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41. 发明授权

US08560063B2 Post-defibrillation pacing methods and devices 有权
标题翻译：除颤起搏方法和装置
公开(公告)号：US08560063B2
公开(公告)日：2013-10-15
申请号：US10238343
申请日：2002-09-10
申请人： Raymond E. Ideker , Gregory P. Walcott
发明人： Raymond E. Ideker , Gregory P. Walcott
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3688
摘要： Methods, systems and computer program products for cardiac pacing are provided. A defibrillation shock is applied to a heart of the patient and a pacing stimulation signal is automatically applied to the heart of the patient subsequent to termination of the delivery of the defibrillation shock. The pacing stimulation may be applied to the heart of the patient within about two seconds of termination of the defibrillation shock. The pacing stimulation signal may be applied to the heart of the patient subsequent to termination of the defibrillation shock irrespective of a characterization of electrical activity detected in the heart. The pacing stimulation may be single and/or paired pacing stimulation.
摘要翻译：提供心脏起搏的方法，系统和计算机程序产品。除颤休克被施加到患者的心脏，并且起搏刺激信号在除颤休克的递送终止之后被自动应用于患者的心脏。起搏刺激可以在除颤休克终止后约两秒钟内施加到患者的心脏。除了在心脏中检测到的电活动的表征之外，起搏刺激信号可以在除颤休克终止之后施加到患者的心脏。起搏刺激可以是单次和/或一次的起搏刺激。

42. 发明授权

US07139608B2 Pacing methods and devices using feedback controlled timing 有权
标题翻译：使用反馈控制时序的起搏方法和装置
公开(公告)号：US07139608B2
公开(公告)日：2006-11-21
申请号：US10210587
申请日：2002-07-31
申请人： Raymond E. Ideker , Gregory P. Walcott
发明人： Raymond E. Ideker , Gregory P. Walcott
IPC分类号： A61N1/18
CPC分类号： A61N1/3682 , A61N1/36521 , A61N1/36578 , A61N1/368 , A61N1/3684
摘要： Methods, systems and computer program products for cardiac pacing are provided. For pacing using biventricular synchronization in a patient, a first stimulation signal is applied to a first region of a heart of the patient at a first time and a second stimulation signal applied to a second region of the heart of the patient at a second time to provide biventricular synchronization stimulation of the heart. Cardiac function of the patient associated with application of the first and the second stimulation signals is sensed and a timing relationship of the first stimulation signal to the second stimulation signal is adjusted based on the sensed cardiac function. Additionally, a cardiac timing interval, such as the A-V timing interval, may be adjusted by applying stimulation to a heart of the patient utilizing a cardiac timing interval, detecting a change in cardiac function by sensing cardiac function associated with application of the stimulation using the cardiac timing interval and adjusting the cardiac timing interval directly from the detected change in cardiac function.
摘要翻译：提供心脏起搏的方法，系统和计算机程序产品。对于在患者中使用双心室同步的起搏，第一刺激信号在第一时间施加到患者心脏的第一区域，并且第二刺激信号在第二时间施加到患者心脏的第二区域提供双心室同步刺激的心脏。感测与施加第一和第二刺激信号相关联的患者的心脏功能，并且基于感测到的心脏功能来调整第一刺激信号与第二刺激信号的定时关系。此外，可以通过利用心脏定时间隔对患者的心脏施加刺激来调整心脏定时间隔，例如AV定时间隔，通过感测与应用刺激相关联的心脏功能来检测心脏功能的变化，心脏定时间隔，并且从检测到的心脏功能变化直接调整心脏定时间隔。

43. 发明授权

US07020530B1 Method and apparatus for passive cardiac stimulation 失效
标题翻译：被动心脏刺激的方法和装置
公开(公告)号：US07020530B1
公开(公告)日：2006-03-28
申请号：US10019873
申请日：2000-03-30
申请人： Raymond E. Ideker , Steven D. Girouard
发明人： Raymond E. Ideker , Steven D. Girouard
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/056 , A61N1/36114
摘要： This invention is a passive conductor assembly for use with an implanted device having an intra-cavitarily or trans-venously disposed electrode. The assembly can include electrical components in electrical communication therewith which provide for the manipulation, and/or modification of the electrical stimulus or waveform generated by the implanted stimulus generator, which can be designed, for example, to selectively stimulate only neural tissue, not cardiac tissue or vice versa through the same passive conductor assembly.
摘要翻译：本发明是一种与具有腔内或反静置电极的植入装置一起使用的无源导体组件。组件可以包括与其通信的电气部件，其提供对由植入的刺激发生器产生的电刺激或波形的操纵和/或修改，其可被设计为仅选择性地仅刺激神经组织，而不是心脏组织，反之亦然。

