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41. 发明授权

US09993311B2 Visualizing surgical trajectories 有权
公开(公告)号：US09993311B2
公开(公告)日：2018-06-12
申请号：US13383671
申请日：2010-07-13
申请人： Johannes Cornelis Koudijs , Martin Bergtholdt , Heinrich Schulz , Hubert Cecile Francois Martens , Gerrit-jan Bloem , Johan Gerard Kleibeuker
发明人： Johannes Cornelis Koudijs , Martin Bergtholdt , Heinrich Schulz , Hubert Cecile Francois Martens , Gerrit-jan Bloem , Johan Gerard Kleibeuker
IPC分类号： A61B34/10 , A61B90/10 , A61B34/20
CPC分类号： A61B90/10 , A61B34/10 , A61B34/20 , A61B2034/107
摘要： A method and system are provided for visualizing a surgical path for a surgical tool. The method comprises a step of receiving anatomical information about a position of at least one anatomical structure in a region to undergo surgery, geometric information describing the surgical path and at least one safety margin defining a minimal distance between the surgical tool and the anatomical structure. The method further comprises defining a critical segment of the surgical path, in which critical segment a distance to the anatomical structure is smaller than the safety margin. Then a graphical representation of the surgical path is provided, wherein the critical segment is highlighted.

42. 发明授权

US09585594B2 Method of producing personalized RF coil array for MR imaging guided interventions 有权
标题翻译：制作用于MR成像指导干预的个性化RF线圈阵列的方法
公开(公告)号：US09585594B2
公开(公告)日：2017-03-07
申请号：US14117556
申请日：2012-05-09
申请人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
发明人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
IPC分类号： A61B5/05 , G01R33/34 , H01F41/04 , A61B5/055 , H01F3/02 , B29C67/00 , G06F17/50
CPC分类号： A61B5/055 , A61B34/20 , A61B2034/2065 , A61B2090/374 , B29C64/386 , B29C67/0088 , G01R33/34007 , G01R33/34084 , G06F17/50 , H01F3/02 , H01F41/04 , Y10T29/49018 , Y10T29/49069 , Y10T29/49073 , Y10T29/49075 , Y10T29/532
摘要： A method of manufacturing a personalized radio frequency (RF) coil array for magnetic resonance (MR) imaging guided interventions includes: acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body; planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body portion is determined; and arranging one or more RF coils on a substrate which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF coils from the field of the intervention is optimized.
摘要翻译：制造用于磁共振（MR）成像引导干预的个性化射频（RF）线圈阵列的方法包括：获取反映患者身体的一部分的解剖结构的诊断图像数据; 基于诊断图像数据规划干预，其中确定患者身体部位内的介入场; 以及将一个或多个RF线圈布置在适于患者解剖结构的衬底上，使得经由来自干预领域的一个或多个RF线圈的MR信号采集的信噪比得以优化。

