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41. 发明申请

US20100047795A1 Promoter Variants Of The Alpha-7 Nicotinic Acetylcholine Receptor 有权
标题翻译： α-7烟碱乙酰胆碱受体的启动子变体
公开(公告)号：US20100047795A1
公开(公告)日：2010-02-25
申请号：US12474402
申请日：2009-05-29
申请人： Sherry Leonard , Robert Freedman
发明人： Sherry Leonard , Robert Freedman
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/85 , G01N33/6896 , G01N2333/705 , G01N2800/302
摘要： The present invention is directed to methods and compositions related to α7 acetylcholine nicotinic receptor genes, in particular, the human α7 nicotinic acetylcholine receptor gene. The human α7 nicotinic acetylcholine receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal α7 alleles, as well as methods and compositions for development of therapeutics.
摘要翻译：本发明涉及与α7乙酰胆碱烟碱受体基因，特别是人α7烟碱乙酰胆碱受体基因有关的方法和组合物。人α7烟碱乙酰胆碱受体基因与疾病精神分裂症的病理生理学方面相关。本发明还提供筛选异常α7等位基因群的方法和组合物，以及用于开发治疗剂的方法和组合物。

42. 发明授权

US07624794B2 Non-conductive and non-magnetic flowline for electromagnetic measurements on reservoir fluids at high pressures 失效
标题翻译：用于在高压下对储层流体进行电磁测量的非导电和非磁性流线
公开(公告)号：US07624794B2
公开(公告)日：2009-12-01
申请号：US11419233
申请日：2006-05-19
申请人： Robert Freedman , Krishnamurthy Ganesan , Douglas W. Grant
发明人： Robert Freedman , Krishnamurthy Ganesan , Douglas W. Grant
IPC分类号： E21B47/00
CPC分类号： E21B49/08 , G01V3/32
摘要： An apparatus and method to perform measurements on fluid in a wellbore fluid sample tool in which at least a portion of the flowline of the sample tool is made of a non-magnetic and non-conductive material.
摘要翻译：对井筒流体样品工具中的流体进行测量的装置和方法，其中样品工具的流线的至少一部分由非磁性和非导电材料制成。

43. 发明申请

US20070048727A1 Biliary barrier 审中-公开
标题翻译：胆道屏障
公开(公告)号：US20070048727A1
公开(公告)日：2007-03-01
申请号：US11436042
申请日：2006-05-17
申请人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers , Robert Freedman
发明人： Michael Shuler , Gregory Baxter , Aaron Sin , Andrew Harrison , Scott Meyers , Robert Freedman
IPC分类号： C12M3/00
CPC分类号： C12M23/34 , B01L3/5027 , C12M21/08 , C12M23/16 , C12M23/44 , C12M29/04 , C12M35/08
摘要： Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.
摘要翻译：公开了用于微量药代动力学的系统和方法。各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小室进行体外模拟。与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。流体系统之间的相互作用可以通过微量可渗透构件进行模拟。在一个实例中，可以通过具有通过粘合剂结合到可渗透底物的肝细胞的微量可渗透材料来模拟血液 - 胆汁相互作用。

44. 发明授权

US07091719B2 Method for determining properties of formation fluids 有权
标题翻译：确定地层流体性质的方法
公开(公告)号：US07091719B2
公开(公告)日：2006-08-15
申请号：US10836788
申请日：2004-04-30
申请人： Robert Freedman
发明人： Robert Freedman
IPC分类号： G01V3/00
CPC分类号： G01V11/00
摘要： A method for determining a property of fluids in formations surrounding an earth borehole includes the following steps: producing, from measurements on a multiplicity of fluid samples, a database of stored fluid property training values related to stored fluid measurement training values; deriving, from the database, radial basis function parameters; deriving formation fluid measurement values; and determining, using radial basis function interpolation, the property of formation fluids from values in the database, the parameters, and the derived formation fluid measurement values.
摘要翻译：用于确定围绕地球钻孔的地层中的流体性质的方法包括以下步骤：通过对多个流体样本的测量产生与存储的流体测量训练值相关的存储的流体属性训练值的数据库; 从数据库中推导径向基函数参数; 得出地层流体测量值; 并根据数据库中的数值，参数和导出的地层流体测量值来确定地层流体的性质。

