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41. 发明授权

US08529901B2 Composition of a first non-labeled monoclonal antibody binding to a tumor antigen and a non-cross reactive second monoclonal antibody labeled with a NIR fluorescence label 有权
标题翻译：结合肿瘤抗原的第一非标记单克隆抗体和用NIR荧光标记标记的非交叉反应性第二单克隆抗体的组成
公开(公告)号：US08529901B2
公开(公告)日：2013-09-10
申请号：US12599713
申请日：2008-06-04
申请人： Max Hasmann , Helmut Lenz , Werner Scheuer
发明人： Max Hasmann , Helmut Lenz , Werner Scheuer
IPC分类号： A61K39/395
CPC分类号： A61K49/0058 , A61K39/39558 , A61K49/0032
摘要： This invention relates to a composition of a non-labeled monoclonal antibody binding to a tumor antigen and a second monoclonal antibody labeled with a NIR fluorescence label, binding to the same tumor antigen, wherein the first and second antibody exhibit no cross reactivity. The composition can be used for the treatment of patients suffering of solid tumors which are associated with an overexpression of such a tumor antigen. The invention further relates to a the co-administration of said first and second antibody as wells as to a method of acquiring a NIR fluorescence images of such tumors or the patients suffering from such tumors during the treatment of said patient with such composition.
摘要翻译：本发明涉及结合肿瘤抗原的非标记单克隆抗体的组合物和用NIR荧光标记物标记的第二单克隆抗体，其结合相同的肿瘤抗原，其中第一抗体和第二抗体不显示交叉反应性。该组合物可用于治疗与这种肿瘤抗原的过表达相关的实体瘤患者。本发明还涉及所述第一和第二抗体的共同给药，以获得在用所述组合物治疗所述患者期间获得这种肿瘤的NIR荧光图像或患有此类肿瘤的患者的方法。

42. 发明申请

US20130181713A1 CONTROLLING GRADIENT COILS TAKING THE INDUCTIVE COUPLING INTO ACCOUNT 有权
标题翻译：控制电感线圈进入帐户
公开(公告)号：US20130181713A1
公开(公告)日：2013-07-18
申请号：US13552442
申请日：2012-07-18
申请人： Eva Eberlein , Ralph Kimmlingen , Helmut Lenz , Franz Schmitt
发明人： Eva Eberlein , Ralph Kimmlingen , Helmut Lenz , Franz Schmitt
IPC分类号： G01R33/54 , G01R33/385
CPC分类号： G01R33/543 , G01R33/385 , G01R33/3852
摘要： A gradient pulse generator generates reference current signals for a plurality of gradient coils of a gradient coil system of a magnetic resonance system and supplies each of the reference current signals to a controller assigned to one of the gradient coils. Also supplied to the respective controller is an actual current signal that is characteristic of the current flowing in the respective gradient coil. Each of the controllers generates a control signal and accordingly drives a gradient power amplifier assigned to the respective gradient coil. The gradient power amplifiers apply a current to the gradient coils assigned to the gradient power amplifiers in accordance with the generated control signals. Each of the controllers is also supplied with the reference current signal or the actual current signal of at least one other gradient coil or the time derivative of the reference current signal or the actual current signal.
摘要翻译：梯度脉冲发生器产生用于磁共振系统的梯度线圈系统的多个梯度线圈的参考电流信号，并将每个参考电流信号提供给分配给一个梯度线圈的控制器。还提供给相应控制器的是实际电流信号，其是在各个梯度线圈中流动的电流的特征。每个控制器产生控制信号，并相应地驱动分配给相应梯度线圈的梯度功率放大器。梯度功率放大器根据所生成的控制信号向分配给梯度功率放大器的梯度线圈施加电流。每个控制器还提供参考电流信号或至少一个其他梯度线圈的实际电流信号或参考电流信号或实际电流信号的时间导数。

43. 发明授权

US07955806B2 Detection of a therapeutic antibody in an experimental animal 有权
标题翻译：实验动物中治疗性抗体的检测
公开(公告)号：US07955806B2
公开(公告)日：2011-06-07
申请号：US11792910
申请日：2005-12-22
申请人： Helmut Lenz , Kay-Gunnar Stubenrauch
发明人： Helmut Lenz , Kay-Gunnar Stubenrauch
IPC分类号： G01N33/53 , G01N33/564
CPC分类号： G01N33/6854 , C07K16/4283
摘要： The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with an antibody binding to a therapeutic antibody and not binding to the immunoglobulin of said experimental animal, c) optionally incubating said sample with a reagent appropriate for the selective detection of total, active or antigen-bound therapeutic antibody, and d) correlating the complex formed in (b) or (c) to the concentration of said therapeutic antibody. A monoclonal antibody directed to a certain epitope that is present on all classes of human immunoglobulin of class G, but not on the immunoglobulin of any experimental animal except on the IgG of chimpanzees was used (MAB-M-R10Z8E9).
摘要翻译：本发明涉及治疗性抗体领域。它特别涉及实验动物中治疗性抗体的研究。本发明公开了一种检测从实验动物获得的样品中的治疗性抗体的方法，包括以下步骤：a）提供待分析的样品，b）将所述样品与结合治疗性抗体的抗体孵育，所述实验动物的免疫球蛋白，c）任选地使用适于选择性检测总体，活性或抗原结合的治疗性抗体的试剂培养所述样品，以及d）使（b）或（c）中形成的复合物与所述治疗性抗体。（MAB-M-R10Z8E9）使用针对存在于G类人免疫球蛋白的所有类别但不在任何实验动物的免疫球蛋白上的特定表位的单克隆抗体，除了黑猩猩的IgG。

