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41. 发明授权

US07400979B2 Method of identifying inhibitors of Lck 有权
标题翻译：鉴定Lck抑制剂的方法
公开(公告)号：US07400979B2
公开(公告)日：2008-07-15
申请号：US10212346
申请日：2002-08-05
申请人： David W. Borhani , David Calderwood , Richard W. Dixon , Gavin C. Hirst , Peter Hrnciar , Andreas Loew , Adelaine Leung , Kurt Ritter
发明人： David W. Borhani , David Calderwood , Richard W. Dixon , Gavin C. Hirst , Peter Hrnciar , Andreas Loew , Adelaine Leung , Kurt Ritter
IPC分类号： G06F17/11 , G06F17/50 , G06F19/00
CPC分类号： C12N9/1205 , C07K2299/00
摘要： The present invention relates to polypeptides which comprise the ligand binding domain of Lck, crystalline forms of these polypeptides, and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Lck. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain. The invention also relates to the use of the three dimensional structure of the Lck catalytic domain both alone, or in complex with inhibitors, in methods of designing and/or identifying potential selective inhibitors of Lck activity, for example, compounds which inhibit the binding of a native substrate to the Lck catalytic domain selectively.
摘要翻译：本发明涉及包含Lck的配体结合结构域，这些多肽的结晶形式的多肽，以及这些结晶形式用于确定Lck催化结构域的三维结构的多肽。本发明还涉及在设计和/或鉴定Lck活性的潜在抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制结合的化合物天然底物到Lck催化结构域。本发明还涉及在设计和/或鉴定Lck活性的潜在选择性抑制剂的方法中单独或与抑制剂复合的Lck催化结构域的三维结构的用途，例如抑制Lck活性结合的化合物选择性地对Lck催化结构域的天然底物。

42. 发明申请

US20070008764A1 Circuit for addressing a memory 失效
标题翻译：寻址存储器的电路
公开(公告)号：US20070008764A1
公开(公告)日：2007-01-11
申请号：US10571191
申请日：2004-08-23
申请人： Andreas Loew
发明人： Andreas Loew
IPC分类号： G11C11/00
CPC分类号： G06F5/10 , H04L7/0012
摘要： A circuit is proposed which has a memory to which input data can be written at different write addresses with a first clock rate and from which output data can be read at different read addresses with a second clock rate. The memory can be fed a write reset pulse that resets the write address to an initial value. In addition, the memory can be fed a read reset pulse by means of which the data are output in a fixed temporal relationship. Finally, the circuit proposed is provided with switching means in order to derive the read reset pulse from the write reset pulse. This ensures that the two reset pulses cannot occur simultaneously.
摘要翻译：提出一种电路，其具有存储器，可以以第一时钟速率以不同的写入地址写入输入数据，并且可以以第二时钟速率从不同的读取地址读取输出数据。可以为存储器馈送写入复位脉冲，将写入地址重置为初始值。此外，存储器可以被馈送读取复位脉冲，借助该读取复位脉冲以固定的时间关系输出数据。最后，所提出的电路设置有开关装置，以便从写入复位脉冲导出读出的复位脉冲。这确保了两个复位脉冲不能同时发生。

43. 发明申请

US20050036678A1 Reduction of rounding errors during the processing of digital image data 失效
标题翻译：减少数字图像数据处理过程中的舍入误差
公开(公告)号：US20050036678A1
公开(公告)日：2005-02-17
申请号：US10879451
申请日：2004-06-29
申请人： Andreas Loew
发明人： Andreas Loew
IPC分类号： G06T1/00 , G06K9/00 , G06T5/50 , G06T7/00 , H04N5/222
CPC分类号： G06T5/50
摘要： In order to avoid rounding errors as a result of restricted accuracy of the processing unit in a video processing arrangement, a comparison is carried out between processed image data and unprocessed image data. For this purpose, the unprocessed image data is buffer-stored in a memory and is supplied together with the processed image data to a comparator, which compares the difference between the processed image data and the unprocessed image data with a threshold value Either the processed image data or the unprocessed image data is produced at the output of the arrangement, by means of a multiplexer, as a function of the result of the comparison. A rounding element between the processing unit and the multiplexer rounds the processed image data before it is emitted, if the processing stage has not itself carried out a rounding process.
摘要翻译：为了避免由于视频处理装置中的处理单元的精度受限而导致的舍入误差，在处理的图像数据和未处理的图像数据之间进行比较。为此，未处理的图像数据被缓冲存储在存储器中并与处理的图像数据一起提供给比较器，比较器将处理后的图像数据与未处理的图像数据之间的差异与阈值进行比较处理的图像作为比较结果的函数，通过多路复用器，在布置的输出处产生数据或未处理的图像数据。如果处理单元本身没有进行舍入处理，则处理单元和多路复用器之间的舍入元素在处理的图像数据被发射之前使其处理。

