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41. 发明授权

US09179850B2 Systems, methods and devices for a skull/brain interface 有权
标题翻译：颅脑/脑界面的系统，方法和装置
公开(公告)号：US09179850B2
公开(公告)日：2015-11-10
申请号：US11929801
申请日：2007-10-30
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/05 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B18/18 , A61N1/20 , A61N1/30 , A61N1/36 , A61N5/06
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： A form of neuromodulation is conveyed from an external source to an interior of the skull to modulate neural activity. One or more apertures are formed through or partially through the skull to provide an interface for neuromodulation delivery. Parameters of one or more states of the brain may be sensed through an interface formed with one or more apertures extending all or part of the way through the skull. A device provides an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be configured for ion conduction of electrical signals, enabling DC or near DC stimulation of target neurons.
摘要翻译：一种形式的神经调节从外部来源输送到颅骨内部以调节神经活动。通过或部分穿过颅骨形成一个或多个孔，以提供用于神经调节递送的界面。可以通过形成有一个或多个孔的界面来感测脑的一个或多个状态的参数，所述一个或多个孔延伸穿过颅骨的全部或部分。装置提供颅骨外部与脑之间的界面，该界面包括足以穿过颅骨的整个厚度或颅骨厚度的至少一部分的长度的通道。通道可以被配置用于电信号的离子传导，使得能够对目标神经元进行DC或近DC刺激。

42. 发明授权

US08965513B2 Systems, methods and devices for a skull/brain interface 有权
标题翻译：颅脑/脑界面的系统，方法和装置
公开(公告)号：US08965513B2
公开(公告)日：2015-02-24
申请号：US12260958
申请日：2008-10-29
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/04 , A61B5/04 , A61N1/05 , A61B18/02 , A61B18/14 , A61B18/18 , A61N1/20 , A61N1/30 , A61N1/36 , A61N5/06
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
摘要翻译：公开了系统，方法和装置，用于将信号引导和聚焦到脑中用于神经调节，并用于引导和聚焦来自脑的信号或其他能量用于测量，热传递和成像。可以使用颅骨中的孔和/或可植入颅骨的通道装置来促进方向和聚焦。所公开的系统，方法和装置可以促进多种神经病症的治疗和诊断。

43. 发明授权

US08740765B1 Magnetic pulsing system for inducing electric currents in a human body 有权
标题翻译：用于在人体内诱导电流的磁脉冲系统
公开(公告)号：US08740765B1
公开(公告)日：2014-06-03
申请号：US13571833
申请日：2012-08-10
申请人： Robert E. Fischell , Scott J. S. Fischell , David R. Fischell , Emily Ma , Kuen Chang , Dave Vondle , Benjamin Pless
发明人： Robert E. Fischell , Scott J. S. Fischell , David R. Fischell , Emily Ma , Kuen Chang , Dave Vondle , Benjamin Pless
IPC分类号： A61N2/04
CPC分类号： A61N2/02 , A61N2/008
摘要： Disclosed is a means and method for the treatment of migraine headaches and other disorders of the human body by the application of one or more intense magnetic pulses. By placing an intense magnetic field pulse(s) onto a certain region of the brain, an electrical current can be generated in the cerebral cortex that can stop a migraine headache in some patients or at least decrease its severity. The device to perform this function can be called a “magnetic pulser system.” This system can be made in one piece and powered by plugging into a household or automobile receptacle or from a battery. The pulser system uses capacitors that are first charged to a high voltage and then discharged into a coil that creates the intense magnetic pulse. Both visual and auditory signals can be provided by the pulser system to assist the patient in using the device.
摘要翻译：公开了通过施加一个或多个强磁脉冲来治疗偏头痛和人体其它疾病的方法和方法。通过将强磁场脉冲放置在大脑的某一区域，可以在大脑皮质中产生电流，这可以阻止一些患者的偏头痛，或至少降低其严重程度。执行此功能的设备可以称为“磁脉冲发生器系统”。该系统可以制成一体，并通过插入家用或汽车插座或从电池供电。脉冲发生器系统使用首先充电到高电压然后放电到产生强磁脉冲的线圈中的电容器。视觉和听觉信号都可以由脉冲发生器系统提供，以帮助患者使用该装置。

44. 发明授权

US08339262B2 Patient identification system 有权
标题翻译：病人识别系统
公开(公告)号：US08339262B2
公开(公告)日：2012-12-25
申请号：US12036210
申请日：2008-02-22
申请人： Benjamin Pless
发明人： Benjamin Pless
IPC分类号： G08B13/14
CPC分类号： G06K7/10396 , A61B5/0404 , A61B5/1113 , A61B90/90 , A61B90/98 , G06F21/35 , G06F21/6254 , G06F2221/2101 , G06F2221/2111 , G06K7/01 , G07C9/00111
摘要： The patient identification system of the preferred embodiments includes a transponder that is affixed to a patient and functions to communicate information that identifies the patient to a device or series of devices. The series of devices includes at least a first device that collects data from the patient and communicates with the transponder. The patient identification system is preferably designed to identify a patient, and more specifically to identify a patient to be associated with the data collected by the device. The patient identification system, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译：优选实施例的患者识别系统包括固定到患者的应答器，并且用于将识别患者的信息传送到设备或一系列设备。该系列装置至少包括从患者收集数据并与应答器通信的第一装置。患者识别系统优选地被设计为识别患者，并且更具体地，旨在识别与由装置收集的数据相关联的患者。然而，患者识别系统可以替代地在任何合适的环境中使用，并且由于任何合适的原因。

