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41. 发明申请

US20190201195A1 SURGICAL METHODS OF REPLACING PROSTHETIC HEART VALVES 审中-公开
公开(公告)号：US20190201195A1
公开(公告)日：2019-07-04
申请号：US16298616
申请日：2019-03-11
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
IPC分类号： A61F2/24 , A61L27/36 , A61F2/90
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

42. 发明申请

US20190183640A1 RETAINING MECHANISMS FOR PROSTHETIC VALVES 审中-公开
公开(公告)号：US20190183640A1
公开(公告)日：2019-06-20
申请号：US16283637
申请日：2019-02-22
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe , Francesco Maisano , Oded Meiri
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0467 , A61B2017/32004 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2445 , A61F2220/0016 , A61F2230/0054 , A61F2250/006 , A61F2310/00023 , A61M25/10 , A61M25/104 , A61M2025/0004
摘要： Prosthetic valve systems for treating a native valve exhibiting regurgitation comprising a support structure in which a separate prosthetic heart valve (THV) can be placed. The support structure can be configured to be positioned at the native valve. After the support structure is deployed at the native valve, a prosthetic valve can be deployed within the support structure. The support structure can comprise a main body formed by formed by a plurality of inner strut members and a plurality of outer strut members, wherein the plurality of inner strut members and the plurality of outer members are coupled together and have gaps located between inner strut members and the outer strut members. Other embodiments are also disclosed.

43. 发明申请

US20190183354A1 MONITORING BLOOD PRESSURE IN THE INFERIOR VENA CAVA 审中-公开
公开(公告)号：US20190183354A1
公开(公告)日：2019-06-20
申请号：US16215872
申请日：2018-12-11
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe
IPC分类号： A61B5/0215 , A61B5/07 , A61B5/00
CPC分类号： A61B5/0215 , A61B5/076 , A61B5/486 , A61B5/6862 , A61B5/6882 , A61B5/7275 , A61B5/741 , A61B5/746 , A61B2562/0247 , A61B2562/162
摘要： Disclosed herein are devices, systems, and methods for monitoring blood pressure in the inferior vena cava (IVC) to diagnose acute decompensated heart failure (ADHF). An underlying principle of the disclosed systems and methods is that it is possible to reduce or prevent hospitalization by monitoring blood pressure in the IVC because an increase in IVC pressure is correlated with worsening renal function, causing fluid overload. Accordingly, the disclosed systems and methods monitor renal function by monitoring IVC pressure to detect early signs of ADHF by identifying increases in pressure over time. To monitor pressure in the IVC, a pressure sensor can be implanted in the IVC and can wirelessly transmit sensor data to a monitor device worn by the subject. If a pressure trend exceeds a specified threshold, the monitor device can generate an alert.

44. 发明申请

US20190159686A1 ATRIAL STRETCH MEASUREMENT FOR ATRIAL FIBRILLATION PREVENTION 审中-公开
公开(公告)号：US20190159686A1
公开(公告)日：2019-05-30
申请号：US16179669
申请日：2018-11-02
申请人： Edwards Lifesciences Corporation
发明人： Gregory Bak-Boychuk , Stanton J. Rowe
IPC分类号： A61B5/02 , A61B5/11 , A61B5/00 , A61B5/07 , A61B5/021 , A61B5/06
摘要： A stretch-measurement probe includes an elongate outer sleeve, expansion feature associated with a distal portion of the outer sleeve, and an elongate inner rod disposed at least partially within the outer sleeve. The expansion feature is configured to allow a longitudinal distance between a proximal end of the outer sleeve and the distal end of the outer sleeve to be varied.

45. 发明申请

US20190091017A1 REPLACEMENT PROSTHETIC HEART VALVES 审中-公开
公开(公告)号：US20190091017A1
公开(公告)日：2019-03-28
申请号：US16197280
申请日：2018-11-20
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe , Larry L. Wood , Henry Bourang , George Bakis , Benjamin Spenser , Netanel Benichou , Assaf Bash , Yaron Keidar
IPC分类号： A61F2/24 , A61F2/90 , A61L27/36
摘要： A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state. The system is particularly suited for rapid deployment of heart valves in a conventional open-heart surgical environment.

