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41. 发明申请

US20070208155A1 Hybrid polymer materials from reactive extrusion for medical devices 有权
标题翻译：用于医疗器械的反应挤出的混合聚合物材料
公开(公告)号：US20070208155A1
公开(公告)日：2007-09-06
申请号：US11366230
申请日：2006-03-02
申请人： Michele Zoromski , Liliana Atanasoska , Robert Warner
发明人： Michele Zoromski , Liliana Atanasoska , Robert Warner
IPC分类号： C08G77/42 , C08G65/336
CPC分类号： C08G77/42 , A61L27/26 , A61L27/34 , A61L29/049 , A61L29/085 , A61L31/041 , A61L31/10 , C08L51/06 , C08L83/10
摘要： The present disclosure relates to hybrid polymers, methods of making such hybrid polymers, and medical devices that include the hybrid polymers. Such hybrid polymers are suitable for forming biomaterials in a predetermined shape for use in medical devices and medical device components. The hybrid polymers of the present disclosure are formed through a reactive extrusion process prior to being formed into the predetermined shape of the medical device or medical device component.
摘要翻译：本公开涉及混合聚合物，制备这种杂化聚合物的方法，以及包括杂化聚合物的医疗装置。这样的混合聚合物适用于形成用于医疗装置和医疗装置部件的预定形状的生物材料。本公开的混合聚合物在形成医疗装置或医疗装置部件的预定形状之前通过反应性挤出工艺形成。

42. 发明申请

US20070149743A1 Polymeric hybrid precursors, polymeric hybrid precursor composite matrices, medical devices, and methods 有权
标题翻译：聚合杂化前体，聚合混合前体复合基质，医疗器械和方法
公开(公告)号：US20070149743A1
公开(公告)日：2007-06-28
申请号：US11317613
申请日：2005-12-23
申请人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Robert Warner
发明人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Robert Warner
IPC分类号： C08G77/04 , C08L83/04
CPC分类号： C08G18/718 , A61L27/48 , C08G18/4854 , C08G77/458 , C08G2270/00 , C08L83/14 , C08L83/16 , Y10S528/901 , C08L83/04 , C08L77/00
摘要： Polymeric hybrid precursors, mixtures of polymeric hybrid precursors and polymers, and polymer composite matrices prepared from the mixture of the polymeric hybrid precursors and the polymer. The mixture of the polymeric hybrid precursors and the polymer can undergo a process to form the polymer composite matrix having a cross-linked network of a silasesquioxane based polymer formed from the polymeric hybrid precursors that interpenetrates the polymer. The polymeric hybrid precursors include chemical linkage moieties that are capable of forming non-covalent bonds with portions of the polymer. The polymer composite matrices are useful as biomaterials in medical devices.
摘要翻译：聚合杂化前体，聚合杂化前体和聚合物的混合物以及由聚合物混合前体和聚合物的混合物制备的聚合物复合基体。聚合物混合前体和聚合物的混合物可以经历形成聚合物复合基质的方法，该聚合物复合基质具有由互穿聚合物的聚合杂化前体形成的硅烷基倍半硅烷基聚合物的交联网络。聚合物混合前体包括能够与部分聚合物形成非共价键的化学连接部分。聚合物复合基质可用作医疗器械中的生物材料。

