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41. 发明申请

US20080180559A1 Apparatus, methods and systems for amplifier 有权
标题翻译：放大器的装置，方法和系统
公开(公告)号：US20080180559A1
公开(公告)日：2008-07-31
申请号：US11700487
申请日：2007-01-31
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H04N3/14 , H04N5/335 , H03F1/36 , H03F3/68
CPC分类号： H04N5/3741 , H03F3/45188 , H04N5/378
摘要： Various embodiments comprise apparatus, methods, and systems that include an amplification apparatus comprising a first input, a second input, and an output, a first plurality of series-connected transistors including a first transistor having a first channel ratio and a first gate coupled to the first input, and a second plurality of series-connected transistors including a second transistor having a second channel ratio that is greater than the first channel ratio, the second transistor including a second gate coupled to the second input.
摘要翻译：各种实施例包括包括包括第一输入，第二输入和输出的放大装置的装置，方法和系统，第一多个串联连接的晶体管，其包括具有第一沟道比的第一晶体管和耦合到所述第一输入端和所述第二多个串联连接的晶体管包括具有大于所述第一沟道比的第二沟道比的第二晶体管，所述第二晶体管包括耦合到所述第二输入的第二栅极。

42. 发明授权

US07310252B2 Closed-loop high voltage booster 有权
公开(公告)号：US07310252B2
公开(公告)日：2007-12-18
申请号：US11414365
申请日：2006-05-01
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H02M3/18 , G05F1/00
CPC分类号： H02M3/073 , H04N5/335
摘要： A voltage boosting circuit with a closed-loop control mechanism and a controllable slew rate. A tracking capacitor and a control current form the closed-loop and are used to adjust the slew rate of the boosting circuit. The closed-loop control and adjustable slew rate improve the accuracy and predictability of the boosting circuit's final boosted output voltage.

43. 发明申请

US20070010662A1 VGF fusion polypeptides 审中-公开
标题翻译： VGF融合多肽
公开(公告)号：US20070010662A1
公开(公告)日：2007-01-11
申请号：US11329372
申请日：2006-01-10
申请人： Hai Yan , Thomas Boone
发明人： Hai Yan , Thomas Boone
IPC分类号： C07K14/475 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.
摘要翻译：本发明提供新型VGF多肽和选择性结合剂。本发明还提供用于产生VGF多肽的宿主细胞和方法。本发明还提供用于诊断，治疗，改善和/或预防与VGF多肽相关的疾病，病症和病症的VGF药物组合物和方法。

44. 发明申请

US20060238634A1 Apparatus and method for providing anti-eclipse operation for imaging sensors 有权
标题翻译：用于为成像传感器提供防食操作的装置和方法
公开(公告)号：US20060238634A1
公开(公告)日：2006-10-26
申请号：US11110874
申请日：2005-04-21
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H04N5/335
CPC分类号： H04N5/3598
摘要： An anti-eclipse circuit of an image pixel includes an output line for receiving a reset output signal from a pixel and a circuit coupled to the output line for detecting when a pixel reset voltage at a pixel output is below a predetermined level, and, in response, for increasing a reset voltage at the pixel output to a value above the predetermined level. The detecting and increasing circuit comprises a charge amplifier circuit for receiving the reset output signal at the output line and a voltage generating circuit coupled to the output line responsive to the output of the charge amplifier circuit.
摘要翻译：图像像素的日食电路包括用于接收来自像素的复位输出信号的输出线和耦合到输出线的电路，用于检测像素输出处的像素复位电压何时低于预定水平，并且在响应，用于将像素输出处的复位电压增加到高于预定电平的值。检测和增加电路包括用于在输出线处接收复位输出信号的电荷放大器电路和响应于电荷放大器电路的输出耦合到输出线的电压产生电路。

45. 发明申请

US20060231732A1 Method and apparatus employing dynamic element matching for reduction of column-wise fixed pattern noise in a solid state imaging sensor 有权
公开(公告)号：US20060231732A1
公开(公告)日：2006-10-19
申请号：US11104434
申请日：2005-04-13
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： H01L27/00
CPC分类号： H04N5/3658 , H04N5/378
摘要： An imager having a switching circuit that couples pixel columns to different sample and hold circuits to reduce the noticeability of column-wise fixed pattern noise. A controller randomly couples a pixel column to a sample and hold circuit, therefore fixed pattern noise emanating from a particular sample and hold circuit is not always associated with a single pixel column. Therefore the visual perception of fixed pattern noise associated with a particular sample and hold circuit is reduced.