45. 发明申请

US20100101942A1 ELECTROLYTIC CELL WITH CAVITATING JET 失效
标题翻译：电解槽与CAVITATING JET
公开(公告)号：US20100101942A1
公开(公告)日：2010-04-29
申请号：US12296526
申请日：2007-04-20
申请人： Benjamin Pless
发明人： Benjamin Pless
IPC分类号： C25B9/06
CPC分类号： C25B1/02 , C01B3/042 , C01B3/501 , C01B13/0251 , C01B2203/041 , C01B2203/0465 , C01B2203/0861 , C01B2210/0053 , C25B9/06 , Y02E60/364 , Y02P20/134
摘要： The electrolytic cell of the preferred embodiment includes an electrode pair and a cavitating jet. The electrode pair includes a cathode electrode and an anode electrode and defines an electrical path between the cathode electrode and the anode electrode. The cavitating jet, which is located along the electrical path between the cathode electrode and the anode electrode, functions to cavitate a fluid, such as water. The electrode pair and the cavitating jet cooperate to initiate a plasma state in the water. The water in the plasma state acts a virtual electrode with a higher current density than the cathode electrode and/or anode electrode. The plasma virtual electrode, through thermolysis and/or electrolysis, produces hydrogen.
摘要翻译：优选实施例的电解池包括电极对和空化射流。电极对包括阴极电极和阳极电极，并且限定阴极电极和阳极电极之间的电路径。沿着阴极电极和阳极电极之间的电气路径定位的空化射流用于使诸如水之类的流体气蚀。电极对和气蚀射流协同起动在水中的等离子体状态。等离子体状态的水作用于具有比阴极电极和/或阳极电极更高的电流密度的虚拟电极。等离子体虚拟电极通过热解和/或电解产生氢。

46. 发明授权

US07674257B2 Apparatus and method for ablating tissue 失效
标题翻译：用于消融组织的装置和方法
公开(公告)号：US07674257B2
公开(公告)日：2010-03-09
申请号：US10879996
申请日：2004-06-28
申请人： Benjamin Pless , Scott C. Anderson , Jonathan L. Podmore , Matthias Vaska , John E. Crowe , Roxanne L. Richman , Timothy Ciciarelli , David A. Gallup , Jack E. Ulstad, Jr.
发明人： Benjamin Pless , Scott C. Anderson , Jonathan L. Podmore , Matthias Vaska , John E. Crowe , Roxanne L. Richman , Timothy Ciciarelli , David A. Gallup , Jack E. Ulstad, Jr.
IPC分类号： A61B18/04
CPC分类号： A61B17/22012 , A61B5/0422 , A61B17/2202 , A61B18/00 , A61B18/02 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1492 , A61B34/20 , A61B2017/00039 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/22077 , A61B2017/3419 , A61B2018/00023 , A61B2018/0016 , A61B2018/00232 , A61B2018/00261 , A61B2018/00285 , A61B2018/00291 , A61B2018/00351 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2018/00654 , A61B2018/00797 , A61B2018/00839 , A61B2018/142 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/395 , A61B2218/002 , A61B2218/007 , A61N1/06 , A61N1/362 , A61N7/02 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： A control system alters one or more characteristics of an ablating element to ablate tissue. In one aspect, the control system delivers energy nearer to the surface of the tissue by changing the frequency or power. In another aspect, the ablating element delivers focused ultrasound which is focused in at least one dimension. The ablating device may also have a number of ablating elements with different characteristics such as focal length.
摘要翻译：控制系统改变烧蚀元件的一个或多个特征以消融组织。在一个方面，控制系统通过改变频率或功率来传送更接近组织表面的能量。在另一方面，消融元件传递聚焦在至少一个维度上的聚焦超声。烧蚀装置还可以具有许多具有不同特征的烧蚀元件，例如焦距。

47. 发明申请

US20090112279A1 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 有权
标题翻译：用于SKULL / BRAIN接口的系统，方法和设备
公开(公告)号：US20090112279A1
公开(公告)日：2009-04-30
申请号：US12260958
申请日：2008-10-29
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/05
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
摘要翻译：公开了系统，方法和装置，用于将信号引导和聚焦到脑中用于神经调节，并用于引导和聚焦来自脑的信号或其他能量用于测量，热传递和成像。可以使用颅骨中的孔和/或可植入颅骨的通道装置来促进方向和聚焦。所公开的系统，方法和装置可以促进多种神经病症的治疗和诊断。

