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41. 发明授权

US07572441B2 Media and method for treating pathological syndrome 有权
标题翻译：介质和治疗病理综合征的方法
公开(公告)号：US07572441B2
公开(公告)日：2009-08-11
申请号：US10522652
申请日：2002-08-02
申请人： Oleg Iliich Epshtein , Goldberg Evgeny Danilovich , Alexandr Mikhailovich Dygay
发明人： Oleg Iliich Epshtein , Goldberg Evgeny Danilovich , Alexandr Mikhailovich Dygay
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： A61K41/0004 , A61K39/3955 , A61K2039/505 , C07K16/249
摘要： A medicament based on antibodies contains an activated form of monoclonal, polyclonal, or natural antibodies to interferon in low or ultra-low doses prepared by multiple consecutive dilutions and exposure to external factors, preferably in accordance with homeopathic technology. In order to obtain antibodies, human or heterologous interferon alpha, beta, or gamma, including recombinant interferon, is used; a mixture of various, mostly centimal, homeopathic dilutions being employed. A method of treating a pathologic syndrome, whose formation is affected by interferon, consists in the use of activated forms of antibodies to interferon alpha, beta, or gamma in low or ultra-low doses obtained by multiple consecutive dilutions and exposure to external factors.
摘要翻译：基于抗体的药物含有通过多次连续稀释并暴露于外部因素，优选按照顺势疗法技术制备的低或低剂量的干扰素的单克隆抗体，多克隆抗体或天然抗体的活化形式。为了获得抗体，使用人或异源干扰素α，β或γ，包括重组干扰素; 使用各种，大多数为中等程度的顺势疗法稀释液的混合物。治疗其形成受干扰素影响的病理综合征的方法包括使用通过多次连续稀释并暴露于外部因素获得的低或超低剂量的干扰素α，β或γ的活化形式的抗体。

42. 发明申请

US20220213197A1 MEDICAMENT AND METHOD FOR TREATING INFECTIOUS DISEASES 有权
公开(公告)号：US20220213197A1
公开(公告)日：2022-07-07
申请号：US17608270
申请日：2020-08-19
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein , Dmitry Yurievich Pushkar
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , C07K16/24 , A61K9/16 , A61P31/12
摘要： This invention relates to the field of medicine, particularly to a medicament for treating bacterial infections, which presents a technology-processed product resulting from multiple serial dilutions of the stock substances of antibodies to HLA-DRB1 and antibodies to β2-microglobulin, and to a combination of the claimed medicament with antibiotic, to a method of treating bacterial infections, a method of reducing bacterial resistance to antibiotic therapy and a method of enhancing antibiotic efficacy. Besides, this invention relates to a medicament for treating infectious diseases, which exerts antibacterial and antiviral effects and presents a technology-processed product resulting from multiple serial dilutions of the stock substances of a) antibodies to HLA-DRB1, b) antibodies to β2-MG, c) antibodies to IFN-γ and d) antibodies to CD4. This invention ensures an effective treatment of infectious diseases, decreases resistance to antibiotics, enhances the therapeutic efficacy of antibiotics, including efficacy against resistant bacteria, and reduces effective doses of antibiotics.

43. 发明授权

US09945798B2 Method for determining degree of modified potency of a medicament 有权
公开(公告)号：US09945798B2
公开(公告)日：2018-04-17
申请号：US14218793
申请日：2014-03-18
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： G01N30/00 , G01N24/08 , G01N33/68
CPC分类号： G01N24/08 , G01N33/6854 , G01N2030/8813 , G01N33/15
摘要： The invention comprises a method for determining degree of modified potency of a medicament. A medicine is a medicament comprising a therapeutic component and a homeopathic, i.e., activated-potentiated, component, wherein the activated-potentiated component has some physical, chemical or biological affect on the therapeutic component and/or the pharmacological efficacy thereof. The therapeutic component is biologically related to the starting substance of the homeopathic component. An analytical measurement of at least one characteristic parameter of the therapeutic form is made prior to its interaction with the activated-potentiated form. The same analytical measurement(s) are made and after interaction between the therapeutic and activated-potentiated forms. This data is used to confirm the presence of any modified potency is caused by the presence of molecular form in the activated-potentiated form. Further, the claimed analytical measurement of at least one characteristic parameter of the therapeutic form prior to its interaction with the activated-potentiated form and again after such interaction serves to quantify the degree of modifying potency associated with the activated-potentiated form in relative dimensionless activity units (release activity).

