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    • 42. 发明申请
    • Antibodies against CXCR4 and Methods of Use Thereof
    • US20110250165A1
    • 2011-10-13
    • US11883258
    • 2006-02-15
    • Wayne A. MarascoJianhun SuiChen Xu
    • Wayne A. MarascoJianhun SuiChen Xu
    • A61K38/19A61K39/395A61P35/04A61P35/00A61P37/06C07K16/28A61P31/18
    • C07K16/2866A61K2039/505C07K16/005C07K2317/21C07K2317/622
    • The invention provides human monoclonal antibodies, scFv antibodies, scFv-Fc fusions, a dAb (domain antibodies), Fab, Fab′ and F(ab)′2 fragments, single chain antibodies and/or minibodies that specifically bind to CXCR4. Also provided are methods of treating and/or preventing a CXCR4 disease or disorder such as cancer and X4-tropic HIV-I infection as well as uses of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of a CXCR4 disorder. The invention also provides methods of preventing diseases or disorders associated with CXCR4 function or expression. The invention further provides for the use of the antibodies (or fragments thereof) of the invention in the manufacture of a medicament for the prevention of diseases or disorders associated with CXCR4 expression. Also provided are methods of treating or preventing cancer metastasis in a patient suffering from a cancer involving tumor cells that express CXCR4. The invention also encompasses the use of such antibodies and antibody fragments in the manufacture of a medicament for the treatment or prevention of cancer metastasis. The invention also includes methods of treating or preventing cancer metastasis in a patient suffering from a hypoxic tumor, such as any solid tumor characterized by HIF-dependent CXCR4 activation. The antibodies and fragments disclosed herein can be used in the manufacture of a medicament for the prevention of cancer metastasis in a patient suffering from a hypoxic tumor. The invention additionally provides methods of mobilizing CD34+ stem cells from the bone marrow as wells methods of blocking chemotaxis of CXCR4-expressing cells in response to SDF-1. Also provided are methods of treating or preventing graft-versus-host disease as well as the use of the antibodies and fragments thereof in the manufacture of a medicament for the prevention or treatment of GVHD. Finally, the invention also provides methods of inhibiting the formation of new tumor blood vessels and/or inhibiting tumor cell angiogenesis.
    • 43. 发明授权
    • Image-document retrieving apparatus, method of retrieving image document, program, and recording medium
    • 图像文件检索装置,检索图像文档,程序和记录介质的方法
    • US08027550B2
    • 2011-09-27
    • US11998793
    • 2007-11-30
    • Mang ChenBo WuYadong WuChen Xu
    • Mang ChenBo WuYadong WuChen Xu
    • G06K9/54G06F17/00
    • G06K9/4604G06K9/00456G06K2209/01
    • Feature vectors used in discrimination of images include information on feature blocks of images in an image-document retrieving apparatus of the present invention. Text areas of a page image document are combined to form rectangular images. On the basis of information on the rectangular images that are extracted, a geometric structure of the page is analyzed, the page image document is divided into plural blocks, and then a plurality of feature blocks describing features of the page document image are selected from the plural blocks. The feature vectors are constituted of information on the feature blocks thus selected. This makes it possible to provide an image-document retrieving apparatus and a method of retrieving image documents, by which retrieval of image documents containing mainly text and a graphic is improvable in accuracy.
    • 用于鉴别图像的特征向量包括关于本发明的图像文档检索装置中的图像的特征块的信息。 页面图像文档的文本区域被组合以形成矩形图像。 基于提取的矩形图像的信息,分析页面的几何结构,将页面图像文档分割成多个块,然后从描述页面文档图像的特征的多个特征块中选择 多个块。 特征矢量由这样选择的特征块的信息构成。 这使得可以提供图像文档检索装置和检索图像文档的方法,通过该图像文档检索可以精确地改进主要包含文本和图形的图像文档。
    • 46. 发明申请
    • Information processing device, information processing system, information processing method, program, and storage medium
    • 信息处理装置,信息处理系统,信息处理方法,程序和存储介质
    • US20080244378A1
    • 2008-10-02
    • US12002671
    • 2007-12-18
    • Mang ChenBo WuYadong WuChen XuNing Le
    • Mang ChenBo WuYadong WuChen XuNing Le
    • G06F17/21
    • G06K9/033G06K9/00456
    • An information processing device includes: a feature extracting section for extracting, as format information, a format feature of a process-target document from image data of the process-target document, on which filling-in spaces of plural items are printed; a document recognizing section for comparing the format information of the process-target document with registered format information stored in a storage device, and specifying a registered document that corresponds to the process-target document, the registered format information regarding format features of registered documents; a data acquiring section for converting characters in the image data of the process-target document into text data; and a distributing section for grouping the image data and text data of the characters into plural groups according to a separation rule that is set for the registered document, the characters being written in the fill-in spaces of the items of the process-target document, and for transmitting the different groups to different external devices. With this, information such as personal information to be protected can be processed, preventing an operator dealing with the information from obtaining the whole information.
    • 一种信息处理设备,包括:特征提取部分,用于从打印有多个项目的填充空间的处理对象文档的图像数据中提取作为格式信息的处理对象文档的格式特征; 文档识别部分,用于将处理目标文档的格式信息与存储在存储装置中的登记格式信息进行比较,并且指定对应于处理目标文档的注册文档,关于注册文档的格式特征的注册格式信息; 数据获取部分,用于将处理目标文档的图像数据中的字符转换为文本数据; 以及分配部,用于根据为登记文件设定的分离规则,将图像数据和文字数据分组成多个组,所述字符被写入处理对象文档的项目的填写空间中 ,并将不同组发送到不同的外部设备。 因此,可以处理诸如要保护的个人信息的信息,从而防止处理信息的操作者获得整个信息。