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41. 发明申请

US20050059018A1 Virulence-associated nucleic acids and proteins and uses thereof 审中-公开
标题翻译：与毒力相关的核酸和蛋白质及其用途
公开(公告)号：US20050059018A1
公开(公告)日：2005-03-17
申请号：US10660811
申请日：2003-09-12
申请人： Laurence Rahme , Jianxin He , Regina Baldini , Jens Solsbacher , Peter Wagner
发明人： Laurence Rahme , Jianxin He , Regina Baldini , Jens Solsbacher , Peter Wagner
IPC分类号： A61K39/00 , C07H21/04 , C07K14/21 , C07K14/785 , C12Q20060101 , C12Q1/68
CPC分类号： C07K14/21 , A61K39/00 , A61K2039/53 , C07K2319/00 , C12Q1/689 , C12Q2600/158
摘要： The present invention features methods and compositions relating to bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides. Based on the present invention, a pathogenic infection may be treated, prevented, or reduced by administering to an infected mammal or plant a therapeutically effective amount of a composition that inhibits the expression or activity of a polypeptide encoded by the virulence factors. Also disclosed are methods for producing such polypeptides by recombinant techniques as well as methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.
摘要翻译：本发明涉及与细菌毒力多肽和编码这种多肽的核酸序列（例如DNA）有关的方法和组合物。基于本发明，可以通过向感染的哺乳动物或植物施用治疗有效量的抑制由毒力因子编码的多肽的表达或活性的组合物来治疗，预防或减少致病性感染。还公开了通过重组技术产生此类多肽的方法以及利用这些多肽筛选抗细菌或抑菌化合物的方法。

42. 发明申请

US20050015398A1 Provision of information in an automation system 有权
标题翻译：在自动化系统中提供信息
公开(公告)号：US20050015398A1
公开(公告)日：2005-01-20
申请号：US10494737
申请日：2002-10-21
申请人： Michael Schlereth , Peter Wagner
发明人： Michael Schlereth , Peter Wagner
IPC分类号： G05B23/02 , G06F17/00
CPC分类号： G05B23/0264 , Y10S707/99943
摘要： The invention relates to a system and a method for providing information in an automation system, which permits scaled access to said information. The system contains storage means for storing information in the form of an information hierarchy, whereby said storage means form hierarchical tiers and to enhance the information the system comprises first storage means of lower-level hierarchical tiers for the provision of information to second storage means of higher-level hierarchical tiers. The system also contains an engineering system for generating the information from projected information of the automation system and for the automatic projection of the storage means and access means, for accessing the stored information.
摘要翻译：本发明涉及一种用于在自动化系统中提供信息的系统和方法，其允许对所述信息的缩放访问。该系统包括用于以信息层级形式存储信息的存储装置，由此所述存储装置形成分级层并且增强该信息，该系统包括用于向第二存储装置提供信息的较低级别层级的第一存储装置更高层次的层级。该系统还包括用于从自动化系统的投影信息和存储装置和访问装置的自动投影产生用于访问存储的信息的信息的工程系统。

43. 发明授权

US06780582B1 Arrays of protein-capture agents and methods of use thereof 失效
标题翻译：蛋白质捕获剂的阵列及其使用方法
公开(公告)号：US06780582B1
公开(公告)日：2004-08-24
申请号：US09574692
申请日：2000-05-17
申请人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
发明人： Peter Wagner , Steffen Nock , Dana Ault-Riche , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y5/00 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y30/00 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
摘要翻译：提供了可用于同时检测生物体中细胞或细胞群的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。特别描述了各种抗体阵列。还公开了制备和使用蛋白质捕获剂的阵列的方法。本发明阵列对于各种蛋白质组学应用特别有用，包括评估细胞中蛋白质表达和修饰的模式。