44. 发明申请

US20160159916A1 METHOD OF TREATING DIABETES, AND DISEASES ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE 审中-公开
标题翻译：治疗糖尿病的方法以及与不利的葡萄糖耐量相关的疾病
公开(公告)号：US20160159916A1
公开(公告)日：2016-06-09
申请号：US15041582
申请日：2016-02-11
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , A61K41/0004 , A61K2039/505
摘要： The present application provides a method of treating diabetes mellitus, impaired glucose tolerance and obesity associated with diabetes mellitus or impaired glucose tolerance, the method comprising administering to a subject in need thereof a homeopathically potentized form of at least one antibody to the beta-subunit of the insulin receptor.
摘要翻译：本申请提供了一种治疗糖尿病，葡萄糖耐量降低和与糖尿病相关的肥胖或葡萄糖耐量降低的方法，所述方法包括向有需要的受试者施用顺势疗效强化的至少一种抗体的β-亚单位的抗体胰岛素受体。

45. 发明授权

US09308275B2 Method of increasing the effect of an activated-potentiated form of an antibody 有权
标题翻译：增加活化增强形式抗体的作用的方法
公开(公告)号：US09308275B2
公开(公告)日：2016-04-12
申请号：US13135901
申请日：2011-07-15
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K47/48 , A61K41/00 , C07K16/18 , C07K16/28 , C07K16/40 , A61K39/395 , A61K39/00
CPC分类号： C07K16/40 , A61K9/20 , A61K39/3955 , A61K41/0004 , A61K2039/507 , C07K16/18 , C07K16/2869
摘要： The preset invention provides a method of increasing the effect of an activated-potentiated form of an antibody to an endogenous biological molecule by combining said endogenous biological molecule with an activated-potentiated form of an antibody to endothelial NO-synthase.The present invention also provides a pharmaceutical composition comprising a) an activated-potentiated form of an antibody to an endogenous biological molecule, and b) an activated-potentiated form of an antibody to NO synthase.
摘要翻译：本发明提供了通过将所述内源性生物分子与内皮NO合成酶的活化增强形式的抗体组合来增加活化增强形式的抗体对内源性生物分子的作用的方法。本发明还提供一种药物组合物，其包含a）活化增强形式的内源性生物分子的抗体，和b）活化增强形式的NO合成酶抗体。

46. 发明申请

US20160009809A1 VETERINARY COMPOSITION AND METHOD OF IMPROVING LIVABILITY OF ANIMALS, PROMOTING LIVE WEIGHT GAIN IN MAMMALS AND BIRDS, ENHANCING THE EFFECTIVENESS OF IMMUNIZATION, AND PREVENTING AND/OR TREATING INFECTIOUS DISEASES 审中-公开
标题翻译：动物组合物和改善动物活力的方法，促进哺乳动物体重和体重增加，增强免疫力的有效性，预防和/或治疗感染性疾病
公开(公告)号：US20160009809A1
公开(公告)日：2016-01-14
申请号：US14730775
申请日：2015-06-04
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： C07K16/28
CPC分类号： C07K16/2869 , A61K41/0004 , A61K2039/505 , A61K2039/545
摘要： The present application provides a veterinary composition comprising an activated-potentiated form of an antibody to insulin receptor which can be used for improving livability of animals, primarily, promoting live-weight gain and growth of mammals and birds (preferably food-producing animals and poultry), enhancing the effectiveness of immunization, preventing and/or treating a broad range of diseases (including infectious diseases of various etiology), and increasing livestock performance, reproduction and survival.
摘要翻译：本申请提供了一种兽用组合物，其包含活化增强形式的胰岛素受体抗体形式，其可用于改善动物的活力，主要是促进哺乳动物和鸟的活重增长和生长（优选食物生产动物和家禽），提高免疫的有效性，预防和/或治疗广泛的疾病（包括各种病因的传染病），以及增加家畜的表现，繁殖和生存。

