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41. 发明授权

US08551069B2 Methods and apparatus for treating contrast nephropathy 有权
标题翻译：治疗对比肾病的方法和装置
公开(公告)号：US08551069B2
公开(公告)日：2013-10-08
申请号：US11368809
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton
IPC分类号： A61M31/00 , A61K9/22 , A61N1/00 , A61F7/00 , A61H1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了方法和装置，例如通过脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，通过热技术等来治疗对比肾病。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

42. 发明授权

US08548600B2 Apparatuses for renal neuromodulation and associated systems and methods 有权
标题翻译：肾脏神经调节装置及相关系统及方法
公开(公告)号：US08548600B2
公开(公告)日：2013-10-01
申请号：US13619851
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61F2/00 , A61N1/00 , A61N1/30 , A61M31/00 , A61B18/18
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

43. 发明申请

US20120197198A1 APPARATUSES FOR BILATERAL RENAL NEUROMODULATION 审中-公开
标题翻译：用于双侧肾神经修复的装置
公开(公告)号：US20120197198A1
公开(公告)日：2012-08-02
申请号：US13361685
申请日：2012-01-30
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61M5/142 , A61N1/05
CPC分类号： A61N1/0551 , A61B18/12 , A61B18/14 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61M5/1408 , A61M5/14276 , A61M2210/1082 , A61N1/0412 , A61N1/05 , A61N1/327 , A61N1/36007 , A61N1/36017 , A61N7/00
摘要： Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了双侧肾神经调节的方法和装置，例如通过脉冲电场，通过刺激电场，经由局部药物递送，经由高频超声波，通过热技术等。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

44. 发明申请

US20120130289A1 METHODS FOR RENAL NEUROMODULATION 审中-公开
标题翻译：方法用于肾神经修复
公开(公告)号：US20120130289A1
公开(公告)日：2012-05-24
申请号：US13361620
申请日：2012-01-30
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61N1/40 , A61F7/00 , A61M5/00 , A61M31/00 , A61F7/12 , A61B18/12 , A61N7/00
CPC分类号： A61N1/05 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36117 , A61N1/3627 , A61N1/40
摘要： Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗高血压的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和 /或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

45. 发明授权

US08150519B2 Methods and apparatus for bilateral renal neuromodulation 有权
标题翻译：双侧肾神经调节的方法和装置
公开(公告)号：US08150519B2
公开(公告)日：2012-04-03
申请号：US11368836
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61N1/00 , A61N1/30 , A61F7/00 , A61K9/22
CPC分类号： A61N1/0551 , A61B18/12 , A61B18/14 , A61B18/1492 , A61B2018/00267 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61M5/1408 , A61M5/14276 , A61M2210/1082 , A61N1/0412 , A61N1/05 , A61N1/327 , A61N1/36007 , A61N1/36017 , A61N7/00
摘要： Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了双侧肾神经调节的方法和装置，例如通过脉冲电场，通过刺激电场，经由局部药物递送，经由高频超声波，通过热技术等。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，改变基因表达，动作电位减弱或阻断，细胞因子上调和靶神经纤维中的其他条件的变化。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

46. 发明授权

US08145316B2 Methods and apparatus for renal neuromodulation 有权
标题翻译：肾脏神经调节的方法和装置
公开(公告)号：US08145316B2
公开(公告)日：2012-03-27
申请号：US11189563
申请日：2005-07-25
申请人： Mark Deem , Denise Demarais , Douglas Sutton , Hanson Gifford, III , Howard R. Levin , Mark Gelfand , Benjamin J. Clark
发明人： Mark Deem , Denise Demarais , Douglas Sutton , Hanson Gifford, III , Howard R. Levin , Mark Gelfand , Benjamin J. Clark
IPC分类号： A61N1/00 , A61N1/30
CPC分类号： A61N1/36117 , A61B18/1492 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00982 , A61B2018/1435 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N1/36017 , A61N1/36128 , A61N5/00
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for extravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置为用于实现这种神经调节的脉冲电场的血管外递送。

