：US08445254B2
公开(公告)日：2013-05-21
申请号：US12615872
申请日：2009-11-10
申请人： Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
发明人： Roy Curtiss, III , Shifeng Wang , Soo-Young Wanda , Wei Kong
IPC分类号： C12N1/20
CPC分类号： C12N15/74 , A61K35/74 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , C12N1/36
摘要： The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
摘要翻译：本发明涉及用于制备和使用重组细菌的组合物和方法，所述重组细菌能够调节一种或多种感兴趣的抗原的减弱和/或调控表达。

43. 发明申请

US20130004537A1 BACTERIUM COMPRISING A REGULATED rfaH NUCLEIC ACID 有权
标题翻译：包含调节的rfaH核酸的细菌
公开(公告)号：US20130004537A1
公开(公告)日：2013-01-03
申请号：US13574718
申请日：2011-01-21
申请人： Roy Curtiss, III , Qingke Kong
发明人： Roy Curtiss, III , Qingke Kong
IPC分类号： C12N1/21 , A61P37/04 , A61K39/02
CPC分类号： C07K14/3156 , A61K39/0275 , A61K39/092 , A61K2039/522 , A61K2039/523 , C07K14/255 , C12N1/36 , C12N9/1048 , Y02A50/47 , Y02A50/482
摘要： The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present invention encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and a regulated rfc nucleic acid, while additional embodiments encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and at least one nucleic acid encoding at least one exogenous antigen.
摘要翻译：本发明包括包含调节的rfaH核酸的重组细菌，以及包含所述重组细菌的疫苗。本发明的其它实施方案包括包含调节的rfaH核酸和调节的rfc核酸的重组细菌，而另外的实施方案包括包含调节的rfaH核酸和至少一种编码至少一种外源抗原的核酸的重组细菌。

44. 发明授权

US08133493B2 Regulated attenuation of live vaccines to enhance cross-protective immunogenicity 有权
标题翻译：活疫苗的调节减毒以增强交叉保护性免疫原性
公开(公告)号：US08133493B2
公开(公告)日：2012-03-13
申请号：US10511616
申请日：2003-04-15
申请人： Roy Curtiss, III
发明人： Roy Curtiss, III
IPC分类号： A61K39/02 , A61K39/112 , A61K45/00 , G01N33/569 , C12P1/00
CPC分类号： C12N1/36 , A61K39/0258 , A61K39/0275 , A61K2039/522 , C07K14/255 , C12N15/74 , Y02A50/474 , Y02A50/482
摘要： A live attenuated derivative of a pathogenic bacterium intended for use as a vaccine.
摘要翻译：用作疫苗的致病菌的活减毒衍生物。

45. 发明申请

US20110287052A1 RECOMBINANT BACTERIUM CAPABLE OF ELICITING AN IMMUNE RESPONSE AGAINST STREPTOCOCCUS PNEUMONIAE 有权
标题翻译：能够应对针对肺结核的免疫应答的重组细菌
公开(公告)号：US20110287052A1
公开(公告)日：2011-11-24
申请号：US13088141
申请日：2011-04-15
申请人： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
发明人： Roy Curtiss, III , Javier Santander-Morales , Soo-Young Wanda , Shifeng Wang , Karen Brenneman , Huoying Shi , Wei Xin , Qingke Kong
IPC分类号： A61K39/09 , A61P31/04 , C12N1/21
CPC分类号： A61K39/092 , A61K2039/522 , A61K2039/523 , Y02A50/484
摘要： The invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.
摘要翻译：本发明包括能够引起针对肺炎链球菌的免疫应答的重组细菌，包含该细菌的疫苗以及使用该细菌的方法。

46. 发明申请

US20100303863A1 RECOMBINANT EDWARDSIELLA BACTERIUM 有权
标题翻译：重组EDWARDSIELLA BACTERIUM
公开(公告)号：US20100303863A1
公开(公告)日：2010-12-02
申请号：US12789869
申请日：2010-05-28
申请人： Roy Curtiss, III , Javier Santander
发明人： Roy Curtiss, III , Javier Santander
IPC分类号： A61K39/02 , C12N1/21 , A61P31/04 , A61P31/10 , A61P33/00 , A61P31/12
CPC分类号： C12N1/36 , A61K39/02 , A61K2039/523 , C07K14/24
摘要： The present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.
摘要翻译：本发明包括重组爱德华氏菌，其组合物及其使用方法。

47. 发明申请

US20100285592A1 SINGLE EXPRESSION VECTOR FOR GENERATION OF A VIRUS WITH A SEGMENTED GENOME 有权
标题翻译：用于产生具有分离基因的病毒的单个表达载体
公开(公告)号：US20100285592A1
公开(公告)日：2010-11-11
申请号：US12759842
申请日：2010-04-14
申请人： Roy Curtiss, III , Xiangmin Zhang
发明人： Roy Curtiss, III , Xiangmin Zhang
IPC分类号： C12N15/64 , C12N15/63
CPC分类号： C12N7/00 , C07K14/005 , C12N15/85 , C12N2760/16051 , C12N2760/16122 , C12N2760/16151 , C12N2800/103 , C12N2830/36 , C12N2840/20
摘要： The present invention encompasses an expression vector that is capable of generating a virus from a segmented genome. In particular, a single expression vector may be utilized to produce influenza virus in cultured cells. The expression vector can be delivered in a purified DNA form or by a suitably designed bacterial carrier to cells in culture or to animals. This invention increases the virus generation efficiency, which benefits vaccine development. The bacterial carrier harboring such a plasmid encoding an attenuated virus may be used as a vaccine against corresponding viral disease.
摘要翻译：本发明包括能够从分段基因组产生病毒的表达载体。特别地，单个表达载体可用于在培养的细胞中产生流感病毒。表达载体可以纯化的DNA形式或适当设计的细菌载体递送至培养物或动物细胞。本发明增加病毒生成效率，有利于疫苗开发。携带这种编码减毒病毒的质粒的细菌载体可以用作针对相应病毒性疾病的疫苗。

