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41. 发明授权

US07541448B2 Oligonucleotides containing molecular rods 失效
标题翻译：含分子棒的寡核苷酸
公开(公告)号：US07541448B2
公开(公告)日：2009-06-02
申请号：US11001785
申请日：2004-12-02
申请人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
发明人： Dieter Heindl , Astrid Reiser , Karim Tabiti , Martina Junius , Alexander Hauber
IPC分类号： C07H21/02 , C07H21/04 , C07H19/04 , G01N33/53 , C12Q1/68
CPC分类号： C07H21/00 , Y10S436/808
摘要： The invention is directed to an oligonucleotide comprising a molecular rod, wherein preferentially the molecular rod covalently connects the 3′ end of a first nucleotide residue with the 5′ end of a second nucleotide residue. Such oligonucleotides are highly advantageous for real time PCR melting curve analysis.
摘要翻译：本发明涉及包含分子棒的寡核苷酸，其中优先分子棒共价连接第一个核苷酸残基的3'末端与第二个核苷酸残基的5'末端。这样的寡核苷酸对于实时PCR融合曲线分析是非常有利的。

42. 发明申请

US20080213809A1 STABLE NAD/NADH DERIVATIVES 有权
标题翻译：稳定的NAD / NADH衍生物
公开(公告)号：US20080213809A1
公开(公告)日：2008-09-04
申请号：US12020244
申请日：2008-01-25
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Claudia Gaessler-Dietsche
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Claudia Gaessler-Dietsche
IPC分类号： C12Q1/54 , C12Q1/32 , C07H19/20 , C12N9/04 , C12N9/00 , C12N1/00
CPC分类号： C12Q1/32
摘要： The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
摘要翻译：本发明提供式（I）的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生物化学检测方法和试剂盒中的用途。

43. 发明授权

US07332354B2 Compounds for chemiluminescense procedures 失效
标题翻译：化学发光法的化合物
公开(公告)号：US07332354B2
公开(公告)日：2008-02-19
申请号：US10479320
申请日：2002-05-28
申请人： Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Erasmus Huber , Ursula Klause
发明人： Dieter Heindl , Rupert Herrmann , Hans-Peter Josel , Erasmus Huber , Ursula Klause
IPC分类号： G01N33/532 , G01N33/533 , C12P7/40 , C07D219/00 , C07D277/62
CPC分类号： C07D401/12 , C07D219/06 , C07D417/04 , C07D417/14 , C12Q1/28 , G01N33/533 , G01N33/582 , Y10S435/968 , Y10S436/80 , Y10S436/904
摘要： The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.
摘要翻译：本发明涉及包含发光部分前体和离去基团的前体的化合物，其通过酰胺或酯键彼此结合，并且其特征在于，离去基团前体在氧化时转化为离去基团。本发明还涉及另外包含使用这种化合物的偶联基团用于标记生物分子的化合物，更一般地，在化学发光检测程序中使用这些化合物。

44. 发明申请

US20070184453A1 Fret process 审中-公开
标题翻译：反应过程
公开(公告)号：US20070184453A1
公开(公告)日：2007-08-09
申请号：US10678440
申请日：2003-10-01
申请人： Gregor Sagner , Dieter Heindl , Ingrid Bechler , Christina Krause
发明人： Gregor Sagner , Dieter Heindl , Ingrid Bechler , Christina Krause
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6818
摘要： The present invention is directed to hybridization probes hybridizing adjacently to another at a target nucleic acid sequence, wherein one member of said hybridization probes comprises (i) a nucleotide sequence entity which is substantially complementary to the sequence of the target nucleic acid, (ii) a fluorescent entity being either a FRET donor entity or a FRET acceptor entity, and (iii) a spacer entity connecting the nucleotide sequence entity and the fluorescent entity.
摘要翻译：本发明涉及在目标核酸序列上与另一种相邻地杂交的杂交探针，其中所述杂交探针的一个成员包含（i）与靶核酸序列基本上互补的核苷酸序列实体，（ii）荧光实体是FRET供体实体或FRET受体实体，和（iii）连接核苷酸序列实体和荧光实体的间隔实体。

