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41. 发明授权

US06405065B1 Non-invasive in vivo tissue classification using near-infrared measurements 失效
标题翻译：使用近红外测量的非侵入性体内组织分类
公开(公告)号：US06405065B1
公开(公告)日：2002-06-11
申请号：US09487547
申请日：2000-01-19
申请人： Stephen F. Malin , Timothy L. Ruchti , Jessica Rennert
发明人： Stephen F. Malin , Timothy L. Ruchti , Jessica Rennert
IPC分类号： A61B500
CPC分类号： G01N21/4785 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/7264 , A61B5/7267 , A61B2560/0223 , G01N21/359 , Y10S128/923
摘要： An in vivo, non-invasive method of tissue classification using near-IR (NIR) spectral measurements. A classification model is based on NIR spectral absorbance measurements from an exemplary population. Spectral features representing variation between tissue types are identified. Analytic techniques enhance the features of interest and correct spectral interference to improve the predictive ability of the classification model. A classification routine defines classes based on variation between tissue types, such that variation within a class is small compared to variation between classes. A decision rule assigns individual samples from the exemplary population to classes. An in-vivo, non-invasive procedure applies the classification model to individual tissue samples. A preferred embodiment of the invention distinguishes transgenic mice from non-transgenic individuals based on variation in fat composition within muscle tissue.
摘要翻译：使用近红外（NIR）光谱测量的体内非侵入性组织分类方法。分类模型基于来自示例性群体的近红外光谱吸收测量。识别表示组织类型之间变化的光谱特征。分析技术增强了感兴趣的特征和正确的光谱干扰，从而提高了分类模型的预测能力。分类程序基于组织类型之间的变化来定义类，使得类之间的变化与类之间的变化相比较小。决策规则将个体样本从示例性群体分配到类别。体内非侵入性手术将分类模型应用于个体组织样本。本发明的优选实施方案基于肌肉组织内脂肪组成的变化来区分转基因小鼠与非转基因个体。

42. 发明授权

US09240002B2 Systems and methods for a graphical interface including a graphical representation of medical data 有权
标题翻译：图形界面的系统和方法，包括医疗数据的图形表示
公开(公告)号：US09240002B2
公开(公告)日：2016-01-19
申请号：US13588026
申请日：2012-08-17
申请人： James A. Hume , Robert M. Hume , Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund
发明人： James A. Hume , Robert Mayer , Devy Amy Lee , Gabriele Ott , Candida Arvelo , Timothy L. Ruchti , Tamas Ban , Mohammad M. Khair , Nancy H. Hedlund
IPC分类号： G06F3/048 , G06Q10/10 , G06Q50/22 , G06F19/00
CPC分类号： G06Q10/10 , A61M2205/502 , A61M2205/52 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H10/60 , G16H15/00 , G16H40/63 , G16H50/20 , G16H50/70
摘要： This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.
摘要翻译：本公开描述了用于包括医学数据的图形表示的图形界面的系统和方法。图形界面平台可以接收医疗数据并提供医疗安全报告功能，包括历史数据的报告和实时的可视化监视数据。图形界面平台可以被配置为在通过可视表示性能度量进行报告周期的同时，识别在操作中的医疗设备的潜在问题和修正。

43. 发明申请

US20150141955A1 INFUSION PUMP AUTOMATION SYSTEM AND METHOD 审中-公开
标题翻译：输液泵自动化系统及方法
公开(公告)号：US20150141955A1
公开(公告)日：2015-05-21
申请号：US14547376
申请日：2014-11-19
申请人： Timothy L. Ruchti , Harsh Dharwad , Lynn D. Neuhardt , Aaron P. Perez
发明人： Timothy L. Ruchti , Harsh Dharwad , Lynn D. Neuhardt , Aaron P. Perez
IPC分类号： A61M5/172 , A61M5/142
CPC分类号： G16H20/17 , A61M5/142 , A61M2005/14208 , A61M2205/502 , G06F19/00 , G06F19/3418 , G06F19/3468 , G16H40/67
摘要： An infusion pump automation system and method includes an infusion pump, an infusion pump and a remote processor. The remote processor is remote to the infusion pump and includes a controller interface and a controller, such that the controller bidirectionally communicates with the infusion pump, determines a current infusion state of the infusion pump and a current infusion pump user interface state and accepts a command to change the infusion state of the infusion pump from an external server. The controller determines if the command is consistent with the current infusion state of the infusion pump and the current infusion pump user interface state, executes the command if the command is able to be successfully executed, and confirms that the command is successfully executed.
摘要翻译：输液泵自动化系统和方法包括输液泵，输液泵和远程处理器。远程处理器远离输液泵并且包括控制器接口和控制器，使得控制器与输注泵双向通信，确定输注泵的当前输液状态和当前输液泵用户界面状态并接受命令从外部服务器改变输液泵的输液状态。控制器确定命令是否与输液泵的当前输液状态和当前输液泵用户界面状态一致，如果能够成功执行命令，则执行命令，并确认命令是否成功执行。

