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41. 发明授权

US5001678A System for detecting surrounding environmental conditions using a multiple number of incoming signals 失效
标题翻译：使用多个输入信号检测周围环境条件的系统
公开(公告)号：US5001678A
公开(公告)日：1991-03-19
申请号：US366513
申请日：1989-06-15
申请人： Itsuo Fukuoka , Hiroshi Nagano
发明人： Itsuo Fukuoka , Hiroshi Nagano
IPC分类号： G01S15/89 , G01S3/802 , G01S7/523
CPC分类号： G01S3/8022 , Y10S367/903
摘要： A detection system forms a plurality of reception beams successively in angular directions by receiving incoming signals from various directions in a manner that the Doppler effect is produced to vary the carrier frequency of the incoming signals. The detection system displays underwater conditions on an indicator. To determine the underwater conditions, the detection system uses a plurality of ultrasonic transducers for receiving incoming signals, a plurality of preamplifiers for amplifying the reception signals produced by the ultrasonic transducers. A first coupling device which connects at least two of the ultrasonic transducers to a single preamplifier, and a matched filter for pulse-compressing reception signals produced by the ultrasonic transducers. A second coupling device successively couples the output terminals of the preamplifiers to an input terminal of the matched filter. The indicator displays output signals from the matched filter. The use of the first coupling device reduces the number of the preamplifiers.
摘要翻译：检测系统通过以产生多普勒效应以改变输入信号的载波频率的方式从各个方向接收输入信号而在角度方向上连续地形成多个接收波束。检测系统在指示器上显示水下条件。为了确定水下条件，检测系统使用多个超声换能器来接收输入信号，多个前置放大器用于放大由超声换能器产生的接收信号。将至少两个超声换能器连接到单个前置放大器的第一耦合装置和用于脉冲压缩由超声换能器产生的接收信号的匹配滤波器。第二耦合装置将前置放大器的输出端子连续地耦合到匹配滤波器的输入端子。指示器显示匹配滤波器的输出信号。使用第一耦合装置减少前置放大器的数量。

42. 发明授权

US4070417A Stretched polyester film from a polymer blend 失效
标题翻译：由聚合物共混物制成的拉伸聚酯膜
公开(公告)号：US4070417A
公开(公告)日：1978-01-24
申请号：US642184
申请日：1975-12-18
申请人： Tsutomu Isaka , Hiroshi Nagano , Tetsushi Murakami , Koichi Matsunami , Yukio Yamane
发明人： Tsutomu Isaka , Hiroshi Nagano , Tetsushi Murakami , Koichi Matsunami , Yukio Yamane
IPC分类号： C08L67/00 , B29C49/00 , B29C55/00 , B29C55/02 , B32B27/32 , B32B27/36 , B41M1/30 , B65D33/00 , C08J5/18 , C08L67/02
CPC分类号： C08L67/02 , B32B27/36 , B41M1/30 , C08L67/025
摘要： A transparent polyester film having excellent printability, flexing resistance and pinhole resistance and further excellent interlaminar strength, which is made from a polymer mixture or blend comprising (i) a polyester consisting essentially of a residue of dibasic acids wherein at least 80 % by mol is terephthalic acid and a residue of at least one glycol and (ii) a block copolyester consisting of a crystalline polyester (hard) segment having a high melting point and a soft polymer segment having a low melting point and a number average molecular weight of 400 to 8,000, said soft polymer segment having a low melting point being contained in an amount of 0.5 to 10 % by weight on the basis of the whole weight of the polymer mixture or blend, and said crystalline polyester segment having a melting point of at least 170.degree. C when a polymer is produced by the monomers composing the segment alone and said soft polymer segment having a melting or softening point of 100.degree. C or lower.
摘要翻译：一种由聚合物混合物或共混物制成的具有优异的可印刷性，抗弯曲性和针孔抗性以及更好的层间强度的透明聚酯薄膜，其包含（i）基本上由二元酸残基组成的聚酯，其中至少80摩尔％对苯二甲酸和至少一种二醇的残基和（ii）由具有高熔点的结晶聚酯（硬）链段和软聚合物链段组成的嵌段共聚酯，所述软聚合物链段具有低熔点和数均分子量为400至 8,000，所述具有低熔点的所述软聚合物链段以基于聚合物混合物或共混物的全部重量的0.5至10重量％的量包含，并且所述结晶聚酯链段的熔点为至少170 当聚合物由单独构成段的单体和所述软聚合物链段的熔点或软化点为100℃或更低时产生时。