45. 发明授权

US07053611B2 Method and apparatus for using pulsed field gradient NMR measurements to determine fluid properties in a fluid sampling well logging tool 有权
标题翻译：使用脉冲场梯度NMR测量来确定流体采样测井工具中的流体特性的方法和装置
公开(公告)号：US07053611B2
公开(公告)日：2006-05-30
申请号：US10860956
申请日：2004-06-04
申请人： Robert Freedman
发明人： Robert Freedman
IPC分类号： G01V3/00
CPC分类号： G01N24/081 , G01V3/32
摘要： A method for determining a formation fluid property includes acquiring a suite of nuclear magnetic resonance (NMR) measurements of a fluid sample using a pulse sequence that includes pulsed field gradient pulses for encoding diffusion information, wherein each NMR measurement in the suite is acquired with a different value in a parameter in the pulsed field gradient pulses for producing a different diffusion effect, wherein the acquiring is performed in a formation fluid sampling tool in a borehole; inverting the suite of NMR measurements to produce a distribution function that relates diffusion properties of the fluid sample with an NMR property of the fluid sample; and determining the formation fluid property from the distribution function.
摘要翻译：用于确定地层流体性质的方法包括使用包括用于编码扩散信息的脉冲场梯度脉冲的脉冲序列获取流体样品的一套核磁共振（NMR）测量，其中套件中的每个NMR测量采用在用于产生不同扩散效应的脉冲场梯度脉冲中的参数中的不同值，其中所述获取在钻孔中的地层流体采样工具中执行; 将NMR测量结合在一起以产生分布函数，该分布函数将流体样品的扩散性质与流体样品的NMR性质相关联; 并根据分布函数确定地层流体特性。

46. 发明申请

US20050096714A1 Apparatus for altering the body temperature of a patient 有权
标题翻译：用于改变患者体温的装置
公开(公告)号：US20050096714A1
公开(公告)日：2005-05-05
申请号：US10950152
申请日：2004-09-24
申请人： Robert Freedman , Robert Schock , Marc Cote , William Ohley
发明人： Robert Freedman , Robert Schock , Marc Cote , William Ohley
IPC分类号： A61H31/00 , A61B17/00 , A61F7/00 , A61M16/06
CPC分类号： A61F7/02 , A61B2017/00199 , A61F7/00 , A61F7/0053 , A61F2007/0001 , A61F2007/0054 , A61F2007/0056 , A61F2007/0091 , A61F2007/0093 , A61F2007/0296
摘要： An apparatus for adjusting the body temperature of a patient comprises an enclosure defining an interior space for receiving at least a portion of a patient's body therein. The enclosure is adapted for substantially sealingly enclosing the portion of the patient's body within the interior space with the enclosure. Heat transfer liquid may then be circulated through the interior space of the enclosure via an inlet and an outlet for flow over the patient's body in direct liquid contact therewith to promote heat transfer between the patient's body and said heat transfer liquid. The heat transfer liquid may be either warmer or cooler than the patient's body temperature, to either warm or cool the portion. Controlled cooling may be employed to induce therapeutic hypothermia, while controlled warming may be employed to counteract unintended hypothermia. The apparatus further comprises a portable control unit that includes a liquid delivery system, a power source, a control system and a user interface for powering and controlling the liquid delivery system.
摘要翻译：用于调节患者体温的装置包括限定内部空间的外壳，用于在其中接收患者身体的至少一部分。外壳适于基本上密封地将外壳内的空间内的患者身体的部分封闭。传热液体然后可以通过入口和出口循环通过外壳的内部空间，以便与患者的身体直接液体接触，以促进患者身体和所述传热液体之间的热传递。传热液体可以比患者的体温更温暖或更冷，来加热或冷却部分。可采用控制冷却来诱导治疗性低温，同时可采用可控制的温热来抵消非预期的低体温。该装置还包括便携式控制单元，其包括液体输送系统，电源，控制系统和用于为液体输送系统供电和控制的用户界面。