43. 发明申请

US20150000112A1 PERSONALIZED RF COIL ARRAY FOR MR IMAGING GUIDED INTERVENTIONS 有权
标题翻译：用于MR成像引导干预的个性化RF线圈阵列
公开(公告)号：US20150000112A1
公开(公告)日：2015-01-01
申请号：US14117556
申请日：2012-05-09
申请人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
发明人： Hubert Cecile Francois Martens , Elizabeth Anne Moore , Celilia Possanzini , Marco Hubertus Johannes Nijenhuis , Michel Gerardus Pardoel , Clemens Bos , Aaldert Jan Elevelt , Daniel Wirtz
IPC分类号： A61B5/055 , B29C67/00 , G06F17/50 , A61B19/00 , G01R33/34
CPC分类号： A61B5/055 , A61B34/20 , A61B2034/2065 , A61B2090/374 , B29C64/386 , B29C67/0088 , G01R33/34007 , G01R33/34084 , G06F17/50 , H01F3/02 , H01F41/04 , Y10T29/49018 , Y10T29/49069 , Y10T29/49073 , Y10T29/49075 , Y10T29/532
摘要： The invention relates to a method of manufacturing a personalized RF coil array for MR imaging guided interventions. The method comprises the steps of: —acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body (10); —planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body (10) portion is determined; —arranging one or more RF antennae (11, 12, 13) on a substrate (19), which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF antennae (11, 12, 13) from the field of the intervention is optimized. Moreover, the invention relates to a computer program and to a computer workstation.
摘要翻译：本发明涉及制造用于MR成像引导干预的个性化RF线圈阵列的方法。该方法包括以下步骤： - 获取反映患者身体（10）的一部分的解剖结构的诊断图像数据; - 根据所述诊断图像数据计划干预，其中确定所述患者体内（10）部分内的介入场; - 将一个或多个RF天线（11,12,13）布置在适于患者解剖结构的衬底（19）上，使得经由所述一个或多个的MR信号获取的信噪比优化了来自干预领域的射频天线（11,12,13）。此外，本发明涉及计算机程序和计算机工作站。

44. 发明授权

US08694105B2 Neurostimulation system having a controller for controlling the supply of electrical pulses 有权
标题翻译：神经刺激系统具有用于控制电脉冲供应的控制器
公开(公告)号：US08694105B2
公开(公告)日：2014-04-08
申请号：US12667399
申请日：2008-07-03
申请人： Hubert Cecile Francois Martens , Michel Marcel Jose Decre , Eugenio Cantatore
发明人： Hubert Cecile Francois Martens , Michel Marcel Jose Decre , Eugenio Cantatore
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： The invention relates to a neurostimulation system, particularly for deep brain stimulation (DBS), comprising a spatial array (130) of stimulation electrodes (132) and an associated controller (110). The controller (110) is adapted to sequentially supply electrical pulses to different subsets of the stimulation electrodes (132). Preferably, the controller (110) comprises a single pulse-generator (112) and a multiplexing unit (111) for distributing the pulses to different stimulation electrodes. The stimulation electrodes (132) may preferably be arranged on probes (131).
摘要翻译：本发明涉及神经刺激系统，特别是对于深脑刺激（DBS），其包括刺激电极（132）的空间阵列（130）和相关联的控制器（110）。控制器（110）适于顺序地向刺激电极（132）的不同子集提供电脉冲。优选地，控制器（110）包括用于将脉冲分配到不同刺激电极的单个脉冲发生器（112）和多路复用单元（111）。刺激电极（132）可以优选地布置在探针（131）上。

45. 发明授权

US08498709B2 Planning system for neurostimulation therapy 有权
标题翻译：神经刺激治疗计划系统
公开(公告)号：US08498709B2
公开(公告)日：2013-07-30
申请号：US13285136
申请日：2011-10-31
申请人： Hubert Cecile Francois Martens
发明人： Hubert Cecile Francois Martens
IPC分类号： A61N1/18
CPC分类号： A61N1/37247 , A61N1/00
摘要： A system for planning implantation of a neurostimulation probe is provided. The system comprises an input for receiving anatomical data comprising information regarding a position and an orientation of at least one fiber bundle in a target region, an input for receiving therapeutic information comprising information regarding a stimulation preferability of the at least one fiber bundle, an optimization module for based on the position, the orientation and the stimulation preferability of the at least one fiber bundle calculating at least one optimal position and at least one optimal orientation for implantation of the neurostimulation probe at which optimal position and orientation the probe is capable of generating an electric field gradient substantially parallel to at least one fiber bundle with a high stimulation preferability and/or substantially perpendicular to at least one fiber bundle with a low stimulation preferability and an output for providing the optimal position and orientation.
摘要翻译：提供了一种用于规划神经刺激探针植入的系统。该系统包括用于接收包括关于目标区域中的至少一个纤维束的位置和取向的信息的解剖数据的输入，用于接收包括关于至少一个纤维束的刺激优选性的信息的治疗信息的输入，优化模块，用于基于所述至少一个纤维束的位置，方向和刺激优选性计算至少一个最佳位置和至少一个用于植入神经刺激探针的最佳取向，其中探针能够产生最佳位置和取向基本平行于具有高刺激优选性和/或基本垂直于具有低刺激优选性的至少一个纤维束的至少一个纤维束的电场梯度和用于提供最佳位置和取向的输出。

