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41. 发明授权

US06509455B1 Recombinant narbonolide polyketide synthase 失效
公开(公告)号：US06509455B1
公开(公告)日：2003-01-21
申请号：US09657440
申请日：2000-09-07
申请人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C07H2104
CPC分类号： C07H17/08 , C07D323/00 , C12N9/14 , C12N15/52 , C12N15/65 , C40B40/00
摘要： Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

42. 发明授权

US6117659A Recombinant narbonolide polyketide synthase 失效
公开(公告)号：US6117659A
公开(公告)日：2000-09-12
申请号：US320878
申请日：1999-05-27
申请人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C07B61/00 , C07D323/00 , C07H17/08 , C12N1/21 , C12N9/14 , C12N15/52 , C12N15/65 , C12P7/02
CPC分类号： C07H17/08 , C07D323/00 , C12N15/52 , C12N15/65 , C12N9/14 , C40B40/00
摘要： Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

43. 发明授权

US09133687B2 Tubing pressure insensitive pressure compensated actuator for a downhole tool and method 有权
标题翻译：用于井下工具和方法的管道压力不敏感压力补偿执行器
公开(公告)号：US09133687B2
公开(公告)日：2015-09-15
申请号：US13210999
申请日：2011-08-16
申请人： James T. Sloan , Ronald J. Garr , Robert McDaniel , Don A. Hopmann , David E. Schneider
发明人： James T. Sloan , Ronald J. Garr , Robert McDaniel , Don A. Hopmann , David E. Schneider
IPC分类号： E21B34/10 , E21B34/14 , E21B34/00
CPC分类号： E21B34/10 , C25F3/02 , C25F7/00 , E21B34/101 , E21B34/14 , E21B2034/005
摘要： A tubing pressure insensitive, pressure compensated actuator system includes a housing having a bore therein. A force transmitter sealingly moveable within the bore. The force transmitter defining with the bore two fluid chambers. The two fluid chambers being in fluid communication with each other, one at each longitudinal end of the force transmitter. An activator in one or both of the two fluid chambers and operatively connected to the force transmitter. At least two seals sealingly positioned between the housing and the force transmitter. One of the seals disposed near one end of the force transmitter and another of the seals disposed near another end of the force transmitter. A separate compensation piston disposed in the housing so as to expose one end of the compensation piston to tubing pressure and to expose the other end of the compensation piston to a fluid volume including the fluid chambers. Also included is a method for reducing force requirements of an actuator.
摘要翻译：管压不敏感的压力补偿致动器系统包括其中具有孔的壳体。在孔内密封地移动的力传递器。力传递器用孔两个流体室来定义。两个流体室彼此流体连通，一个在力传递器的纵向端。在两个流体室中的一个或两个中的活化剂并且可操作地连接到力传递器。密封地定位在壳体和力传递器之间的至少两个密封件。设置在力传送器的一端附近的密封件之一和设置在力传送器的另一端附近的另一个密封件。单独的补偿活塞设置在壳体中，以便将补偿活塞的一端暴露于管道压力并将补偿活塞的另一端暴露于包括流体室的流体体积。还包括减少致动器的力要求的方法。

