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41. 发明授权

US09895700B2 Systems and methods for controlling plasma flow rates for therapeutic exchange procedures 有权
公开(公告)号：US09895700B2
公开(公告)日：2018-02-20
申请号：US14524513
申请日：2014-10-27
申请人： Fenwal, Inc.
发明人： Lan T. Nguyen , Jonathan Prendergast , John T. Foley
IPC分类号： B04B11/04 , B04B13/00 , A61M1/36 , B04B5/04
CPC分类号： B04B11/04 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2205/331 , B04B5/0442 , B04B13/00 , B04B2013/006
摘要： Systems and methods are provided for improving the flow rate of plasma being removed from a blood separation chamber during a blood separation procedure. The system includes a blood separation chamber in which plasma is separated from cellular blood components and an outlet line for removing the separated plasma from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the separated plasma in the outlet line, with each optical sensor assembly checking for the presence of cellular components in the separated plasma. If the primary optical sensor assembly detects such a condition while the secondary optical sensor assembly does not, then a controller may take steps to resolve the conflict and continue the procedure.

42. 发明授权

US09671349B2 Method and apparatus to verify correct replacement fluid in a therapeutic exchange procedure 有权
公开(公告)号：US09671349B2
公开(公告)日：2017-06-06
申请号：US14068241
申请日：2013-10-31
申请人： FENWAL, INC.
发明人： Matthew Schoonover , Lan T. Nguyen , David Stude , Elizabeth Nelson
IPC分类号： G01N21/00 , G01N21/84 , G01N33/487 , G01N33/49 , A61M1/34
CPC分类号： G01N21/84 , A61M1/342 , A61M1/3437 , A61M1/3455 , A61M1/3496 , A61M2205/18 , A61M2205/27 , A61M2205/3306 , A61M2205/60 , A61M2205/6009 , G01N33/487 , G01N33/49
摘要： A method and apparatus are provided for automatically detecting the type of replacement fluid loaded by the operator during a therapeutic exchange procedure and to provide a warning alarm if an incorrect fluid is used. After the operator connects the container of replacement fluid to the replacement fluid line of a single-use kit and enters into the controller an identification of the exchange procedure to be performed, the replacement fluid is flowed through a segment of the kit in proximity to a sensor associated with the hardware component that detects the type of fluid flowing through the segment. The controller verifies whether the replacement fluid detected in the segment corresponds to that appropriate for the selected exchange procedure, and notifies the operator in the event that an incorrect replacement fluid has been loaded.

43. 发明授权

US09393359B2 Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution 有权
$Systems and methods for achieving target post-procedure fraction of cells remaining, hematocrit, and blood volume during a therapeutic red blood cell exchange procedure with optional isovolemic hemodilution$
标题翻译：用于在治疗性红细胞交换程序期间实现目标细胞残留的系统和方法，血细胞比容和血容量与任选的异构体血液稀释
公开(公告)号：US09393359B2
公开(公告)日：2016-07-19
申请号：US13840113
申请日：2013-03-15
申请人： Fenwal, Inc.
发明人： Daniel R. Boggs , Kyungyoon Min , Lan T. Nguyen , John T. Foley , Brian Case
IPC分类号： A61M1/36 , A61M1/38 , A61M1/34
CPC分类号： A61M1/3455 , A61M1/342 , A61M1/3437 , A61M1/3458 , A61M1/3496 , A61M1/3672 , A61M1/38 , A61M1/385 , A61M2205/3334 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/207 , G06F19/00
摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.
摘要翻译：公开了用于进行治疗性红细胞交换程序的系统和方法。一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。分离器与第一流路连通，用于从血浆中分离至少红细胞。第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。流量控制器与流动路径相关联，以控制流动路径之间的流体连通。控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。

44. 发明申请

US20140008277A1 Control Of Interface Between Separated Blood Components Under Lipemic And Hemolytic Conditions 有权
标题翻译：控制血液和溶血条件下分离血液成分之间的界面
公开(公告)号：US20140008277A1
公开(公告)日：2014-01-09
申请号：US14021355
申请日：2013-09-09
申请人： Fenwal, Inc.
发明人： John. T. Foley , Lan T. Nguyen , Jonathan Prendergast , Jeffrey Maher , Christopher Mikkelson
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3693 , A61M2202/0415 , A61M2205/331 , B04B2013/006
摘要： Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a blood separation chamber configured to separate blood into first and second blood components and an outlet line for removing at least a portion of the first blood component from the blood separation chamber. A primary optical sensor assembly is associated with the blood separation chamber to directly monitor the interior of the blood separation chamber. A secondary optical sensor assembly is associated with the outlet line to monitor the first blood component in the outlet line. The system also includes a controller programmed to select between the primary optical sensor assembly and the secondary optical sensor assembly for monitoring contamination of the first blood component. The system is particularly advantageous for preventing contamination of separated plasma which is lipemic or hemolytic.
摘要翻译：提供血液分离系统和方法用于控制分离的血液成分之间的界面。该系统包括：血液分离室，被配置为将血液分离成第一和第二血液成分;以及出血管线，用于从血液分离室除去至少一部分第一血液成分。主要的光学传感器组件与血液分离室相关联，以直接监测血液分离室的内部。第二光学传感器组件与出口管线相关联，以监测出口管线中的第一血液成分。该系统还包括编程为在主光学传感器组件和次级光学传感器组件之间进行选择的控制器，用于监测第一血液成分的污染。该系统特别有利于防止污染血浆或溶血性血浆的污染。

