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41. 发明申请

US20080004355A1 Method for Inhibiting Telomerase Activity and an Agent for Inhibiting the Same 审中-公开
标题翻译：抑制端粒酶活性的方法及其抑制剂
公开(公告)号：US20080004355A1
公开(公告)日：2008-01-03
申请号：US11793959
申请日：2005-12-27
申请人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Kensaku Imai
发明人： Naoya Wada , Takashi Okamoto , Keiji Tanigaki , Hirofumi Doi , Kensaku Imai
IPC分类号： A61K35/00 , A61P35/00 , C12N15/63 , C12N5/00 , C12N9/10 , C12Q1/34 , C12Q1/48 , C12Q1/68
CPC分类号： C12Y207/07049 , A61K45/06 , C12N9/1241 , G01N33/574 , G01N2333/9125 , G01N2333/916 , G01N2500/02
摘要： A method is described for enhancing degradation of telomerase. This method includes inhibiting the binding of TERT (telomerase catalytic subunit) to USP21, the binding of NEDD8-conjugated TERT to USP21, or the NEDD8 deconjugation by USP21 from NEDD8-conjugated TERT. A method of inhibiting telomerase activity is also described. The method includes utilizing the method of enhancing the degradation. A method of identifying a compound that inhibits the binding or the NEDD8 deconjugation is further described. An agent for inhibiting telomerase activity is described. An agent for preventing and/or treating diseases attributable to the enhanced telomerase activity is described and includes an inhibitory agent. Also, a method of preventing and/or treating diseases is described and includes using the inhibition method or the inhibitory agent. Further, a reagent kit is described.
摘要翻译：描述了一种增强端粒酶降解的方法。该方法包括抑制TERT（端粒酶催化亚单位）与USP21的结合，NEDD8缀合的TERT与USP21的结合，或者通过NEDD8缀合的TERT的USP21的NEDD8解缀。还描述了抑制端粒酶活性的方法。该方法包括利用增强降解的方法。进一步描述鉴定抑制结合或NEDD8解缀合的化合物的方法。描述了抑制端粒酶活性的药剂。描述了用于预防和/或治疗归因于增强的端粒酶活性的疾病的药剂，并且包括抑制剂。此外，描述了预防和/或治疗疾病的方法，并且包括使用抑制方法或抑制剂。此外，描述了试剂盒。

42. 发明授权

US07177543B2 Method for routing optical packets using multiple wavelength labels, optical packet router using multiple wavelength labels, and optical packet network that uses multiple wavelength labels 有权
标题翻译：使用多个波长标签路由光分组的方法，使用多个波长标签的光分组路由器，以及使用多个波长标签的光分组网络
公开(公告)号：US07177543B2
公开(公告)日：2007-02-13
申请号：US11095514
申请日：2005-04-01
申请人： Naoya Wada , Hiroaki Harai , Wataru Chujo , Fumito Kubota
发明人： Naoya Wada , Hiroaki Harai , Wataru Chujo , Fumito Kubota
IPC分类号： H04J14/00
CPC分类号： H04Q11/0005 , H04Q11/0066 , H04Q2011/002 , H04Q2011/0032 , H04Q2011/0039 , H04Q2011/0077
摘要： A method for routing optical packets using multiple wavelength labels includes converting optical packet address signals to a plurality of optical pulses having different time-deviated wavelengths by executing a first operation to impart a wavelength dependent delay time with respect to a plurality of optical pulses having different wavelengths at a same time axis position. When the optical pulses are transmitted along a predetermined optical path having dispersion the dispersion is compensated for by executing a second operation on the optical pulses corresponding to a reverse process of the operation to impart a wavelength dependent delay time. This second operation results in the generation of a plurality of optical pulses having different wavelengths at a given point on the time axis. The pulse signals thus generated are used to determine the packet transmission route.
摘要翻译：用于使用多个波长标签路由光学分组的方法包括通过执行第一操作来将光分组地址信号转换为具有不同时间偏移波长的多个光脉冲，以便相对于具有不同波长的多个光脉冲赋予波长依赖的延迟时间波长在同一时间轴位置。当沿着具有色散的预定光路传输光脉冲时，通过对对应于操作的反向处理的光脉冲执行第二操作来补偿色散，以赋予与波长相关的延迟时间。该第二操作导致在时间轴上的给定点产生具有不同波长的多个光脉冲。这样产生的脉冲信号用于确定分组传输路由。