48. 发明授权

US07195757B2 Modulation of immune responses to foreign antigens expressed by recombinant attenuated bacterial vectors 有权
标题翻译：调节由重组减毒细菌载体表达的对外源抗原的免疫应答
公开(公告)号：US07195757B2
公开(公告)日：2007-03-27
申请号：US10414533
申请日：2003-04-15
申请人： Roy Curtiss, III , Ho Young Kang
发明人： Roy Curtiss, III , Ho Young Kang
IPC分类号： A01N63/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/523 , Y02A50/482
摘要： The present invention relates to immunogenic compositions comprising a live attenuated derivative of a pathogenic Enterobacteriaceae bacteria. The attenuated derivative of a pathogenic Enterobacteriaceae bacteria comprises a polynucleotide that encodes a foreign antigen. The attenuated derivative of the pathogenic Enterobacteriaceae bacteria has increased expression of Type 1 fimbriae relative to the pathogenic Enterobacteriaceae bacteria from which the attenuated derivative was derived. The present invention also relates to immunogenic compositions that elicit an enhanced Th2 immune response in an individual. The present invention further provides a method of modulating the immune response of an individual comprising administering to said individual the immunogenic compositions of the present invention.
摘要翻译：本发明涉及包含致病性肠杆菌科细菌的活减毒衍生物的免疫原性组合物。致病性肠杆菌科细菌的减毒衍生物包含编码外源抗原的多核苷酸。致病性肠杆菌科细菌的减毒衍生物相对于衍生衍生物的致病性肠杆菌科细菌，增加了1型菌毛的表达。本发明还涉及在个体中引起增强的Th2免疫应答的免疫原性组合物。本发明还提供调节个体的免疫应答的方法，包括向所述个体施用本发明的免疫原性组合物。

49. 发明授权

US5888799A Recombinant avirulent bacterial antigen delivery system 失效
标题翻译：重组无毒性细菌抗原递送系统
公开(公告)号：US5888799A
公开(公告)日：1999-03-30
申请号：US236941
申请日：1994-05-02
申请人： Roy Curtiss, III
发明人： Roy Curtiss, III
IPC分类号： C07K14/195 , C07K14/315 , C12N1/21 , C12N9/10 , C12P21/00 , C12N1/20 , C12N1/00 , A61K39/108 , A61K39/112
CPC分类号： A61K39/0275 , A61K39/092 , C07K14/195 , C07K14/315 , C12N9/1051 , C12P21/00 , A61K2039/523 , A61K2039/542
摘要： This invention relates to a vaccine for the immunization of a vertebrate, comprising:an avirulent derivative of a pathogenic microbe that expresses a recombinant gene derived from a pathogen of said vertebrate it being provided that said avirulent microbe does not normally exchange genetic material with said pathogen, to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.
摘要翻译：本发明涉及用于免疫脊椎动物的疫苗，其包含：表达源自所述脊椎动物的病原体的重组基因的致病微生物的无毒性衍生物，其中所述无毒力微生物通常不与所述病原体交换遗传物质以产生能够在所述脊椎动物中针对所述病原体诱导免疫应答的抗原。

50. 发明授权

US5424065A Vaccines containing avirulent phop-type microorganisms 失效
标题翻译：含有无毒phop型微生物的疫苗
公开(公告)号：US5424065A
公开(公告)日：1995-06-13
申请号：US981935
申请日：1992-11-19
申请人： Roy Curtiss, III , Jorge Galan
发明人： Roy Curtiss, III , Jorge Galan
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , C07K14/255 , C12N1/21 , C12N9/02 , C12N9/16 , C12N15/62 , C12N15/65 , C12N15/74 , C12R1/42
CPC分类号： C12R1/42 , A61K39/0275 , C07K14/255 , C12N15/625 , C12N15/65 , C12N15/74 , C12N9/0008 , C12N9/16 , C12Y102/01011 , A61K2039/522 , C07K2319/00 , C07K2319/02 , C07K2319/034 , C07K2319/40
摘要： The phoP gene and its equivalents are of a type which have "global regulation of pathogenicity", i.e., they coordinately regulate a number of genes including those that encode bacterial virulence factors. In Salmonella, the phoP gene product also controls the expression of non-specific acid phosphatase from the phoN gene. A central feature of the invention are microorganisms which are avirulent as a result, in whole or in part, of a mutation in phoP, but which retain their immunogenicity. These cells are suitable as components of live vaccines.
摘要翻译： phoP基因及其等同物是具有“致病性的全局调节”的类型，即它们协调地调节许多基因，包括编码细菌毒力因子的基因。在沙门氏菌中，phoP基因产物也控制来自phoN基因的非特异性酸性磷酸酶的表达。本发明的中心特征是微生物，其全部或部分无光毒性，其在phoP中的突变，但保留其免疫原性。这些细胞适合作为活疫苗的组分。

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