45. 发明申请

US20060216736A1 Labeling reagent 有权
标题翻译：标记试剂
公开(公告)号：US20060216736A1
公开(公告)日：2006-09-28
申请号：US11370527
申请日：2006-03-08
申请人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
发明人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
IPC分类号： C12Q1/68 , C07H21/02 , C12P19/34 , C07H19/22
CPC分类号： C07H19/23 , C07H21/00
摘要： The current invention restates substituted nitroindole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted nitroindole nucleosides can be used as labeling reagents for the facile preparation of, e.g., optimized hybridization probes, simple probes, TAQMAN-probes or molecular beacon probes.
摘要翻译：本发明将取代的硝基吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块。取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。这些修饰的核苷允许进入广泛的应用领域。这些新的取代的硝基吲哚核苷可以用作易于制备例如优化的杂交探针，简单探针，TAQMAN探针或分子信标探针的标记试剂。

46. 发明申请

US20060172358A1 Novel chemiluminescent compounds and their use 失效
标题翻译：新型化学发光化合物及其用途
公开(公告)号：US20060172358A1
公开(公告)日：2006-08-03
申请号：US11339713
申请日：2006-01-25
申请人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni
发明人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni
IPC分类号： G01N33/537 , C07D417/02 , C07D405/02 , C07D413/02 , C07D409/02 , C07K16/46
CPC分类号： C07D417/04 , A61K49/0013 , G01N33/533 , G01N33/582
摘要： The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.
摘要翻译：本发明涉及新颖的化学发光化合物，这些化合物的合成方法，包含这些化合物的衍生物和缀合物，以使用这些化合物或其缀合物在基于化学发光的测定中，特别是在免疫测定中。

47. 发明授权

US06184379B2 Rhodamine derivatives and the use thereof 有权
标题翻译：罗丹明衍生物及其用途
公开(公告)号：US06184379B2
公开(公告)日：2001-02-06
申请号：US09324265
申请日：1999-06-02
申请人： Hans-Peter Josel , Rupert Herrmann , Dieter Heindl , Klaus Muhlegger , Gregor Sagner , Karl Heinz Drexhage , Jorg Frantzeskos , Jutta Arden-Jacob
发明人： Hans-Peter Josel , Rupert Herrmann , Dieter Heindl , Klaus Muhlegger , Gregor Sagner , Karl Heinz Drexhage , Jorg Frantzeskos , Jutta Arden-Jacob
IPC分类号： C07D49147
CPC分类号： C09B11/24 , Y10S436/80
摘要： The invention concerns rhodamine derivatives of the general formulae in which Ca-Cd each denote a C atom, and Ca and Cb as well as Cc and Cd are either linked together by a single bond or by a double bond; X1 to X16 denote independently of one another halogen, sulfonic acid, hydrogen or an alkyl residue with 1-20 C atoms in which the alkyl residue can be substituted with one or several halogen or sulfonic acid residues; R1 and R2 are either identical or different and denote either hydrogen, alkyl with 1-20 C atoms, polyoxyhydrocarbyl units, phenyl or phenylalkyl with 1-3 carbon atoms in the alkyl chain in which the alkyl and/or phenyl residues can be substituted by one or several hydroxy, halogen, sulfonic acid, amino, carboxy or alkoxycarbonyl groups where alkoxy can have 1-4 carbon atoms, R1 contains at least one activatable group, R2 and X4 can be optionally linked together via a bridge composed of 0-2 C atoms. In contrast to the prior art, these compounds are characterized in that A1, A2 and A3 can independently of one another denote hydrogen, cyano, halogen and sulfonic acid; B1 denotes either halogen, cyano or hydrogen; B2 denotes hydrogen, amide, halogen and an alkyl residue with 1-20 C atoms. In addition the invention concerns activated rhodamine derivatives, correspondingly conjugated biomolecules and their use in diagnostic systems.
摘要翻译：本发明涉及一般式的罗丹明衍生物，其中Ca-Cd各自表示C原子，Ca和Cb以及C c和Cd通过单键或双键连接在一起; X1至X16彼此独立地表示卤素，磺酸，氢或具有1-20个C原子的烷基残基，其中烷基残基可被一个或几个卤素或磺酸残基取代; R 1和R 2可以相同或不同，表示氢，具有1-20个C原子的烷基，聚氧烃基单元，烷基链中具有1-3个碳原子的苯基或苯基烷基，其中烷基和/或苯基残基可被一个或几个羟基，卤素，磺酸，氨基，羧基或烷氧基羰基，其中烷氧基可以具有1-4个碳原子，R 1包含至少一个可活化基团，R 2和X 4可以任选地通过由0-2 C原子。与现有技术相反，这些化合物的特征在于，A1，A2和A3可以彼此独立地表示氢，氰基，卤素和磺酸; B1表示卤素，氰基或氢; B2表示氢，酰胺，卤素和具有1-20个C原子的烷基。此外，本发明涉及活化的罗丹明衍生物，相应的共轭生物分子及其在诊断系统中的用途。

