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    • 45. 发明授权
    • Pneumatic tire having directional tread pattern
    • 具有定向胎面花纹的气动轮胎
    • US06206064B1
    • 2001-03-27
    • US09056823
    • 1998-04-08
    • Ichiro Takahashi
    • Ichiro Takahashi
    • B60C1113
    • B60C11/0302B60C11/0309B60C11/033B60C11/13B60C11/1323B60C2011/0374B60C2011/0388
    • At a portion of an inclined main groove from a tread center to an auxiliary groove of a pneumatic tire, an angle of inclination &thgr;1 of a groove wall surface at a block step-in end side is set to be smaller than an angle of inclination &thgr;2 of a groove wall surface at a block kick-out end side. Therefore, rigidity of step-in ends of blocks defined by inclined main grooves is lowered such that a striking sound can be reduced. Further, at a portion of the inclined main groove from the auxiliary groove to a tread end, an angle of inclination &thgr;1 of a groove wall surface at a block step-in end side is set to be greater than an angle of inclination &thgr;2 of a groove wall surface at a block kick-out end side. Therefore, rigidity of kick-out end sides of blocks defined by the inclined main grooves is lowered. Heel-and-toe wear which occurs at the kick-out end sides is suppressed, and an increase in pattern noise caused by heel-and-toe wear is suppressed.
    • 在从胎面中心到充气轮胎的辅助槽的倾斜主槽的一部分处,块踏入端侧的槽壁表面的倾斜角θ1被设定为小于倾斜角度θ2 在块踢出端侧的槽壁表面。 因此,由倾斜的主槽限定的块的阶梯端部的刚性降低,使得可以降低打击声。 此外,在从辅助槽到胎面端的倾斜主槽的一部分处,在块踏入端侧的槽壁表面的倾斜角θ1被设定为大于倾斜主角 在块踢出端侧的槽壁表面。 因此,由倾斜主槽限定的块的突出端侧的刚性降低。 抑制了在踢出端侧发生的脚跟磨损,并且抑制了由脚跟和趾部磨损引起的图案噪声的增加。
    • 46. 发明授权
    • Method for preparing vaccine for dental caries and vaccinal compositions
for dental caries used as nasal drop
    • 用于龋齿疫苗的方法和用作鼻滴的龋齿的疫苗组合物
    • US5352450A
    • 1994-10-04
    • US529602
    • 1990-05-29
    • Toshihiko KogaNobuo OkahashiIchiro TakahashiKoji ShibuyaHirotaka Ohta
    • Toshihiko KogaNobuo OkahashiIchiro TakahashiKoji ShibuyaHirotaka Ohta
    • A61K9/00A61K39/00C07K14/315A61K39/02C12P21/06C12P21/04
    • A61K9/0043C07K14/315A61K39/00
    • A method for preparing a vaccine for dental caries comprises the step of culturing a variant which is obtained by integrating a protein antigen (PAc)-expressing gene into the chromosomal gene of a Streptococcus mutans GS-5 strain to obtain the protein antigen, the protein antigen being produced on the surface of cells of oral Streptococcus mutans or it being extracellularly produced by the microorganism and having a molecular weight ranging from about 170,000 to 220,000. Streptococcus mutans GS-5 (K-3), in which a protein antigen-expressing gene is integrated into the chromosomal gene thereof, has an ability of producing the protein antigen on the surface of the cells or extracellularly. A preventive vaccine composition for dental caries for nasal drops comprises the protein antigen thus produced by the strain: Streptcoccus mutans, the vaccine being intranasally administered. The method makes it possible to enhance the yield of PAc and to simplify processes for purifying PAc. The vaccine composition makes-it possible to internally easily absorb the protein antigen, PAc, in high efficiency and it also makes it possible to effectively increase the antibody titer observed after the administration thereof.
