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41. 发明申请

US20120039849A1 TETRAHYDROTHIAZOLOPYRIDINE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE 失效
标题翻译：磷脂酰肌醇三激酶的四氢吡咯并吡啶抑制剂
公开(公告)号：US20120039849A1
公开(公告)日：2012-02-16
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/437 , A61K31/497 , A61P25/00 , A61P29/00 , C12N9/99 , A61P37/06 , A61K38/21 , A61K38/07 , A61K39/395 , C07D471/04 , A61P37/02
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

42. 发明申请

US20090227607A1 DEAZAPURINES USEFUL AS INHIBITORS OF JANUS KINASES 审中-公开
标题翻译： DEAZAPURINES有用作JANK KINASES的抑制剂
公开(公告)号：US20090227607A1
公开(公告)日：2009-09-10
申请号：US12245069
申请日：2008-10-03
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04 , C12N9/99
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

43. 发明申请

US20090088445A1 Deazapurines useful as inhibitors of Janus kinases 失效
标题翻译：脱氮嘌呤可用作Janus激酶抑制剂
公开(公告)号：US20090088445A1
公开(公告)日：2009-04-02
申请号：US11732845
申请日：2007-04-05
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

44. 发明申请

US20070004762A9 Pyrrolopyrimidines useful as inhibitors of protein kinase 失效
标题翻译：吡咯并嘧啶可用作蛋白激酶的抑制剂
公开(公告)号：US20070004762A9
公开(公告)日：2007-01-04
申请号：US11346048
申请日：2006-02-02
申请人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
发明人： Mark Ledeboer , Albert Pierce , Guy Bemis , Luc Farmer , Tiansheng Wang , David Messersmith , John Duffy , Francesco Salituro , Jian Wang
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

45. 发明授权

US6076805A Rope pulling device 失效
标题翻译：绳牵引装置
公开(公告)号：US6076805A
公开(公告)日：2000-06-20
申请号：US382322
申请日：1999-08-24
申请人： David Messersmith
发明人： David Messersmith
IPC分类号： B66D3/14 , B21F9/00
CPC分类号： B66D3/14
摘要： A rope pulling device includes a come-along (20) having a frame (30) on which are mounted an anchor end grip assembly (200) and a load end grip assembly (300). During operation, the anchor end grip assembly is locked on the rope. A hook (100) is carried on the spindle (62) of the ratchet assembly (60). A lever assembly (50) drives a pawl assembly (80) which rotates the ratchet assembly in the forward direction. The hook causes rope to move through the unlocked load end grip assembly and to wind about the spindle. When the spindle is full, the load end grip assembly is locked. A lock assembly (70), which prevents counter-rotation of the spindle is released, allowing the spindle to be reversed and emptied. Slack rope is then passed around the hook, and wound about the spindle for approximately two turns. The load end grip assembly may then be released and the spindle may again be filled with rope, thereby pulling the load (400) closer to the anchor (500).
摘要翻译：绳索牵引装置包括具有框架（30）的落地（20），安装有锚固端部夹持组件（200）和负载端部夹持组件（300）。在操作期间，锚固端部把手组件被锁定在绳索上。钩子（100）被承载在棘轮组件（60）的主轴（62）上。杠杆组件（50）驱动棘爪组件（80），棘爪组件（80）使棘轮组件沿向前方向旋转。钩子使绳索移动通过解锁的装载端部把手组件并围绕主轴卷绕。当主轴已满时，装载端把手组件被锁定。释放防止主轴反向旋转的锁组件（70），从而允许主轴反向和倒空。然后将松紧绳绕过钩子，围绕主轴缠绕大约两圈。然后可以释放负载端部夹持组件，并且主轴可以再次用绳索填充，从而将负载（400）拉近更靠近锚固件（500）。

46. 发明授权

US5319143A Bis(aminoethanethiols) 失效
标题翻译：双（氨基乙硫醇）
公开(公告)号：US5319143A
公开(公告)日：1994-06-07
申请号：US923859
申请日：1992-07-31
申请人： David Messersmith , David P. Waller
发明人： David Messersmith , David P. Waller
IPC分类号： C07C323/25 , C07C323/24
CPC分类号： C07C323/25
摘要： There are disclosed certain bis(aminoethanethiols) and the salts thereof which find utility as intermediates in the preparation of certain dye-providing compounds useful in photographic imaging systems.
摘要翻译：公开了某些二（氨基乙硫醇）及其盐可用作制备用于照相成像系统的某些提供染料的化合物的中间体。

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