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41. 发明授权

US09042955B2 Reference electrodes having an extended lifetime for use in long term amperometric sensors 有权
标题翻译：参考电极具有延长的使用寿命，用于长期电流传感器
公开(公告)号：US09042955B2
公开(公告)日：2015-05-26
申请号：US13595789
申请日：2012-08-27
申请人： Zenghe Liu , Benjamin J. Feldman , Brian Cho , Udo Hoss
发明人： Zenghe Liu , Benjamin J. Feldman , Brian Cho , Udo Hoss
IPC分类号： G01N27/30 , C12Q1/00
CPC分类号： A61B5/1486 , A61B5/14532 , C12Q1/006 , G01N27/301 , G01N27/3272
摘要： The present application provides Ag/AgCl based reference electrodes having an extended lifetime that are suitable for use in long term amperometric sensors. Electrochemical sensors equipped with reference electrodes described herein demonstrate considerable stability and extended lifetime in a variety of conditions.
摘要翻译：本申请提供了具有适用于长期电流计传感器的延长寿命的基于Ag / AgCl的参比电极。配备有本文所述的参考电极的电化学传感器在各种条件下显示出相当大的稳定性和延长的寿命。

42. 发明授权

US08650751B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08650751B2
公开(公告)日：2014-02-18
申请号：US12569350
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R43/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

43. 发明授权

US08444834B2 Redox polymers for use in analyte monitoring 有权
标题翻译：用于分析物监测的氧化还原聚合物
公开(公告)号：US08444834B2
公开(公告)日：2013-05-21
申请号：US12051835
申请日：2008-03-19
申请人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： G01N27/327 , C07F15/00
CPC分类号： C07F15/0026 , C12Q1/002 , C12Q1/004
摘要： Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译：描述了用作电化学生物传感器中的氧化还原介体的聚合物。连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。

44. 发明授权

US08272125B2 Method of manufacturing in vitro analyte sensors 有权
标题翻译：制造体外分析物传感器的方法
公开(公告)号：US08272125B2
公开(公告)日：2012-09-25
申请号：US12569179
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R9/00 , H05K3/02
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： Provided are methods of manufacturing a plurality of electrochemical sensors. The methods include forming a plurality of working electrodes on a first electrode region of a substrate, forming a plurality of counter electrodes on a second electrode region of the substrate, disposing a spacer layer on one of the first and second electrode regions, folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure, and separating or cutting the layered structure to form individual electrochemical sensors.
摘要翻译：提供制造多个电化学传感器的方法。所述方法包括在基板的第一电极区域上形成多个工作电极，在基板的第二电极区域上形成多个对置电极，在第一和第二电极区域之一上设置间隔层，折叠基板其中间隔层在第一电极区域和第二电极区域之间以形成层状结构，并且分离或切割层状结构以形成单独的电化学传感器。

45. 发明授权

US08268143B2 Oxygen-effect free analyte sensor 有权
标题翻译：无氧效应的分析物传感器
公开(公告)号：US08268143B2
公开(公告)日：2012-09-18
申请号：US12172589
申请日：2008-07-14
申请人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： C12Q1/32
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61B2560/0252 , A61B2560/0276 , A61M5/1723 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/201 , C12Q1/004 , C12Q1/32
摘要： The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
摘要翻译：本发明提供一种电化学传感器，其具有基本上没有任何“氧效应”的感测化学物质。电化学传感器可用于确定来自受试者的生物样品中分析物的水平。本发明还提供了包括电化学传感器的传感器组件及其使用方法。