44. 发明授权

US06720157B2 Chips having elevated sample surfaces 失效
公开(公告)号：US06720157B2
公开(公告)日：2004-04-13
申请号：US09792335
申请日：2001-02-23
申请人： Pierre F. Indermuhle , Frank G. Zaugg , Peter Wagner , Steffen Nock
发明人： Pierre F. Indermuhle , Frank G. Zaugg , Peter Wagner , Steffen Nock
IPC分类号： G01N3353
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00382 , B01J2219/00497 , B01J2219/00504 , B01J2219/00509 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00725 , B01L3/0241 , B01L3/0248 , B01L3/0262 , B01L3/5085 , B01L3/5088 , B01L2300/0809 , B01L2300/0848 , B01L2400/022 , B01L2400/0688 , B33Y80/00 , B82Y30/00 , C40B40/10 , C40B60/14 , Y10T436/11 , Y10T436/114165 , Y10T436/117497 , Y10T436/118339 , Y10T436/143333 , Y10T436/156666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A chip is disclosed. The chip includes a base including a non-sample surface and at least one structure includes a pillar. Each structure includes a sample surface that is elevated with respect to the non-sample surface and each structure may be adapted to receive a sample.

45. 发明授权

US06630358B1 Arrays of proteins and methods of use thereof 失效
公开(公告)号：US06630358B1
公开(公告)日：2003-10-07
申请号：US09570363
申请日：2000-05-12
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thinfilms on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.

46. 发明授权

US06596545B1 Microdevices for screening biomolecules 失效
标题翻译：用于筛选生物分子的微型设备
公开(公告)号：US06596545B1
公开(公告)日：2003-07-22
申请号：US09353554
申请日：1999-07-14
申请人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
发明人： Peter Wagner , Dana Ault-Riche , Steffen Nock , Christian Itin
IPC分类号： G01N33543
CPC分类号： B82Y30/00 , Y10S435/805 , Y10S435/81 , Y10T436/143333
摘要： Devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules immobilized on the surface of the devices of the present invention include proteins, polypeptides, polynucleotides, polysaccharides, phospolipids, and related unnatural polymers of biological relevance. These devices are useful drug development, functional proteomics and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.
摘要翻译：提供了使用微型微加工装置并行，体外筛选生物分子活性的装置。固定在本发明装置表面上的生物分子包括具有生物相关性的蛋白质，多肽，多核苷酸，多糖，磷脂和相关的非天然聚合物。这些装置是有用的药物开发，功能蛋白质组学和临床诊断，并且优选用于相关蛋白家族的并行筛选。

47. 发明授权

US06435922B2 Electrical connector 有权
标题翻译：电连接器
公开(公告)号：US06435922B2
公开(公告)日：2002-08-20
申请号：US09865671
申请日：2001-05-29
申请人： Markus Keiser , Peter Wagner
发明人： Markus Keiser , Peter Wagner
IPC分类号： H01R13187
CPC分类号： H01R4/4881
摘要： A cylindrical coaxial electrical connector comprising a male portion and a female portion, the connector being of the type that includes an intermediate strip of contact springs of elastic material, the springs being united at their ends by two continuous side strips and each having a succession of tongues extending the side strip outwards, said intermediate strip being placed in an annular housing in one or other of the two portions, said housing having two side flanks with walls that are perpendicular to the axis of the connector, wherein each elastic tongue has a first face bent towards the bottom of the housing and then bent in the opposite direction to form an end face rising up towards the outside of the housing, the end of said face bearing against the side flank of said annular housing.
摘要翻译：一种包括阳部分和阴部分的圆柱形同轴电连接器，所述连接器是包括弹性材料的接触弹簧的中间带的类型，所述弹簧在其端部由两个连续的侧条条组合，并且每个具有一系列舌片向外延伸侧条，所述中间条被放置在两个部分中的一个或另一个中的环形壳体中，所述壳体具有两个侧面，其侧壁垂直于连接器的轴线，其中每个弹性舌片具有第一所述面朝向所述壳体的底部弯曲，然后沿相反方向弯曲以形成朝向所述壳体的外部上升的端面，所述面的端部抵靠所述环形壳体的侧面。