46. 发明申请

US20120120091A1 VISUALIZING SURGICAL TRAJECTORIES 有权
标题翻译：可视化外科手术
公开(公告)号：US20120120091A1
公开(公告)日：2012-05-17
申请号：US13383671
申请日：2010-07-13
申请人： Johannes Cornelis Koudijs , Martin Bergtholdt , Heinrich Schulz , Hubert Cecile Francois Martens , Gerrit-jan Bloem , Johan Gerard Kleibeuker
发明人： Johannes Cornelis Koudijs , Martin Bergtholdt , Heinrich Schulz , Hubert Cecile Francois Martens , Gerrit-jan Bloem , Johan Gerard Kleibeuker
IPC分类号： G09G5/02
CPC分类号： A61B90/10 , A61B34/10 , A61B34/20 , A61B2034/107
摘要： A method and system are provided for visualizing a surgical path (31, 41, 51) for a surgical tool. The method comprises a step of receiving (21) anatomical information (14) about a position of at least one anatomical structure (32, 33, 34, 35) in a region to undergo surgery, geometric information (15) describing the surgical path (31, 41, 51) and at least one safety margin defining a minimal distance between the surgical tool and the anatomical structure (32, 33, 34, 35). The method further comprises defining (23) a critical segment (43, 44, 45) of the surgical path (31, 41, 51), in which critical segment (43, 44, 45) a distance to the anatomical structure (32, 33, 34, 35) is smaller than the safety margin. Then a graphical representation (30, 40, 50) of the surgical path (31, 41, 51) is provided (24), wherein the critical segment (43, 44, 45) is highlighted.
摘要翻译：提供了一种用于可视化外科手术工具的手术路径（31,41,51）的方法和系统。该方法包括以下步骤：接收（21）解剖信息（14），该解剖信息关于在进行手术的区域中的至少一个解剖结构（32,33,34,35）的位置，描述手术路径的几何信息（15） 31,31,51）以及限定所述外科手术工具与所述解剖结构（32,33,34,35）之间的最小距离的至少一个安全余量。该方法还包括限定（23）外科路径（31,41,51）的临界段（43,44,45），其中临界区段（43,44,45）与解剖结构（32,44） 33,34,35）小于安全幅度。然后提供手术路径（31,41,51）的图形表示（30,40,50）（24），其中临界段（43,44,45）被突出显示。

47. 发明授权

US07903512B2 Multi-speed recording for multi-layer disc 有权
标题翻译：多层光盘多段录像
公开(公告)号：US07903512B2
公开(公告)日：2011-03-08
申请号：US11569075
申请日：2005-05-10
申请人： Ronald Joseph Antonius Van Den Oetelaar , Hubert Cecile Francois Martens , Wilhelmus Robert Koppers , Pierre Hermanus Woerlee
发明人： Ronald Joseph Antonius Van Den Oetelaar , Hubert Cecile Francois Martens , Wilhelmus Robert Koppers , Pierre Hermanus Woerlee
IPC分类号： G11B7/00
CPC分类号： G11B7/0045 , G11B7/00456 , G11B7/00736 , G11B7/24038 , G11B2007/0013
摘要： The present invention relates to a recording apparatus, record carrier and method of recording data on at least two layers of a recording medium by using a radiation power, wherein individual recording speeds are determined for respective ones of the at least two layers at different values of the radiation power. A recording speed to be used for recording on an individual one of the at least two recording layers is selected based on a maximum radiation power specified for the recording operation, and the speed of the recording operation is controlled individually for each of the at least two layers based on the selected recording speed. The determination of the individual recording speeds at different radiation power values may be written or embossed on the record carrier. Furthermore, a recording sequence used for recording on the recording layers can be set based on the sensitivities and thus recording speeds. Thereby, total recording time can be minimized for multi-layer recording media.
摘要翻译：本发明涉及一种通过使用辐射功率在至少两层记录介质上记录数据的记录装置，记录载体和方法，其中以不同的值辐射功率。基于为记录操作指定的最大辐射功率来选择用于记录在至少两个记录层中的单个记录层上的记录速度，并且对于至少两个记录层中的每一个分别控制记录操作的速度基于所选记录速度的层。在不同辐射功率值下的单个记录速度的确定可以被写入或压印在记录载体上。此外，可以基于灵敏度和因此记录速度来设置用于记录层上的记录的记录顺序。因此，对于多层记录介质，总记录时间可以最小化。