43. 发明申请

US20070072978A1 Organic-inorganic hybrid particle material and polymer compositions containing same 有权
标题翻译：有机 - 无机杂化颗粒材料和含有它们的聚合物组合物
公开(公告)号：US20070072978A1
公开(公告)日：2007-03-29
申请号：US11235743
申请日：2005-09-27
申请人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Mark Wolters , Robert Warner
发明人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Mark Wolters , Robert Warner
IPC分类号： B05D7/00 , C08K3/22
CPC分类号： A61L27/427 , A61L31/124 , C08G77/458 , Y10T428/2982
摘要： Particulate materials useful as fillers, reinforcing agents, radioopacifiers, or impact modifiers. The particulate material has an average particle size range of about 10,000 nm or less and comprises an organic-inorganic hybrid material that has a ceramic material network having organic polymer segments distributed throughout the ceramic network. The ceramic network may be prepared by a sol-gel technique. The particulate material may be compounded in thermoplastic polymer compositions useful in a variety of applications such as preparation of medical device components.
摘要翻译：可用作填料，增强剂，放射线光刻胶或抗冲改性剂的颗粒材料。颗粒材料具有约10,000nm或更小的平均粒度范围，并且包含具有分布在整个陶瓷网络中的有机聚合物链段的陶瓷材料网络的有机 - 无机混合材料。陶瓷网络可以通过溶胶 - 凝胶技术制备。颗粒材料可以在可用于各种应用的热塑性聚合物组合物中复合，例如制备医疗装置组分。

44. 发明申请

US20050103577A1 Elevator door safety control device 审中-公开
标题翻译：电梯门安全控制装置
公开(公告)号：US20050103577A1
公开(公告)日：2005-05-19
申请号：US10715849
申请日：2003-11-19
申请人： Robert Warner
发明人： Robert Warner
IPC分类号： B66B13/26
CPC分类号： B66B13/26
摘要： An elevator door closure control system and method are provided and include an elevator light screen signal detector module having first and second electrical connectors, a signal detection element configured to detect a carrier wave control signal and output a signal in response thereto, and a switch configured to change from a first state to a second state (or vice versa) in response to a signal detection element output signal or a control signal from a controller. The electrical connectors permit connection of the module to a light screen receiver array output and an elevator door controller input so as to place the switch in series with the receiver array output. The switch second state causes, in one aspect, the elevator doors to remain open for a preset time or until the light source array detects the arrival of an appliance, person, or object in its beam path(s).
摘要翻译：提供了一种电梯门关闭控制系统和方法，包括具有第一和第二电连接器的电梯光屏信号检测器模块，被配置为检测载波控制信号并响应于此输出信号的信号检测元件，以及配置响应于来自控制器的信号检测元件输出信号或控制信号，从第一状态变为第二状态（反之亦然）。电连接器允许模块连接到屏幕接收器阵列输出和电梯门控制器输入，以将开关与接收器阵列输出串联。在一个方面，开关第二状态导致电梯门保持打开预定时间，或者直到光源阵列检测到器具，人或物体到达其光束路径中。

45. 发明授权

US5891134A System and method for applying thermal energy to tissue 失效
标题翻译：将热能施加到组织的系统和方法
公开(公告)号：US5891134A
公开(公告)日：1999-04-06
申请号：US719133
申请日：1996-09-24
申请人： Colin Goble , Robert Warner
发明人： Colin Goble , Robert Warner
IPC分类号： A61B18/04 , A61B18/08 , A61B18/14 , A61B18/16 , A61F7/08 , A61F7/12 , A61N5/00
CPC分类号： A61B18/08 , A61F7/123 , A61B18/14 , A61B2018/00559
摘要： An apparatus, system, and method for treating body tissue using controlled application of heat includes a control unit providing electrical power to a bipolar electrode positioned within an expandable member filled with conductive fluid. Electrical power applied to the bipolar electrode by the control unit causes current to pass from the active electrode, into the conductive fluid, and to the return electrode, thereby heating the conductive fluid. The temperature of the conductive fluid is monitored by the control unit, and power is increased and decreased in accordance with a comparison of the monitored temperature against the desired temperature range. The control unit also includes a pressure sensor for regulating the pressure in the bladder. Pressure and temperature displays and other operator controls are located on the control unit.
摘要翻译：使用受控的加热处理身体组织的装置，系统和方法包括向位于填充有导电流体的可扩张构件内的双极电极提供电力的控制单元。通过控制单元施加到双极性电极的电力使得电流从有源电极传导到导电流体中并返回到返回电极，从而加热导电流体。导电流体的温度由控制单元监控，并且根据所监测的温度与期望的温度范围的比较来提高和降低功率。控制单元还包括用于调节气囊中的压力的压力传感器。压力和温度显示器和其他操作员控制器位于控制单元上。