43. 发明授权

US09931822B2 Polyester film, use thereof and metal laminated sheet made of said film, and metal can and metal lid made of the sheet 有权
公开(公告)号：US09931822B2
公开(公告)日：2018-04-03
申请号：US10945468
申请日：2004-09-20
申请人： Keizo Kawahara , Katsuya Ito , Kazutake Okamoto , Hideki Shimizu , Hiroshi Nagano , Mitsuo Inoue , Shoichi Gyobu
发明人： Keizo Kawahara , Katsuya Ito , Kazutake Okamoto , Hideki Shimizu , Hiroshi Nagano , Mitsuo Inoue , Shoichi Gyobu
IPC分类号： B32B27/36 , B32B15/09 , C08J5/18 , C08L67/02
CPC分类号： B32B27/36 , B32B15/09 , B32B2307/536 , B32B2367/00 , C08J5/18 , C08J2367/02 , C08L67/02 , Y10T428/31681 , Y10T428/31786 , C08L2666/18
摘要： A polyester film made from two kinds of polyester resins and having a specific DSC (and a specific glass transition point) is provided, (i) which is superior in mechanical property, capable of thermocompression bonding with a metal sheet, despite a high degree of crystallization of the film, reduces quality change of plastic film laminated on the metal sheet even if faced with variation of conditions of thermocompression bonding with the metal sheet, and which is capable of thermocompression bonding even at a relatively low temperature, (ii) which is superior in formability, (iii) which is superior in flavoring property and impact resistance, and which obliterates occurrence of whitening or delamination of the film, or microcracks on the film, even if the film in the metal laminated sheet obtained by thermocompression bonding of the film on the metal sheet or on the surface of a metal can obtained by subjecting the metal laminated sheet to various form processings is crystallized, and (iv) which satisfies productivity at an industrial scale.

44. 发明授权

US08097640B2 Prophylactic or therapeutic agent for diabetic maculopathy 失效
标题翻译：预防或治疗糖尿病性黄斑病变
公开(公告)号：US08097640B2
公开(公告)日：2012-01-17
申请号：US12842391
申请日：2010-07-23
申请人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
发明人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
IPC分类号： A01N43/50
CPC分类号： A61K31/4166 , A01K2227/106 , A01K2267/0362 , A01K2267/0375 , C07D491/10 , G01N33/5088 , G01N2800/042
摘要： A prophylactic or therapeutic agent for diabetic maculopathy, which can be administered for a long time and exhibits efficacy in a mechanism different from that of existing medicines. The invention relates to a prophylactic or therapeutic agent for diabetic maculopathy, comprising, as an active ingredient, a compound represented by the general formula: wherein X represents a halogen or a hydrogen atom, R1 and R2 concurrently or differently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto and optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle. Preferably, the compound is (2S,4S)-6-fluoro -2′,5′-dioxospiro chroman-4,4′-imidazolidine]-2-carboxamide. The invention also provides a model animal with diabetic maculopathy produced by subjecting a diabetic animal to intraocular ischemia/reperfusion to express edema in a retinal visual cell layer or in a macula lutea.
摘要翻译：用于糖尿病性黄斑病变的预防或治疗剂，其可以长时间施用并且以与现有药物不同的机制显示功效。本发明涉及一种糖尿病性黄斑病变的预防或治疗剂，其特征在于，作为活性成分，含有下列通式表示的化合物：其中，X表示卤素或氢原子，R 1和R 2可以同时或不同地表示氢原子或任选取代的C 1至C 6烷基，或R 1和R 2与连接的氮原子和任选另外的氮原子或氧原子一起形成5-至6-元杂环。优选地，该化合物是（2S，4S）-6-氟-2'，5'-二氧杂环苯并二氢吡喃-4,4'-咪唑烷] -2-甲酰胺。本发明还提供了一种通过使糖尿病动物进行眼内缺血/再灌注以在视网膜视细胞层或黄斑黄斑中表达水肿而产生的糖尿病性黄斑变性的模型动物。