46. 发明授权

US06966224B2 Micromachined vibratory gyroscope with electrostatic coupling 有权
标题翻译：具有静电耦合的微机械振动陀螺仪
公开(公告)号：US06966224B2
公开(公告)日：2005-11-22
申请号：US10792043
申请日：2004-03-02
申请人： Hai Yan , Roland Burghardt , Bernhard Hartmann , Konrad Kapser , Matthias Rose
发明人： Hai Yan , Roland Burghardt , Bernhard Hartmann , Konrad Kapser , Matthias Rose
IPC分类号： G01C19/5712 , G01P9/04
CPC分类号： G01C19/5719 , Y10T74/1275
摘要： Micromachined vibratory gyroscope having two or more coplanar movable masses suspended over a planar substrate. Two perpendicular axes (x and y) are defined within the substrate plane, while a third, the z-axis or input axis, is defined to be perpendicular to the substrate plane. The movements of the two masses along the x-axis are coupled through an electrostatic coupling means so that the natural resonant frequency of the in-phase mode and that of the anti-phase mode are separated from each other for the resonances along the x-axis. When the two masses are driven to vibrate along the x-axis in the anti-phase mode and the device experiences rotation about the z-axis, Coriolis forces act differentially on the masses in the Y-direction, causing the two masses to dither in an anti-phase motion along the y-axis. The anti-phase dithering along the y-axis can be sensed directly by a rate sensor to measure the rate of rotation about the z-axis. Alternatively, the anti-phase dithering of the first and second bodies along the y-axis can be transferred to other movable bodies (i.e., rate-sensing masses) whose movement is then sensed to measure the rate of rotation about the z-axis. The sensing bodies are preferably suspended in such manner that, in the absence of Coriolis forces, the x-axis motion of the vibrating masses does not affect the sensing bodies. That inhibits motion of the sensing bodies in response to linear acceleration within the plane of the substrate, but permits those bodies to respond readily to the Coriolis-induced motion about an axis perpendicular to the substrate plane.
摘要翻译：微机械振动陀螺仪具有悬挂在平面基板上的两个或更多个共面可移动质量块。两个垂直轴（x和y）被限定在衬底平面内，而第三个z轴或输入轴被定义为垂直于衬底平面。沿着x轴的两个质量块的移动通过静电耦合装置耦合，使得同相模式和反相模式的固有谐振频率彼此分离，用于沿x轴的谐振，轴。当两个质量被驱动以反相模式沿着x轴振动并且该装置经受围绕z轴的旋转时，科里奥利力在Y方向上的质量作用差异地导致两个质量在沿y轴的反相运动。可以通过速率传感器直接感测沿y轴的反相抖动，以测量围绕z轴的旋转速率。或者，沿着y轴的第一和第二主体的相位抖动可以传递到其它可移动体（即，速率感测质量），其移动然后被感测以测量围绕z轴的旋转速率。感测体优选地以这样的方式悬挂，即在没有科里奥利力的情况下，振动块的x轴运动不影响感测体。这可以抑制感测体响应于衬底平面内的线性加速度的运动，但是允许这些物体容易地响应于围绕垂直于衬底平面的轴的科里奥利诱发的运动。