46. 发明授权

US08507639B2 Radiopaque amide polymers and medical devices formed thereof 有权
标题翻译：不透射线的酰胺聚合物及其形成的医疗器械
公开(公告)号：US08507639B2
公开(公告)日：2013-08-13
申请号：US11519139
申请日：2006-09-11
申请人： Liliana Atanasoska , Scott Schewe , Robert Warner
发明人： Liliana Atanasoska , Scott Schewe , Robert Warner
IPC分类号： C08G69/08
CPC分类号： A61L31/18 , A61L27/18 , A61L27/34 , A61L29/06 , A61L29/085 , A61L29/18 , A61L31/06 , A61L31/10 , C08F20/56 , C08G69/48 , C08L77/12
摘要： Radiopaque polymers have a main chain and a plurality of amide groups which have bound to the amide nitrogen atom thereof an organohalide group that is pendant to the polymer main chain, the organo halide group including one or more iodine and/or bromine atoms thereon. The polymer may be a modified polyamide polymer, copolymer or block copolymer or a modified poly(meth)acrylamide or (meth)acrylamide copolymer or block copolymer. The polymers may be employed in medical devices and are useful for instance to track the movement of a catheter through the body or the inflation of a balloon at a site. The polymers may be made by coupling reactions performed on preexisting amide polymers.
摘要翻译：不透射线聚合物具有主链和多个与其酰胺氮原子结合的酰胺基，该有机卤化物基团垂直于聚合物主链，有机卤化物基团包括一个或多个碘和/或溴原子。聚合物可以是改性聚酰胺聚合物，共聚物或嵌段共聚物或改性聚（甲基）丙烯酰胺或（甲基）丙烯酰胺共聚物或嵌段共聚物。聚合物可以用于医疗装置中，并且可用于例如跟踪导管穿过身体的运动或在现场的气囊膨胀。聚合物可以通过对预先存在的酰胺聚合物进行的偶联反应来制备。

47. 发明授权

US08008395B2 Organic-inorganic hybrid particle material and polymer compositions containing same 有权
标题翻译：有机 - 无机杂化颗粒材料和含有它们的聚合物组合物
公开(公告)号：US08008395B2
公开(公告)日：2011-08-30
申请号：US11235743
申请日：2005-09-27
申请人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Mark Wolters , Robert Warner
发明人： Michele Zoromski , Liliana Atanasoska , Scott Schewe , Mark Wolters , Robert Warner
IPC分类号： C08K3/34 , C08L67/00 , C08G69/26
CPC分类号： A61L27/427 , A61L31/124 , C08G77/458 , Y10T428/2982
摘要： Particulate materials useful as fillers, reinforcing agents, radioopacifiers, or impact modifiers. The particulate material has an average particle size range of about 10,000 nm or less and comprises an organic-inorganic hybrid material that has a ceramic material network having organic polymer segments distributed throughout the ceramic network. The ceramic network may be prepared by a sol-gel technique. The particulate material may be compounded in thermoplastic polymer compositions useful in a variety of applications such as preparation of medical device components.
摘要翻译：可用作填料，增强剂，放射线光刻胶或抗冲改性剂的颗粒材料。颗粒材料具有约10,000nm或更小的平均粒度范围，并且包含具有分布在整个陶瓷网络中的有机聚合物链段的陶瓷材料网络的有机 - 无机混合材料。陶瓷网络可以通过溶胶 - 凝胶技术制备。颗粒材料可以在可用于各种应用的热塑性聚合物组合物中复合，例如制备医疗装置组分。