44. 发明申请

US20140350513A1 MULTI-SENSOR INFUSION SYSTEM FOR DETECTING AIR OR AN OCCLUSION IN THE INFUSION SYSTEM 审中-公开
标题翻译：用于检测输血系统中的空气或渗漏的多传感器输注系统
公开(公告)号：US20140350513A1
公开(公告)日：2014-11-27
申请号：US14285797
申请日：2014-05-23
申请人： Meriyan Oruklu , Timothy L. Ruchti , Paul T. Kotnik , Anatoly S. Belkin , Brian G. Markey
发明人： Meriyan Oruklu , Timothy L. Ruchti , Paul T. Kotnik , Anatoly S. Belkin , Brian G. Markey
IPC分类号： A61M5/168 , A61M5/50
CPC分类号： A61M5/16854 , A61M5/365 , A61M5/5086 , A61M2005/16863 , A61M2005/16868 , A61M2005/16872 , A61M2205/18 , A61M2205/3317 , A61M2205/332 , A61M2205/3331 , A61M2205/3351 , A61M2205/3355 , A61M2205/3576 , A61M2205/52
摘要： An infusion system for being operatively connected to a fluid delivery line and to an infusion container includes a pump, a plurality of different types of sensors connected to the pump or the fluid delivery line, at least one processor, and a memory. The plurality of different types of sensors are configured to indicate whether air is in the fluid delivery line. The memory includes programming code for execution by the at least one processor. The programming code is configured to, based on measurements taken by the plurality of different types of sensors, determine: whether there is air in the fluid delivery line; whether there is a partial occlusion or a total occlusion in the fluid delivery line; or a percentage of the air present in the fluid delivery line or the probability of the air being in the fluid delivery line.
摘要翻译：用于可操作地连接到流体输送管线和输注容器的输注系统包括泵，连接到泵或流体输送管线的多个不同类型的传感器，至少一个处理器和存储器。多个不同类型的传感器被配置为指示空气是否在流体输送管线中。存储器包括用于由至少一个处理器执行的编程代码。编程代码被配置为基于由多种不同类型的传感器所采取的测量来确定：流体输送管线中是否存在空气; 是否在流体输送管线中存在部分闭塞或完全闭塞; 或存在于流体输送管线中的空气的百分比或空气在流体输送管线中的可能性。

45. 发明申请

US20130085689A1 FROTH DETECTION SYSTEM AND METHOD 有权
标题翻译：快速检测系统和方法
公开(公告)号：US20130085689A1
公开(公告)日：2013-04-04
申请号：US13630031
申请日：2012-09-28
申请人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
发明人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
IPC分类号： G06F19/00
CPC分类号： A61M5/365 , A61M1/3626 , A61M5/142 , A61M2205/3375 , G06F19/00 , G06F19/3481
摘要： An infusion system includes a pump, a fluid delivery line, at least one sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The at least one sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the at least one sensor. The memory is in electronic communication with the processor. The memory comprises programming code for execution by the processor. The programming code is configured to determine a percentage of the air within an observed volume of the fluid delivery line.
摘要翻译：输液系统包括泵，流体输送管线，至少一个传感器，处理器和存储器。流体输送管线连接到泵以输送流体。所述至少一个传感器连接到所述流体输送管线，用于发出和接收信号以检测所述流体输送管线中是否存在空气。处理器与泵和至少一个传感器电子通信。存储器与处理器进行电子通信。存储器包括用于由处理器执行的编程代码。编程代码被配置为确定流体输送管线的观察体积内的空气的百分比。