43. 发明申请

US20050180750A1 Method for routing optical packets using multiple wavelength labels, optical packet router using multiple wavelength labels, and optical packet network that uses multiple wavelength labels 有权
标题翻译：使用多个波长标签路由光分组的方法，使用多个波长标签的光分组路由器，以及使用多个波长标签的光分组网络
公开(公告)号：US20050180750A1
公开(公告)日：2005-08-18
申请号：US11095514
申请日：2005-04-01
申请人： Naoya Wada , Hiroaki Harai , Wataru Chujo , Fumito Kubota
发明人： Naoya Wada , Hiroaki Harai , Wataru Chujo , Fumito Kubota
IPC分类号： H04B10/2507 , H04B10/25 , H04B10/27 , H04B10/54 , H04B10/556 , H04B10/572 , H04L12/70 , H04L12/701 , H04Q3/52 , H04Q11/00 , H04J14/00
CPC分类号： H04Q11/0005 , H04Q11/0066 , H04Q2011/002 , H04Q2011/0032 , H04Q2011/0039 , H04Q2011/0077
摘要： A method for routing optical packets using multiple wavelength labels includes converting optical packet address signals to a plurality of optical pulses having different time-deviated wavelengths by executing a first operation to impart a wavelength dependent delay time with respect to a plurality of optical pulses having different wavelengths at a same time axis position. When the optical pulses are transmitted along a predetermined optical path having dispersion the dispersion is compensated for by executing a second operation on the optical pulses corresponding to a reverse process of the operation to impart a wavelength dependent delay time. This second operation results in the generation of a plurality of optical pulses having different wavelengths at a given point on the time axis. The pulse signals thus generated are used to determine the packet transmission route.
摘要翻译：用于使用多个波长标签路由光学分组的方法包括通过执行第一操作来将光分组地址信号转换为具有不同时间偏移波长的多个光脉冲，以便相对于具有不同波长的多个光脉冲赋予波长依赖的延迟时间波长在同一时间轴位置。当沿着具有色散的预定光路传输光脉冲时，通过对对应于操作的反向处理的光脉冲执行第二操作来补偿色散，以赋予与波长相关的延迟时间。该第二操作导致在时间轴上的给定点产生具有不同波长的多个光脉冲。这样产生的脉冲信号用于确定分组传输路由。

44. 发明申请

US20050065082A1 C-jun phosphorylation inhibitors 审中-公开
标题翻译： C-jun磷酸化抑制剂
公开(公告)号：US20050065082A1
公开(公告)日：2005-03-24
申请号：US10509307
申请日：2003-03-31
申请人： Hirofumi Doi , Naoya Wada , Hiroto Nakajima
发明人： Hirofumi Doi , Naoya Wada , Hiroto Nakajima
IPC分类号： A61K38/17 , A61P25/00 , A61K38/52 , C12N9/99
CPC分类号： A61K38/1709
摘要： In the present invention, BMAL1, BPL1, KIAA1491 complete (SEQ ID NO: 1), and KIAA0596CT (SEQ ID NO:2), have a function for interacting with JNK3, wherein these peptides, as well as peptides derived therefrom can be used to inhibit c-Jun from being phosphorylated and exhibiting its functions (such as transcription activation activity). Inhibition of the phosphorylation of c-Jun suppresses apoptosis, such as nerve cell apoptosis. Thus, the present invention also provides a drug, a pharmaceutical composition and a method for use in preventing and/or treating a neurodegenerative disease (such as polyglutamine disease and Alzheimer's disease).
摘要翻译：在本发明中，BMAL1，BPL1，KIAA1491完整（SEQ ID NO：1）和KIAA0596CT（SEQ ID NO：2）具有与JNK3相互作用的功能，其中可以使用这些肽以及由其衍生的肽以抑制c-Jun被磷酸化并显示其功能（例如转录激活活性）。抑制c-Jun磷酸化抑制细胞凋亡，如神经细胞凋亡。因此，本发明还提供了用于预防和/或治疗神经退行性疾病（如聚谷氨酰胺病和阿尔茨海默病）的药物，药物组合物和方法。

45. 发明授权

US10046330B2 Regenerated cutting blade and shearing type grinder 有权
公开(公告)号：US10046330B2
公开(公告)日：2018-08-14
申请号：US14417344
申请日：2012-08-28
申请人： Naoya Wada , Naoki Ueno , Yasuhiko Honda , Isao Nagai
发明人： Naoya Wada , Naoki Ueno , Yasuhiko Honda , Isao Nagai
IPC分类号： B02C18/00 , B02C18/18 , B02C18/14
摘要： A regenerated cutting blade to be mounted and used in a shearing type grinder. The cutting blade includes a fixed part and a blade tip projecting outward from this fixed part, in which the blade tip has a leading edge pointed toward the rotating direction. Side edges 110 on the lateral side outer periphery including the blade tip, the leading end edge and the side edges are regenerated and formed by build-up welding. The lateral sides are provided with slip preventive build-up welding parts 111, 112, 113 extending from the side edges 110 toward the central side of its rotation or the central direction, and the build-up welding parts are formed by three regenerating processes.