44. 发明申请

US20100119457A1 COMPOSITION OF LABELED AND NON-LABELED MONOCLONAL ANTIBODIES 审中-公开
标题翻译：标签和非标签单克隆抗体的组成
公开(公告)号：US20100119457A1
公开(公告)日：2010-05-13
申请号：US12593621
申请日：2008-03-27
申请人： Helmut Lenz , Wemer Scheuer
发明人： Helmut Lenz , Wemer Scheuer
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/0058 , A61K49/0032
摘要： This invention relates to a composition of labeled and non-labeled monoclonal antibodies directed to a human transmembrane protein for the simultaneous treatment and diagnosis of diseases which are associated with an overexpression of such a protein especially of cancer. The invention further relates to a method of first administering said composition, determine the change of labeled antibody concentration and afterwards administering the non-labeled monoclonal antibodies only such that the minimum required concentration of such non-labeled antibody for a favorable therapeutical effect is achieved and maintained in the treatment, while unfavorable side effects are minimized due to the lower systemic antibody concentration.
摘要翻译：本发明涉及针对人跨膜蛋白的标记和非标记的单克隆抗体的组合物，用于同时治疗和诊断与这种特别是癌症的蛋白质的过度表达有关的疾病。本发明还涉及首先施用所述组合物的方法，确定标记的抗体浓度的变化，然后仅施用非标记的单克隆抗体，使得达到有利治疗效果的这种非标记抗体的最低要求浓度，维持治疗，而由于较低的全身抗体浓度，不利的副作用被最小化。

45. 发明授权

US07498963B2 Method for generating a modulator input signal and premodulator 失效
标题翻译：用于产生调制器输入信号和预调制器的方法
公开(公告)号：US07498963B2
公开(公告)日：2009-03-03
申请号：US11784047
申请日：2007-04-05
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03M1/00
CPC分类号： H03F3/2173
摘要： A method for generating at least one modulator input signal from at least one regulator signal is provided. The method comprising: generating at least one dither signal based on the periodic output of elements of a discrete dither sequence of the basic form DF=0, 1, 2 . . . 2(m−n)−1; and adding the at least one dither signal to the regulator signal. The regulator signal comprises a digital regulator signal with a length of m bits, and the modulator input signal comprises a digital modulator input signal with a length of n bits, where m>n.
摘要翻译：提供了一种用于从至少一个调节器信号产生至少一个调制器输入信号的方法。该方法包括：基于基本形式DF = 0,1,2的离散抖动序列的元素的周期性输出来产生至少一个抖动信号。。。 2（m-n）-1; 以及将所述至少一个抖动信号添加到所述调节器信号。调节器信号包括长度为m位的数字调节器信号，并且调制器输入信号包括长度为n位的数字调制器输入信号，其中m> n。

46. 发明授权

US07482145B2 Deglycosylated enzymes for conjugates 有权
标题翻译：用于缀合物的去糖基化酶
公开(公告)号：US07482145B2
公开(公告)日：2009-01-27
申请号：US11227881
申请日：2005-09-15
申请人： Wolfgang Hoesel , Werner Hoelke , Beata Kanne , Helmut Lenz , Rainer Mueller
发明人： Wolfgang Hoesel , Werner Hoelke , Beata Kanne , Helmut Lenz , Rainer Mueller
IPC分类号： C12N9/96 , C12N9/12
CPC分类号： G01N33/581 , G01N33/535
摘要： By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the sensitivity of an assay for detecting the presence or determining the quantity of a target molecule, in which the conjugate is used as a labelled component, can be increased. The present invention provides conjugates, methods for providing the same, use of such conjugates as well as kits containing the conjugates.
摘要翻译：在形成缀合物之前，即在将酶连接到能够结合靶分子的分子之前，将来自真核生物的酶脱糖基化，用于检测靶分子的存在或确定目标分子的量的测定的灵敏度，其中缀合物用作标记组分，可以增加。本发明提供缀合物，提供该缀合物的方法，使用这种缀合物以及含有缀合物的试剂盒。