    • 制备龋齿疫苗的方法包括将通过将表达蛋白质抗原(PAc)的基因整合到变形链球菌GS-5株的染色体基因而获得的变体的方法来获得蛋白质抗原,所述蛋白质 抗原在口腔变形链球菌的细胞表面产生,或由微生物细胞外产生,分子量范围为约17万至22万。 其中将表达蛋白质抗原的基因整合到其染色体基因中的变形链球菌GS-5(K-3)具有在细胞表面或细胞外产生蛋白质抗原的能力。 用于鼻滴龋齿的预防性疫苗组合物包含由菌株:由变形链球菌产生的蛋白质抗原,该疫苗被鼻内给药。 该方法可以提高PAc的产率并简化PAc的纯化过程。 疫苗组合物能够高效地内部容易地吸收蛋白质抗原PAc,并且还可以有效地增加施用后观察到的抗体滴度。
    • 47. 发明授权
    • Pneumatic safety tire
    • 气动安全轮胎
    • US4917164A
    • 1990-04-17
    • US251941
    • 1988-09-29
    • Hisao UshikuboTouru TsudaIchiro Takahashi
    • Hisao UshikuboTouru TsudaIchiro Takahashi
    • B60C9/14B60C13/00B60C15/06B60C17/00B60C17/08
    • B60C17/0009B60C15/06B60C9/14Y10T152/10864
    • To improve the load supporting capability of a pneumatic safety tire and to prevent the tire bead portion from coming off from the rim seat both during run-flat (flat punctured tire) travel, the pneumatic safety tire comprises a pair of crescent-shaped cross-section reinforcing rubber layers each having the thicknest portion at the tire side portion and a pair of beak-shaped cross-section rim-fixed protruding hard-rubber members each disposed under the reinforcing rubber layer in such a way that annular circumferential bonding surfaces between the two are inclided axially outwardly or inwardly in annular wedge shape. Further, to prevent creases from being produced during green tire forming process and cracks from being produced during run-flat travel in or near the bonding surfaces, crescent-shaped reinforcing layer and the beak-shaped rim-fixed protruding members are extrusion-formed simultaneously before a green tire is formed.
    • 为了提高气动安全轮胎的负荷支持能力,并且在平坦(平坦的穿刺轮胎)行驶期间,防止轮胎胎圈部分从轮辋座脱离,气动安全轮胎包括一对月牙形横截面, 在轮胎侧部分具有最厚部分的截面增强橡胶层和分别设置在增强橡胶层下面的一对喙形横截面边缘固定的突出硬橡胶构件,使得环形周向接合表面 两个以环形楔形形状轴向向外或向内倾斜。 此外,为了防止在生胎成形过程中产生褶皱和在接合表面中或附近的平面行进期间产生裂纹,新月形加强层和喙形边缘固定突出构件同时挤出成形 在生胎之前。
    • 50. 发明申请
    • Treatment tool for endoscope
    • 内窥镜治疗工具
    • US20080033238A1
    • 2008-02-07
    • US11796785
    • 2007-04-30
    • Ichiro Takahashi
    • Ichiro Takahashi
    • A61B1/005
    • A61B17/072A61B10/02A61B18/14A61B18/1445A61B2018/1407A61B2018/141A61B2018/1861
    • A treatment tool for an endoscope includes: a treatment portion that is positioned on a distal end side and of which at least a portion is formed from an electroconductive material; an operating wire that is formed from an electroconductive material and is connected to the treatment portion; a sheath that is formed from an electrically non-conductive material through which the operating wire is inserted; a base that is fixed to a base end side of the sheath; an operating section that is rotatably mounted on the base and is connected to a base end side of the operating wire, and that causes the treatment portion to move forwards and backwards and to rotate via the operating wire; and a plug that is provided on the base and is electrically connected to the operating wire.
    • 一种用于内窥镜的处理工具,包括:处理部,其位于前端侧,至少一部分由导电材料形成; 由导电材料形成并连接到处理部分的操作线; 由导电材料制成的护套,通过该护套插入操作线; 固定在护套的基端侧的基部; 操作部,其可旋转地安装在所述基座上并连接到所述操作线的基端侧,并且使所述处理部向前后移动并经由所述操作线旋转; 以及设置在基座上并且电连接到操作线的插头。