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41. 发明授权

US06689883B1 Substituted pyridines and pyridazines with angiogenesis inhibiting activity 有权
标题翻译：具有血管生成抑制活性的取代的哒嗪
公开(公告)号：US06689883B1
公开(公告)日：2004-02-10
申请号：US09672294
申请日：2000-09-28
申请人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen James Boyer , Julie A. Dixon , Teddy Kite Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： C07D23714
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Substituted pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
摘要翻译：含有A，B，D，E和L的环的具有血管生成抑制活性的取代的哒嗪和广泛结构的哒嗪是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。

42. 发明授权

US5840758A Oxime derivatives of fenamates as inhibitors of prostaglandin biosynthesis 失效
标题翻译：芥酸肟衍生物作为前列腺素生物合成的抑制剂
公开(公告)号：US5840758A
公开(公告)日：1998-11-24
申请号：US659474
申请日：1996-06-06
申请人： Clint D. W. Brooks , Teodozyj Kolasa , Wendy Lee , Andrew O. Stewart
发明人： Clint D. W. Brooks , Teodozyj Kolasa , Wendy Lee , Andrew O. Stewart
IPC分类号： C07C251/16 , C07C251/60 , C07C259/06 , C07D257/04 , A61K31/41 , A61K31/165 , A61K31/19 , A61K31/275
CPC分类号： C07D257/04 , C07C251/16 , C07C251/60 , C07C259/06 , Y10S514/824 , Y10S514/825 , Y10S514/863 , Y10S514/886 , Y10S514/887 , Y10S514/916
摘要： Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; A is selected from (a) optionally substituted alkylene, (b) optionally substituted cycloalkylene, (c) optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, (d) optionally substituted alkenylene and (e) ##STR2## X is absent or is alkylene; Z is selected from (a) hydrogen, (b) COM wherein M is selected from --OR.sup.4, --NR.sup.6 R.sup.7, and a pharmaceutically acceptable metabolically cleavable group, (c) --OR.sup.2, (d) tetrazolyl, (e) --CH(OR.sup.2)--CH.sub.2 OR.sup.8, (f) --CH(OR.sup.2)--CH.sub.2 --CH.sub.2 OR.sup.8, (g) --CH(OR.sup.2)--CH(OR.sup.8)--CH.sub.2 OR.sup.9, and (h).dbd.N--OR.sup.2 ; and R.sup.1 is selected from hydrogen, alkyl, and optionally substituted phenyl, are prostaglandin biosynthesis inhibitors and are useful in the treatment of inflammatory disease states. Also disclosed are prostaglandin inhibiting compositions, a method of inhibiting prostaglandin biosynthesis in a mammal.
摘要翻译：具有式“IMAGE”的化合物或其药学上可接受的盐，其中Y选自卤素，烷基和卤代烷基; n为0,1,2或3; A选自（a）任选取代的亚烷基，（b）任选取代的亚环烷基，（c）任选取代的亚环烷基，其中一个或两个碳原子被一个或两个独立地选自O，S和N的杂原子置换，（ d）任选取代的亚烯基和（e）X不存在或是亚烷基; Z选自（a）氢，（b）COM，其中M选自-OR4，-NR6R7和药学上可接受的代谢可裂解基团，（c）-OR2，（d）四唑基，（e）-CH（OR2））-CH 2 OR 8，（f）-CH（OR 2）-CH 2 -CH 2 OR 8，（g）-CH（OR 2）-CH（OR 8）-CH 2 OR 9和（h）= N-OR 2; 并且R 1选自氢，烷基和任选取代的苯基，是前列腺素生物合成抑制剂，并且可用于治疗炎性疾病状态。还公开了前列腺素抑制组合物，在哺乳动物中抑制前列腺素生物合成的方法。

43. 发明授权

US5446062A ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase 失效
标题翻译：（（4-烷氧基吡喃-4-基）取代的）醚，芳基烷基 - ，芳基烯基 - 和芳基炔基）尿素抑制剂5-脂氧合酶
公开(公告)号：US5446062A
公开(公告)日：1995-08-29
申请号：US152569
申请日：1993-11-12
申请人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Chernesky , Wendy Lee
发明人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Chernesky , Wendy Lee
IPC分类号： C07D309/10 , C07D405/12 , A61K31/35 , C07D405/10
CPC分类号： C07D405/12 , C07D309/10
摘要： Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene; R.sup.1 and R.sup.2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR.sup.10, and ##STR4## L.sup.3 is selected from alkylene of one to three carbon atoms, propenylene, propynylene, ##STR5## and R.sup.3, R.sup.4, and R.sup.5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
摘要翻译：其中W选自的结构的化合物，其中Q是氧或硫，R6和R7是氢或烷基，或R6和R7与它们所连接的氮原子一起定义为式Z是-CH 2 - ，氧，硫或-NR 9，L 1和L 2选自价键，亚烷基，亚丙烯基和亚丙炔基; R 1和R 2独立地选自烷基，烷氧基，卤代烷基，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基; Y选自氧，> NR10，并且 L3选自1至3个碳原子的亚烷基，亚丙烯基，亚丙炔基，R 3，R 4和R 5是氢或1-4个碳原子的烷基抑制白三烯的合成。这些化合物可用于治疗或改善过敏性和炎性疾病状态。

