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41. 发明授权

US07432113B2 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 失效
公开(公告)号：US07432113B2
公开(公告)日：2008-10-07
申请号：US11134749
申请日：2005-05-19
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

42. 发明申请

US20050221506A1 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 有权
公开(公告)号：US20050221506A1
公开(公告)日：2005-10-06
申请号：US10814695
申请日：2004-03-30
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N21/65 , G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

43. 发明申请

US20050221510A1 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 失效
公开(公告)号：US20050221510A1
公开(公告)日：2005-10-06
申请号：US11134749
申请日：2005-05-19
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N21/65 , G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.

44. 发明申请

US20050221509A1 Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) 失效
标题翻译：使用表面增强拉曼散射（SERS）进行生物分子检测的金属表面改性
公开(公告)号：US20050221509A1
公开(公告)日：2005-10-06
申请号：US11134747
申请日：2005-05-19
申请人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
发明人： Tae-Woong Koo , Selena Chan , Xing Su , Jingwu Zhang , Lei Sun
IPC分类号： G01N21/65 , G01N33/553
CPC分类号： G01N21/658
摘要： The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods of the invention, a wide variety of biomolecules can be detected with a greater sensitivity and reliability.
摘要翻译：本发明基于这样的发现：本文所述的用于生产金属胶体的方法导致胶体表现出增加的信号增强和生物分子的SERS检测的再现性。因此，使用本发明的方法，可以以更高的灵敏度和可靠性检测各种各样的生物分子。

45. 发明授权

US07476501B2 Methods and device for DNA sequencing using surface enhanced raman scattering (SERS) 失效
标题翻译：使用表面增强拉曼散射（SERS）进行DNA测序的方法和装置
公开(公告)号：US07476501B2
公开(公告)日：2009-01-13
申请号：US10108128
申请日：2002-03-26
申请人： Selena Chan , Xing Su , Tae-Woong Koo
发明人： Selena Chan , Xing Su , Tae-Woong Koo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01L3/5027 , C12Q2565/60 , C12Q2565/631 , C12Q2565/632 , G01N21/658 , G01N33/587 , G01N2021/653 , G01N2021/656
摘要： The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, exonuclease treatment of the nucleic acids 109 results in the release of nucleotides 110. The nucleotides may pass from a reaction chamber 101 through a microfluidic channel 102 and enter a nanochannel or microchannel 103. The nanochannel or microchannel 103 may be packed with nanoparticle 111 aggregates containing hot spots for Raman detection. As the nucleotides 110 pass through the nanoparticle 111 hot spots, they may be detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Identification of the sequence of nucleotides 110 released from the nucleic acid 109 provides the nucleic acid sequence. Other embodiments of the invention concern apparatus 100 for nucleic acid sequencing.
摘要翻译：本文公开的方法和装置涉及通过增强拉曼光谱进行的核酸测序。在本发明的某些实施方案中，核酸109的核酸外切酶处理导致核苷酸110的释放。核苷酸可以从反应室101通过微流体通道102并进入纳米通道或微通道103.纳米通道或微通道103可以填充含有用于拉曼检测的热点的纳米颗粒111聚集体。当核苷酸110通过纳米颗粒111热点时，它们可以通过表面增强拉曼光谱（SERS），表面增强共振拉曼光谱（SERRS）和/或相干抗斯托克斯拉曼光谱（CARS）来检测。从核酸109释放的核苷酸序列110的鉴定提供了核酸序列。本发明的其它实施方案涉及用于核酸测序的设备100。

46. 发明申请

US20070154967A1 Chemiluminescence sensor array 有权
标题翻译：化学发光传感器阵列
公开(公告)号：US20070154967A1
公开(公告)日：2007-07-05
申请号：US11321050
申请日：2005-12-30
申请人： Narayan Sundararajan , Tae-Woong Koo
发明人： Narayan Sundararajan , Tae-Woong Koo
IPC分类号： G01N33/543 , C12M3/00
CPC分类号： G01N21/763 , G01N33/54366 , G01N33/54373 , Y10T29/49826
摘要： Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.
摘要翻译：本发明的实施方案涉及使用这些装置和方法监测分子结合的综合化学发光装置和方法。这些装置和方法可以用于例如鉴定与抗体结合的抗原。这些装置包括化学发光材料和集成在一起的检测器。