46. 发明授权

US10195026B2 Mitral valve anchoring 有权
公开(公告)号：US10195026B2
公开(公告)日：2019-02-05
申请号：US14802922
申请日：2015-07-17
申请人： Edwards Lifesciences Corporation
发明人： Emil Karapetian , Austin Bly , Stanton J. Rowe
IPC分类号： A61F2/24
摘要： Disclosed herein are prosthetic devices and related methods for implantation at the native mitral valve of the heart by drawing an atrial portion and a ventricular portion toward each other from opposite sides of the native mitral valve, clamping the native mitral valve therebetween. One or more retention members passing through the mitral valve orifice or through a puncture in the native valve anatomy can couple the atrial and ventricular members together and keep them anchored onto the native mitral valve anatomy. The atrial portion can seat against the atrial side of the mitral annulus while the ventricular portion can include hooks and/or a sub-annular ring that engage and capture the native mitral valve apparatus to provide anchorage. The described technology can avoid the need to use sutures to anchor a prosthetic device at the mitral valve region.

47. 发明授权

US09775591B2 Sealing devices and related delivery apparatuses 有权
公开(公告)号：US09775591B2
公开(公告)日：2017-10-03
申请号：US14549444
申请日：2014-11-20
申请人： Edwards Lifesciences Corporation
发明人： Sergio Delgado , Ralph Schneider , Stanton J. Rowe , Ming H. Wu , Mohammad Jafari , Jon Boomgarden
IPC分类号： A61B17/00 , A61B17/03 , A61B17/34 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/3209
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/0644 , A61B17/068 , A61B17/3209 , A61B17/3423 , A61B17/3431 , A61B17/3462 , A61B17/3468 , A61B17/3478 , A61B2017/00247 , A61B2017/00252 , A61B2017/00477 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00668 , A61B2017/00867 , A61B2017/00986 , A61B2017/0414 , A61B2017/0427 , A61B2017/0464 , A61B2017/0641 , A61B2017/0645 , A61B2017/3425 , A61B2017/3458 , A61B2017/346 , A61B2017/3464
摘要： Embodiments of the present disclosure are directed to implantable sealing devices, delivery apparatuses, and methods of their use, for closing surgical openings or defects in a sidewall of a vessel in a subject. In several embodiments, the disclosed implantable sealing devices, delivery apparatuses, and methods can be used to close a surgical opening in a sidewall of the heart.

48. 发明授权

US09474605B2 Devices and methods for reducing cardiac valve regurgitation 有权
标题翻译：减少心脏瓣膜反流的装置和方法
公开(公告)号：US09474605B2
公开(公告)日：2016-10-25
申请号：US13895572
申请日：2013-05-16
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe , Robert Schwartz , Robert Van Tassel , Vivian Khalil , Erin Spinner , Neil Zimmerman , Alexander J. Siegel
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2424 , A61F2/2433 , A61F2/2454 , A61F2/246 , A61F2/2463 , A61F2/2466 , A61F2210/0014 , A61F2210/0061 , A61F2230/0023 , A61F2250/0003 , A61F2250/001
摘要： The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve—i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.
摘要翻译：本发明涉及用于改善有缺陷心脏瓣膜的功能的装置和方法，特别是涉及通过房室心脏瓣膜（即二尖瓣和三尖瓣瓣）来减少反流。对于三尖瓣修复，该装置包括部署在右心室的组织中的锚定件，在通向右心房的孔中，或锚定到三尖瓣。柔性锚杆连接到锚固件上，导管上的接合元件越过锚杆。导管附接到接合元件的近端，并且锁定机构固定接合元件相对于锚固轨道的位置。最后，有一个近端锚固特征，将接合导管的近端固定在毗邻锁骨下静脉的位置。接合元件包括惰性覆盖物，并通过与瓣膜传递接触来帮助减少反流。

