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    • 50. 发明授权
    • Method for production of L-glutamine
    • L-谷氨酰胺的生产方法
    • US08187843B2
    • 2012-05-29
    • US12439300
    • 2007-08-30
    • Yugo AdachiMikiro HayashiAkihiro SenooYoshiyuki YonetaniShin-ichi Hashimoto
    • Yugo AdachiMikiro HayashiAkihiro SenooYoshiyuki YonetaniShin-ichi Hashimoto
    • C12P13/14
    • C12N9/1205C12N9/0008C12P13/14
    • According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology of 80% or more to the amino acid sequence shown by any one of SEQ ID NO:1 to 3, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, has been reduced or lost, and wherein the activity of (3) a protein having the amino acid sequence shown by SEQ ID NO:4, or (4) a protein having a homology of 80% or more to the amino acid sequence shown by SEQ ID NO:4, and having substantially the same activity as the activity of a protein having the amino acid sequence shown by SEQ ID NO:4, has been reduced or lost, and a process for producing L-glutamine using the microorganism and the like.
    • 根据本发明,可以提供属于棒状杆菌属的微生物,其中(1)具有SEQ ID NO:1〜3或(2)中任一项所示的氨基酸序列的蛋白质的活性, 与SEQ ID NO:1〜3中任一项所示的氨基酸序列具有80%以上的同源性的蛋白质,并且具有与具有下述任一项所示的氨基酸序列的蛋白质的活性基本上相同的活性 SEQ ID NO:1至3已经被还原或丧失,并且其中(3)具有SEQ ID NO:4所示氨基酸序列的蛋白质的活性,或(4)具有80%同源性的蛋白质或 更多地与SEQ ID NO:4所示的氨基酸序列相比,具有与SEQ ID NO:4所示的氨基酸序列的蛋白质的活性基本上相同的活性已被减少或丧失, 使用微生物等的L-谷氨酰胺。