46. 发明申请

US20140212094A1 OPTICAL FIBER-BASED OPTICAL FUNCTIONAL DEVICE CARTRIDGE MODULE 有权
标题翻译：基于光纤的光功能器件盒模块
公开(公告)号：US20140212094A1
公开(公告)日：2014-07-31
申请号：US14343176
申请日：2012-07-19
申请人： Naoya Wada , Tetsuya Kobayashi , Yusaku Tottori
发明人： Naoya Wada , Tetsuya Kobayashi , Yusaku Tottori
IPC分类号： G02B6/26
CPC分类号： G02B6/26 , G02B6/264 , G02B6/32 , G02B6/3616
摘要： A cartridge-type optical functional module can achieve excellent optical coupling and has an optical fiber-type module or a waveguide-type module. The present invention relates to a cartridge-type optical functional module which has: first and second optical fiber collimators; an optical functional object which has an optical fiber-type module or a waveguide-type module; and a base section. The optical functional object has a third collimator, and a first alignment mechanism for aligning the position of the third collimator in the optical functional object.
摘要翻译：盒式光学功能模块可以实现优异的光耦合，并具有光纤型模块或波导型模块。本发明涉及一种盒式光学功能模块，其具有：第一和第二光纤准直器; 具有光纤型模块或波导型模块的光学功能对象; 和基础部分。光学功能物体具有第三准直仪和用于对准第三准直仪在光学功能物体中的位置的第一对准机构。

47. 发明授权

US08571418B2 High resolution optical waveform shaping device having phase shift compensation associated with optical intensity modulation 有权
标题翻译：具有与光强调制相关联的相移补偿的高分辨率光波形整形装置
公开(公告)号：US08571418B2
公开(公告)日：2013-10-29
申请号：US12664659
申请日：2008-06-12
申请人： Naoya Wada , Seitetsu Boku , Takuya Yoda
发明人： Naoya Wada , Seitetsu Boku , Takuya Yoda
IPC分类号： H04B10/04 , H04B10/12 , H04B10/00 , G02F1/035 , G02B27/28 , G02B27/00 , G02B1/10
CPC分类号： G02B27/0977 , G02B27/0905 , G02B27/0944 , G02F1/093 , G02F2203/26
摘要： It is an object of the present invention to provide an optical waveform shaping device of high resolution.The above-mentioned problem is solved by an optical waveform shaping device (10) comprising a branching filter (11) for dividing the light beam from a light source into light beams of each frequency, a condensing part (12) for condensing a plurality of light beams divided by the branching filter (11), a polarization separation means (13) for adjusting the polarizing planes of the light beams having passed through the condensing part (12), and a spatial light modulator (14) having a phase modulation part and an intensity modulation part where the light beams having passed through the polarizing plate (13) are incident.
摘要翻译：本发明的目的是提供一种高分辨率的光波形整形装置。上述问题由光波形整形装置（10）解决，光波形整形装置（10）包括用于将来自光源的光束分成每个频率的光束的分束滤波器（11），用于冷凝多个由分支滤波器（11）分割的光束，用于调节通过聚光部分（12）的光束的偏振面的偏振光分离装置（13）和具有相位调制部分的空间光调制器（14）以及通过偏振片（13）的光束入射的强度调制部。