47. 发明授权

US06875606B1 Human α-7 nicotinic receptor promoter 失效
标题翻译：人类α-7烟碱受体启动子
公开(公告)号：US06875606B1
公开(公告)日：2005-04-05
申请号：US08956518
申请日：1997-10-23
申请人： Sherry Leonard , Robert Freedman
发明人： Sherry Leonard , Robert Freedman
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/705 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P19/34 , C12Q1/68 , C07H21/02 , C12N15/11 , C12N15/63 , C12N15/81 , C12N15/85
CPC分类号： C07K14/70571 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： The present invention is directed to methods and compositions related to α7 acetylcholine nicotinic receptor genes, in particular, the human α7 nicotinic acetylcholine receptor gene. This α7 acetylcholine nicotinic receptor gene is associated with the pathophysiological aspects of the disease schizophrenia. The present invention further provides methods and compositions to screen populations for abnormal α7, as well as methods and compositions for development of therapeutics.
摘要翻译：本发明涉及与α7乙酰胆碱烟碱受体基因，特别是人α7烟碱乙酰胆碱受体基因相关的方法和组合物。该α7乙酰胆碱烟碱受体基因与疾病精神分裂症的病理生理学方面相关。本发明还提供筛选异常α7群体的方法和组合物，以及用于开发治疗剂的方法和组合物。

48. 发明授权

US06838875B2 Processing NMR data in the presence of coherent ringing 有权
标题翻译：在相干振铃存在下处理NMR数据
公开(公告)号：US06838875B2
公开(公告)日：2005-01-04
申请号：US10142558
申请日：2002-05-10
申请人： Robert Freedman
发明人： Robert Freedman
IPC分类号： G01R33/44 , G01R33/50 , G01V3/32 , G01V3/00
CPC分类号： G01N24/081 , G01R33/50 , G01V3/32
摘要： A method for processing Nuclear magnetic resonance (NMR) well logging data in the presence of coherent transient signals and offsets is disclosed. The method comprises the addition of R and X-Channel transients and offsets to the relaxation model appropriate for a user selected pulse sequence. The effects of the ringing and offsets are automatically compensated for by fitting R and X-Channel spin-echo data to the relaxation model.

49. 发明授权

US5168234A Method and apparatus for measuring azimuthal as well as longitudinal waves in a formation traversed by a borehole 失效
标题翻译：用于测量AZIMUTHAL的方法和装置，作为一个由BOREHOLE转移的形成的纵向波
公开(公告)号：US5168234A
公开(公告)日：1992-12-01
申请号：US579435
申请日：1990-09-07
申请人： Robert Freedman
发明人： Robert Freedman
IPC分类号： G01V3/30
CPC分类号： G01V3/30
摘要： A new type of microwave azimuthal wave propagation, never before known to exist, provides the basis for a new formation evaluation measurement for Electromagnetic Wave Propagation Tools (EPT). Although prior art tools measure longitudinally propagated waves which propagate in the formation along the direction of the longitudinal axis in the borehole, the newly discovered azimuthal waves propagate in the formation around the borehole. The new azimuthal waves propagate around the borehole like planewaves except for a spreading loss which is independent of the properties of the media. Measurements of phase shifts and attenuation between azimuthally spaced receivers determine formation azimuthal microwave dielectric properties. A new antenna configuration and a new method for determining azimuthal microwave dielectric properties is disclosed in this specification, the antenna configuration alternatingly measuring both longitudinal and azimuthl waves propagation thereby providing a new measurement with extremely high vertical resolution as compared to the resolution obtained by measuring longitudinal waves using prior art EPT tools.

50. 发明授权

US4916616A Self-consistent log interpretation method 失效
标题翻译：自我一致的日志解释方法
公开(公告)号：US4916616A
公开(公告)日：1990-04-10
申请号：US939400
申请日：1986-12-08
申请人： Robert Freedman , John E. Puffer
发明人： Robert Freedman , John E. Puffer
IPC分类号： E21B49/00 , G01V11/00 , G06F17/40
CPC分类号： E21B49/00 , G01V11/00
摘要： Responses of subsurface formations adjacent a well borehole are obtained from a number of types of well logs. The well logs typically include a resistivity log, a gamma ray log, a density log, a neutron log and an induction or electromagnetic wave log. Parameters of interest are determined in evaluating whether the subsurface formations are of interest for petroleum contents by a non-linear programming technique based on the log responses obtained. The parameters of interest are maintained self-consistent, i.e. their contribution to log measurements is based on the same value for the parameter in its effect on each log in which they produce a response.
摘要翻译：从井眼相邻的地下构造的响应是从许多类型的测井得到的。测井通常包括电阻率测井，伽马射线测井仪，密度测井仪，中子测井仪和感应或电磁波测井仪。利用基于所获得的对数响应的非线性规划技术来评估地下构造是否对石油含量感兴趣来确定感兴趣的参数。感兴趣的参数保持自我一致，即它们对日志测量的贡献取决于其在产生响应的每个日志上对其参数的相同值。

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