44. 发明授权

US06760621B2 Method for improving cardiac function following delivery of a defibrillation shock 失效
标题翻译：递送除颤休克后改善心脏功能的方法
公开(公告)号：US06760621B2
公开(公告)日：2004-07-06
申请号：US10012115
申请日：2001-11-13
申请人： Gregory P. Walcott , Fred William Chapman , Raymond E. Ideker
发明人： Gregory P. Walcott , Fred William Chapman , Raymond E. Ideker
IPC分类号： A61N139
CPC分类号： A61N1/3962
摘要： A method of reducing the likelihood of pulseless electrical activity (PEA) after defibrillation in a subject comprises administering to a subject afflicted with fibrillation a first treatment waveform, the first treatment waveform insufficient to defibrillate the heart; and then administering to the subject a second treatment waveform that defibrillates the heart and restores organized electrical activity in the heart. The first treatment waveform reduces the likelihood of onset of PEA following the second treatment waveform, as compared to that likelihood which would be present in the absence of the first treatment waveform.
摘要翻译：降低受试者除颤后的无脉动电活动（PEA）的可能性的方法包括向患有纤维性颤动的受试者施用不足以使心脏去纤颤的第一治疗波形的第一治疗波形; 然后向受试者施用除颤心脏并恢复心脏中有组织的电活动的第二治疗波形。与在不存在第一处理波形时将出现的可能性相比，第一处理波形减少了第二处理波形之后的PEA发生的可能性。

45. 发明授权

US06643545B2 Method and apparatus for delivering an optimum shock duration in treating cardiac arrhythmias 失效
标题翻译：用于在治疗心律失常中提供最佳休克持续时间的方法和装置
公开(公告)号：US06643545B2
公开(公告)日：2003-11-04
申请号：US09915898
申请日：2001-07-26
申请人： Raymond E. Ideker , Gregory P. Walcott , Stephen J. Hahn
发明人： Raymond E. Ideker , Gregory P. Walcott , Stephen J. Hahn
IPC分类号： A61N139
CPC分类号： A61N1/3937
摘要： The present invention provides apparatus and methods for delivering an optimum electrical shock in treating cardiac arrhythmias. The apparatus comprises means for producing an electrical waveform signal at least two electrodes The voltage or current of the signal is then detected to determine the signal time constant. The signal time constant is then used in conjunction with a model time constant to determine when the peak amplitude is reached. The waveform is then interrupted when the peak amplitude is reached. Also provided are methods of selecting a cardiac defibrillator by measuring the impedance of implanted electrodes and then selecting a defibrillator having a capacitor which provides an RC time constant equal to that of a model time constant.
摘要翻译：本发明提供了用于在治疗心律失常中递送最佳电击的装置和方法。该装置包括用于在至少两个电极产生电波形信号的装置。然后检测信号的电压或电流以确定信号时间常数。然后将信号时间常数与模型时间常数结合使用以确定何时达到峰值振幅。当达到峰值振幅时，波形中断。还提供了通过测量注入电极的阻抗然后选择具有提供等于模型时间常数的RC时间常数的电容器的除颤器来选择心脏除颤器的方法。

46. 发明授权

US06484057B2 Pacing methods and devices for treating cardiac arrhythmias and fibrillation 有权
公开(公告)号：US06484057B2
公开(公告)日：2002-11-19
申请号：US09742651
申请日：2000-12-21
申请人： Raymond E. Ideker , Jonathan C. Newton
发明人： Raymond E. Ideker , Jonathan C. Newton
IPC分类号： A61N1368
CPC分类号： A61N1/3622 , A61N1/3684
摘要： Pacing systems for the heart employ multi-site contact points about desired localized regions to deliver pacing train stimulation pulses to the myocardium. The stimulation pulses can have an electric strength in the range of about 5-10 times the diastolic pacing threshold. The electrodes can be arranged as a single continuous body line electrode or as a plurality of point electrodes and even as contiguous body electrodes occupying increased portions of the myocardium over conventional pacing electrodes. Configuring the electrodes in spaced apart operational pairs (with simultaneous excitation) may capture increased areas of the myocardium. The pacing stimulation may be used as an alternative to conventional defibrillation treatments (shocks) or to reduce the strength of the defibrillation shock pulse.