45. 发明授权

US07910615B2 Prophylactic or therapeutic agent for diabetic maculopathy 有权
标题翻译：预防或治疗糖尿病性黄斑病变
公开(公告)号：US07910615B2
公开(公告)日：2011-03-22
申请号：US10587320
申请日：2005-01-28
申请人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
发明人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
IPC分类号： A01N43/50
CPC分类号： A61K31/4166 , A01K2227/106 , A01K2267/0362 , A01K2267/0375 , C07D491/10 , G01N33/5088 , G01N2800/042
摘要： A prophylactic or therapeutic agent for diabetic maculopathy, which can be administered for a long time and exhibits efficacy in a mechanism different from that of existing medicines. The invention relates to a prophylactic or therapeutic agent for diabetic maculopathy, comprising, as an active ingredient, a compound represented by the general formula: wherein X represents a halogen or a hydrogen atom, R1 and R2 concurrently or differently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto and optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle. Preferably, the compound is (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide. The invention also provides a model animal with diabetic maculopathy produced by subjecting a diabetic animal to intraocular ischemia/reperfusion to express edema in a retinal visual cell layer or in a macula lutea.
摘要翻译：用于糖尿病性黄斑病变的预防或治疗剂，其可以长时间施用并且以与现有药物不同的机制显示功效。本发明涉及一种糖尿病性黄斑病变的预防或治疗剂，其特征在于，作为活性成分，含有下列通式表示的化合物：其中，X表示卤素或氢原子，R 1和R 2可以同时或不同地表示氢原子或任选取代的C 1至C 6烷基，或R 1和R 2与连接的氮原子和任选另外的氮原子或氧原子一起形成5-至6-元杂环。优选地，化合物是（2S，4S）-6-氟-2'，5'-二氧代螺[苯并二氢吡喃-4,4'-咪唑烷] -2-甲酰胺。本发明还提供了一种通过使糖尿病动物进行眼内缺血/再灌注以在视网膜视细胞层或黄斑黄斑中表达水肿而产生的糖尿病性黄斑变性的模型动物。

46. 发明申请

US20090152095A1 EASY-TO-TEAR STRETCHED ALIPHATIC POLYESTER FILM 审中-公开
标题翻译：简单易用的拉链聚酯薄膜
公开(公告)号：US20090152095A1
公开(公告)日：2009-06-18
申请号：US12359579
申请日：2009-01-26
申请人： Keizou Kawahara , Shigeto Yoshida , Masayuki Tsutsumi , Daisuke Sakura , Akinobu Nagara , Yoshiko Akitomo , Noriko Takahashi , Naonobu Oda , Kazumoto Imai , Kunio Takeuchi , Hiroshi Nagano , Hisato Kobayashi , Keiji Mori , Yasuhisa Fujita
发明人： Keizou Kawahara , Shigeto Yoshida , Masayuki Tsutsumi , Daisuke Sakura , Akinobu Nagara , Yoshiko Akitomo , Noriko Takahashi , Naonobu Oda , Kazumoto Imai , Kunio Takeuchi , Hiroshi Nagano , Hisato Kobayashi , Keiji Mori , Yasuhisa Fujita
IPC分类号： B29D7/01
CPC分类号： C08J5/18 , C08J2367/04 , Y10T428/1352
摘要： The easy-to-tear stretched aliphatic polyester film of the present invention is characterized in that the edge tear strength in the longitudinal direction and the transverse direction is not more than 22 N. The easy-to-tear stretched aliphatic polyester film of the present invention is produced by a method of irradiation of actinic rays on an aliphatic polyester film or a method of film-forming a film obtained by laminating aliphatic polyesters having different melting points in three layers of A/B/A under particular film-forming conditions.
摘要翻译：本发明的容易撕裂的拉伸脂肪族聚酯膜的特征在于，纵向和横向的边缘撕裂强度不大于22N。本发明的容易撕裂的拉伸脂肪族聚酯膜本发明通过在脂肪族聚酯膜上照射光化学射线的方法或通过在特定的成膜条件下层压三层A / B / A的不同熔点的脂肪族聚酯而成膜的方法来制造。

