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41. 发明授权

US5503632A Electrotransport device having improved cathodic electrode assembly 失效
标题翻译：具有改进的阴极电极组件的电子运输装置
公开(公告)号：US5503632A
公开(公告)日：1996-04-02
申请号：US225125
申请日：1994-04-08
申请人： Ronald P. Haak
发明人： Ronald P. Haak
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/0444
摘要： An improved cathodic iontophoresis electrode assembly (8, 38) is provided having a reducible cathodic electrode (12,22) and a drug reservoir (14, 24) containing an anionic drug. The cathodic electrode (12, 22) is separated from the drug reservoir (14, 24) by means of a layer (30) of a cation exchange material. The cation exchange material is loaded with cations which are able to react with anions produced during reduction of the electrode (12, 22) to form an electrically neutral or substantially insoluble (eg, water insoluble) compound. The cathodic electrode (12, 22) is preferably composed of silver chloride which produces chloride ions during reduction. The cation exchange material is preferably loaded with silver or copper cations which react with the chloride ions to produce a neutral and relatively insoluble metal chloride salt.
摘要翻译：提供了一种改进的阴极离子电渗电极组件（8,38），其具有可还原阴极电极（12,22）和含有阴离子药物的药物储存器（14,24）。阴极电极（12,22）通过阳离子交换材料层（30）与药物储存器（14,24）分离。阳离子交换材料装载有能够在还原电极（12,22）期间产生的阴离子反应以形成电中性或基本上不溶的（例如水不溶性）化合物的阳离子。阴极电极（12,22）优选由还原期间产生氯离子的氯化银构成。阳离子交换材料优选负载有与氯离子反应产生中性和相对不溶性金属氯化物盐的银或铜阳离子。

42. 发明授权

US5445606A Indicator for iontophoresis system 失效
标题翻译：离子电渗系统指示剂
公开(公告)号：US5445606A
公开(公告)日：1995-08-29
申请号：US69061
申请日：1993-05-28
申请人： Ronald P. Haak , Felix Theeuwes , David K. Roe
发明人： Ronald P. Haak , Felix Theeuwes , David K. Roe
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0448 , A61N1/325 , A61N1/0436 , A61N1/044
摘要： Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and displaying the cumulative amount of the medicament delivered to the body by monitoring the amount of a metal, initially present at the anode (45), that is transferred to the cathode (41) in a subsidiary electrolyte cell (47) through which the drive current for the apparatus (11) passes. Optionally, the apparatus also provides a plurality of light emitting devices (63-1) that display a measure of the cumulative amount of medicament delivered, by use of visually distinguishable light colors or by use of binary encoding in the light display.
摘要翻译：提供了用于通过离子电渗法将药物，药物或其它治疗剂透皮地递送到身体的装置（11）。装置（11）提供了一种装置（13），用于通过监测最初存在于阳极（45）的金属的量来测量和显示递送到身体的药物的累积量，该金属的量转移到阴极（41））连接在辅助电解质电池（47）中，用于装置（11）的驱动电流通过该辅助电解质电池（47）。可选地，该装置还提供多个发光装置（63-1），其通过使用视觉上可区分的光色或通过在光显示器中使用二进制编码来显示传送的药物的累积量的量度。

43. 发明授权

US5374242A Iontophoretic delivery device and power supply therefor 失效
标题翻译：离子渗透输送装置及其电源
公开(公告)号：US5374242A
公开(公告)日：1994-12-20
申请号：US164663
申请日：1993-12-07
申请人： Ronald P. Haak , Larry A. Mc Nichols , John D. Badzinski
发明人： Ronald P. Haak , Larry A. Mc Nichols , John D. Badzinski
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoretic drug-delivery device incorporating a power supply which minimizes the cost of the batteries needed by operating the batteries in a series configuration at the start of delivery, when the patient's skin resistance is high, and by switching the batteries into a parallel configuration when skin resistance drops. An automatic switching circuit for achieving this transition is included.
摘要翻译：一种离子电渗药物输送装置，其包含电源，其在患者开始输送时，当患者的皮肤电阻高时将串联配置中的电池操作所需的电池成本最小化，并且通过将电池切换成并行配置，皮肤阻力下降。包括用于实现该转换的自动切换电路。

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