47. 发明授权

US06470211B1 Method and apparatus for treating cardiac arrhythmia 失效
标题翻译：治疗心律失常的方法和装置
公开(公告)号：US06470211B1
公开(公告)日：2002-10-22
申请号：US09641571
申请日：2000-08-18
申请人： Raymond E. Ideker , Bruce H. KenKnight
发明人： Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; and a control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.
摘要翻译：用于病人心脏的心房和心室的除颤或心脏复律的可植入系统包括：配置用于定位在心脏右心室中的第一导管; 构造成用于定位穿过冠状窦口和心脏冠状窦的第二导管，其中第一和第二导管一起携带至少三个除颤电极; 电源; 以及与电源和电极可操作地相关联的控制电路。控制电路被配置为通过至少两个电极输送心房除颤脉冲，或者通过至少两个电极的心室除颤脉冲。

48. 发明授权

US5987354A Dual shock atrial defibrillation apparatus 失效
标题翻译：双休心房除颤器
公开(公告)号：US5987354A
公开(公告)日：1999-11-16
申请号：US950341
申请日：1997-10-14
申请人： Randolph A. Cooper , Raymond E. Ideker
发明人： Randolph A. Cooper , Raymond E. Ideker
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61N1/3918 , A61N1/3956 , A61N1/395
摘要： An implantable system for the defibrillation of the atria of a patient's heart includes a pair of atrial defibrillation electrodes configured for delivering a first atrial defibrillation pulse in the heart, and a pulse generator operatively associated with the first pair of atrial defibrillation electrodes for delivering the first atrial defibrillation pulse. The pulse generator delivers a second second atrial defibrillation pulse after the first defibrillation pulse without intervening monitoring thereof to reduce the voltage necessary for the shock, and the pain associated therewith.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括一对构造成用于递送心脏中的第一心房除颤脉冲的心房除颤电极，以及可操作地与第一对心房除颤电极相关联的脉冲发生器，用于输送第一心房除颤脉冲。脉冲发生器在第一次除颤脉冲之后递送第二次心房除颤脉冲，而不进行监测，以减少冲击所需的电压以及与之相关的疼痛。

49. 发明授权

US5697928A Cardic electrode catheter 失效
标题翻译：心电极导管
公开(公告)号：US5697928A
公开(公告)日：1997-12-16
申请号：US717371
申请日：1996-09-23
申请人： Gregory P. Walcott , Raymond E. Ideker , Jay Alan Warren
发明人： Gregory P. Walcott , Raymond E. Ideker , Jay Alan Warren
IPC分类号： A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B2018/0075 , A61B2018/00869 , A61B2018/124 , A61B2018/1467
摘要： An electrode catheter is disclosed for creating a linear lesion in heart tissue of a heart chamber in order to correct cardiac arrhythmia. The catheter is elongated in dimension such that, upon insertion of the catheter in the patient, the catheter substantially continuously contacts either the endocardial or epicardial heart tissue. The catheter includes a plurality of electrodes and the electrodes are positioned at spaced intervals along the catheter. The electrodes are then sequentially energized with a radio frequency in conjunction with a back plate attached to the patient such that the electrodes form a continuous lesion conforming in shape to the shape of the catheter on the heart tissue. This lesion, furthermore, is of sufficient depth such that the lesion interrupts electrical nodal conduction across the lesion.
摘要翻译：公开了用于在心室的心脏组织中产生线性损伤以矫正心律失常的电极导管。导管的尺寸是细长的，使得当将导管插入患者体内时，导管基本上连续接触心内膜或心外膜心脏组织。导管包括多个电极，并且电极沿着导管间隔开定位。然后电极依次通过射频与连接到患者的背板通电，使得电极形成与心脏组织上的导管形状一致的连续病变。此外，这种病变具有足够的深度，使得病变中断穿过病变的电节点传导。

50. 发明授权

US5540723A Method and apparatus for delivering an optimum shock duration in treating cardiac arrhythmias 失效
标题翻译：用于在治疗心律失常中提供最佳休克持续时间的方法和装置
公开(公告)号：US5540723A
公开(公告)日：1996-07-30
申请号：US132373
申请日：1993-10-06
申请人： Raymond E. Ideker , Gregory P. Walcott , Stephen J. Hahn
发明人： Raymond E. Ideker , Gregory P. Walcott , Stephen J. Hahn
IPC分类号： A61N1/39
CPC分类号： A61N1/3937
摘要： The present invention provides apparatus and methods for delivering an optimum electrical shock in treating cardiac arrhythmias. The invention comprises apparatus for producing an electrical waveform signal at least at two electrodes. The voltage or current of the signal is then detected to determine the signal time constant. The signal time constant is then used in conjunction with a model time constant to determine when the peak amplitude is reached. The waveform is then interrupted when the peak amplitude is reached. Also provided are methods of selecting a cardiac defibrillator by measuring the impedance of implanted electrodes and then selecting a defibrillator having a capacitor which provides an RC time constant equal to that of a model time constant.
摘要翻译：本发明提供了用于在治疗心律失常中递送最佳电击的装置和方法。本发明包括至少在两个电极产生电波形信号的装置。然后检测信号的电压或电流以确定信号时间常数。然后将信号时间常数与模型时间常数结合使用以确定何时达到峰值振幅。当达到峰值振幅时，波形中断。还提供了通过测量注入电极的阻抗然后选择具有提供等于模型时间常数的RC时间常数的电容器的除颤器来选择心脏除颤器的方法。

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