46. 发明申请

US20120165637A1 Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems 审中-公开
标题翻译：校准分析物测量装置的方法，以及相关方法，装置和系统
公开(公告)号：US20120165637A1
公开(公告)日：2012-06-28
申请号：US13415834
申请日：2012-03-08
申请人： Benjamin J. Feldman , Geoffrey V. McGarraugh
发明人： Benjamin J. Feldman , Geoffrey V. McGarraugh
IPC分类号： A61B5/145 , G01N35/00
CPC分类号： A61B5/1495 , A61B5/0004 , A61B5/0024 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/6898 , A61B5/7246 , A61B5/742 , A61B5/746 , A61B5/7475
摘要： The invention relates to a method for calibrating an analyte-measurement device that is used to evaluate a concentration of analyte in bodily fluid at or from a measurement site in a body. The method involves measuring a concentration, or calibration concentration, of an analyte in blood from an “off-finger” calibration site, and calibrating the analyte-measurement device based on that calibration concentration. The invention also relates to a device, system, or kit for measuring a concentration of an analyte in a body, which employs a calibration device for adjusting analyte concentration measured in bodily fluid based on an analyte concentration measured in blood from an “off-finger” calibration site.
摘要翻译：本发明涉及一种用于校准分析物测量装置的方法，其用于评估体内或体外的测量部位体液中分析物的浓度。该方法包括测量来自“脱手”校准位点的血液中分析物的浓度或校准浓度，以及基于该校准浓度校准分析物测量装置。本发明还涉及一种用于测量身体中分析物浓度的装置，系统或试剂盒，该装置，系统或试剂盒使用校准装置，用于基于在来自“脱手指”的血液中测量的分析物浓度来调节在体液中测量的分析物浓度 “校准站点。

47. 发明申请

US20120132525A1 REDOX POLYMERS FOR USE IN ANALYTE MONITORING 有权
标题翻译：用于分析监测的REDOX聚合物
公开(公告)号：US20120132525A1
公开(公告)日：2012-05-31
申请号：US12051835
申请日：2008-03-19
申请人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： G01N33/50 , C08F126/06
CPC分类号： C07F15/0026 , C12Q1/002 , C12Q1/004
摘要： Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译：描述了用作电化学生物传感器中的氧化还原介体的聚合物。连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。

48. 发明授权

US08182670B2 Small volume in vitro analyte sensor and methods of making 有权
公开(公告)号：US08182670B2
公开(公告)日：2012-05-22
申请号：US12569164
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

49. 发明授权

US08142643B2 Small volume in vitro analyte sensor 有权
标题翻译：体积小体积分析物传感器
公开(公告)号：US08142643B2
公开(公告)日：2012-03-27
申请号：US12568858
申请日：2009-09-29
申请人： Adam Heller , Benjamin J. Feldman , James Say , Mark S. Vreeke
发明人： Adam Heller , Benjamin J. Feldman , James Say , Mark S. Vreeke
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , A61B5/1411 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15105 , A61B5/15113 , A61B5/15144 , A61B5/157 , A61B2560/0223 , A61B2562/0295 , C12Q1/001 , C12Q1/004 , C12Q1/006 , G01N27/3273 , G01N33/5438 , G01N2333/904
摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.
摘要翻译：设计用于确定体积小于约1μL的样品中分析物的量和浓度的传感器。该传感器具有涂覆有不可浸出的氧化还原介体的工作电极。氧化还原介体作为分析物和电极之间的电子转移剂。此外，可以加入第二电子转移剂，例如酶，以促进分析物的电氧化或电还原。氧化还原介体通常是与聚合物结合的氧化还原化合物。优选的氧化还原介体是可空气氧化的。分析物的量可以通过库仑法测定。一种特定的库仑技术包括两次或更多次测量工作电极与计数器或参考电极之间的电流。通过该电流流向或来自分析物的电荷与样品中分析物的量相关。还可以使用其他电化学检测方法，例如电流，伏安和电位技术。本发明可用于测定生物液体如血液或血清中生物分子如葡萄糖或乳酸盐的浓度。提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

50. 发明申请

US20120028283A1 Analyte Sensors Having Temperature Independent Membranes 有权
标题翻译：具有温度独立膜的分析物传感器
公开(公告)号：US20120028283A1
公开(公告)日：2012-02-02
申请号：US13192184
申请日：2011-07-27
申请人： Udo Hoss , Benjamin J. Feldman , Tianmei Ouyang
发明人： Udo Hoss , Benjamin J. Feldman , Tianmei Ouyang
IPC分类号： C12Q1/54 , A61B5/145 , C12M1/34
CPC分类号： A61B5/1468 , A61B5/14507 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/14865 , A61B5/4839 , C12Q1/002
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其具有基本上与温度无关的分析物渗透性的膜结构。这些装置还包括设置在体内分析物传感器的工作电极上的感测层，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

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