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41. 发明申请

US20070012886A1 Systems. processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique 有权
标题翻译：系统。用于通过光学相干测距技术评估与解剖结构相关联的信息的过程和软件布置
公开(公告)号：US20070012886A1
公开(公告)日：2007-01-18
申请号：US11414564
申请日：2006-04-28
申请人： Guillermo Tearney , Brett Bouma , John Evans
发明人： Guillermo Tearney , Brett Bouma , John Evans
IPC分类号： G01T1/10
CPC分类号： G06T7/0014 , A61B5/0033 , A61B5/0066 , A61B10/02 , A61B2010/0003 , A61B2017/00827 , G06F19/321 , G06T11/003 , G06T2207/10101 , G06T2207/20081 , G06T2207/30004 , G06T2207/30096
摘要： Software systems, arrangements and processes for evaluating an image associated with at least one portion of an anatomical structure are provided. For example, first information associated with the at least one portion of the anatomical structure second information associated with the at least one portion of the anatomical structure can be received. Third information can be generated by determining a relationship between the first information and the second information. Further, the image can be evaluated using a predetermined pathological scoring criteria and the third information.
摘要翻译：提供了用于评估与解剖结构的至少一部分相关联的图像的软件系统，布置和过程。例如，可以接收与解剖结构的至少一个部分相关联的与解剖结构的至少一个部分相关联的第二信息的第一信息。可以通过确定第一信息和第二信息之间的关系来生成第三信息。此外，可以使用预定的病理评分标准和第三信息来评估图像。

42. 发明申请

US20060227333A1 Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
标题翻译：光学相干断层扫描中的斑点减少通过路径长度编码角复合
公开(公告)号：US20060227333A1
公开(公告)日：2006-10-12
申请号：US10551735
申请日：2004-03-31
申请人： Guillermo Tearney , Nicusor Iftimia , Brett Bouma
发明人： Guillermo Tearney , Nicusor Iftimia , Brett Bouma
IPC分类号： G01B11/02
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。本发明允许通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。因此，提供了用于照射样品的装置探针导管和方法。具体地，干涉仪可以转发电磁辐射。此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射样品的装置。这种布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

43. 发明申请

US20060058622A1 Method and apparatus for imaging of vessel segments 有权
标题翻译：用于血管段成像的方法和装置
公开(公告)号：US20060058622A1
公开(公告)日：2006-03-16
申请号：US11211483
申请日：2005-08-24
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma
IPC分类号： A61B5/05
CPC分类号： A61B5/6852 , A61B5/0062 , A61B5/0066 , A61B5/0084 , A61B5/02007
摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.
摘要翻译：提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。该装置包括制品（例如，壳体），流体输送装置和成像装置。壳体包括形成在制品中的孔。流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品在结构的表面上被平移，而成像结构的表面。

44. 发明申请

US20070233396A1 METHOD AND APPARATUS FOR OPTICAL IMAGING VIA SPECTRAL ENCODING 有权
标题翻译：通过光谱编码进行光学成像的方法和装置
公开(公告)号：US20070233396A1
公开(公告)日：2007-10-04
申请号：US11537170
申请日：2006-09-29
申请人： Guillermo Tearney , Dvir Yelin , Brett Bourna
发明人： Guillermo Tearney , Dvir Yelin , Brett Bourna
IPC分类号： G01N33/48
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和布置，用于获得与诸如解剖结构的一部分的样本相关联的信息。可以使用可以基于从样本上的位置获得的信号的第一数据和第二数据来生成信息，其中可以通过将从样本接收的第二信号与第三参考信号组合来获得第二数据。也可以基于该信息生成样本的一部分的图像。例如，第一数据可以与光谱编码显微镜数据相关联，并且第二数据可以与光学相干断层扫描数据相关联。