48. 发明申请

US20100191490A1 METHOD AND DEVICE FOR DETERMINING THE STATE OF CHARGE OF A BATTERY 审中-公开
标题翻译：用于确定电池充电状态的方法和装置
公开(公告)号：US20100191490A1
公开(公告)日：2010-07-29
申请号：US12667395
申请日：2008-07-03
申请人： Hubert Cecile Francois Martens , Petrus Henricus Laurentius Notten
发明人： Hubert Cecile Francois Martens , Petrus Henricus Laurentius Notten
IPC分类号： G01R31/36 , H02J7/00
CPC分类号： G01R31/3648 , G01R31/374 , G01R31/392 , H01M10/44 , Y10T307/625
摘要： For medical implants it is not only important to have a battery powering the implant with a long run-time, but to know exactly at any point in time how long the remaining run-time is. On the other hand the implant together with its battery shall be as user-friendly as possible requiring no or hardly any interaction with the device except for recharging of the battery. To better address these concerns, a method for determining the state of charge of a battery is suggested comprising the steps: charging the battery, discharging of the battery, predicting the state of charge of the battery using a recharge prediction unit, wherein the recharge prediction unit is disconnected from the battery during the discharging of the battery. The prediction of the state of charge of the battery during the discharge of the battery, i.e. during powering of a device connected to the battery, without carrying out any measurements during the discharging of the battery, enables a local separation of the battery or the implant powered by the battery and the recharge prediction unit during the discharge cycle of the battery.
摘要翻译：对于医疗植入物，不仅重要的是在长时间运行时为电池供电植入电池，而是在任何时间准确地知道剩余运行时间多长时间。另一方面，植入物与其电池一起应尽可能方便，除了电池的再充电之外，不需要或几乎不与该装置进行任何相互作用。为了更好地解决这些问题，提出了一种用于确定电池的充电状态的方法，包括以下步骤：对电池充电，对电池放电，使用再充电预测单元预测电池的充电状态，其中再充电预测在电池放电期间，设备与电池断开连接。在电池放电期间，即在连接到电池的装置的供电期间，在电池放电期间不进行任何测量的情况下，电池的充电状态的预测使得电池或植入物的局部分离在电池的放电循环期间由电池和充电预测单元供电。