47. 发明授权

US08288167B2 Chemiluminescence sensor array 有权
标题翻译：化学发光传感器阵列
公开(公告)号：US08288167B2
公开(公告)日：2012-10-16
申请号：US12471286
申请日：2009-05-22
申请人： Narayan Sundararajan , Tae-Woong Koo
发明人： Narayan Sundararajan , Tae-Woong Koo
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N33/54366 , G01N33/54373 , Y10T29/49826
摘要： Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.
摘要翻译：本发明的实施方案涉及使用这些装置和方法监测分子结合的综合化学发光装置和方法。这些装置和方法可以用于例如鉴定与抗体结合的抗原。这些装置包括化学发光材料和集成在一起的检测器。

48. 发明申请

US20100055713A1 CHEMILUMINESCENCE SENSOR ARRAY 有权
标题翻译：亮度传感器阵列
公开(公告)号：US20100055713A1
公开(公告)日：2010-03-04
申请号：US12471286
申请日：2009-05-22
申请人： Narayan Sundararajan , Tae-Woong Koo
发明人： Narayan Sundararajan , Tae-Woong Koo
IPC分类号： G01N33/53 , B05D1/36
CPC分类号： G01N21/763 , G01N33/54366 , G01N33/54373 , Y10T29/49826
摘要： Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.
摘要翻译：本发明的实施方案涉及使用这些装置和方法监测分子结合的综合化学发光装置和方法。这些装置和方法可以用于例如鉴定与抗体结合的抗原。这些装置包括化学发光材料和集成在一起的检测器。

49. 发明授权

US07537934B2 Chemiluminescence sensor array 有权
标题翻译：化学发光传感器阵列
公开(公告)号：US07537934B2
公开(公告)日：2009-05-26
申请号：US11321050
申请日：2005-12-30
申请人： Narayan Sundararajan , Tae-Woong Koo
发明人： Narayan Sundararajan , Tae-Woong Koo
IPC分类号： G01N21/76
CPC分类号： G01N21/763 , G01N33/54366 , G01N33/54373 , Y10T29/49826
摘要： Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.
摘要翻译：本发明的实施方案涉及使用这些装置和方法监测分子结合的综合化学发光装置和方法。这些装置和方法可以用于例如鉴定与抗体结合的抗原。这些装置包括化学发光材料和集成在一起的检测器。

50. 发明申请

US20080160603A1 Flow stabilization in micro-and nanofluidic devices 审中-公开
标题翻译：微流体和纳流体装置中的流动稳定
公开(公告)号：US20080160603A1
公开(公告)日：2008-07-03
申请号：US11647908
申请日：2006-12-28
申请人： Narayan Sundararajan , Tae-Woong Koo
发明人： Narayan Sundararajan , Tae-Woong Koo
IPC分类号： C12M1/40 , B01L11/00 , G01F1/05
CPC分类号： F16K99/0028 , B01L3/50273 , B01L3/502746 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2300/0887 , B01L2300/0896 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B82Y30/00 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K2099/0078 , F16K2099/0094 , G01F1/7086 , Y10T137/2574
摘要： Embodiments of the present invention provide microfluidic devices having deformable polymer membranes as components. The devices can be fabricated from a single polymeric block. Actuation of the membranes within the device allows the fluid contained within a microfluidic channel to be manipulated. Exemplary microfluidic devices, such as, peristaltic pumps, sample sorters, and flow stabilizers are described.
摘要翻译：本发明的实施方案提供了具有可变形聚合物膜作为组分的微流体装置。这些装置可以由单个聚合物块制成。器件内膜的致动允许微流体通道中包含的流体被操纵。描述了微流体装置，例如蠕动泵，样品分选机和流动稳定器。

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