45. 发明授权

US6134003A Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope 失效
标题翻译：使用光纤成像导丝，导管或内窥镜执行光学测量的方法和装置
公开(公告)号：US6134003A
公开(公告)日：2000-10-17
申请号：US607787
申请日：1996-02-27
申请人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
发明人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
IPC分类号： G01B11/00 , A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B8/12 , A61B10/00 , A61M25/00 , G01B9/02 , G01B11/02 , G01B11/12 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/35 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , G11B7/005 , G11B7/125 , G11B7/24 , H01S5/14
CPC分类号： B82Y15/00 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/445 , A61B5/6852 , G01B11/00 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B9/02002 , G01B9/02004 , G01B9/02007 , G01B9/0201 , G01B9/0205 , G01B9/02091 , G01J1/00 , G01N21/4795 , G02B5/1828 , G11B7/005 , G11B7/127 , A61B2562/0242 , A61B3/1005 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , G11B7/24 , H01S5/141
摘要： An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.
摘要翻译：用于执行光学相干断层摄影的成像系统包括光辐射源; 参考光学反射器; 通向参考光反射器的第一光路; 以及耦合到内窥镜单元的第二光路。内窥镜单元优选地包括限定孔的细长壳体; 可旋转的单模光纤，其具有定位在所述细长壳体的所述孔的长度内并延伸所述细长壳体的所述孔的长度的近端和远端; 以及耦合到可旋转单模光纤的远端的光学系统，定位成将光辐射从单模光纤传输到结构，并将反射的光辐射从结构传输到单模光纤。该系统还包括一个光束分配器，将沿着第一光路的光辐射源的光辐射分成沿着第二光路; 以及检测器，其被定位成接收来自沿着第一光路传输的反射器的反射光辐射以及沿着第二光路从结构传输的反射光辐射。检测器响应于来自参考反射器的反射光辐射和来自结构的反射光辐射产生信号，以及响应于来自检测器的信号产生结构图像的处理器。该系统提供图像的旋转和纵向扫描。

46. 发明授权

US06501551B1 Fiber optic imaging endoscope interferometer with at least one faraday rotator 失效
标题翻译：具有至少一个法拉第旋转器的光纤成像内窥镜干涉仪
公开(公告)号：US06501551B1
公开(公告)日：2002-12-31
申请号：US09414293
申请日：1999-10-05
申请人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
发明人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
IPC分类号： G01B902
CPC分类号： G11B7/005 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/1005 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0084 , A61B5/445 , A61B5/6852 , A61B2562/0242 , B82Y15/00 , G01B9/02002 , G01B9/02004 , G01B9/02007 , G01B9/0201 , G01B9/0205 , G01B9/02091 , G01B11/00 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B2290/65 , G01B2290/70 , G01J1/00 , G01N21/4795 , G11B7/127 , G11B7/24 , G11B2007/0013 , H01S5/141
摘要： An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.
摘要翻译：用于执行光学相干断层摄影的成像系统包括光辐射源; 参考光学反射器; 通向参考光反射器的第一光路; 以及耦合到内窥镜单元的第二光路。内窥镜单元优选地包括限定孔的细长壳体; 可旋转的单模光纤，其具有定位在所述细长壳体的所述孔的长度内并延伸所述细长壳体的所述孔的长度的近端和远端; 以及耦合到可旋转单模光纤的远端的光学系统，定位成将光辐射从单模光纤传输到结构，并将反射的光辐射从结构传输到单模光纤。该系统还包括一个光束分配器，将沿着第一光路的光辐射源的光辐射分成沿着第二光路; 以及检测器，其被定位成接收来自沿着第一光路传输的反射器的反射光辐射以及沿着第二光路从结构传输的反射光辐射。检测器响应于来自参考反射器的反射光辐射和来自结构的反射光辐射产生信号，以及响应于来自检测器的信号产生结构图像的处理器。该系统提供图像的旋转和纵向扫描。

