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41. 发明申请

US20100196268A1 Compositions and methods for treatment of tumors by direct administration of a radioisotope 审中-公开
标题翻译：通过直接施用放射性同位素治疗肿瘤的组合物和方法
公开(公告)号：US20100196268A1
公开(公告)日：2010-08-05
申请号：US12798473
申请日：2010-04-05
申请人： R. Keith Frank , Kenneth McMillan , Jaime Simon , H.Max Loy, JR. , Stanley D. Stearns , Edna Sue McMillan
发明人： R. Keith Frank , Kenneth McMillan , Jaime Simon , H.Max Loy, JR. , Stanley D. Stearns , Edna Sue McMillan
IPC分类号： A61K51/00 , A61P35/00
CPC分类号： A61K51/1217
摘要： This invention provides a safer and more effective treatment for non-intracavitary undesirable tissue masses, especially bone cancer and soft tissue tumors. The method involves the direct administration of a therapeutically-effective dose of a formulated radioisotope composition nearby or directly into the tissue mass. Small volumes of the composition are used.Administration of the dose for bone cancer may be done through a hole or multiple holes created in the bone using a miniature drill. Delivery of the dose directly into a tumor may be accomplished using a microsyringe or a miniature pump capable of accurately delivering microliter amounts of material.
摘要翻译：本发明为非腔内不期望的组织块，特别是骨癌和软组织肿瘤提供更安全和更有效的治疗。该方法包括在组织块中直接施用治疗有效剂量的配制的放射性同位素组合物或直接施用于组织块。使用小体积的组合物。可以通过使用微型钻头在骨头中产生的孔或多个孔来进行骨癌剂量的施用。可以使用能够精确地递送微量的材料的微量注射器或微型泵来将剂量直接递送到肿瘤中。

42. 发明授权

US07045116B2 Treatment of osteomyelitis with radiopharmaceuticals 失效
公开(公告)号：US07045116B2
公开(公告)日：2006-05-16
申请号：US10317738
申请日：2002-12-11
申请人： Dana W. Simon , Alan D. Strickland , Jaime Simon , Daniel J. Macey , R. Keith Frank , Kenneth McMillan
发明人： Dana W. Simon , Alan D. Strickland , Jaime Simon , Daniel J. Macey , R. Keith Frank , Kenneth McMillan
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0478 , A61K51/0489
摘要： This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.

43. 发明授权

US5447603A Process for removing metal ions from liquids 失效
标题翻译：从液体中除去金属离子的方法
公开(公告)号：US5447603A
公开(公告)日：1995-09-05
申请号：US89354
申请日：1993-07-09
申请人： Robert J. Michalowski , Steven H. Christiansen , R. Keith Frank , Teresa Littleton , Jaime Simon , Walter Vaughn , David A. Wilson
发明人： Robert J. Michalowski , Steven H. Christiansen , R. Keith Frank , Teresa Littleton , Jaime Simon , Walter Vaughn , David A. Wilson
IPC分类号： D21C9/00 , D21C9/10 , D21H21/06 , D21H17/67
CPC分类号： D21H21/06 , D21C9/002 , D21C9/1042
摘要： The invention is an improvement in a process for making cellulosic articles said process involving a separation of cellulosic material from a mixture containing a liquid, metal cations, and cellulosic material. The improvement involves adding to the mixture at least one retaining material which binds at least one metal cation and, in the separation, is retained with the cellulosic material. Suitable retaining agents are either organic or inorganic and include chelate-forming polymers, both synthetic and natural, colloidal suspensions of inorganic compounds, and mixed metal hydroxides. In each case, the metal cations remain in the cellulosic article, e.g. paper, rather going into waste water from which they would otherwise need to be removed.
摘要翻译：本发明是制造纤维素制品的方法的改进，所述方法涉及从含有液体，金属阳离子和纤维素材料的混合物中分离纤维素材料。该改进涉及向混合物中加入至少一种结合至少一种金属阳离子的保留材料，并且在分离中将其与纤维素材料保持在一起。合适的保留剂是有机或无机的，并且包括无机化合物的合成和天然胶体悬浮液和混合金属氢氧化物的螯合形成聚合物。在每种情况下，金属阳离子保留在纤维素制品中，例如，纸，而是进入废水，否则他们将需要从中除去。