48. 发明授权

US5880679A Method for protecting vehicles against unauthorized use 失效
标题翻译：保护车辆免受未经授权使用的方法
公开(公告)号：US5880679A
公开(公告)日：1999-03-09
申请号：US614929
申请日：1996-03-11
申请人： Siegleif Lenart , Thomas Rick , Peter Wagner , Gerrit Huy , Ralf Piske
发明人： Siegleif Lenart , Thomas Rick , Peter Wagner , Gerrit Huy , Ralf Piske
IPC分类号： B60R25/04 , G06F7/04 , B60T7/16 , B60T31/16
CPC分类号： B60R25/102 , B60R25/04 , B60R25/33 , B60W2550/402
摘要： The invention relates to a method for protecting against unauthorized use of a vehicle which has bidirectional communication with a master station, whereby it is possible not only to transmit exclusively a position message of the vehicle to the master station or to transmit exclusively enabling signals to the vehicle from the master station, but also to make the communication appropriate to requirements. The necessary transmission of information is substantially reduced in that the enabling signal is broadcast only when requested by the vehicle. On the other hand, it is still not possible for the enabling to be carried out at the vehicle end only.
摘要翻译：本发明涉及一种用于防止未经授权使用与主站双向通信的车辆的方法，由此可能不仅仅将车辆的位置消息专门发送到主站，或者将专用的信号发送到主站车辆从主站，还要使通信适合要求。基本上减少了必要的信息传输，因为使能信号仅在车辆请求时被广播。另一方面，仍然不可能仅在车辆端执行。

49. 发明授权

US4837624A Recognition and compensation of errors in a digital video signal 失效
标题翻译：识别和补偿数字视频信号中的错误
公开(公告)号：US4837624A
公开(公告)日：1989-06-06
申请号：US45693
申请日：1987-04-30
申请人： Jurgen Heitmann , Peter Wagner
发明人： Jurgen Heitmann , Peter Wagner
IPC分类号： H04N7/26 , H04N5/21
CPC分类号： H04N5/21
摘要： Digital video signals are subjected to band limiting by a high pass filter with a pass band terminating somewhat above half of the digital sampling frequency. The filtered signal is in effect subtracted from the original signal in an addition circuit with suitably phased inputs in order to make available a substitute signal of the interpolation low pass filtered kind. A circuit for determining the presence of an erroneous digital word accepts the high pass filtered signal, differentiates it twice and then digitally rectifies it in order to detect a possible maximum at half the sampling rate. When such a maximum is found, a changeover switch is caused to substitute the interpolation-low-pass-filtered signal for the orginal signal. Only a single digital filter is necessary for this operation. The high pass filter is a FIR filter of, for example, eleventh order and the middle coefficient is in effect changed from minus 1 to 0 when the delay equalized original signal is added to the output of the high pass filter.
摘要翻译：数字视频信号通过高通滤波器进行频带限制，该通带滤波器的终端略高于数字采样频率的一半。滤波后的信号实际上在具有合适的相位输入的加法电路中从原始信号中减去，以便提供内插低通滤波种的替代信号。用于确定错误数字字的存在的电路接受高通滤波的信号，将其区分两次，然后对其进行数字整流，以便以一半采样速率检测可能的最大值。当发现这样的最大值时，使用切换开关代替原始信号的内插低通滤波信号。此操作只需要一个数字滤波器。高通滤波器是例如第11级的FIR滤波器，当将延迟均衡的原始信号添加到高通滤波器的输出时，中间系数实际上从负1变为0。

50. 发明授权

US08794944B2 Screw spindle machine and method of manufacturing the same 有权
标题翻译：螺杆主轴机及其制造方法
公开(公告)号：US08794944B2
公开(公告)日：2014-08-05
申请号：US13394654
申请日：2010-09-28
申请人： Peter Wagner
发明人： Peter Wagner
IPC分类号： F01C21/00 , F03C2/00 , F03C4/00
CPC分类号： F04C2/16 , F04C2/086 , F04C2230/21 , F04C2240/30 , F04C2240/802
摘要： A screw spindle machine having a tubular casing (10) that is made of cast metal and is lined with a wear resistant layer (16), with the wear resistant layer (16) being encapsulated in a steel shell (20) that matches the outer peripheral shape of the layer (16).
摘要翻译：一种螺杆机床，其具有由铸造金属制成的管状壳体（10），并且内衬有耐磨层（16），其中耐磨层（16）被封装在与外壳相匹配的钢壳（20）中层（16）的周边形状。

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