44. 发明申请

US20120309765A1 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE 审中-公开
标题翻译： 5-ANILINOIMIDAZOPYRIDINES和使用方法
公开(公告)号：US20120309765A1
公开(公告)日：2012-12-06
申请号：US13586147
申请日：2012-08-15
申请人： Stephen Price , Robert Heald , Wendy Lee , Mark E. Zak , Joanne Frances Mary Hewitt
发明人： Stephen Price , Robert Heald , Wendy Lee , Mark E. Zak , Joanne Frances Mary Hewitt
IPC分类号： A61K31/437 , A61P29/00 , A61P35/00 , A61K31/4985
CPC分类号： C07D471/04 , C07D235/00 , C07D401/04 , C07D487/04
摘要： The invention relates to a method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of an imidazopyridine of formula I with anti-hyperproliferative activity.
摘要翻译：本发明涉及抑制哺乳动物异常细胞生长或治疗过度增殖性疾病的方法，包括向所述哺乳动物施用治疗有效量的具有抗过度增殖活性的式I咪唑并吡啶。

45. 外观设计

USD665614S1 Packaged blanket 有权
公开(公告)号：USD665614S1
公开(公告)日：2012-08-21
申请号：US29408087
申请日：2011-12-06
申请人： Wendy Lee
设计人： Wendy Lee

46. 发明授权

US07977333B2 Substituted pyridines and pyridazines with angiogenesis inhibiting activity 有权
标题翻译：取代的吡啶和哒嗪具有血管生成抑制活性
公开(公告)号：US07977333B2
公开(公告)日：2011-07-12
申请号：US10720702
申请日：2003-11-24
申请人： Jacques P. Dumas , Stephen J. Boyer , Julie A. Dixon , Teddy K. Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
发明人： Jacques P. Dumas , Stephen J. Boyer , Julie A. Dixon , Teddy K. Joe , Harold C. E. Kluender , Wendy Lee , Dhanapalan Nagarathnam , Robert N. Sibley , Ning Su
IPC分类号： A61K31/535 , A61K31/50 , C07D237/30 , C07D237/32 , C07D237/34 , C07D413/14
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
摘要翻译：具有血管生成抑制活性的取代的吡啶和哒嗪和广义结构式，其中含有A，B，D，E和L的环是苯基或含氮杂环; 基团X和Y可以是各种定义的连接单元中的任何一种; R 1和R 2可以被定义为独立的取代基或一起可以是环定义的桥; 环J可以是芳基，吡啶基或环烷基; 和G基团可以是各种定义的取代基中的任何一种。还公开了含有这些材料的药物组合物，以及使用这些材料治疗具有异常血管生成或超敏性过程特征的病症的哺乳动物的方法。

47. 发明申请

US20110086841A1 N-9 SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 有权
标题翻译： N-9替代的嘌呤化合物，组合物和使用方法
公开(公告)号：US20110086841A1
公开(公告)日：2011-04-14
申请号：US12943284
申请日：2010-11-10
申请人： Zhonghua Pei , Joseph P. Lyssikatos , Kevin Hon Luen Lau , Wendy Lee , Kirk D. Robarge
发明人： Zhonghua Pei , Joseph P. Lyssikatos , Kevin Hon Luen Lau , Wendy Lee , Kirk D. Robarge
IPC分类号： A61K31/5377 , C07D473/40 , A61P35/00 , A61P35/02
CPC分类号： A61K31/52 , A61K31/5377 , C07D473/34
摘要： The present invention relates to compounds of Formula I: wherein R1, R2, R3, A1, A2, A3, A4 and D have the meaning described herein. The present invention also relates to pharmaceutical compositions comprising such compounds and therapeutic uses thereof.
摘要翻译：本发明涉及式I化合物：其中R1，R2，R3，A1，A2，A3，A4和D具有本文所述的含义。本发明还涉及包含这些化合物的药物组合物及其治疗用途。