44. 发明授权

US5137709A Layered mixed metal hydroxides for the stabilization of radioactive colloids 失效
标题翻译：层状混合金属氢氧化物用于放射性胶体的稳定化
公开(公告)号：US5137709A
公开(公告)日：1992-08-11
申请号：US656397
申请日：1991-02-15
申请人： Jaime Simon , David A. Wilson , Kenneth McMillan , Harrell L. Huff
发明人： Jaime Simon , David A. Wilson , Kenneth McMillan , Harrell L. Huff
IPC分类号： A61K51/00 , A61K51/12 , A61P29/00 , C01G51/00 , C01G53/00 , G21G4/08
CPC分类号： A61K51/1217 , A61K2121/00 , A61K2123/00
摘要： A stabilized radionuclide-colloid composition useful in therapeutic radiation ablation therapies is disclosed. The composition contains a viscosity modifier layered mixed metal hydroxide and optionally an ion exchange medium to stabilize the radioactive colloid.
摘要翻译：公开了一种稳定的放射性核素 - 胶体组合物，用于治疗性放射线消融治疗。组合物含有粘度调节剂层状混合金属氢氧化物和任选的离子交换介质以稳定放射性胶体。

45. 发明授权

US09603954B2 Methods for generating radioimmunoconjugates 有权
公开(公告)号：US09603954B2
公开(公告)日：2017-03-28
申请号：US13386316
申请日：2010-07-22
申请人： Jaime Simon , A. Gaylord King , Josue Manuel Moreno Bermudez
发明人： Jaime Simon , A. Gaylord King , Josue Manuel Moreno Bermudez
IPC分类号： A61K51/10
CPC分类号： A61K51/1027
摘要： Methods for generating an Ac-225 radioconjugate comprising a monoclonal antibody (mAb) (IgG) is disclosed. The Ac-225 radioimmunoconjugate is an [Ac-225]-p-SCN-Bn-DOT AIHuM195 radioimmunoconjugate.

46. 发明授权

US06506363B1 Radioiodinated sulfonated phenols and process therefore 失效
标题翻译：因此，放射性碘化磺化酚和过程
公开(公告)号：US06506363B1
公开(公告)日：2003-01-14
申请号：US09671982
申请日：2000-09-28
申请人： Jaime Simon , R. Keith Frank , Alan D. Strickland
发明人： Jaime Simon , R. Keith Frank , Alan D. Strickland
IPC分类号： A61K5100
CPC分类号： A61K51/04 , A61K51/0406
摘要： The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.
摘要翻译：本发明涉及糠醛的放射性碘化酚类化合物的用途：m和n独立地为0,1,2或3，X为在生理pH下为负或带正电的基团，R，R 1，R 2和R 3为独立地是氢，C 1 -C 4烷基或羧基，I *为123 I，131 I或125 I及其药学上可接受的盐。该化合物在可植入导管中的近距离放射治疗的动物体内被配制和使用。此外，由于这些化合物的肾脏清除速度快，因此可用于研究肾功能。还公开了制备这些化合物的方法。

47. 发明授权

US4758635A Polyamindoamine based metal ion control compound 失效
标题翻译：聚胺二胺基金属离子对照化合物
公开(公告)号：US4758635A
公开(公告)日：1988-07-19
申请号：US626801
申请日：1984-07-02
申请人： David A. Wilson , Druce K. Crump , Jaime Simon
发明人： David A. Wilson , Druce K. Crump , Jaime Simon
IPC分类号： B01J45/00 , C02F5/12 , C02F5/14 , C08G73/02 , C08G83/00
CPC分类号： B01J45/00 , C02F5/12 , C02F5/14 , C08G73/028
摘要： New derivatives of polyamidoamines which contain at least one phosphonic, alkylphosphonic, hydroxyalkyl, carboxyalkly, alkylsulfonic or salts of the acid groups as substituents on a nitrogen are useful as chelating and/or threshold agents for preventing precipitation of metal ions. The preferred agents contain phosphonic acid groups or their salts.
摘要翻译：含有至少一个膦酸，烷基膦酸，羟基烷基，羧基，烷基磺酸或作为氮上的取代基的酸基的盐的聚酰氨基胺的新衍生物可用作用于防止金属离子沉淀的螯合剂和/或阈值剂。优选的试剂含有膦酸基团或其盐。

