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41. 发明申请

US20070148748A1 Fermentation process using specific oxygen uptake rates as a process control 有权
标题翻译：使用特定氧气摄取速率的发酵过程作为过程控制
公开(公告)号：US20070148748A1
公开(公告)日：2007-06-28
申请号：US11707188
申请日：2007-02-14
申请人： Pim Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Hoek , Aristos Aristidou , Brian Rush
IPC分类号： C12P7/56 , C12N1/18
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
摘要翻译：比氧吸收（OUR）用作发酵过程中的过程控制参数。在至少在发酵过程的生产阶段确定OUR，并调整工艺参数以将OUR保持在所需范围内。当使用已经被破坏的天然PDC途径的微生物进行发酵以使其不再起作用时，本发明特别适用。这种微生物在严格的无氧条件下往往产生不良。通过监测OUR控制的微量曝气允许优化微生物的性能。

42. 发明授权

US07091014B1 Transformed microorganisms with improved properties 失效
标题翻译：具有改进性能的转化微生物
公开(公告)号：US07091014B1
公开(公告)日：2006-08-15
申请号：US09423554
申请日：1999-03-11
申请人： Aristos Aristidou , John Londesborough , Merja Penttilä , Peter Richard , Laura Ruohonen , Hans Söderlund , Anita Teleman , Mervi Toivari
发明人： Aristos Aristidou , John Londesborough , Merja Penttilä , Peter Richard , Laura Ruohonen , Hans Söderlund , Anita Teleman , Mervi Toivari
IPC分类号： C12P7/06 , C12N1/14
CPC分类号： C12N9/0016 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12P7/06 , C12P7/18 , C12P7/625 , C12P13/04 , C12P13/08 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce useful products more efficiently. The microorganisms express at least one enzyme that causes the functional coupling of the oxidation and reduction of substrates by two pyridine nucleotide-linked dehydrogenase reactions with different specificities for the NAD/NADH and NADP/NADPH coenzyme couples and so facilitates the transfer of electrons between the two coenzyme couples through the said substrates. In particular the invention relates to increasing the yields of products such as ethanol or amino acids from carbon and nitrogen sources such as biomass comprising hexoes, pentoses or their polymers.
摘要翻译：本发明涉及用于生物技术的生产微生物的基因工程，以改善其性质，使得它们更有效地生产有用的产品。微生物表达至少一种酶，其通过与NAD / NADH和NADP / NADPH辅酶偶合的不同特异性的两个吡啶核苷酸连接的脱氢酶反应引起底物的氧化和还原的功能偶联，并且因此促进电子在两种辅酶对通过所述底物。特别地，本发明涉及从碳和氮源例如包含己糖，戊糖或其聚合物的生物质中提高产物如乙醇或氨基酸的产率。

43. 发明授权

US07939298B2 Fermentation process using specific oxygen uptake rates as a process control 有权
标题翻译：使用特定氧气摄取速率的发酵过程作为过程控制
公开(公告)号：US07939298B2
公开(公告)日：2011-05-10
申请号：US11707188
申请日：2007-02-14
申请人： Pim Van Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Van Hoek , Aristos Aristidou , Brian Rush
IPC分类号： C12P21/00 , C12N1/15
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.
摘要翻译：比氧吸收（OUR）用作发酵过程中的过程控制参数。在至少在发酵过程的生产阶段确定OUR，并调整工艺参数以将OUR保持在所需范围内。当使用已经被破坏的天然PDC途径的微生物进行发酵以使其不再起作用时，本发明特别适用。这种微生物在严格的无氧条件下往往产生不良。通过监测OUR控制的微量曝气允许优化微生物的性能。

44. 发明申请

US20120034666A1 METHODS OF INCREASING DIHYDROXY ACID DEHYDRATASE ACTIVITY TO IMPROVE PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开
标题翻译：增加二羟酸脱水酶活性的方法，以提高燃料，化学品和氨基酸的生产
公开(公告)号：US20120034666A1
公开(公告)日：2012-02-09
申请号：US13279166
申请日：2011-10-21
申请人： Andrew C. HAWKINS , Aristos Aristidou , Doug Lies , Lynne H. Albert
发明人： Andrew C. HAWKINS , Aristos Aristidou , Doug Lies , Lynne H. Albert
IPC分类号： C12P7/16 , C12N1/19
CPC分类号： C12N9/88 , C07K14/395 , C12N9/13 , C12P7/16 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y208/01007 , Y02E50/10
摘要： The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Nfs1 proteins or homologs thereof and/or one or more polynucleotides encoding one or more Isd11 proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明涉及包含一种或多种二羟基酸脱水酶（DHAD） - 生物合成途径的重组微生物，以及使用所述重组微生物产生源自所述DHAD需要生物合成途径的有益代谢物的方法。在本发明的各个方面，重组微生物可被改造以过表达一种或多种编码一种或多种Nfs1蛋白或其同系物的多核苷酸和/或一种或多种编码一种或多种Isd11蛋白或其同系物的多核苷酸。在一些实施方案中，重组微生物可以包含细胞溶质定位的DHAD酶。在另外的实施方案中，重组微生物可以包含线粒体定位的DHAD酶。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物，和非发酵酵母微生物。

45. 发明授权

US07232664B2 Fermentation process using specific oxygen uptake rates as a process control 有权
公开(公告)号：US07232664B2
公开(公告)日：2007-06-19
申请号：US10449911
申请日：2003-05-30
申请人： Pim Van Hoek , Aristos Aristidou , Brian Rush
发明人： Pim Van Hoek , Aristos Aristidou , Brian Rush
IPC分类号： C12P1/00 , C12P7/00 , C12P7/40 , G01N33/53 , C12N1/20
CPC分类号： C12P7/56 , C12N1/16 , C12N9/0006 , C12N15/815 , C12P7/625 , C12Q1/02 , G01N2333/39 , Y02P20/52
摘要： Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using a microorganism having a natural PDC pathway that has been disrupted so that it no longer functions. Microorganisms of this sort often produce poorly under strictly anaerobic conditions. Microaeration controlled by monitoring OUR allows the performance of the microorganism to be optimized.

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