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41. 发明授权

US4531373A Directional solidification for the controlled freezing of biomaterials 失效
标题翻译：用于生物材料受控冷冻的定向凝固
公开(公告)号：US4531373A
公开(公告)日：1985-07-30
申请号：US664164
申请日：1984-10-24
申请人： Boris Rubinsky
发明人： Boris Rubinsky
IPC分类号： A01N1/02 , F25D13/06 , F26B5/06 , G01N1/42
CPC分类号： G01N1/42 , A01N1/02 , A01N1/0257 , F25D13/062 , F26B5/06
摘要： Controlled freezing of a material (12) is accomplished by positioning an aliquot of the material (12) upon one surface (26) of a longitudinally extending substrate (14). First (30) and second (36) bases are provided each having heat transfer surfaces (32,40) which are adapted to sit in heat transfer relation with the other surface (24) of the substrate (14). The temperature of the first base (30) is controlled to be above the freezing temperature of the material (12). The temperature of the second base (36) is controlled to be below the freezing temperature of the material (12). The substrate (14) is moved longitudinally across the first base (30) in the direction of second base (36) while maintaining heat transfer relation of both bases (30,36) with the first surface (24) of the substrate (14). The frezzing rate of the material (12) is closely controlled and frozen material (12) can be produced in a continuous process.
摘要翻译：通过将材料（12）的等分试样定位在纵向延伸的基底（14）的一个表面（26）上来实现材料（12）的受控冷冻。提供第一（30）和第二（36）基座，每个基座具有适于与衬底（14）的另一表面（24）保持热传递关系的传热表面（32,40）。第一基座（30）的温度被控制为高于材料（12）的冷冻温度。将第二基座（36）的温度控制在材料（12）的冷冻温度以下。基板（14）沿着第二基座（36）的方向纵向移动穿过第一基座（30），同时保持两个基座（30,36）与基板（14）的第一表面（24）的热传递关系，。材料（12）的高效率被严格控制，冷冻材料（12）可以连续生产。

42. 发明申请

US20120034131A1 APPARATUS, SYSTEM AND METHOD FOR PREVENTING BIOLOGICAL CONTAMINATION TO MATERIALS DURING STORAGE USING PULSED ELECTRICAL ENERGY 审中-公开
标题翻译：装置，系统和方法，用于防止在使用脉冲电能存储期间对材料的生物污染
公开(公告)号：US20120034131A1
公开(公告)日：2012-02-09
申请号：US13259516
申请日：2010-03-24
申请人： Boris Rubinsky , Michael Belkin , Alexander Goldberg , Ariel Sverdlik
发明人： Boris Rubinsky , Michael Belkin , Alexander Goldberg , Ariel Sverdlik
IPC分类号： A61L2/03
CPC分类号： A23L3/32 , A23B4/012 , A23L3/005 , A61L2/035 , A61L12/023
摘要： A container having a main storage space for holding a matter, having an inlet/outlet opening and fitted with a PEF system. The PEF system comprises two or more electrodes disposed within said container and contacting the matter; and electric pulse source connected to the two or more electrodes and adapted to pass pulsed electric energy through the matter. The PEF system being activated to deliver a treatment protocol to the matter.
摘要翻译：具有用于保持物品的主存储空间的容器，具有入口/出口开口并装配有PEF系统。 PEF系统包括设置在所述容器内并接触物体的两个或更多个电极; 并且电脉冲源连接到两个或更多个电极并且适于通过该物质传递脉冲电能。 PEF系统被激活以提供治疗方案。

43. 发明授权

US08101421B2 Volumetric induction phase shift detection system for determining tissue water content properties 有权
标题翻译：用于确定组织含水量特性的体积感应相移检测系统
公开(公告)号：US08101421B2
公开(公告)日：2012-01-24
申请号：US13028082
申请日：2011-02-15
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01N27/00 , G01N33/48 , G01R27/08 , G01R25/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差和第二感应线圈（或天线）位于组织样本的相对侧上。

44. 发明授权

US08048067B2 Tissue ablation with irreversible electroporation 有权
标题翻译：组织消融与不可逆电穿孔
公开(公告)号：US08048067B2
公开(公告)日：2011-11-01
申请号：US10571162
申请日：2004-12-21
申请人： Rafael Davalos , Boris Rubinsky
发明人： Rafael Davalos , Boris Rubinsky
IPC分类号： A61B18/18
CPC分类号： A61B18/12 , A61B18/1233 , A61B18/1477 , A61B2018/00577 , A61B2018/00613 , A61B2018/1425 , A61N1/0412 , A61N1/0472 , A61N1/05 , A61N1/327
摘要： A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.
摘要翻译：公开了一种用于消除不想要的组织的新方法，例如癌性或非癌性肿瘤的细胞。它涉及通过施加电脉冲将电极放置在不期望的组织附近或附近，从而在不期望的组织的整个区域内引起细胞的不可逆电穿孔。电脉冲不可逆地渗透细胞膜，从而引起细胞死亡。不可逆透化的细胞留在原位，并通过身体免疫系统去除。通过使用不可逆电穿孔而不引起热损伤可实现的组织消融量是相当大的。

45. 发明申请

US20110193575A1 VOLUMETRIC INDUCTION PHASE SHIFT DETECTION SYSTEM FOR DETERMINING TISSUE WATER CONTENT PROPERTIES 有权
标题翻译：用于确定组织水含量特性的体积感应相位移动检测系统
公开(公告)号：US20110193575A1
公开(公告)日：2011-08-11
申请号：US13028082
申请日：2011-02-15
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01R27/08
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差和第二感应线圈（或天线）位于组织样本的相对侧上。