46. 发明申请

US20130046508A1 PATTERN RECOGNITION SYSTEM AND METHOD FOR THE DETECTION OF STUCK FLUID DROPLETS IN A FLUID DELIVERY LINE OF AN INFUSION SYSTEM 有权
标题翻译：用于检测流体输送系统中流体液滴的模式识别系统和方法
公开(公告)号：US20130046508A1
公开(公告)日：2013-02-21
申请号：US13588049
申请日：2012-08-17
申请人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
发明人： Kunal Sur , Paul T. Kotnik , Anatoly S. Belkin , John Hicks Dumas, III , Timothy L. Ruchti
IPC分类号： G06F15/00
CPC分类号： A61M5/365 , A61M5/142 , A61M2205/18 , A61M2205/50
摘要： An infusion system includes a pump, a fluid delivery line, a sensor, a processor, and a memory. The fluid delivery line is connected to the pump for delivering fluid. The sensor is connected to the fluid delivery line for emitting and receiving signals to detect whether there is air in the fluid delivery line. The processor is in electronic communication with the pump and the sensor. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to analyze the signals to determine if a stuck fluid droplet is stuck within the fluid delivery line at a location of the sensor.
摘要翻译：输液系统包括泵，流体输送管线，传感器，处理器和存储器。流体输送管线连接到泵以输送流体。传感器连接到流体输送管线，用于发出和接收信号，以检测流体输送管线中是否有空气。处理器与泵和传感器电子通信。存储器与处理器进行电子通信。存储器包括用于由处理器执行的编程代码。编程代码被配置为分析信号以确定在传感器的位置处的卡住的流体液滴是否粘附在流体输送管线内。

47. 发明授权

US06411373B1 Fiber optic illumination and detection patterns, shapes, and locations for use in spectroscopic analysis 失效
标题翻译：用于光谱分析的光纤照明和检测图案，形状和位置
公开(公告)号：US06411373B1
公开(公告)日：2002-06-25
申请号：US09415389
申请日：1999-10-08
申请人： Jeffrey J. Garside , Stephen Monfre , Barry C. Elliott , Timothy L. Ruchti , Glenn Aaron Kees , Frank S. Grochocki
发明人： Jeffrey J. Garside , Stephen Monfre , Barry C. Elliott , Timothy L. Ruchti , Glenn Aaron Kees , Frank S. Grochocki
IPC分类号： G01N3348
CPC分类号： G01N21/474
摘要： The invention provides a design process that is used in the determination of the pattern of detector and illumination optical fibers at the sampling area of a subject. Information about the system, specifically a monochromator (e.g. to determine the optimal number of fibers at an output slit) and the bundle termination at a detector optics stack (e.g. to determine the optimal number of fibers at the bundle termination), is of critical importance to this design. It is those numbers that determine the ratio and number of illumination to detection fibers, significantly limiting and constraining the solution space. Additional information about the estimated signal and noise in the skin is necessary to maximize the signal-to-noise ratio in the wavelength range of interest. Constraining the fibers to a hexagonal perimeter and prescribing a hex-packed pattern, such that alternating columns contain illumination and detection fibers, yields optimal results. In the preferred embodiment of the invention, two detectors share the totality of the detection fibers at the sampling interface. A third group of detection fibers is used for classification purposes.
摘要翻译：本发明提供了一种设计过程，其用于确定被检体的取样区域处的检测器和照明光纤的图案。关于系统的信息，特别是单色仪（例如，确定输出狭缝处的光纤的最佳数量）和检测器光学堆叠处的束终止（例如，以确定束终止时的最佳光纤数量）是至关重要的到这个设计。这些数字决定了对检测光纤的照射比例和数量，显着限制和限制了解决方案的空间。关于皮肤估计的信号和噪声的附加信息对于使感兴趣的波长范围内的信噪比最大化是必要的。将纤维限制在六边形周边，并规定六方填充图案，使得交替的列包含照明和检测纤维，产生最佳结果。在本发明的优选实施例中，两个检测器在采样接口处共享检测光纤的总体。第三组检测纤维用于分类目的。