48. 发明申请

US20050021353A1 DONATION SYSTEM AND METHOD 审中-公开
标题翻译：捐赠制度与方法
公开(公告)号：US20050021353A1
公开(公告)日：2005-01-27
申请号：US10707715
申请日：2004-01-06
申请人： Karen Aviles , Mary Craig , Jason Halpern , Wendy Lee , Anna Mariella , Anne O'Malley , Barbara Reveron-Lens
发明人： Karen Aviles , Mary Craig , Jason Halpern , Wendy Lee , Anna Mariella , Anne O'Malley , Barbara Reveron-Lens
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/0279 , G06Q30/02 , G06Q30/04
摘要： The present invention includes an automatic bill payment enrollment system for recurring donations, which allows donors to automatically charge charitable donations on a recurring basis to a financial account. In one embodiment, the invention uses a donation portal having various webpages to allow a donor to donate to all U.S. 501(c)(3) organizations. In an alternative embodiment, a donor may donate to any other desired organizations. The system may also incorporate a filter for restricting monies being sent to terrorist organizations. The invention also includes a loyalty point system, wherein loyalty points may be donated to a charity. In another exemplary embodiment, the invention also facilitates employee gift matching.
摘要翻译：本发明包括用于经常性捐赠的自动账单支付注册系统，其允许捐赠者自动将慈善捐赠以一定的方式从金融账户中收取。在一个实施例中，本发明使用具有各种网页的捐赠门户，以允许捐赠者捐赠给所有美国501（c）（3）组织。在替代实施例中，捐赠者可以捐赠给任何其他期望的组织。该系统还可以包含一个过滤器，用于限制发送给恐怖组织的款项。本发明还包括忠诚点系统，其中忠诚点可以捐赠给慈善机构。在另一示例性实施例中，本发明还便于员工礼物匹配。

49. 发明授权

US5484786A Pyran-4-ylmethyl substituted arylalkylaryl-, arylalkenylylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase 失效
标题翻译：吡喃-4-基甲基取代的芳烷基芳基 - ，芳基烯基芳基 - 和芳基炔基芳基脲抑制剂5-脂氧合酶
公开(公告)号：US5484786A
公开(公告)日：1996-01-16
申请号：US111090
申请日：1993-08-24
申请人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Chernesky , Wendy Lee
发明人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Chernesky , Wendy Lee
IPC分类号： C07D309/04 , C07D309/06 , C07D405/12 , A61K31/35 , A61K31/495 , C07D239/04 , C07D315/00
CPC分类号： C07D405/12 , C07D309/04 , C07D309/06
摘要： Compounds of structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.5 and R.sup.6 are independently selected from hydrogen and alkyl, or R.sup.5 and R.sup.6, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## L.sup.1 and L.sup.2 are independently selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is oxygen, >NR.sup.9 where R.sup.9 is hydrogen or alkyl, or ##STR4## where n=0, 1, or 2, and A is selected from ##STR5## inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
摘要翻译：其中W选自的结构的化合物，其中Q是氧或硫，R5和R6独立地选自氢和烷基，或R5和R6连同它们所连接的氮原子定义式为基团的基团，L1和L2独立地选自价键，亚烷基，亚丙烯基和亚丙炔基，R 1，R 2，R 3和R 4独立地选自烷基，烷氧基，卤代烷基，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基，Y是氧，NR9，其中R9是氢或烷基，或者其中n = 0,1或2的A，并且A选自抑制白细胞三烯的生物合成。这些化合物可用于治疗或改善过敏性和炎性疾病状态。

50. 发明授权

US5346914A (4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase 失效
标题翻译：（4-烷氧基吡喃-4-基）取代的芳烷基芳基 - ，芳基烯基芳基 - 和芳基炔基芳基脲抑制剂5-脂氧合酶
公开(公告)号：US5346914A
公开(公告)日：1994-09-13
申请号：US61988
申请日：1993-05-14
申请人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Dorn , Wendy Lee
发明人： Joseph F. Dellaria , Anwer Basha , Lawrence A. Black , Linda J. Dorn , Wendy Lee
IPC分类号： C07D309/12 , C07D405/12 , A61K31/35 , A61K31/415 , A61K31/495 , C07D309/10 , C07D405/10
CPC分类号： C07D405/12 , C07D309/12
摘要： Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
摘要翻译：其中W选自其中Q是氧或硫的结构的化合物，R6和R7是氢或烷基，或R6和R7与它们所连接的氮原子一起定义为烷基，卤代烷基，任选取代的苯基，羟基烷基，氨基烷基，羧基烷基，（烷氧基羰基）烷基和（烷基氨基羰基）烷基; Z是-CH 2 - ，氧，硫或-NR 9，其中R 9是氢或烷基，L 1和L 2选自价键，亚烷基，亚丙烯基和亚丙炔基，R 1，R 2，R 3和R 4独立地选自烷基卤素，卤素，氰基，氨基，烷氧基羰基和二烷基氨基羰基，Y选自氧，-NR10，其中R10是氢或烷基，和其中n = 0,1或2，R5是烷基，抑制白三烯的生物合成。这些化合物可用于治疗或改善过敏性和炎性疾病状态。

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