44. 发明申请

US20130043039A1 TUBING PRESSURE INSENSITIVE PRESSURE COMPENSATED ACTUATOR FOR A DOWNHOLE TOOL AND METHOD 有权
标题翻译：用于井下工具和方法的管道压力敏感压力补偿执行器
公开(公告)号：US20130043039A1
公开(公告)日：2013-02-21
申请号：US13210999
申请日：2011-08-16
申请人： James T. Sloan , Ronald J. Garr , Robert McDaniel , Don A. Hopmann , David E. Schneider
发明人： James T. Sloan , Ronald J. Garr , Robert McDaniel , Don A. Hopmann , David E. Schneider
IPC分类号： E21B34/06
CPC分类号： E21B34/10 , C25F3/02 , C25F7/00 , E21B34/101 , E21B34/14 , E21B2034/005
摘要： A tubing pressure insensitive, pressure compensated actuator system includes a housing having a bore therein. A force transmitter sealingly moveable within the bore. The force transmitter defining with the bore two fluid chambers. The two fluid chambers being in fluid communication with each other, one at each longitudinal end of the force transmitter. An activator in one or both of the two fluid chambers and operatively connected to the force transmitter. At least two seals sealingly positioned between the housing and the force transmitter. One of the seals disposed near one end of the force transmitter and another of the seals disposed near another end of the force transmitter. A separate compensation piston disposed in the housing so as to expose one end of the compensation piston to tubing pressure and to expose the other end of the compensation piston to a fluid volume including the fluid chambers. Also included is a method for reducing force requirements of an actuator.
摘要翻译：管压不敏感的压力补偿致动器系统包括其中具有孔的壳体。在孔内密封地移动的力传递器。力传递器用孔两个流体室来定义。两个流体室彼此流体连通，一个在力传递器的纵向端。在两个流体室中的一个或两个中的活化剂并且可操作地连接到力传递器。密封地定位在壳体和力传递器之间的至少两个密封件。设置在力传送器的一端附近的密封件之一和设置在力传送器的另一端附近的另一个密封件。单独的补偿活塞设置在壳体中，以便将补偿活塞的一端暴露于管道压力并将补偿活塞的另一端暴露于包括流体室的流体体积。还包括减少致动器的力要求的方法。

45. 发明授权

US07189549B2 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof 有权
标题翻译：编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
公开(公告)号：US07189549B2
公开(公告)日：2007-03-13
申请号：US10461194
申请日：2003-06-13
申请人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
发明人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
IPC分类号： C12N9/02 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/74
CPC分类号： C07D491/08 , C07D225/06 , C12N15/52 , C12Q1/689 , C12Q1/6895
摘要： The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
摘要翻译：本发明涉及重组聚酮化合物合成酶，聚酮化合物修饰蛋白和涉及聚酮化合物生物合成或功能的其它蛋白质。本发明提供了格尔德霉素和草甘膦聚酮化合物合酶的结构域，编码这种酶的多核苷酸，以及可以有利地表达这种编码多核苷酸的宿主细胞。

46. 发明授权

US07033818B2 Recombinant polyketide synthase genes 有权
公开(公告)号：US07033818B2
公开(公告)日：2006-04-25
申请号：US10125815
申请日：2002-04-18
申请人： Zhihao Hu , Robert McDaniel , Daniel V. Santi
发明人： Zhihao Hu , Robert McDaniel , Daniel V. Santi
IPC分类号： C12N1/20 , C07H21/04
CPC分类号： C12N9/0006 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/90 , C12N15/52 , C12P19/62
摘要： Regions of sequence identity are recurrent in some modular polyketide synthase (PKS) gene clusters. Such sequences are potentially detrimental to the stability of PKS gene clusters and expression plasmids for the genes in the gene cluster. PKS gene and gene cluster stability can be improved, and reproducible polyketide titers can be obtained using those genes and gene clusters when the regions of sequence identity are reduced or eliminated by replacing one or more identical or homologous segments with non-homologous segments that encode the same or a substantially similar amino acid sequence.

47. 发明申请

US20060078682A1 Particles for use as proppants or in gravel packs, methods for making and using the same 有权
标题翻译：用作支撑剂或砾石包装的颗粒，制造和使用它们的方法
公开(公告)号：US20060078682A1
公开(公告)日：2006-04-13
申请号：US11230693
申请日：2005-09-20
申请人： Robert McDaniel , Avis McCrary
发明人： Robert McDaniel , Avis McCrary
IPC分类号： B32B5/16 , B32B27/00
CPC分类号： C09K3/1436 , C09K8/62 , C09K8/805 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： Disclosed herein is a coated particle comprising a substrate comprising an inorganic material, wherein the inorganic material comprises silica and alumina in a silica to alumina weight ratio of about 2.2 to about 5; and wherein the inorganic material has a bulk density of less than or equal to about 1 g/cm3; and a coating disposed upon the substrate. Disclosed herein too is a method of treating a subterranean formation comprising injecting a fracturing fluid into the subterranean formation; wherein the fracturing fluid comprises an inorganic particle that comprises silica and alumina in a silica to alumina weight ratio of about 2.2 to about 5; and wherein the inorganic particle has a bulk density of less than or equal to about 1 g/cm3.
摘要翻译：本文公开了包含含有无机材料的基材的涂覆颗粒，其中所述无机材料包含氧化硅和氧化铝，二氧化硅与氧化铝的重量比为约2.2至约5; 并且其中所述无机材料具有小于或等于约1g / cm 3的堆积密度; 以及设置在基板上的涂层。本文还公开了一种处理地下地层的方法，包括将压裂流体注入到地下地层中; 其中所述压裂流体包括无机颗粒，所述无机颗粒包含氧化硅和氧化铝，二氧化硅与氧化铝的重量比为约2.2至约5; 并且其中所述无机颗粒的堆积密度小于或等于约1g / cm 3。