49. 发明申请

US20100100152A1 ELECTRODE SYSTEM FOR DEEP BRAIN STIMULATION 审中-公开
标题翻译：用于深层脑刺激的电极系统
公开(公告)号：US20100100152A1
公开(公告)日：2010-04-22
申请号：US12528848
申请日：2008-02-25
申请人： Hubert Cecile Francois Martens , Michel Marcel Jose Decre , Eugenio Cantatore
发明人： Hubert Cecile Francois Martens , Michel Marcel Jose Decre , Eugenio Cantatore
IPC分类号： A61N1/05 , A61N1/36 , H05K13/00
CPC分类号： A61N1/0534 , A61B5/04001 , A61B5/6868 , Y10T29/49117
摘要： The invention relates to an electrode system (200) that is particularly suited for deep brain stimulation. According to a preferred embodiment, the electrode system (200) comprises an elongated probe body (202) carrying a plurality of annular stimulation electrodes (201) of radius r and axial extension h that are axially distributed at distances d. The axial extension h is preferably smaller than the diameter 2r and preferably larger than the distance d. Moreover, the electrode system (200) optionally comprises a plurality of microelectrodes (203) projecting radially away from the probe body (202), said microelectrodes (203) being suited for recording neurophysio logic potentials.
摘要翻译：本发明涉及一种特别适用于深部脑刺激的电极系统（200）。根据优选实施例，电极系统（200）包括细长的探针体（202），该探针体（202）承载在距离d处轴向分布的半径r和轴向延伸部分h的多个环形刺激电极（201）。轴向延伸部分h优选地小于直径2r，优选地大于距离d。此外，电极系统（200）可选地包括多个径向远离探针体（202）突出的微电极（203），所述微电极（203）适于记录神经生物逻辑电位。

50. 发明申请

US20100076516A1 REMAINING TIME INDICATION FOR A RECHARGEABLE IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：不可再生可植入医疗器械的时间指示
公开(公告)号：US20100076516A1
公开(公告)日：2010-03-25
申请号：US12442740
申请日：2007-09-20
申请人： Alexander Padiy , Hubert Cecile Francois Martens
发明人： Alexander Padiy , Hubert Cecile Francois Martens
IPC分类号： A61N1/08
CPC分类号： A61N1/3708 , A61M5/14276 , A61M2205/8212 , A61M2205/8237 , A61N1/37258 , A61N1/3787
摘要： An implantable medical device for delivering a therapeutic output to a patient, comprising: a rechargeable electrical power source having a useful life; a therapeutic delivery device operatively coupled to the power source and adapted to deliver the therapeutic output to the patient; a power source recharge timing indicator operatively coupled to the power source, wherein the timing indicator includes means for determining and communicating when the remaining usage time before full drainage of the power source drops below a first predetermined level based on measurement of one or more physical characteristics of the power source and of the medical device; and safe mode means operatively coupled to the timing indicator, power source and therapeutic delivery device, wherein the safe mode means, upon activation, is capable of causing one or more actions to reduce the power consumption of the medical device; wherein the safe mode means is activated by receiving communications from the timing indicator that the remaining usage time before full drainage of the power source has dropped below one or more second predetermined levels, thereby preventing excessive power drainage from the power source which would result in damage to the power source and/or medical device and/or injury to the patient. A method for preventing excessive power drainage and indicating the remaining discharge time of the power source of an implantable medical device for delivering a therapeutic output to a patient, which would result in damage to the power source and/or medical device and/or injury to the patient is also disclosed.
摘要翻译：一种用于将治疗输出递送给患者的可植入医疗装置，包括：具有使用寿命的可再充电电源; 治疗递送装置，其可操作地耦合到所述电源并且适于将所述治疗输出递送给所述患者; 电源充电定时指示器，其操作地耦合到所述电源，其中所述定时指示器包括用于基于一个或多个物理特性的测量来确定和通信电源全排水之前的剩余使用时间何时下降到低于第一预定水平的装置的电源和医疗设备; 以及可操作地耦合到定时指示器，电源和治疗递送装置的安全模式装置，其中安全模式意味着在启动时能够引起一个或多个动作来降低医疗装置的功率消耗; 其中所述安全模式装置通过从所述定时指示器接收到所述电源的全排水之前的剩余使用时间已经降到一个或多个第二预定水平以下的通信而被激活，由此防止从所述电源的过度的电力引流将导致损坏到电源和/或医疗装置和/或对患者的伤害。一种用于防止过度的电力排出并且指示用于将治疗输出递送给患者的可植入医疗装置的电源的剩余放电时间的方法，其将导致电源和/或医疗装置的损坏和/或对患者也被披露。

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