45. 发明授权

US11678825B2 Methods and systems for collecting samples in a photopheresis procedure 有权
公开(公告)号：US11678825B2
公开(公告)日：2023-06-20
申请号：US16590903
申请日：2019-10-02
申请人： Fenwal, Inc.
发明人： Tanima Jahan Abedin , Nicole F. Young , Lan T. Nguyen , Zahra R. Ali
IPC分类号： A61B5/00 , A61B5/15 , A61M1/36
CPC分类号： A61B5/150992 , A61M1/3683
摘要： Methods and systems for sampling blood components in a photopheresis procedure are disclosed. The methods include collecting samples at selected times during a photopheresis procedure.

46. 发明授权

US11666926B2 Collection of mononuclear cells upon mid-procedure termination 有权
公开(公告)号：US11666926B2
公开(公告)日：2023-06-06
申请号：US17143267
申请日：2021-01-07
申请人： Fenwal, Inc.
发明人： Lan T. Nguyen , Zahra R. Ali , Angela N. Carlson , Korri Hershenhouse , Molly Erickson
IPC分类号： B04B5/04 , A61M1/36 , A61M1/30 , A61M1/02
CPC分类号： B04B5/0442 , A61M1/02 , A61M1/304 , A61M1/3672 , A61M1/3683 , A61M1/3693 , A61M1/3696 , A61M1/30 , A61M1/36
摘要： Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination.

47. 发明授权

US11590270B2 Systems and methods for monitoring and controlling fluid balance during a biological fluid procedure 有权
公开(公告)号：US11590270B2
公开(公告)日：2023-02-28
申请号：US17162217
申请日：2021-01-29
申请人： Fenwal, Inc.
发明人： Zahra R. Ali , Lan T. Nguyen
IPC分类号： A61M1/36 , A61M1/38 , A61M1/02
摘要： An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

48. 发明申请

US20220305187A1 System And Method For Plasma Purification Prior To Mononuclear Cell Collection 有权
公开(公告)号：US20220305187A1
公开(公告)日：2022-09-29
申请号：US17838410
申请日：2022-06-13
申请人： Fenwal, Inc.
发明人： Katherine N. Radwanski , Lan T. Nguyen , Jonathan W. Prendergast
IPC分类号： A61M1/36 , A61M1/34 , A61M1/26 , A61M1/02
摘要： A method of collecting mononuclear cells includes separating whole blood into plasma and cellular components, purifying the plasma through a plasma adsorption column to create purified plasma, combining the cellular components with the purified plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. Alternatively, whole blood may be flowed through an adsorption column to create purified whole blood, with the purified whole blood then being separated into mononuclear cells and at least one component.

49. 发明授权

US11383015B2 System and method for plasma purification prior to mononuclear cell collection 有权
公开(公告)号：US11383015B2
公开(公告)日：2022-07-12
申请号：US15390549
申请日：2016-12-26
申请人： Fenwal, Inc.
发明人： Katherine N. Radwanski , Lan T. Nguyen , Jonathan W. Prendergast
IPC分类号： A61M1/36 , A61M1/02 , A61M1/34 , A61M1/26 , B04B3/00
摘要： A method of collecting mononuclear cells includes separating plasma from cellular components of whole blood. The cellular components, which include mononuclear cells and red blood cells, are combined with plasma replacement fluid to form a first mixture. The mononuclear cells of the first mixture are separated from the red blood cells of the first mixture, which may be followed by extracorporeal photopheresis being performed on the mononuclear cells.

50. 发明申请

US20210146031A1 SYSTEMS AND METHODS FOR MONITORING AND CONTROLLING FLUID BALANCE DURING A BIOLOGICAL FLUID PROCEDURE 有权
公开(公告)号：US20210146031A1
公开(公告)日：2021-05-20
申请号：US17162217
申请日：2021-01-29
申请人： Fenwal, Inc.
发明人： Zahra R. Ali , Lan T. Nguyen
IPC分类号： A61M1/36 , A61M1/38 , A61M1/02
摘要： An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

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