47. 发明申请

US20090036693A1 METHOD OF PURIFYING UBIQUINONE-10 审中-公开
标题翻译：净化UBIQUINONE-10的方法
公开(公告)号：US20090036693A1
公开(公告)日：2009-02-05
申请号：US11916839
申请日：2006-06-09
申请人： Hiroshi Nagano , Hiroto Yamanashi , Hideki Murata
发明人： Hiroshi Nagano , Hiroto Yamanashi , Hideki Murata
IPC分类号： C07C50/28
CPC分类号： B01J20/26 , B01D15/1821 , B01D15/185 , B01J20/261 , B01J20/267 , C07C46/10 , C07C50/06
摘要： According to the present invention, a method of purifying ubiquinone-10, which includes separating and removing a substance structurally similar to ubiquinone-10 contained in a starting material solution containing ubiquinone-10 by the use of a porous crosslinked acrylic polymer, more preferably, a method of purifying ubiquinone-10 by separating and removing a substance structurally similar to ubiquinone-10 contained in a starting material solution, which includes feeding a starting material solution containing ubiquinone-10 in a simulated moving bed chromatography apparatus wherein a solution can circulate in one direction in a packed-bed wherein a porous crosslinked acrylic polymer is packed, and flowing an eluent in the packed-bed in one direction, is provided.
摘要翻译：根据本发明，一种纯化泛醌-10的方法，其包括通过使用多孔交联的丙烯酸类聚合物分离除去与含有泛醌-10的原料溶液中所含的泛醌-10结构相似的物质，更优选地，通过分离除去与原料溶液中所含的泛醌-10结构相似的物质来纯化泛醌-10的方法，其包括在模拟的移动床层析装置中加入含有泛醌-10的原料溶液，其中溶液可以在在填充床中的一个方向，其中填充有多孔交联的丙烯酸类聚合物，并且在一个方向上使填充床中的洗脱液流动。

48. 发明授权

US07034011B2 Method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate 失效
标题翻译：稳定还原烟酰胺腺嘌呤二核苷酸或还原烟酰胺腺嘌呤二核苷酸磷酸的方法
公开(公告)号：US07034011B2
公开(公告)日：2006-04-25
申请号：US10502922
申请日：2003-12-03
申请人： Hideo Kawabe , Hideki Murata , Hiroshi Nagano
发明人： Hideo Kawabe , Hideki Murata , Hiroshi Nagano
IPC分类号： A61K31/70 , C07H19/207
CPC分类号： A61K31/7084 , A61K2300/00
摘要： It is an object of the present invention to provide a method of stabilizing reduced nicotinamide adenine dinucleotide or reduced nicotinamide adenine dinucleotide phosphate [hereinafter abbreviated as NAD(P)H] and a preparation containing NAD(P)H stabilized by the method.As the method of stabilizing NAD(P)H, a method of adding astaxanthin to NAD(P)H is provided.
摘要翻译：本发明的目的是提供一种稳定还原型烟酰胺腺嘌呤二核苷酸或还原型烟酰胺腺嘌呤二核苷酸磷酸酯（以下简称为NAD（P）H）的方法和通过该方法稳定化的含有NAD（P）H的制剂。作为稳定NAD（P）H的方法，提供了将虾青素加入到NAD（P）H中的方法。

