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41. 发明申请

US20090162936A1 Method For Transfer Of Gene Into Fat Cell Or Progenitor Fat Cell 有权
标题翻译：将基因转移到脂肪细胞或祖细胞脂肪细胞的方法
公开(公告)号：US20090162936A1
公开(公告)日：2009-06-25
申请号：US11917853
申请日：2006-06-12
申请人： Takahiro Marui , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
发明人： Takahiro Marui , Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： C12N15/867
CPC分类号： C12N15/86 , C07K14/78 , C12N2533/52 , C12N2740/13045 , C12N2810/857
摘要： A method for transferring a gene into a fat cell or progenitor fat cell comprising the step of infecting the fat cell or progenitor cell with a retrovirus vector having a foreign gene in the presence of a substance having both of a retrovirus-binding site and a target cell-binding site in the molecule or a mixture of a substance having a retrovirus-binding site and a substance having a target cell-binding site, the target cell-binding site having a region that can bind to VLA-5 and/or a region that can bind to VLA-4.
摘要翻译：一种将基因转移到脂肪细胞或祖细胞脂肪细胞中的方法，包括在具有逆转录病毒结合位点和靶标的物质存在的情况下用具有外来基因的逆转录病毒载体感染所述脂肪细胞或祖细胞的步骤分子中的细胞结合位点或具有逆转录病毒结合位点的物质与具有靶细胞结合位点的物质的混合物，所述靶细胞结合位点具有能够结合VLA-5的区域和/或可以结合VLA-4的区域。

42. 发明申请

US20090099101A1 Drugs, foods or drinks with the use of algae-derived physiologically active substances 审中-公开
标题翻译：使用藻类来源的生理活性物质的药物，食品或饮料
公开(公告)号：US20090099101A1
公开(公告)日：2009-04-16
申请号：US12222492
申请日：2008-08-11
申请人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Takanari Tominaga , Eiji Nishiyama , Nobuto Koyama , Takeshi Sakai , Fu-Gong Yu , Katsushige Ikai , Ikunoshin Kato
IPC分类号： A61K31/70 , A61K31/335
CPC分类号： A01N43/04 , A23L3/3472 , A23L3/3544 , A23L3/3562 , A23L33/105 , A61K31/341 , A61K31/7048
摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1): foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.
摘要翻译：用于治疗，改善或预防对由式（1）表示的3,6-脱水吡喃半乳糖敏感的疾病的药物组合物：含有作为活性成分的至少一种选自上述组分的组分的食品，饮料，化妆品等，所述化合物，其醛，其水合物和2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。该化合物还显示例如细胞凋亡诱导活性，制癌活性和对活性氧，脂质过氧化物自由基和NO的产生的抑制活性，这使得它也可用作抗氧化剂和防腐剂的活性成分。

43. 发明申请

US20080160584A1 alpha-AGARASE AND PROCESS FOR PRODUCING THE SAME 失效
标题翻译： α-淀粉酶及其生产方法
公开(公告)号：US20080160584A1
公开(公告)日：2008-07-03
申请号：US12027738
申请日：2008-02-07
申请人： Jun TOMONO , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
发明人： Jun TOMONO , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
IPC分类号： C12P19/04 , C12N9/00
CPC分类号： C12Y302/01158 , C12N9/2465 , C12P19/04 , C12P19/24
摘要： A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.
摘要翻译：具有α-琼脂糖酶活性的多肽，编码该多肽的基因，通过遗传工程生产该多肽的方法以及使用该多肽制备琼脂低聚糖的方法。

44. 发明申请

US20080096249A1 AGARASE AND GENE THEREOF 失效
标题翻译：其基因及其基因
公开(公告)号：US20080096249A1
公开(公告)日：2008-04-24
申请号：US11948650
申请日：2007-11-30
申请人： Jun TOMONO , Hiroaki Sagawa , Ikunoshin Kato
发明人： Jun TOMONO , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： C12N9/00 , C12N15/00 , C12N15/11 , C12P21/04 , C12N5/06
CPC分类号： C12Y302/01081 , C12N9/2468
摘要： Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process for producing agaro-oligosaccharide; and a process for extracting a substance such as a nucleic acid from an agarose gel.
摘要翻译：高效生产琼脂寡糖的生产; 具有琼脂糖酶活性的多肽，其可用于例如从琼脂糖凝胶中有效地提取诸如核酸的物质; 多肽的氨基酸序列; 编码该多肽的基因; 一种生产该多肽的方法; 制备琼脂寡糖的方法; 以及从琼脂糖凝胶中提取核酸等物质的方法。

45. 发明授权

US07351556B2 α-agarase and process for producing the same 失效
标题翻译： α-琼脂糖酶及其制备方法
公开(公告)号：US07351556B2
公开(公告)日：2008-04-01
申请号：US11553912
申请日：2006-10-27
申请人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
发明人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
IPC分类号： C12P19/44 , C12N9/24
CPC分类号： C12Y302/01158 , C12N9/2465 , C12P19/04 , C12P19/24
摘要： A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.
摘要翻译：具有α-琼脂糖酶活性的多肽，编码该多肽的基因，通过遗传工程生产该多肽的方法以及使用该多肽制备琼脂低聚糖的方法。

46. 发明申请

US20070060641A1 Therapeutic agent 审中-公开
标题翻译：治疗剂
公开(公告)号：US20070060641A1
公开(公告)日：2007-03-15
申请号：US10557268
申请日：2004-05-18
申请人： Tatsuji Enoki , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji Enoki , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/343 , A61K31/225 , A61K31/19 , A61K31/192 , A61K31/11
CPC分类号： A61K31/11 , A23K20/00 , A23L33/10
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.
摘要翻译：本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