48. 发明申请

US20090112278A1 Systems, Methods and Devices for a Skull/Brain Interface 审中-公开
标题翻译：颅骨/脑界面的系统，方法和设备
公开(公告)号：US20090112278A1
公开(公告)日：2009-04-30
申请号：US12243733
申请日：2008-10-01
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/00
CPC分类号： A61N1/36025 , A61B5/4064 , A61B5/4076 , A61B5/4094 , A61B5/6864 , A61B8/0808 , A61B18/02 , A61B18/14 , A61B90/10 , A61B2018/1807 , A61B2090/103 , A61N1/0484 , A61N1/0492 , A61N1/0529 , A61N1/0534 , A61N1/0536 , A61N1/0539 , A61N1/205 , A61N1/303 , A61N1/36017 , A61N5/0601
摘要： Disclosed are methods, devices, and systems for inducing neuromodulation by focusing a source of stimulation through a skull/brain interface in the form of an aperture formed in the skull, a naturally occurring fenestration in the skull, or a transcranial channel. Further disclosed are methods, devices, and systems for identifying where to locate skull/brain interfaces, accessories that can be used with the interfaces, and features for controlling stimulation delivered through the interfaces. Multiple indications for the skull/brain interfaces are also disclosed, including diagnosis and treatment of neurological disorders and conditions such as epilepsy, movement disorders, depression, Alzheimer's disease, autism, coma, and pain.
摘要翻译：公开了用于通过将颅骨/脑界面以颅骨形成的孔的形式聚焦刺激源，颅骨中天然存在的开窗或经颅通道来诱导神经调节的方法，装置和系统。还公开了用于识别在哪里定位颅骨/脑界面的方法，装置和系统，可以与界面一起使用的附件以及用于控制通过界面传递的刺激的特征。还公开了颅骨/脑界面的多种适应症，包括诊断和治疗诸如癫痫，运动障碍，抑郁症，阿尔茨海默病，孤独症，昏迷和疼痛的神经障碍和病症。

49. 发明申请

US20090112277A1 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 有权
公开(公告)号：US20090112277A1
公开(公告)日：2009-04-30
申请号：US11929801
申请日：2007-10-30
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/05 , A61B18/00
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： A method is disclosed for conveying a form of neuromodulation (e.g., electrical, chemical, optical, or thermal) from an external neuromodulation source interiorly of the skull to modulate neural activity. The method involves forming one or more apertures through or partially through the skull to provide an interface for delivering the neuromodulation. A method is disclosed for sensing one or more parameters characteristic of one or more states of the brain through an interface formed with one or more apertures extending all the way or part of the way through the skull. A device is disclosed that is implantable in the skull of a human patient to provide an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be provided in a wide variety of shapes and sizes with or without inner lumens. The channels may be configured for ion conduction of electrical signals, enabling DC or near DC stimulation of target neurons. Methods and devices for transferring energy (e.g., thermal energy) generated inside the skull to the outside of the skull and vice versa are also disclosed.

50. 发明申请

US20090112273A1 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 有权
标题翻译：用于SKULL / BRAIN接口的系统，方法和设备
公开(公告)号：US20090112273A1
公开(公告)日：2009-04-30
申请号：US12234297
申请日：2008-09-19
申请人： Brett Wingeier , Benjamin Pless
发明人： Brett Wingeier , Benjamin Pless
IPC分类号： A61N1/00
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： A method is disclosed for conveying a form of neuromodulation (e.g., electrical, chemical, optical, or thermal) from an external neuromodulation source interiorly of the skull to modulate neural activity. The method involves forming one or more apertures through or partially through the skull to provide an interface for delivering the neuromodulation. A method is disclosed for sensing one or more parameters characteristic of one or more states of the brain through an interface formed with one or more apertures extending all the way or part of the way through the skull. A device is disclosed that is implantable in the skull of a human patient to provide an interface between the exterior of the skull and the brain that includes a channel of a length sufficient to traverse the entire thickness of the skull or at least a part of the thickness of the skull. The channels may be provided in a wide variety of shapes and sizes with or without inner lumens. The channels may be configured for ion conduction of electrical signals, enabling DC or near DC stimulation of target neurons. Methods and devices for transferring energy (e.g., thermal energy) generated inside the skull to the outside of the skull and vice versa are also disclosed.
摘要翻译：公开了用于从颅骨内部的外部神经调节源输送神经调节（例如电学，化学，光学或热学）形式以调节神经活动的方法。该方法包括通过或部分穿过颅骨形成一个或多个孔，以提供用于递送神经调节的界面。公开了一种用于通过由一个或多个延伸穿过颅骨的方式或部分延伸的一个或多个孔形成的界面来感测脑的一个或多个状态的一个或多个状态的一个或多个特征的方法。公开了一种可植入人类患者颅骨的装置，以提供在颅骨外部与脑部之间的界面，该界面包括足以穿过颅骨的整个厚度的长度的通道，或至少部分颅骨厚度通道可以以具有或不具有内腔的多种形状和尺寸来提供。通道可以被配置用于电信号的离子传导，使得能够对目标神经元进行DC或近DC刺激。还公开了将头骨内产生的能量（例如，热能）转移到颅骨外部的方法和装置，反之亦然。

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