49. 发明申请

US20060057346A1 Heat-shrinkable polyester film 有权
标题翻译：热收缩聚酯薄膜
公开(公告)号：US20060057346A1
公开(公告)日：2006-03-16
申请号：US10512412
申请日：2003-04-23
申请人： Hideki Ito , Norimi Tabota , Hiroshi Nagano
发明人： Hideki Ito , Norimi Tabota , Hiroshi Nagano
IPC分类号： B32B27/32
CPC分类号： C08J5/18 , B29C61/0608 , B29C63/423 , B29K2067/00 , B29K2995/0049 , B29L2031/723 , B29L2031/744 , C08J2367/02 , Y10T428/1328 , Y10T428/1331
摘要： A heat-shrinkable polyester film characterized in that: (A) the heat shrinkage percentages in the maximum shrinkage direction thereof is 10 to 50% in hot water at 70° C.; (B) the heat shrinkage percentages in the maximum shrinkage direction thereof is 70% or more and that in the direction orthogonal to the maximum shrinkage direction is 10% or less in hot water at 85° C.; and (C) when the heat shrinkage percentage in the maximum shrinkage direction in hot water at 95° C. is designated as X0 (%) and the heat shrinkage percentage in the maximum shrinkage direction of a film obtained by previously heat-shrinking said film to an extent of 10% in hot water at 95° C. is designated as X10 (%), the difference in heat shrinkage percentage Δ (%) calculated according to the following equation is 10 to 20%. Δ=X0−X10
摘要翻译：一种热收缩性聚酯膜，其特征在于：（A）在70℃的热水中，其最大收缩方向的热收缩率为10〜50％。（B）在85℃的热水中，其最大收缩方向的热收缩率为70％以上，与最大收缩方向正交的方向的热收缩率为10％以下。

50. 发明申请

US20050103029A1 Refrigerator having alarm device for alarming leakage of refrigerant 审中-公开
标题翻译：冰箱具有用于制冷剂泄漏报警的报警装置
公开(公告)号：US20050103029A1
公开(公告)日：2005-05-19
申请号：US10501489
申请日：2002-12-27
申请人： Keizou Kawahara , Shigeto Yoshida , Masayuki Tsutsumi , Daisuke Sakura , Akinobu Nagara , Yoshiko Akitomo , Noriko Takahashi , Naonobu Oda , Kazumoto Imai , Kunio Takeuchi , Hiroshi Nagano , Hisato Kobayashi , Keiji Mori , Yasuhisa Fujita
发明人： Keizou Kawahara , Shigeto Yoshida , Masayuki Tsutsumi , Daisuke Sakura , Akinobu Nagara , Yoshiko Akitomo , Noriko Takahashi , Naonobu Oda , Kazumoto Imai , Kunio Takeuchi , Hiroshi Nagano , Hisato Kobayashi , Keiji Mori , Yasuhisa Fujita
IPC分类号： F25D29/00 , F25B49/00 , G01K13/00
CPC分类号： F25D29/008 , F25B2400/12 , F25B2500/222 , F25D2700/02
摘要： A detector (29) detects that a refrigerant gas has leaked from a refrigeration cycle, or detects in advance that a refrigerant is to leak. The alarming device (27) gives users an alarming signal warning against the refrigerant leak. The alarming device (27) is caused to stop giving an alarming signal after users open doors of storage compartments including a refrigerator compartment (4), a vegetable storage compartment (5) and a freezer compartment (6). For example, after all the doors of the storage compartments are opened, giving the alarming signal is stopped. Otherwise, giving the alarming signal is stopped after the door of a storage compartment into which cold air flows by causing a damper (12) to open is opened.
摘要翻译：检测器（29）检测制冷剂气体从制冷循环泄漏，或者预先检测制冷剂泄漏。报警装置（27）为用户提供警告信号，防止制冷剂泄漏。在用户打开包括冷藏室（4），蔬菜储藏室（5）和冷冻室（6）的储藏室的门后，使报警装置（27）停止发出报警信号。例如，在储存室的所有门打开之后，停止报警信号。否则，通过使阻尼器（12）打开而冷气流入的储藏室的门被打开之后停止报警信号。

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