48. 发明申请

US20050233431A1 Recombinant narbonolide polyketide synthase 审中-公开
标题翻译：重组纳博内酯聚酮化合物合成酶
公开(公告)号：US20050233431A1
公开(公告)日：2005-10-20
申请号：US10846335
申请日：2004-05-14
申请人： Gary Ashley , Melanie Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C07B61/00 , C07D323/00 , C07H17/08 , C12N1/21 , C12N9/14 , C12N15/52 , C12N15/65 , C12P17/08 , C12P19/62 , C12N9/16 , C07H21/04 , C12N15/74
CPC分类号： C07D323/00 , C07H17/08 , C12N9/14 , C12N15/52 , C12N15/65 , C12P17/08 , C12P19/62 , C40B40/00
摘要： Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
摘要翻译：用于编码全部或部分纳博内酯聚酮化合物合成酶的重组DNA化合物用于在宿主细胞中表达重组聚酮化合物合成酶基因，用于生产可用作抗生素的纳博内酯，纳博内酯衍生物和聚酮化合物，并且作为合成具有药品价值。

49. 发明授权

US06524841B1 Recombinant megalomicin biosynthetic genes and uses thereof 有权
标题翻译：重组巨球蛋白生物合成基因及其用途
公开(公告)号：US06524841B1
公开(公告)日：2003-02-25
申请号：US09679279
申请日：2000-10-04
申请人： Robert McDaniel , Yanina Volchegursky
发明人： Robert McDaniel , Yanina Volchegursky
IPC分类号： C12N120
CPC分类号： C12N9/0006 , C07K2319/00 , C12N9/10 , C12N9/1048 , C12N9/90 , C12N15/52 , C12P19/62
摘要： Recombinant nucleic acids that encode all or a portion of the megAI gene of the megalomicin polyketide synthase (PKS) of Micromonospora megalomicea are used to produce recombinant PKS enzymes in host cells to make megalomicin, megalomicin derivatives, and other polyketides that are useful as antibiotics, motilides, and antiparasitics.
摘要翻译：编码Micromonospora megalomicea的美卡米单抗聚合酮合成酶（PKS）的megAI基因的全部或部分的重组核酸用于在宿主细胞中产生重组PKS酶，以制备可用作抗生素的大米金霉素，美卡米毒素衍生物和其它聚酮化合物，运动员和反寄生。

50. 发明授权

US06503741B1 Polyketide synthase genes from Streptomyces venezuelae 失效
标题翻译：来自维他命C链球菌的聚酮化合物合成酶基因
公开(公告)号：US06503741B1
公开(公告)日：2003-01-07
申请号：US09141908
申请日：1998-08-28
申请人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
发明人： Gary Ashley , Melanie C. Betlach , Mary Betlach , Robert McDaniel , Li Tang
IPC分类号： C12N900
CPC分类号： C12N9/14 , C12N15/65
摘要： Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
摘要翻译：聚酮化合物的组合文库可以通过适当操作宿主模块化的聚酮化合物合酶基因簇（例如编码picromycin的PKS的簇）来获得。组合文库可用作药物活性化合物的来源。此外，使用该方法制备新的聚酮化合物和抗生素。

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