47. 发明申请

US20110130834A1 BRONCHIAL FLOW CONTROL DEVICES AND METHODS OF USE 审中-公开
公开(公告)号：US20110130834A1
公开(公告)日：2011-06-02
申请号：US12940787
申请日：2010-11-05
申请人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
发明人： Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
IPC分类号： A61F2/04
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
摘要翻译：描述了患者肺容积减少的方法和系统。所述方法包括在肺的支气管通道中植入流量控制装置。流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。阀保护器具有足够的刚性以保持阀构件的形状不被压缩。

48. 发明申请

US20090275879A1 METHOD FOR TREATING SUBCUTANEOUS TISSUES 有权
标题翻译：治疗组织炎症组织的方法
公开(公告)号：US20090275879A1
公开(公告)日：2009-11-05
申请号：US12467234
申请日：2009-05-15
申请人： Mark E. Deem , Hanson S. Gifford, III , Douglas Sutton
发明人： Mark E. Deem , Hanson S. Gifford, III , Douglas Sutton
IPC分类号： A61B17/20
CPC分类号： A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61K9/0009 , A61K41/0028 , A61M37/0092 , A61M2037/003 , A61N1/0412 , A61N1/0492 , A61N1/327 , A61N2007/0008 , A61N2007/0039
摘要： An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
摘要翻译：公开了一种在低声压超声波范围内使用声波处理皮下组织的装置和方法。该方法包括注射增强剂，其中通过具有在不存在增强剂的情况下不产生组织空泡的能力的超声波产生皮下组织的破坏和皮下空泡生物效应。该装置和使用方法可用于治疗包括脂肪团，脂肪瘤和肿瘤在内的皮下异常。

49. 发明授权

US07601128B2 Apparatus for treating subcutaneous tissues 有权
标题翻译：用于治疗皮下组织的装置
公开(公告)号：US07601128B2
公开(公告)日：2009-10-13
申请号：US11334805
申请日：2006-01-17
申请人： Mark E. Deem , Hanson S. Gifford, III , Douglas Sutton
发明人： Mark E. Deem , Hanson S. Gifford, III , Douglas Sutton
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00
CPC分类号： A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61K9/0009 , A61K41/0028 , A61M37/0092 , A61M2037/003 , A61N1/0412 , A61N1/0492 , A61N1/327 , A61N2007/0008 , A61N2007/0039
摘要： An assembly for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The assembly comprises an acoustic wave generator and transducer for the generation and transmission of unfocused acoustic waves, a source of microbubble solution and solution injection members for percutaneously injecting the solution at a treatment area between 1 mm and 5 mm below the dermis. The assembly is useful for treatment of subcutaneous abnormalities including cellulite, lipomas and tumors.
摘要翻译：公开了一种在低声压超声波范围内使用声波处理皮下组织的组件。该组件包括用于产生和传播未聚焦的声波的声波发生器和换能器，用于在真皮之下1mm至5mm之间的处理区域经皮注射溶液的微泡溶液源和溶液注射构件。该组合物可用于治疗包括脂肪团，脂肪瘤和肿瘤的皮下异常。

50. 发明申请

US20070213748A1 Obesity treatment tools and methods 有权
公开(公告)号：US20070213748A1
公开(公告)日：2007-09-13
申请号：US11801450
申请日：2007-05-10
申请人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
发明人： Mark Deem , Douglas Sutton , Hanson Gifford , Bernard Andreas , Ronald French
IPC分类号： A61B17/00
CPC分类号： A61B17/1114 , A61B17/00234 , A61B17/064 , A61B17/0644 , A61B17/122 , A61B2017/00557 , A61B2017/306 , A61B2090/395 , A61F5/0083 , A61F5/0086
摘要： Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., GERD. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety. This may be done by creating a smaller gastric pouch within the stomach directly from the interior of the stomach itself. The smaller pouches may be made through the use of individual anchoring devices, rotating probes, or volume reduction devices. A pyloroplasty procedure may also be performed to render the pyloric sphincter incompetent. A gastric bypass procedure may additionally be performed using atraumatic magnetic anastomoses devices so that sugars and fats are passed directly to the bowel while bypassing the stomach. Many of these procedures may be done in a variety of combinations. Treatment may create enforced behavioral modifications by discouraging the ingestion of high-caloric foods

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