44. 发明授权

US10669323B2 Methods of treating metabolic disorders with dual function fibroblast growth factor 21 proteins 审中-公开
公开(公告)号：US10669323B2
公开(公告)日：2020-06-02
申请号：US15248712
申请日：2016-08-26
申请人： Brian R. Boettcher , Shari Lynn Caplan , Susan E. Cellitti , Douglas S. Daniels , Norio Hamamatsu , Bernhard Hubert Geierstanger , Stuart Licht , Andreas Loew , Stephen Craig Weldon
发明人： Brian R. Boettcher , Shari Lynn Caplan , Susan E. Cellitti , Douglas S. Daniels , Norio Hamamatsu , Bernhard Hubert Geierstanger , Stuart Licht , Andreas Loew , Stephen Craig Weldon
IPC分类号： A61K38/18 , A61K38/26 , C07K14/605 , C07K14/50
摘要： The present invention relates to the identification of dual function fusion proteins comprising fibroblast growth factor 21 (FGF21) and Exenatide, Exendin-4, or GLP-1. Also disclosed are methods for treating metabolic, cardiovascular, and endocrine conditions related to glucose and/or lipid homeostasis.

45. 发明申请

US20180230193A1 TREATMENT OF CANCER USING CHIMERIC CD3 RECEPTOR PROTEINS 审中-公开
公开(公告)号：US20180230193A1
公开(公告)日：2018-08-16
申请号：US15750796
申请日：2016-08-05
申请人： Andreas Loew , Brian Granda , Melissa Ramones
发明人： Andreas Loew , Brian Granda , Melissa Ramones
IPC分类号： C07K14/725 , C07K16/28 , C07K16/30 , C07K19/00
CPC分类号： C07K14/7051 , C07K16/2803 , C07K16/30 , C07K19/00 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C07K2319/70
摘要： The present disclosure features the use of chimeric CD3 proteins to modulate T cell Receptor (TCR) signaling. Specifically, the disclosure is based, in part, on the discovery that chimeric CD3 proteins (e.g., CD3delta, CD3gamma, and CD3epsilon) having all or most of their extracellular domain fused to an antigen binding domain can activate the TCR in the presence of a cognate antigen. The disclosure is further based on the observation that the above chimeric proteins can be potentiated through the inclusion of a co-stimulatory domain in the intracellular portion of the chimeric molecule. Thus, the preferred elements of the engineered signaling complexes of the disclosure include an antigen binding domain, an extracellular domain derived from one of the above CD3 proteins, and an intracellular co-stimulatory domain.

46. 发明授权

US09512199B2 Fibronectin cradle molecules and libraries thereof 有权
标题翻译：纤连蛋白摇篮分子及其文库
公开(公告)号：US09512199B2
公开(公告)日：2016-12-06
申请号：US13813409
申请日：2011-08-01
申请人： Andreas Loew , Brian Edward Vash , Shohei Koide , John Bernard Wojcik , Akiko Koide , Ryan Nicholas Gilbreth
发明人： Andreas Loew , Brian Edward Vash , Shohei Koide , John Bernard Wojcik , Akiko Koide , Ryan Nicholas Gilbreth
IPC分类号： C07K14/78 , C07K16/18 , C07K16/40 , C07K16/42
CPC分类号： C07K14/78 , C07K16/18 , C07K16/40 , C07K16/42 , C07K2317/34 , C07K2318/20
摘要： The here described invention discloses a combination of a top and bottom loop binder library using the CD and the FG loops of a number of FnIII domains (FnIII) (e.g., FnIII7, FnIII10 and FnIII14) together with the surface exposed residues of the beta-sheet. The invention also pertains to a method of forming a library of FnIII domain polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity.
摘要翻译：本文所述的本发明公开了使用CD和多个FnIII结构域（FnIII）（例如FnIII7，FnIII10和FnIII14）的FG环的顶部和底部环结合物文库的组合以及β- 片。本发明还涉及形成用于筛选具有选定结合或酶活性的一种或多种多肽的存在的FnIII结构域多肽文库的方法。