47. 发明申请

US20070009976A1 Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody 审中-公开
标题翻译：无论是否存在相应的治疗性抗体，都可以检测靶抗原
公开(公告)号：US20070009976A1
公开(公告)日：2007-01-11
申请号：US11477772
申请日：2006-06-29
申请人： Helmut Lenz , Werner Scheuer , Martina Thier
发明人： Helmut Lenz , Werner Scheuer , Martina Thier
IPC分类号： G01N33/53
CPC分类号： G01N33/53
摘要： The present invention relates to the field of therapeutic antibodies. The invention especially relates to a method of detecting the target antigen of a therapeutic antibody in a sample comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with said therapeutic antibody under conditions appropriate for binding of said therapeutic antibody to said target antigen, whereby a target antigen-therapeutic antibody-complex is formed, and c) detecting the complex formed in (b).
摘要翻译：本发明涉及治疗性抗体领域。本发明特别涉及一种检测样品中治疗性抗体的靶抗原的方法，包括以下步骤：a）提供待分析的样品，b）在适于所述治疗性抗体结合的条件下，将所述样品与所述治疗性抗体孵育由此形成靶抗原治疗型抗体复合体，c）检测（b）中形成的复合物。

48. 发明申请

US20060040345A1 Deglycosylated enzymes for conjugates 有权
公开(公告)号：US20060040345A1
公开(公告)日：2006-02-23
申请号：US11227881
申请日：2005-09-15
申请人： Wolfgang Hoesel , Werner Hoelke , Beata Kanne , Helmut Lenz , Rainer Mueller
发明人： Wolfgang Hoesel , Werner Hoelke , Beata Kanne , Helmut Lenz , Rainer Mueller
IPC分类号： C12N9/16 , C12P21/06
CPC分类号： G01N33/581 , G01N33/535
摘要： By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the sensitivity of an assay for detecting the presence or determining the quantity of a target molecule, in which the conjugate is used as a labelled component, can be increased. The present invention provides conjugates, methods for providing the same, use of such conjugates as well as kits containing the conjugates.

49. 发明授权

US06448775B1 Gradient amplifier with combined current regulation and differential control 有权
标题翻译：具有组合电流调节和差分控制的梯度放大器
公开(公告)号：US06448775B1
公开(公告)日：2002-09-10
申请号：US09457794
申请日：1999-12-09
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： G01V300
CPC分类号： G01R33/3852
摘要： Gradient amplifier for an MR tomography apparatus has a controller for current control that is connected to a modulator stage upstream before an output stage. The output stage supplies a voltage to a gradient coil connected thereto, thereby producing a coil current in the gradient coil. The controller has a comparator for comparing a reference value of the coil current to the actual value of the coil current, and a P control branch connected downstream from the comparator and an I control branch situated at the output of the P control branch. The outputs of the control branches are fed to an adder via scaling resistors. An output of a differential control stage is fed to the adder. The differential control stage emits an output voltage that relieves the controller, the output voltage being proportional to the slope of a pulse edge of the gradient coil current.
摘要翻译：用于MR断层摄影装置的梯度放大器具有用于电流控制的控制器，其在输出级之前连接到调制器级上游。输出级向与其连接的梯度线圈提供电压，从而在梯度线圈中产生线圈电流。控制器具有用于比较线圈电流的参考值与线圈电流的实际值的比较器，以及连接在比较器下游的P控制分支和位于P控制分支的输出端的I控制分支。控制分支的输出通过缩放电阻馈送到加法器。差分控制级的输出馈入加法器。差分控制级发出释放控制器的输出电压，输出电压与梯度线圈电流的脉冲边沿的斜率成正比。

50. 发明授权

US06184042B2 Method for reducing hook effect in an immunoassay 失效
标题翻译：在免疫测定中减少钩效应的方法
公开(公告)号：US06184042B2
公开(公告)日：2001-02-06
申请号：US08862062
申请日：1997-05-22
申请人： Ulrich Neumann , Helmut Lenz , Norbert Franken
发明人： Ulrich Neumann , Helmut Lenz , Norbert Franken
IPC分类号： G01N33543
CPC分类号： C07K16/26 , G01N33/6857 , G01N33/76 , Y10S435/962
摘要： In order to extend the measuring range and to reduce the Hook effect in an immunological method of determination of an antigen based on the principle of a sandwich assay it is preferable to use a method which is characterized in that the labelled detection molecule is an oligomer of a binding molecule selected from antibody or/and antibody fragment.
摘要翻译：为了延长测量范围，并且基于夹心测定原理，在抗原测定的免疫学方法中降低Hook效应，优选使用其特征在于标记的检测分子是选自抗体或/和抗体片段的结合分子。

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