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41. 发明申请

US20080166733A1 METHOD FOR DETERMINING THE PROGNOSIS OF CANCER PATIENTS BY MEASURING LEVELS OF BAG EXPRESSION 审中-公开
标题翻译：通过测量囊表达水平来确定癌症患者预后的方法
公开(公告)号：US20080166733A1
公开(公告)日：2008-07-10
申请号：US12052693
申请日：2008-03-20
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C12Q1/68 , C12Q1/00 , G01N33/483
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N2800/52
摘要： In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods for predicting the risk of tumor recurrence or spread in an individual having a cancer tumor. Methods for screening a cancer patient to determine the risk of tumor metastasis; methods for determining the proper course of treatment for a patient suffering from cancer; and kits for use in practicing the invention methods.
摘要翻译：根据本发明，提供了确定患有癌症的患者中无疾病或总体存活的预后的方法。还提供了用于预测具有癌肿瘤的个体中肿瘤复发或扩散的风险的方法。筛选癌症患者以确定肿瘤转移风险的方法; 确定患有癌症的患者的适当治疗过程的方法; 以及用于实施本发明方法的试剂盒。

42. 发明授权

US07390656B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US07390656B2
公开(公告)日：2008-06-24
申请号：US11441861
申请日：2006-05-26
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12N5/00 , C07H21/02
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体用于药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。

43. 发明授权

US07373127B2 Digital beam forming for communications systems 有权
标题翻译：通信系统的数字波束形成
公开(公告)号：US07373127B2
公开(公告)日：2008-05-13
申请号：US11115721
申请日：2005-04-27
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： H04B1/06
CPC分类号： H04B7/086 , H04B7/0845 , H04B7/088
摘要： An antenna-receiver communications system and method is provided to mechanize multibeam mobile antenna-receive subsystems. Digital beam forming for modern wideband mobile communications systems is provided. In an aspect, subsystems can simultaneously receive, acquire, track and output a multiplicity of signals from sources of different locations using a single antenna aperture from a mobile platform. The angle of arrival of a signal of interest is continuously determined. Individual phased array antenna output channels are phased aligned as required by the phased array equation and monopulse signal processing. Angle sensing and beamsteering are separated from antenna channel coherent summation. Thus, the angle sensing and beamsteering functions are not required to be computed at the data rate, but can instead be computed at a rate necessary for the beam acquisition and beam tracking function speed requirements. Signal processing computational load and system cost is reduced as compared to current systems.
摘要翻译：提供天线接收机通信系统和方法来机械化多波束移动天线接收子系统。提供了现代宽带移动通信系统的数字波束形成。在一个方面，子系统可以使用来自移动平台的单个天线孔，同时从不同位置的来源接收，获取，跟踪和输出多个信号。连续确定感兴趣信号的到达角度。单相相控阵天线输出通道根据相控阵方程和单脉冲信号处理的要求进行相位对准。角度感测和波束导向与天线信道相干相加分离。因此，角度感测和波束导向功能不需要以数据速率计算，而是可以以波束采集和波束跟踪功能速度要求所需的速率来计算。与现有系统相比，信号处理计算负荷和系统成本降低。

44. 发明授权

US07208581B1 TRAF family proteins 失效
标题翻译： TRAF家族蛋白
公开(公告)号：US07208581B1
公开(公告)日：2007-04-24
申请号：US09706325
申请日：2000-11-03
申请人： Juan M. Zapata , John C. Reed
发明人： Juan M. Zapata , John C. Reed
IPC分类号： C07K16/00 , C12P21/08 , C12N5/06
CPC分类号： C07K16/18
摘要： In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also provides antibodies that can specifically bind to invention TPBDs. Such TPBDs and/or anti-TPBD antibodies are useful for discovery of drugs that suppress autoimmunity, inflammation, allergy, allograph rejection, sepsis, and other diseases.
摘要翻译：根据本发明，提供了新型TRAF-蛋白结合域多肽（TPBD）。本发明还提供编码TPBD的核酸分子，含有这些核酸分子的载体和含有载体的宿主细胞。本发明还提供可以特异性结合本发明的TPBD的抗体。这样的TPBD和/或抗TPBD抗体可用于发现抑制自身免疫，炎症，过敏，同种异体排斥，败血症和其它疾病的药物。

45. 发明授权

US07087386B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
公开(公告)号：US07087386B2
公开(公告)日：2006-08-08
申请号：US10679246
申请日：2003-10-02
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12Q1/68 , C12P21/06 , C07H21/02
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.