47. 发明授权

US07671352B2 Film scanner and detection apparatus therefor 失效
标题翻译：胶片扫描仪及其检测装置
公开(公告)号：US07671352B2
公开(公告)日：2010-03-02
申请号：US11899904
申请日：2007-09-06
申请人： Andreas Loew
发明人： Andreas Loew
IPC分类号： G01N21/86 , H04N5/253
CPC分类号： H04N3/38
摘要： A detection apparatus for detecting perforation holes of a cinematographic film comprises at least one light source, at least one scanning sensor, which is arranged so as to receive light emitted by the light source after interaction with a perforation zone of the film, and an evaluation circuit for detecting, by means of an output signal of the scanning sensor, when an edge of a perforation hole passes through between light source and scanning sensor. The light source emits light which is polarized with a first polarization and the scanning sensor is sensitive selectively to light with a second polarization.
摘要翻译：一种用于检测电影胶片的穿孔的检测装置，包括至少一个光源，至少一个扫描传感器，其布置成在与膜的穿孔区相互作用之后接收由光源发射的光，并且评估电路，用于通过扫描传感器的输出信号，当穿孔的边缘通过光源和扫描传感器之间时，进行检测。光源发射以第一偏振极化的光，并且扫描传感器对具有第二偏振的光有选择性敏感。

48. 发明授权

US07444020B2 Reduction of rounding errors during the processing of digital image data 失效
标题翻译：减少数字图像数据处理过程中的舍入误差
公开(公告)号：US07444020B2
公开(公告)日：2008-10-28
申请号：US10879451
申请日：2004-06-29
申请人： Andreas Loew
发明人： Andreas Loew
IPC分类号： G06K9/00
CPC分类号： G06T5/50
摘要： In order to avoid rounding errors as a result of restricted accuracy of the processing unit in a video processing arrangement, a comparison is carried out between processed image data and unprocessed image data. For this purpose, the unprocessed image data is buffer-stored in a memory and is supplied together with the processed image data to a comparator, which compares the difference between the processed image data and the unprocessed image data with a threshold value. Either the processed image data or the unprocessed image data is produced at the output of the arrangement, by means of a multiplexer, as a function of the result of the comparison. A rounding element between the processing unit and the multiplexer rounds the processed image data before it is emitted, if the processing stage has not itself carried out a rounding process.
摘要翻译：为了避免由于视频处理装置中的处理单元的精度受限而导致的舍入误差，在处理的图像数据和未处理的图像数据之间进行比较。为此，将未处理的图像数据缓冲存储在存储器中，并将其与经处理的图像数据一起提供给比较器，比较器将经处理的图像数据与未处理的图像数据之间的差异与阈值进行比较。处理的图像数据或未处理的图像数据在布置的输出处通过多路复用器作为比较结果的函数产生。如果处理单元本身没有进行舍入处理，则处理单元和多路复用器之间的舍入元素在处理的图像数据被发射之前使其处理。

49. 发明申请

US20080067395A1 Film scanner and detection apparatus therefor 失效
标题翻译：胶片扫描仪及其检测装置
公开(公告)号：US20080067395A1
公开(公告)日：2008-03-20
申请号：US11899904
申请日：2007-09-06
申请人： Andreas Loew
发明人： Andreas Loew
IPC分类号： G01J1/42
CPC分类号： H04N3/38
摘要： A detection apparatus for detecting perforation holes of a cinematographic film comprises at least one light source, at least one scanning sensor, which is arranged so as to receive light emitted by the light source after interaction with a perforation zone of the film, and an evaluation circuit for detecting, by means of an output signal of the scanning sensor, when an edge of a perforation hole passes through between light source and scanning sensor. The light source emits light which is polarized with a first polarization and the scanning sensor is sensitive selectively to light with a second polarization.
摘要翻译：一种用于检测电影胶片的穿孔的检测装置，包括至少一个光源，至少一个扫描传感器，其布置成在与膜的穿孔区相互作用之后接收由光源发射的光，并且评估电路，用于通过扫描传感器的输出信号，当穿孔的边缘通过光源和扫描传感器之间时，进行检测。光源发射以第一偏振极化的光，并且扫描传感器对具有第二偏振的光有选择性敏感。

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