48. 发明申请

US20100268157A1 SYSTEM AND METHOD FOR CONFIGURING A RULE SET FOR MEDICAL EVENT MANAGMENT AND RESPONSES 有权
标题翻译：用于配置医疗事件管理和响应的规则的系统和方法
公开(公告)号：US20100268157A1
公开(公告)日：2010-10-21
申请号：US12761107
申请日：2010-04-15
申请人： Steven R. Wehba , Timothy L. Ruchti
发明人： Steven R. Wehba , Timothy L. Ruchti
IPC分类号： A61M5/142
CPC分类号： A61M5/1723 , A61M2005/1405 , A61M2005/14208 , A61M2005/14296 , A61M2205/18 , A61M2205/3553 , A61M2205/3561 , A61M2205/50 , A61M2205/52 , A61M2230/04 , A61M2230/06 , A61M2230/201 , A61M2230/202 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/50 , G06F19/00 , G06F19/3468 , G16H40/20 , G16H50/20
摘要： A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.
摘要翻译：一种用于配置与用于监视患者和患者护理设备，特别是药物输送泵的医疗监控系统相关联的规则集的系统和方法，其基于与被监测的生物特征信息和设备信息相关联的各种条件和参数以及用于提供用户对这些条件和参数的定义反应。

49. 发明授权

US07440786B2 Method and apparatus for presentation of noninvasive glucose concentration information 失效
标题翻译：用于呈现无创葡萄糖浓度信息的方法和装置
公开(公告)号：US07440786B2
公开(公告)日：2008-10-21
申请号：US11012428
申请日：2004-12-14
申请人： Linda J. Hockersmith , Kevin H. Hazen , Timothy L. Ruchti
发明人： Linda J. Hockersmith , Kevin H. Hazen , Timothy L. Ruchti
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/7415 , A61B5/743 , A61B5/7475 , A61B5/749 , A61B2560/0456 , G06F19/00 , G16H15/00
摘要： The invention relates generally to the extraction and/or presentation of glucose concentrations estimated as a function of time into a format that facilitates conveyance of the underlying information. More particularly, glucose concentration histories are presented in terms of risk of behavior, in a video format, and/or in an audio format. The reduction of data into video format, selected by time period, cluster, or glucose concentration response, into an animated or video presentation allows diagnosis and treatment information to be more readily determined and used. Alternatively, glucose concentrations are output through a voice synthesizer or an earcon. These information presentations are useful for both the medical professional and the end user. The information presentation is preferably used with a noninvasive, implantable, semi-continuous, and/or continuous analyte analyzer, such as a glucose concentration analyzer.
摘要翻译：本发明一般涉及将作为时间的函数估计的葡萄糖浓度的提取和/或表现提升为促进底层信息传递的格式。更具体地，葡萄糖浓度历史以行为风险，视频格式和/或音频格式呈现。将通过时间段，群集或葡萄糖浓度响应选择的视频格式的数据减少为动画或视频呈现允许更容易地确定和使用诊断和治疗信息。或者，葡萄糖浓度通过语音合成器或耳塞输出。这些信息介绍对于医疗专业人员和最终用户都是有用的。信息呈现优选与非侵入性，可植入，半连续和/或连续的分析物分析仪一起使用，例如葡萄糖浓度分析仪。

50. 发明授权

US06671542B2 Non-invasive method of determining skin thickness and characterizing layers of skin tissue in vivo 有权
公开(公告)号：US06671542B2
公开(公告)日：2003-12-30
申请号：US10237457
申请日：2002-09-05
申请人： Jessica Rennert , Glenn Aaron Kees , Timothy L. Ruchti
发明人： Jessica Rennert , Glenn Aaron Kees , Timothy L. Ruchti
IPC分类号： A61B500
CPC分类号： G01N21/274 , A61B5/0059 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49
摘要： A novel approach to measuring the overall and layer-by-layer thickness of in vivo skin tissue based on near infrared absorbance spectra is described. The different biological and chemical compounds present in the various layers of a tissue sample have differing absorbance spectra and scattering properties that enable them to be discerned and quantified, thus allowing an estimate of the thickness of the tissue being sampled. The method of the invention also yields the chemical composition of the absorbing and/or scattering species of each layer. Additionally, a method of path length normalization for the purpose of noninvasive analyte prediction on the basis of skin thickness and layer constituents is provided.

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