48. 发明申请

US20110046539A1 INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER 有权
标题翻译：用于与电力来源连接的治疗药物的内部医疗装置
公开(公告)号：US20110046539A1
公开(公告)日：2011-02-24
申请号：US12939363
申请日：2010-11-04
申请人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
发明人： Liliana Atanasoska , Thomas J. Holman , Jan Weber , Robert Warner , Scott Schewe
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/05 , A61N1/306 , A61N1/327
摘要： The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
摘要翻译：本发明一般涉及含有以下物质的内部（例如，可植入，可插入等）药物递送装置：（a）一种或多种一种或多种治疗剂来源; （b）一个或多个第一电极，（c）一个或多个第二电极和（d）用于在第一和第二电极上施加电压的一个或多个电源。电源可以适应于例如促进受试者内的电辅助治疗剂递送，包括电穿孔和/或离子电渗疗法。在本发明的一个方面中，第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间，使得可以产生被引导到组织中的电场。此外，治疗剂源适于将治疗剂引入电场。另一方面，治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。在另一方面，治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。

49. 发明申请

US20080249464A1 Catheter Having Internal Mechanisms to Encourage Balloon Re-folding 有权
标题翻译：具有鼓励气球折叠的内部机制的导管
公开(公告)号：US20080249464A1
公开(公告)日：2008-10-09
申请号：US11697133
申请日：2007-04-05
申请人： Steve M. Spencer , Robert Warner , Victor L. Schoenle , John Blix , Tracee Eidenschink , Matt Heidner
发明人： Steve M. Spencer , Robert Warner , Victor L. Schoenle , John Blix , Tracee Eidenschink , Matt Heidner
IPC分类号： A61M25/10
CPC分类号： A61M25/1002 , A61M25/1009 , A61M25/1027 , A61M25/1034 , A61M25/1038 , A61M2025/1004 , A61M2025/1013 , A61M2025/1075 , A61M2025/1084
摘要： A balloon catheter that comprises an inner shaft, a balloon and a sleeve that defines a lumen. A portion of the inner shaft is positioned within the lumen and the balloon is engaged to the sleeve at least two engagement points.
摘要翻译：气囊导管，其包括限定内腔的内轴，气囊和套筒。内轴的一部分定位在内腔内，气囊与套筒接合至少两个接合点。

50. 发明申请

US20080097396A1 Medical devices and related systems and methods 有权
标题翻译：医疗器械及相关系统及方法
公开(公告)号：US20080097396A1
公开(公告)日：2008-04-24
申请号：US11442756
申请日：2006-05-30
申请人： Steven M. Spencer , Robert Warner , Michael S. Arney , John Blix
发明人： Steven M. Spencer , Robert Warner , Michael S. Arney , John Blix
IPC分类号： A61M25/00 , A61M25/16 , B29D31/00 , B29C67/00
CPC分类号： B29C45/14614 , A61F2/958 , A61M25/0009 , A61M25/0054 , B29C65/42 , B29C65/70 , B29C66/1142 , B29C66/1162 , B29C66/242 , B29C66/24223 , B29C66/24245 , B29C66/24249 , B29C66/5221 , B29C66/53241 , B29C66/5344 , B29C66/63 , B29C66/71 , B29C66/73152 , B29K2995/007 , B29L2022/022 , B29L2023/183 , B29L2023/186 , B29L2031/7542 , B29L2031/7548 , B29K2077/00 , B29K2075/02 , B29K2075/00 , B29K2071/00 , B29K2067/00 , B29K2059/00 , B29K2055/02 , B29K2033/20 , B29K2033/12 , B29K2033/08 , B29K2031/04 , B29K2027/18 , B29K2027/12 , B29K2027/06 , B29K2023/00
摘要： Medical devices including a proximal tubular member, a distal tubular member, and an intermediate tubular member connecting the proximal tubular member to the distal tubular member, and related methods.
摘要翻译：包括近端管状构件，远端管状构件和将近端管状构件连接到远端管状构件的中间管状构件的医疗装置以及相关方法。

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