47. 发明授权

US06938483B1 Phase-locked mechanical resonator pair and its application in micromachined vibration gyroscope 有权
标题翻译：锁相机械谐振器对及其在微加工振动陀螺仪中的应用
公开(公告)号：US06938483B1
公开(公告)日：2005-09-06
申请号：US10708847
申请日：2004-03-28
申请人： Hai Yan
发明人： Hai Yan
IPC分类号： G01C19/00 , G01C19/56 , G01P15/14
CPC分类号： G01C19/5719
摘要： This invention is related to a phase-locked mechanical resonator pair that comprises at least two mechanical resonators wherein the resonance of the second mechanical resonator is phase-locked to the resonance of the first mechanical, and a micromachined vibration gyroscope that uses such phase-locked mechanical resonator pair as its resonating masses to generate differential Coriolis forces and to achieve inertial cancellation.
摘要翻译：本发明涉及一种锁相机械谐振器对，其包括至少两个机械谐振器，其中第二机械谐振器的谐振被锁定到第一机械的谐振，以及使用这种相位锁定的微机械振动陀螺仪机械谐振器对作为其共振质量以产生差分科里奥利力并实现惯性取消。

48. 发明申请

US20050049180A1 VGF polypeptides and methods of treating VGF-related disorders 审中-公开
标题翻译： VGF多肽和治疗VGF相关疾病的方法
公开(公告)号：US20050049180A1
公开(公告)日：2005-03-03
申请号：US10424385
申请日：2003-04-25
申请人： Hai Yan , Thomas Boone
发明人： Hai Yan , Thomas Boone
IPC分类号： A61K38/00 , C07K14/47 , A61K38/18 , C07K14/475 , C08G63/48 , C08G63/91
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel VGF polypeptides and selective binding agents. The invention also provides host cells and methods for producing VGF polypeptides. The invention further provides VGF pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, conditions, and disorders associated with VGF polypeptides.
摘要翻译：本发明提供新型VGF多肽和选择性结合剂。本发明还提供用于产生VGF多肽的宿主细胞和方法。本发明还提供用于诊断，治疗，改善和/或预防与VGF多肽相关的疾病，病症和病症的VGF药物组合物和方法。

49. 发明授权

US5846800A Nucleic acid molecules encoding a novel receptor-type protein tyrosine phosphatase-.sigma. 失效
标题翻译：编码新型受体型蛋白酪氨酸磷酸酶的核酸分子
公开(公告)号：US5846800A
公开(公告)日：1998-12-08
申请号：US716679
申请日：1996-09-16
申请人： Joseph Schlessinger , Hai Yan
发明人： Joseph Schlessinger , Hai Yan
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61P25/18 , A61P29/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K16/40 , C12N5/10 , C12N9/16 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/42 , C12Q1/68 , C12R1/91 , G01N33/566 , G01N33/573 , C07K14/705
CPC分类号： C07K16/40 , C12N9/16 , C07K2319/00
摘要： The present invention relates to a novel receptor-type protein tyrosine phosphatase protein or glycoprotein, termed RPTP.sigma. (also known as RPTPase-.sigma.), DNA coding therefor, antibodies specific for the protein or glycoprotein, methods for production and identification of the protein, methods for detection of nucleic acid encoding the protein, and methods for screening compounds capable of binding to and either inhibiting or stimulating RPTP.sigma. phosphatase activity.
摘要翻译：本发明涉及新型的受体型蛋白酪氨酸磷酸酶蛋白或糖蛋白，称为RPTP sigma（也称为RPTPase-sigma），其编码的DNA，对蛋白质或糖蛋白有特异性的抗体，蛋白质的生产和鉴定方法，用于检测编码蛋白质的核酸的方法，以及筛选能够结合并抑制或刺激RPTP sigma磷酸酶活性的化合物的方法。

50. 发明授权

US09695400B2 Homozygous and heterozygous IDH1 gene-defective human astrocytoma cell lines 有权
公开(公告)号：US09695400B2
公开(公告)日：2017-07-04
申请号：US13878596
申请日：2011-10-24
申请人： Hai Yan , Darell Bigner , Genglin Jin
发明人： Hai Yan , Darell Bigner , Genglin Jin
IPC分类号： C12N5/00 , C12N5/09
CPC分类号： C12N5/0693
摘要： We provide IDH1 gene-defective cell lines (e.g., IDH1R132H heterozygous and IDH1R132H homozygous) derived from dissociated human astrocytoma samples. The cells can be used alone or in combination with each other or other cell types as a tool for determining the impact of IDH1R132H on cellular biology, tumorigenesis, and metabolic profiles. The cell lines may be used to test and identify therapeutic targets and to screen for molecular therapeutic agents.

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