会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 41. 发明授权
    • Compositions and methods of nematode control
    • 线虫控制的组成和方法
    • US06863881B2
    • 2005-03-08
    • US10629201
    • 2003-07-29
    • David GreensteinMichael A. Miller
    • David GreensteinMichael A. Miller
    • A61K38/00C07K14/435G01N33/50A61K49/00
    • G01N33/5085A01K2217/05A61K38/00C07K14/4354
    • The present invention provides compositions and methods for identifying agents that stimulate or inhibit nematode reproduction, especially related to oocyte maturation, sheath cell contraction, and ovulation. It is disclosed that the major sperm protein (MSP) is acts in signal transduction of female sexual maturation in nematodes. Provided are compositions and methods for identifying anti-nematode agents with MSP as a target and for controlling nematode populations. MSP is an excellent target for identification of anti-nematode factors because it is highly conserved among members of the phylum Nematoda and is not known to exist in other organisms, especially crops, livestock, pets, and humans. Thus, anti-nematode agents that target MSP are less likely to induce severe side effects when administered to a host and the nematode is unlikely to develop resistance to a highly conserved molecule involved in sexual reproduction.
    • 本发明提供用于鉴定刺激或抑制线虫繁殖,特别是与卵母细胞成熟,鞘细胞收缩和排卵相关的药剂的组合物和方法。 据了解,主要精子蛋白(MSP)在线虫中女性性成熟的信号转导中起作用。 提供了用MSP作为靶标和用于控制线虫种群鉴定抗线虫剂的组合物和方法。 MSP是鉴定抗线虫因子的极好目标,因为它在门虫线虫成员中是高度保守的,不知道存在于其他生物体,尤其是作物,家畜,宠物和人类中。 因此,靶向MSP的抗线虫剂在施用于宿主时不太可能引起严重的副作用,并且线虫不太可能对涉及性繁殖的高度保守的分子产生抗性。
    • 44. 发明授权
    • Method of forming a helical ball screw member
    • 形成螺旋滚珠丝杠构件的方法
    • US4760635A
    • 1988-08-02
    • US914981
    • 1986-10-03
    • Michael A. Miller
    • Michael A. Miller
    • B23G1/36F16H25/22B23P13/04
    • F16H25/2204B23G1/36Y10T29/49996Y10T74/19721Y10T74/19781
    • A method of forming a ball screw member from an elongated workpiece having an outer cylindrical surface, as well as the ball screw member formed by the method. A helical ball screw thread is machined on the outer cylindrical surface, the helical ball screw thread having a helical groove and a helical crest surface. An end journal or other end treatment is formed in the workpiece, the end journal or other end treatment being located during the forming operation relative to the helical crest surface. Alternatively the end journal or other end treatment is formed in the workpiece and the helical screw thread is then machined while the outer cylindrical surface is located relative to the end journal or other end treatment during the machining of the helical ball screw thread on the outer cylindrical surface. The outer cylindrical surface of the workpiece may be centerless ground prior to the machining of the helical ball screw thread. The helical crest surface may be ground after the machining of the helical ball screw thread to provide increased concentricity between components of the ball screw member. A high precision ball screw member may be formed from the ball screw member by performing a regrinding operation on the helical groove, the regrinding operation being positioned relative to the helical crest surface.
    • 从具有外圆柱面的细长工件以及通过该方法形成的滚珠丝杠部件形成滚珠丝杠部件的方法。 在外圆柱表面上加工螺旋滚珠丝杠,螺旋滚珠丝杠具有螺旋槽和螺旋形顶表面。 在工件中形成端部轴颈或其他端部处理,端部轴颈或其他端部处理在成形操作期间相对于螺旋形顶表面定位。 或者,端部轴颈或其它端部处理形成在工件中,然后在螺旋滚珠丝杠在外圆柱体的加工过程中加工螺旋螺纹,同时外圆柱面相对于端轴颈定位或其它端部处理 表面。 在加工螺旋滚珠丝杠之前,工件的外圆柱表面可以是无心磨削的。 可以在加工螺旋滚珠丝杠之后研磨螺旋波峰表面,以在滚珠丝杠构件的部件之间提供增加的同心度。 可以通过对螺旋槽进行再磨削操作,由滚珠丝杠构件形成高精度的滚珠丝杠构件,再次研磨操作相对于螺旋形顶面定位。