48. 发明授权

US4500356A Methylenephosphonic acid derivatives of bis(aminoalkyl)piperazines as cement set retarding agents 失效
标题翻译：双（氨基烷基）哌嗪的亚甲基膦酸衍生物作为水泥凝结阻滞剂
公开(公告)号：US4500356A
公开(公告)日：1985-02-19
申请号：US583527
申请日：1984-02-24
申请人： Druce K. Crump , Jaime Simon , David A. Wilson
发明人： Druce K. Crump , Jaime Simon , David A. Wilson
IPC分类号： C04B24/00 , C07F9/6509 , C08G12/40 , C04B7/35
CPC分类号： C07F9/650958 , C04B24/003 , C08G12/40
摘要： Methylenephosphonic acid derivatives of bis(aminoalkyl)piperazine are employed as cement set retarding additives. The compounds must have at least one of the amine hydrogens phosphonomethylated.
摘要翻译：双（氨基烷基）哌嗪的亚甲基膦酸衍生物用作水泥固化阻滞添加剂。化合物必须具有膦酰基甲基化的胺氢中的至少一种。

49. 发明申请

US20130195975A1 IN VIVO USE OF WATER ABSORBENT POLYMERS 审中-公开
标题翻译：吸水聚合物在血液中的使用
公开(公告)号：US20130195975A1
公开(公告)日：2013-08-01
申请号：US13589699
申请日：2012-08-20
申请人： Jaime Simon , Alan D. Strickland
发明人： Jaime Simon , Alan D. Strickland
IPC分类号： A61K31/78 , A61K9/00
CPC分类号： A61K31/78 , A61K9/00 , A61K9/1635 , A61K9/5073 , A61K31/715 , A61K31/716 , A61K31/74 , A61K47/32
摘要： The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.
摘要翻译：本发明是用于从宿主的肠道中除去流体的方法和材料，并且可用于治疗患有流体过载状态的动物或人类患者。在一个实施方案中，本发明方法涉及摄取肠道内涂覆的非全身性，无毒性，不可消化的吸水聚合物，其在通过肠道时吸收流体。聚合物在粪便中排出，其中聚合物和吸收的流体从身体移除。优选的聚合物包括优选以珠粒形式提供的超吸收性丙烯酸聚合物。聚合物可以包括用于选择性地去除血液传播的废物的功能基团，例如。尿素，来自G.I. 道。

50. 发明申请

US20100204457A1 PREPARATION OF ANNEXIN DERIVATIVES 有权
标题翻译：安瓿衍生物的制备
公开(公告)号：US20100204457A1
公开(公告)日：2010-08-12
申请号：US12700312
申请日：2010-02-04
申请人： Jaime Simon
发明人： Jaime Simon
IPC分类号： A61K47/48
CPC分类号： A61K51/088 , A61K47/544 , A61K51/087
摘要： Labeled annexin is formed by reacting annexin or a modified annexin with a phosphatidylserine group or an analogue of phosphatidylserine. This phosphatidylserine annexin conjugate is then reacted with an appropriate label to form a labeled annexin and the annexin is separated from the phosphatidylserine group. The reaction between the phosphatidylserine group and the annexin is calcium ion concentration dependent. Therefore, the reaction can be promoted by having a high calcium ion concentration and the separation of the phosphatidyl group from the annexin group is facilitated by reducing the calcium ion concentration preferably by addition of an appropriate calcium chelating agent.
摘要翻译：标记的膜联蛋白通过膜联蛋白或修饰的膜联蛋白与磷脂酰丝氨酸基团或磷脂酰丝氨酸的类似物反应而形成。然后将该磷脂酰丝氨酸膜联蛋白缀合物与合适的标记反应以形成标记的膜联蛋白，并将膜联蛋白与磷脂酰丝氨酸基团分离。磷脂酰丝氨酸与膜联蛋白之间的反应是钙离子浓度依赖性。因此，通过优选通过加入适当的钙螯合剂来降低钙离子浓度，可以通过具有高的钙离子浓度促进磷脂酰丝氨酸与膜联蛋白基团的分离来促进反应。

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