49. 发明申请

US20140324160A1 LOW-PROFILE HEART VALVE AND DELIVERY SYSTEM 有权
标题翻译：低型心脏瓣膜和输送系统
公开(公告)号：US20140324160A1
公开(公告)日：2014-10-30
申请号：US14326062
申请日：2014-07-08
申请人： Edwards Lifesciences Corporation
发明人： Netanel Benichou , Stanton J. Rowe , Sean Chow
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2220/0075 , A61F2250/0059
摘要： Disclosed replacement heart valves can be designed to be delivered to a native valve site while crimped on a delivery catheter. The crimped profile of the replacement valve can be minimized by, for example, separating a frame or stent structure from a leaflet structure, along the axial direction. Disclosed replacement valves can be transitioned from a delivery configuration, in which the crimped profile can be minimized, to an operating configuration. The replacement valve can be fully assembled in both the delivery and operating configurations. In some embodiments, the leaflets can be positioned outside of the stent in the delivery configuration, and positioned inside of the stent lumen in the operating configuration. Disclosed replacement valves can include a flexible sleeve coupling the leaflets to the stent and facilitating the transition to the operating configuration. Methods of implanting said replacement valves are also disclosed.
摘要翻译：公开的置换心脏瓣膜可被设计成在被输送到输送导管上时被递送到天然瓣膜部位。通过例如将框架或支架结构与小叶结构沿着轴向分离，可以使替换阀的卷曲轮廓最小化。公开的更换阀可以从压接轮廓可以最小化的输送配置转换到操作配置。替换阀可以在输送和操作配置中完全组装。在一些实施例中，小叶可以在输送构型中定位在支架的外部，并且在操作构型中定位在支架内腔的内部。公开的替换阀可以包括将传单联接到支架的柔性套管，并且有助于过渡到操作构型。还公开了植入所述替换阀的方法。

50. 发明授权

US08597348B2 Retaining mechanisms for prosthetic valves 有权
标题翻译：人工瓣膜固定机构
公开(公告)号：US08597348B2
公开(公告)日：2013-12-03
申请号：US13687960
申请日：2012-11-28
申请人： Edwards Lifesciences Corporation
发明人： Stanton J. Rowe , Francesco Maisano , Oded Meiri
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61B17/0467 , A61B2017/32004 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2445 , A61F2220/0016 , A61F2230/0054 , A61F2250/006 , A61F2310/00023 , A61M25/10 , A61M25/104 , A61M2025/0004
摘要： A method of treating a deficient mitral valve without open heart surgery is disclosed. A support band is advanced from a delivery catheter and positioned around native leaflets of the deficient mitral valve. The support band is preferably formed of a shape memory material and is configured to assume a curved shape upon advancement from the delivery catheter. While the support band is positioned around the native leaflets of the mitral valve, an expandable prosthetic heart valve is delivered through an apex of the left ventricle and into the mitral valve. The expandable prosthetic heart valve is then expanded within the mitral valve, thereby causing one or more of the native leaflets of the mitral valve to be frictionally secured between the support band and the prosthetic heart valve.
摘要翻译：公开了一种治疗缺乏二尖瓣无心脏外科手术的方法。支撑带从输送导管前进，并位于缺乏二尖瓣的天然传单周围。支撑带优选地由形状记忆材料形成，并且构造成在从输送导管推进时呈现弯曲形状。当支撑带位于二尖瓣的天然小叶周围时，可扩张的假体心脏瓣膜通过左心室的顶点递送并进入二尖瓣。然后可扩张假体心脏瓣膜在二尖瓣内扩张，从而使二尖瓣的一个或多个天然小叶摩擦地固定在支撑带和假心脏瓣膜之间。

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