48. 发明授权

US09540702B2 Stabilization of enzymes with stable coenzymes 有权
标题翻译：用稳定的辅酶稳定酶
公开(公告)号：US09540702B2
公开(公告)日：2017-01-10
申请号：US13400209
申请日：2012-02-20
申请人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
发明人： Wolfgang Roedel , Carina Horn , Nelli Steinke , Nadine Bucci , Thomas Meier , Rainer Schmuck , Rolf Nagel , Dieter Heindl
IPC分类号： C12N9/04
CPC分类号： C12N9/96 , C12N9/0006 , C12N9/0036 , C12Q1/26 , C12Q1/32 , C12Y101/01001 , C12Y101/01002 , C12Y101/01047 , C12Y101/01049 , C12Y106/05002 , C12Y106/99
摘要： Methods for stabilizing an enzyme by storing the enzyme in the presence of a stabilized coenzyme are disclosed. In addition, an enzyme stabilized with a stabilized coenzyme as well as the use thereof in test elements for detecting analytes are also disclosed. Other aspects include unique compositions, methods, techniques, systems and devices involving enzyme stabilization.
摘要翻译：公开了通过在稳定的辅酶的存在下储存酶来稳定酶的方法。此外，还公开了用稳定的辅酶稳定的酶以及其用于检测分析物的测试元件中的用途。其他方面包括独特的组合物，方法，技术，涉及酶稳定化的系统和装置。

49. 发明授权

US08809013B2 Stable NAD/NADH derivatives 有权
标题翻译：稳定的NAD / NADH衍生物
公开(公告)号：US08809013B2
公开(公告)日：2014-08-19
申请号：US12020244
申请日：2008-01-25
申请人： Dieter Heindl , Joachim Hoenes , Carina Horn , Claudia Gaessler-Dietsche
发明人： Dieter Heindl , Joachim Hoenes , Carina Horn , Claudia Gaessler-Dietsche
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32
摘要： The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.
摘要翻译：本发明提供式（I）的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物及其在生物化学检测方法和试剂盒中的用途。

50. 发明授权

US08592184B2 Nucleic acid amplification in the presence of modified randomers 失效
标题翻译：在改良的随机存在下进行核酸扩增
公开(公告)号：US08592184B2
公开(公告)日：2013-11-26
申请号：US13711846
申请日：2012-12-12
申请人： Dieter Heindl , Waltraud Ankenbauer , Frank Laue
发明人： Dieter Heindl , Waltraud Ankenbauer , Frank Laue
IPC分类号： C12P19/34 , C07H21/00
CPC分类号： C12P19/34 , C12Q1/6848 , C12Q1/686 , C12Q2525/179 , C12Q2525/101
摘要： The present invention is directed to a composition comprising a DNA Polymerase which is preferably thermostable, Deoxynucleotides, at least one primer oligonucleotide or a pair of amplification primers, and randomized 5-8 mer oligonucleotide, characterized in that said oligonucleotide comprises a modification with an organic hydrophobic moiety Such a composition is specifically useful for performing hot start PCR.
摘要翻译：本发明涉及包含优选热稳定性的DNA聚合酶，脱氧核苷酸，至少一种引物寡核苷酸或一对扩增引物和随机化的5-8位寡核苷酸的组合物，其特征在于所述寡核苷酸包含与有机疏水部分这样的组合物特别适用于进行热启动PCR。

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