47. 发明授权

US09228024B2 Method of treating hypertension disorder and a pharmaceutical agent 有权
标题翻译：治疗高血压病和药剂的方法
公开(公告)号：US09228024B2
公开(公告)日：2016-01-05
申请号：US11656217
申请日：2007-01-22
申请人： Oleg Iliich Epshtein , Mark Borisovich Shtark , Tamara Mikhailovna Kolyadko
发明人： Oleg Iliich Epshtein , Mark Borisovich Shtark , Tamara Mikhailovna Kolyadko
IPC分类号： C07K16/44 , C07K16/00 , C07K16/24 , C07K16/26 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K31/277 , A61K39/39583 , A61K41/0004 , A61K2039/505 , A61K2039/545 , C07K16/00 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/243 , C07K16/245 , C07K16/246 , C07K16/248 , C07K16/249 , C07K16/26 , C07K16/28 , C07K16/2806 , C07K16/40 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The present application provides a method of treating hypertension disorders which includes administration of a homeopathically potentized form of antibodies to an antigen, wherein the homeopathically potentized form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent capable of regulating hypertension and pharmaceutical agents thereof.
摘要翻译：本申请提供了一种治疗高血压疾病的方法，其包括向抗原施用顺势疗效强化形式的抗体，其中通过重复连续稀释与外部冲击结合获得顺势疗效强化形式，并且抗原是物质或药剂能够调节高血压及其药剂。

48. 发明授权

US08894995B2 Method of treating a disorder or condition of viral etiology 有权
标题翻译：治疗病毒病因病或病症的方法
公开(公告)号：US08894995B2
公开(公告)日：2014-11-25
申请号：US12765385
申请日：2010-04-22
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K39/395 , C07K16/24 , C07K16/00 , C07K16/44 , C07K16/26 , A61K39/00
CPC分类号： C07K16/44 , A61K31/277 , A61K39/39583 , A61K41/0004 , A61K2039/505 , A61K2039/545 , C07K16/00 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/243 , C07K16/245 , C07K16/246 , C07K16/248 , C07K16/249 , C07K16/26 , C07K16/28 , C07K16/2806 , C07K16/40 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： A method of treating a disorder or condition of viral etiology by administration of an activated form of antibodies to an antigen, wherein said activated form is obtained by repeated consecutive dilution combined with external impact, and the antigen is a substance or a pharmaceutical agent exerting influence upon the mechanisms of formation of this particular pathological syndrome.
摘要翻译：通过向抗原施用活化形式的抗体来治疗病毒病因的病症或病症的方法，其中所述活化形式通过重复连续稀释与外部冲击相结合获得，并且抗原是产生影响的物质或药剂关于形成这种特殊病理综合征的机制。

49. 发明授权

US08703124B2 Combination pharmaceutical composition and methods of treating diseases or conditions associated with the cardiovascular system 失效
标题翻译：组合药物组合物和治疗与心血管系统相关的疾病或病症的方法
公开(公告)号：US08703124B2
公开(公告)日：2014-04-22
申请号：US13135882
申请日：2011-07-15
申请人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladimir Ivanovich Petrov
发明人： Oleg Iliich Epshtein , Svetlana Alexandrovna Sergeeva , Liudmila Fyodorovna Dolgovyh , Vladimir Ivanovich Petrov
IPC分类号： A61K39/395
CPC分类号： C07K16/2869 , A61K41/0004 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/40
摘要： The present application provides a pharmaceutical composition for administration to a patient suffering from at least one symptom of a cardiovascular condition, the composition comprising a) an activated-potentiated form of an antibody to angiotensin II AT1 receptor, and b) an activated-potentiated form of an antibody to endothelial NO-synthase.
摘要翻译：本申请提供了用于给患有心血管疾病的至少一种症状的患者施用的药物组合物，所述组合物包含a）活化增强形式的血管紧张素II AT1受体的抗体形式，以及b）活化增强形式的内皮NO合成酶的抗体。

50. 发明授权

US08637034B2 Pharmaceutical compositions comprising activated-potentiated antibodies to interferon-gamma and S100 protein 有权
标题翻译：药物组合物包含对干扰素-γ和S100蛋白的活化增强的抗体
公开(公告)号：US08637034B2
公开(公告)日：2014-01-28
申请号：US13135881
申请日：2011-07-15
申请人： Oleg Iliich Epshtein
发明人： Oleg Iliich Epshtein
IPC分类号： A61K39/395 , A61K39/00 , A61K38/21 , C07K14/57 , C07K16/24 , C12P21/08
CPC分类号： A61K39/3955 , A61K41/0004 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/18 , C07K16/249 , C07K2317/34 , C07K2317/76
摘要： The preset invention relates to combination pharmaceutical composition comprising an activated-potentiated from of an antibody to gamma interferon, and an activated-potentiated form of an antibody to S-100 protein and method of treating multiple sclerosis and other neurodegenerative diseases, as well as the diseases and conditions associated with neuroinfections.
摘要翻译：本发明涉及组合药物组合物，其包含来自抗体与γ干扰素的活化增强剂，以及S-100蛋白的抗体的活化增强形式以及治疗多发性硬化症和其它神经变性疾病的方法，以及与神经感染相关的疾病和病症。

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