47. 发明授权

US06421164B2 Interferometeric imaging with a grating based phase control optical delay line 失效
标题翻译：基于光栅的相位控制光学延迟线的干涉成像
公开(公告)号：US06421164B2
公开(公告)日：2002-07-16
申请号：US09880120
申请日：2001-06-13
申请人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
发明人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
IPC分类号： G02F111
CPC分类号： B82Y15/00 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/1005 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0084 , A61B5/441 , A61B5/6852 , A61B2562/0242 , G01B9/02002 , G01B9/02091 , G01B11/00 , G01B11/002 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B2290/20 , G01B2290/35 , G01J1/00 , G01N21/4795 , G02B5/1828 , G02B26/06 , G02B27/4233 , G02B27/4244 , G02B27/4255 , G11B7/005 , G11B7/08564 , G11B7/127 , G11B7/1353 , G11B7/24 , G11B2007/0013 , H01S5/141
摘要： An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the mirror tilt produce a change in optical group and phase delay. This apparatus permits the optical group and phase delay to be scanned by scanning the angle of the mirror. In other embodiments, this device permits optical delay scanning without the use of moving parts.
摘要翻译：公开了一种用于执行光学延迟的高速扫描的装置及其用于执行光学干涉测量，测距和成像的应用，包括使用光学相干断层摄影的横截面成像。该装置通过使用衍射光学元件结合成像光学器件实现光学延迟扫描。在一个实施例中，衍射光栅将光束分散成由透镜准直的不同光谱频率或波长分量。镜子放置一个远离镜头的焦距，并且光栅槽密度，光栅输入角度，光栅输出角度和/或镜面倾斜度的变化产生光学组和相位延迟的变化。该装置允许通过扫描反射镜的角度来扫描光学组和相位延迟。在其他实施例中，该装置允许光学延迟扫描而不使用移动部件。

48. 发明授权

US06282011B1 Grating based phase control optical delay line 失效
公开(公告)号：US06282011B1
公开(公告)日：2001-08-28
申请号：US09603806
申请日：2000-06-26
申请人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
发明人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
IPC分类号： G02F111
CPC分类号： B82Y15/00 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/1005 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0084 , A61B5/441 , A61B5/6852 , A61B2562/0242 , G01B9/02002 , G01B9/02091 , G01B11/00 , G01B11/002 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B2290/20 , G01B2290/35 , G01J1/00 , G01N21/4795 , G02B5/1828 , G02B26/06 , G02B27/4233 , G02B27/4244 , G02B27/4255 , G11B7/005 , G11B7/08564 , G11B7/127 , G11B7/1353 , G11B7/24 , G11B2007/0013 , H01S5/141
摘要： An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the mirror tilt produce a change in optical group and phase delay. This apparatus permits the optical group and phase delay to be scanned by scanning the angle of the mirror. In other embodiments, this device permits optical delay scanning without the use of moving parts.

49. 发明授权

US6111645A Grating based phase control optical delay line 失效
标题翻译：基于光栅的相位控制光延迟线
公开(公告)号：US6111645A
公开(公告)日：2000-08-29
申请号：US79687
申请日：1998-05-15
申请人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
发明人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
IPC分类号： A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , G01B9/02 , G01B11/00 , G01B11/02 , G01B11/12 , G01B11/24 , G01J1/00 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , G11B7/005 , G11B7/085 , G11B7/125 , G11B7/135 , G11B7/24 , H01S5/14
CPC分类号： B82Y15/00 , A61B1/00172 , A61B1/00183 , A61B3/1005 , A61B3/102 , A61B3/1225 , A61B5/0064 , A61B5/0066 , A61B5/6852 , G01B11/00 , G01B11/002 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B9/02002 , G01B9/02091 , G01J1/00 , G01N21/4795 , G02B26/06 , G02B27/4233 , G02B27/4244 , G02B27/4255 , G02B5/1828 , G11B7/005 , G11B7/08564 , G11B7/127 , G11B7/1353 , A61B1/00096 , A61B2562/0242 , A61B5/0084 , A61B5/441 , G01B2290/20 , G01B2290/35 , G11B2007/0013 , G11B7/24 , H01S5/141
摘要： An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the mirror tilt produce a change in optical group and phase delay. This apparatus permits the optical group and phase delay to be scanned by scanning the angle of the mirror. In other embodiments, this device permits optical delay scanning without the use of moving parts.
摘要翻译：公开了一种用于执行光学延迟的高速扫描的装置及其用于执行光学干涉测量，测距和成像的应用，包括使用光学相干断层摄影的横截面成像。该装置通过使用衍射光学元件结合成像光学器件实现光学延迟扫描。在一个实施例中，衍射光栅将光束分散成由透镜准直的不同光谱频率或波长分量。镜子放置一个远离镜头的焦距，并且光栅槽密度，光栅输入角度，光栅输出角度和/或镜面倾斜度的变化产生光学组和相位延迟的变化。该装置允许通过扫描反射镜的角度来扫描光学组和相位延迟。在其他实施例中，该装置允许光学延迟扫描而不使用移动部件。

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