46. 发明授权

US06841541B1 Regulation of BCL-2-gene expression 有权
标题翻译： BCL-2基因表达调控
公开(公告)号：US06841541B1
公开(公告)日：2005-01-11
申请号：US09724425
申请日：2000-11-28
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The present invention provides novel anticode oligomers and methods of using them for controlling growth of cancer cells expressing the bcl-2 gene.
摘要翻译：本发明提供了新的抗ode寡聚物和使用它们来控制表达bcl-2基因的癌细胞生长的方法。

47. 发明授权

US06414134B1 Regulation of bcl-2 gene expression 失效
标题翻译：调节bcl-2基因表达
公开(公告)号：US06414134B1
公开(公告)日：2002-07-02
申请号：US09724426
申请日：2000-11-28
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： C07H2104
CPC分类号： C12N15/1135 , A61K38/00 , A61K45/06 , C12N2310/111 , C12N2310/3125 , C12N2310/315
摘要： The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.
摘要翻译：本发明提供了新的抗交联低聚物及其用于控制表达bcl-2基因的癌细胞生长的方法。

48. 发明授权

US06228603B1 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity 失效
标题翻译：用于改变caspase活性的凋亡抑制剂（IAP）蛋白调节剂的筛选试验
公开(公告)号：US06228603B1
公开(公告)日：2001-05-08
申请号：US09058969
申请日：1998-04-10
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

49. 发明授权

US5831066A Regulation of bcl-2 gene expression 失效
公开(公告)号：US5831066A
公开(公告)日：1998-11-03
申请号：US465485
申请日：1995-06-05
申请人： John C. Reed
发明人： John C. Reed
IPC分类号： A61K38/00 , A61K45/06 , A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/12 , C12Q1/68 , C12N15/85
CPC分类号： C12N15/1135 , A61K45/06 , A61K38/00 , C12N2310/111 , C12N2310/3125 , C12N2310/315
摘要： The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.

50. 发明授权

US5747245A Nucleic acids encoding Fas associated proteins and screening assays using same 失效
标题翻译：编码Fas相关蛋白的核酸和使用其的筛选测定
公开(公告)号：US5747245A
公开(公告)日：1998-05-05
申请号：US259514
申请日：1994-06-14
申请人： John C. Reed , Takaaki Sato
发明人： John C. Reed , Takaaki Sato
IPC分类号： A61K38/00 , C12N9/16 , C12N15/10 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6897 , C12N15/1055 , C12N9/16 , A61K38/00
摘要： The present invention provides mammalian protein tyrosine phosphatases, human PTP-BAS type 4, human PTP-BAS type 5a and mouse PTP-BAS type 5b, each of which is a Fas-associated protein (FAP), nucleic acid molecules encoding a PTP-BAS type 4 or a PTP-BAS type 5 and antibodies specific for a PTP-BAS type 4 or for a PTP-BAS type 5. The invention also provides methods for identifying FAP's, which can associate with Fas and can modulate apoptosis. The invention also provides screening assays for identifying an agent that can effectively alter the association of a FAP with Fas and, therefore, can increase or decrease the level of apoptosis in a cell. The invention further provides methods of modulating apoptosis in a cell by introducing into the cell a nucleic acid molecule encoding a PTP-BAS or an antisense nucleotide sequence, which is complementary to a portion of a nucleic acid molecule encoding a PTP-BAS. The invention also provides a method of using a reagent that can specifically bind to a FAP to diagnose a pathology that is characterized by an increased or decreased level of apoptosis in a cell. The invention also provides methods of modulating apoptosis in a cell by contacting the cell with an agent that effectively alters the association of a FAP and Fas in a cell or alters the activity of a FAP in a cell.
摘要翻译：本发明提供哺乳动物蛋白酪氨酸磷酸酶，人PTP-BAS型4，人PTP-BAS型5a和小鼠PTP-BAS型5b，其各自是Fas相关蛋白（FAP），编码PTP- BAS型4或PTP-BAS型5和PTP-BAS型4或PTP-BAS型5特异性抗体。本发明还提供鉴定FAP的方法，其可与Fas结合并可调节细胞凋亡。本发明还提供用于鉴定能够有效改变FAP与Fas的缔合的试剂的筛选测定，因此可以增加或降低细胞凋亡水平。本发明还提供了通过将编码PTP-BAS或反义核苷酸序列的核酸分子与编码PTP-BAS的核酸分子的一部分互补的细胞引入细胞来调节细胞凋亡的方法。本发明还提供了使用能够特异性结合FAP的试剂来诊断细胞凋亡水平升高或降低的病理学的方法。本发明还提供了通过使细胞与有效改变细胞中FAP和Fas的缔合的试剂接触而改变细胞凋亡的方法或改变细胞中FAP的活性的方法。

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