48. 发明申请

US20110013909A1 Optical Code Division Multiplexing Access System 审中-公开
标题翻译：光码分多址接入系统
公开(公告)号：US20110013909A1
公开(公告)日：2011-01-20
申请号：US12918322
申请日：2009-02-19
申请人： Nobuyuki Kataoka , Naoya Wada , Gabriella Cincotti , Xu Wang , Kenichi Kitayama , Akira Sakamoto
发明人： Nobuyuki Kataoka , Naoya Wada , Gabriella Cincotti , Xu Wang , Kenichi Kitayama , Akira Sakamoto
IPC分类号： H04J14/00
CPC分类号： H04J14/0282 , G02B6/02057 , G02B6/12011 , G02B6/12019 , H04J14/005
摘要： Problem An object of the present invention is to provide an optical code division multiple access system which is used by many people.Means for Solving The above problem is solved by an optical code division multiple access, OCDMA, system 5 which have a central office 2 comprising a multi-port optical encoder 1, a decode part 4 comprising a decoder 3 for decoding optical code signals from the multi-port optical encoder 1. The multi-port optical encoder 1 transform input optical signals into optical code signals the wavelength of them differs at predetermined amount based on code pattern. The decoder 3 is super structured fiber Bragg grating, SSFBG, which has center wavelength that corresponds to optical code signal.
摘要翻译：发明内容本发明的目的是提供一种由许多人使用的光码分多址系统。解决方案上述问题通过具有包括多端口光学编码器1的中心局2的光码分多址OCDMA系统5来解决，解码部分4包括：解码器3，用于解码来自多端口光学编码器1.多端口光学编码器1将输入光信号转换为光码信号，其波长根据码模式以预定量不同。解码器3是具有对应于光码信号的中心波长的超结构光纤布拉格光栅SSFBG。

49. 发明授权

US07789334B2 Shredding machine and shredding method 有权
标题翻译：粉碎机和粉碎方法
公开(公告)号：US07789334B2
公开(公告)日：2010-09-07
申请号：US10589927
申请日：2005-02-17
申请人： Naoya Wada , Katsu Matsumoto , Natsuki Takemoto , Takashi Ashino , Masuyuki Mieda
发明人： Naoya Wada , Katsu Matsumoto , Natsuki Takemoto , Takashi Ashino , Masuyuki Mieda
IPC分类号： A47J17/18
CPC分类号： B02C18/16 , B02C18/142 , B02C18/2216 , B02C18/24 , B02C2018/0069 , B02C2018/164
摘要： In order to finely crush a shredable object, two rotational shafts for supporting cutting blades are provided in parallel in the transverse direction inside a shredder main body. The cutting blades that are provided with a plurality of cutting portions protruding from outer peripheral thereof are disposed in the shaft direction of the two rotational shafts so that these cutting portions engage with each other. A throw-in port for a shredable object is provided in one end portion of the rotational shafts in an upper portion of the shredder main body in the shaft direction. A discharge port for the shredable object is provided in the other end portion of the rotational shafts in a lower portion of this shredder main body in the shaft direction. Transverse feeding members for forwarding the shredable object that is thrown into the throw-in port and crushed by the cutting blades, to a discharge port side is provided and, thereby shredding the shredable object for a plurality of times inside the shredder main body.
摘要翻译：为了细碎可撕碎物体，用于支撑切割刀片的两个旋转轴在切碎机主体内沿横向平行设置。设置有从其外周突出的多个切割部的切割刀沿两个旋转轴的轴方向设置，使得这些切割部彼此接合。在切割粉碎机主体的轴向上的上部的旋转轴的一个端部设置有用于可切碎物体的投入口。用于可撕碎物体的排出口设置在该切碎机主体的轴向的下部的旋转轴的另一端部。设置用于将被投入到扔入口并被切割刀片破碎的可切碎物体送入排出口侧的横向供给部件，从而将破碎物体在切碎机主体内分割多次。

50. 发明申请

US20100196005A1 Optical Multiport Spectral Phase Encoder 有权
标题翻译：光学多端口光谱相位编码器
公开(公告)号：US20100196005A1
公开(公告)日：2010-08-05
申请号：US12668025
申请日：2008-07-07
申请人： Naoya Wada , Gabriella Cincotti , Xu Wang , Kenichi Kitayama
发明人： Naoya Wada , Gabriella Cincotti , Xu Wang , Kenichi Kitayama
IPC分类号： H04J14/00 , G02B6/26
CPC分类号： G02B6/29395 , G02B6/12019 , G02B6/29355 , H04J14/005 , H04K1/006
摘要： Data security of a multi-dimensional code system is increased. An optical device is provided with a single input port; a splitter splitting an input light from the input port into a plurality of lights; a plurality of phase shifters each shifting one of the lights split by the splitter; a multi-port encoder/decoder inputting the lights whose phases are shifted by the phase shifters and generating spectral encoded codes; and a plurality of output ports outputting the spectral encoded codes generated by the multi-port encoder/decoder.
摘要翻译：增加了多维码系统的数据安全性。光学装置设置有单个输入端口; 分离器，将输入端口的输入光分成多个光; 多个移相器，每个移动由分离器分裂的一个光; 输入相位被移相器偏移并产生频谱编码的多端口编码器/解码器; 以及输出由多端口编码器/解码器生成的频谱编码码的多个输出端口。

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