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    • 48. 发明授权
    • Method for transdermal iontophoretic delivery of chelated agents
    • 螯合剂透皮离子电渗递送方法
    • US08821945B2
    • 2014-09-02
    • US12459862
    • 2009-07-07
    • Mir ImranMir HashimSanjay PatelRonald J. Berenson
    • Mir ImranMir HashimSanjay PatelRonald J. Berenson
    • A01N59/16A01N59/26A61N1/30
    • A61K41/0047A61K9/0009A61K9/703A61K9/7084A61K33/26A61K33/42A61K41/00A61N1/0496A61N1/30A61N1/325
    • Embodiments provide devices, systems and methods for the transdermal delivery of chelated compounds. One embodiment provides a method for the iontophoretic transdermal delivery of a chelated iron complex for the treatment of anemia. A first patch comprising an active electrode and a chelated iron complex is applied to the skin; a second patch containing an electrode is also applied. An electrical current is then delivered to the skin from the active electrode. The chelated complex is transported across the skin via electromotive force from the current, with the iron being substantially chromogenically unreactive with the skin during transport so that there is little or no tattooing of the skin due to the formation of insoluble oxidative products. The complex is then dissociated by phagocytosis or related process to release the iron where it may be bound by transferrin or ferritin and carried to other sites for storage or metabolic use.
    • 实施方案提供用于经皮递送螯合化合物的装置,系统和方法。 一个实施方案提供了用于治疗贫血的螯合铁络合物的离子电渗疗法透皮递送的方法。 将包含活性电极和螯合铁络合物的第一贴片施加到皮肤上; 还应用了包含电极的第二贴片。 然后从活性电极将电流输送到皮肤。 螯合络合物通过电流从电流传递穿过皮肤,铁在运输过程中与皮肤基本上不发生色素反应,因此由于不溶性氧化产物的形成,皮肤几乎或没有纹身。 然后通过吞噬作用或相关过程解离复合物以释放铁,其中它可被转铁蛋白或铁蛋白结合并携带到其它部位用于储存或代谢使用。
    • 49. 发明申请
    • BIODEGRADABLE MEDICAL IMPLANTS, POLYMER COMPOSITIONS AND METHODS OF USE
    • 生物可降解医用植入物,聚合物组合物和使用方法
    • US20130325108A1
    • 2013-12-05
    • US13261054
    • 2010-06-01
    • Mir ImranSanjay PatelJoel Harris
    • Mir ImranSanjay PatelJoel Harris
    • A61L27/14A61F2/04A61F2/82
    • A61L27/14A61F2/04A61F2/06A61F2/07A61F2/82A61F2210/0004A61L27/26A61L27/58A61L31/041A61L31/148
    • Embodiments of the invention provide compositions comprising bio degradable polymers, medical implants fabricated from these compositions and methods of using such implants. Many embodiments provide medical implants comprising a first polymer backbone having a first rate of biodegradation and a second polymer backbone having a second rate of biodegradation faster than the first rate. In some embodiments, the second backbone is configured to be replaced by a natural tissue layer. The first backbone provides a scaffold for the implant while the second backbone degrades. This scaffold can enhance mechanical properties of the implant including various aspects of mechanical strength such as tensile, bending, hoop and yield strength; and elasticity. The scaffold also serves to maintain a minimum level of structural support of the implant during the period of degradation of the second backbone or for the entire life of the implant so that the implant does not mechanically fail.
    • 本发明的实施方案提供了包含生物可降解聚合物,由这些组合物制造的医疗植入物和使用这种植入物的方法的组合物。 许多实施方案提供医学植入物,其包含具有第一生物降解速率的第一聚合物主链和具有比第一速率快的第二生物降解速率的第二聚合物主链。 在一些实施例中,第二主干被配置为由天然组织层代替。 第一个骨架提供植入物的支架,而第二个骨架降解。 该支架可以增强植入物的机械性能,包括机械强度的各个方面,例如拉伸,弯曲,箍和屈服强度; 和弹性。 支架还用于在第二主骨架的退化期间或植入物的整个寿命期间保持植入物的最小结构支撑水平,使得植入物不会机械地失效。