47. 发明申请

US20050059003A1 Nucleic and amplification methods 失效
标题翻译：核和扩增方法
公开(公告)号：US20050059003A1
公开(公告)日：2005-03-17
申请号：US10486645
申请日：2002-08-20
申请人： Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji Enoki , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q1/6853 , C12Q2600/156 , C12Q2525/186 , C12Q2521/301 , C12Q2531/119 , C12Q2525/117 , C12Q2525/113
摘要： Methods of amplifying a target nucleic acid whereby the target nucleic acid in a sample is highly sensitively and specifically amplified; and compositions and kits to be used in these methods.
摘要翻译：扩增目标核酸的方法，其中样品中的靶核酸被高度敏感和特异性地扩增; 以及用于这些方法的组合物和试剂盒。

48. 发明授权

US06673578B1 Method for synthesizing DNA 失效
标题翻译： DNA合成方法
公开(公告)号：US06673578B1
公开(公告)日：2004-01-06
申请号：US09786684
申请日：2001-05-22
申请人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
发明人： Takashi Uemori , Yoshimi Sato , Mariko Okawa , Tomoko Fujita , Kazue Miyake , Osamu Takeda , Hiroaki Sagawa , Michio Hagiya , Hiroyuki Mukai , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C12P1934
CPC分类号： C12N15/1003 , C12Q1/686 , C12Q2527/125
摘要： A DNA synthesis method with a shortened time period required for DNA synthesis by polymerase chain reaction (PCR), characterized in that a DNA polymerase is used in an amount effective for providing more than 10 ng of amplified DNA fragments of about 2 kb per 50 &mgr;l of a reaction mixture, when PCR is carried out under the following conditions (A) and (B): (A) reaction mixture: 50 &mgr;l volume of a reaction mixture comprising DNA polymerase, 1 ng of genomic DNA from Escherichia coli, and 10 pmol each of primers Eco-1 and Eco-2 (nucleotide sequences of the primers Eco-1 and Eco-2 being shown in SEQ ID NOs: 10 and 11 of Sequence Listing, respectively); and having a composition suitable for the DNA polymerase; and (B) reaction conditions: 35 cycles of PCR, wherein one cycle consists of 99° C., 1 second-66° C., 7 seconds; a kit for DNA synthesis usable for the DNA synthesis method; and an article of manufacture of a PCR agent. According to the present invention, the procedures in the genetic engineering studies and industries involved with PCR can be speeded up.
摘要翻译：一种DNA合成方法，其通过聚合酶链式反应（PCR）进行DNA合成所需的时间缩短，其特征在于使用DNA聚合酶，其量有效提供超过10ng每50ul约2kb的扩增DNA片段的反应混合物，当在以下条件（A）和（B）下进行PCR时：（A）反应混合物：将50体积的包含DNA聚合酶的反应混合物，1ng来自大肠杆菌的基因组DNA和10ng 各引物Eco-1和Eco-2（引物Eco-1和Eco-2的核苷酸序列分别示于序列表的SEQ ID NO：10和11中）并具有适合于DNA聚合酶的组合物; 和（B）反应条件：35个循环的PCR，其中一个循环由99℃，1秒-66℃，7秒; 用于DNA合成方法的DNA合成试剂盒; 以及PCR试剂的制造。根据本发明，可以加快基因工程研究和涉及PCR的行业的程序。

49. 发明授权

US06518302B1 Remedies 失效
标题翻译：补救措施
公开(公告)号：US06518302B1
公开(公告)日：2003-02-11
申请号：US09889728
申请日：2001-07-20
申请人： Eiji Kobayashi , Tuo-Ping Li , Tatsuji Enoki , Takanari Tominaga , Hiroaki Sagawa , Ikunoshin Kato
发明人： Eiji Kobayashi , Tuo-Ping Li , Tatsuji Enoki , Takanari Tominaga , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A01N4302
CPC分类号： C07H3/10 , C07H11/00 , Y10S514/825 , Y10S514/866 , Y10S514/903
摘要： Compounds represented by general formula (I) wherein X represents OH or OSO3H; and R represents a substituent other than OH which allows, after leaving, the induction of unsaturated bonds into the 3- and 4-positions of 3,6-anhydrogalactose or its sulfated derivative, and/or a substituent showing a tissue-specific affinity.
摘要翻译：由通式（I）表示的化合物，其中X表示OH或OSO 3 H; R表示除羟基以外的取代基，其在离去后允许不饱和键诱导3,6-脱水半乳糖或其硫酸化衍生物的3-和4-位，和/或显示组织特异性亲和力的取代基。

50. 发明申请

US20100068192A1 Method for Production of T Cell Population 审中-公开
标题翻译： T细胞群体生产方法
公开(公告)号：US20100068192A1
公开(公告)日：2010-03-18
申请号：US11992661
申请日：2006-09-27
申请人： Tatsuji Enoki , Akiko Kato , Mitsuko Ideno , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji Enoki , Akiko Kato , Mitsuko Ideno , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K35/12 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/19 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C12N15/86 , C12N2501/515 , C12N2501/58 , C12N2740/10043 , A61K2300/00
摘要： A method for preparing a T cell population, wherein the T cell population expresses CD45RA and expresses at least one selected from the group consisting of CD62L, CCR7, CD27, and CD28, characterized in that the method comprises the step of culturing a cell population comprising a T cell, in the presence of fibronectin, a fragment thereof or a mixture thereof.
摘要翻译：一种制备T细胞群体的方法，其中所述T细胞群表达CD45RA并表达选自CD62L，CCR7，CD27和CD28的至少一种，其特征在于所述方法包括培养细胞群的步骤，所述细胞群包含在纤连蛋白存在下，其T细胞，其片段或其混合物。

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