46. 发明授权

US07951582B2 Systems and methods for analyzing and manipulating biological samples 有权
标题翻译：分析和操作生物样品的系统和方法
公开(公告)号：US07951582B2
公开(公告)日：2011-05-31
申请号：US12086780
申请日：2006-11-06
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
IPC分类号： C12M3/00 , C12Q1/02
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译：提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器细胞。

47. 发明授权

US07910374B2 Volumetric induction phase shift detection system for determining tissue water content properties 有权
标题翻译：用于确定组织含水量特性的体积感应相移检测系统
公开(公告)号：US07910374B2
公开(公告)日：2011-03-22
申请号：US12616102
申请日：2009-11-10
申请人： Boris Rubinsky , Cesar A. Gonzalez
发明人： Boris Rubinsky , Cesar A. Gonzalez
IPC分类号： G01N27/00 , G01N33/48 , G01R27/08 , G01R25/00
CPC分类号： A61B5/0537 , A61B5/02042 , A61B5/0205 , A61B5/05 , A61B5/053 , A61B5/4064 , A61B5/413 , A61B5/4244 , A61B5/443 , A61B5/4519 , A61B5/4869 , A61B5/4878 , A61B5/7225 , A61B5/7228 , A61B5/725 , A61B2562/143 , G01N27/026 , G01R33/34 , G01R33/36 , G01R33/4828 , G01R33/483
摘要： A method of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample. An apparatus for determining the condition of a bulk tissue sample, having: a first induction coil (or antenna); a second induction coil (or antenna); an alternating current power supply connected to the first induction coil (or antenna), the alternating current power supply configured to generate a spectrum of currents (or voltage) in the first induction coil (or antenna); and a measurement system connected to the second induction coil (or antenna), wherein the measurement system is configured to measure a phase shift difference in the spectrum of currents (or voltages) between the first and second induction coils (or antennae) when the first and second induction coils (or antennae) are positioned on opposite sides of a tissue sample.
摘要翻译：通过以下步骤确定体组织样本的状况的方法：将体组织样本定位在一对感应线圈（或天线）之间; 通过感应线圈（或天线）中的第一个通过交流（或电压）的频谱; 测量第二个感应线圈（或天线）中产生的交流（或电压）的频谱; 以及比较第一和第二感应线圈（或天线）中的交流电流（或电压）的频谱之间的相移，由此确定本体组织样本的状况。一种用于确定体组织样本的状况的装置，具有：第一感应线圈（或天线）; 第二感应线圈（或天线）; 连接到所述第一感应线圈（或天线）的交流电源，所述交流电源被配置为在所述第一感应线圈（或天线）中产生电流（或电压）的频谱; 以及连接到所述第二感应线圈（或天线）的测量系统，其中所述测量系统被配置为当所述第一感应线圈（或天线））测量所述第一和第二感应线圈（或天线）之间的电流（或电压）的频谱中的相移差并且第二感应线圈（或天线）位于组织样本的相对侧上。

48. 发明申请

US20110034209A1 WIRELESS TECHNOLOGY AS A DATA CONDUIT IN THREE-DIMENSIONAL ULTRASONOGRAY 审中-公开
标题翻译：无线技术作为三维超声波数据传输
公开(公告)号：US20110034209A1
公开(公告)日：2011-02-10
申请号：US12856323
申请日：2010-08-13
申请人： Boris Rubinsky , Antoni Ivorra , Yair Granot , Arie Meir
发明人： Boris Rubinsky , Antoni Ivorra , Yair Granot , Arie Meir
IPC分类号： H04W4/00 , G06K9/00
CPC分类号： G06F19/3418 , G06F19/321 , H04W88/02
摘要： An imaging system, having: an imaging data acquisition device; a remote image reconstruction and data processing facility; and a wireless data transfer to transmit raw data from the data acquisition device to the remote facility. At the facility, the raw data is processed to prepare a diagnostic image that can be transmitted to an expert or non-expert, or transmitted back to the display of the wireless data transfer device.
摘要翻译：一种成像系统，具有：成像数据采集装置; 远程图像重建和数据处理设施; 以及无线数据传输，用于将原始数据从数据采集设备传输到远程设备。在设备处理原始数据以准备可以发送给专家或非专家的诊断图像，或者发送回无线数据传送装置的显示器。

49. 发明授权

US07674249B2 Gels with predetermined conductivity used in electroporation of tissue 有权
标题翻译：具有预定电导率的凝胶用于组织电穿孔
公开(公告)号：US07674249B2
公开(公告)日：2010-03-09
申请号：US11872985
申请日：2007-10-16
申请人： Antoni Ivorra , Boris Rubinsky
发明人： Antoni Ivorra , Boris Rubinsky
IPC分类号： A61M31/00
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

50. 发明申请

US20080214986A1 GELS WITH PREDETERMINED CONDUCTIVITY USED IN ELECTROPORATION OF TISSUE 有权
标题翻译：在组织电导中使用预测的电导率的凝胶
公开(公告)号：US20080214986A1
公开(公告)日：2008-09-04
申请号：US11872985
申请日：2007-10-16
申请人： Antoni Ivorra , Boris Rubinsky
发明人： Antoni Ivorra , Boris Rubinsky
IPC分类号： A61N1/30
CPC分类号： A61K9/0009 , A61K9/0024 , A61M5/329 , A61N1/042 , A61N1/327
摘要： Gel compositions with adjusted conductivity are disclosed which compositions are used for directing reversible electroporation and irreversible electroporation of cells and tissue. The gel compositions are also used in a similar manner in order to carry out thermotherapy on cells and tissues.
摘要翻译：公开了具有调节的电导率的凝胶组合物，其组合物用于引导细胞和组织的可逆电穿孔和不可逆电穿孔。凝胶组合物也以类似的方式使用，以对细胞和组织进行热疗。

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