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41. 发明申请

US20050059144A1 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US20050059144A1
公开(公告)日：2005-03-17
申请号：US10903213
申请日：2004-07-29
申请人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
发明人： Susan Webb , Ola Winqvist , Lars Karlsson , Michael Jackson , Per Peterson
IPC分类号： C12N15/09 , A61K31/00 , A61K35/26 , A61K38/00 , A61K39/00 , A61K48/00 , A61P3/00 , A61P3/10 , A61P21/00 , A61P21/04 , A61P37/00 , A61P37/04 , A61P37/08 , C07K14/705 , C12N5/07 , C12N5/10 , C12N15/12 , C12N5/06 , C12N5/08
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

42. 发明授权

US06803362B2 Heterocyclic compounds 有权
标题翻译：杂环化合物
公开(公告)号：US06803362B2
公开(公告)日：2004-10-12
申请号：US10094357
申请日：2002-03-08
申请人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas I. Carruthers , Wenying Chai , Curt A. Dvorak , James P. Edwards , Cheryl A. Grice , Jill A. Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer D. Kreisberg , Annette K. Kwok , Timothy W. Lovenberg , Kiev S. Ly , Barbara Pio , Chandravadan R. Shah , Siguan Sun , Robin L. Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： A61K3133
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译：杂环化合物及其制备方法和使用方法。

43. 发明授权

US06319562B1 Method for powder coating the surface of heat sensitive objects 失效
标题翻译：粉末涂覆热敏物体表面的方法
公开(公告)号：US06319562B1
公开(公告)日：2001-11-20
申请号：US09543999
申请日：2000-04-06
申请人： Håkan Arvérus , Lars Karlsson , Jaan Kärem , Maria Strid
发明人： Håkan Arvérus , Lars Karlsson , Jaan Kärem , Maria Strid
IPC分类号： B05D106
CPC分类号： B05D3/0218 , B05D1/06 , B05D3/0209 , B05D3/067
摘要： Method and plant for powder coating the surfaces of objects with polymeric powder having a melting and softening temperature near 100° C., said polymeric powder includes a polymer curable under the influence of electromagnetic radiation, the method including a first step in which the objects to be coated are prepared to retain powder charged with static electricity; a second step in which the objects are sprayed with powder charged with static electricity; a third step in which the objects are heated to a surface temperature of about 100° C. thereby melting the powder retained on the surfaces by being expose the objects to infrared radiation and heated air; a fourth step in which the objects are radiated by electromagnetic radiation for initiating of curing of the powder melted to reflow over the surfaces of the objects, the objects simultaneous with the radiation being cooled.
摘要翻译：所述聚合物粉末包括在电磁辐射的影响下可固化的聚合物粉末，所述聚合物粉末包括熔融和软化温度接近100℃的聚合物粉末涂覆物体表面的方法和设备，所述方法包括第一步骤，准备涂层以保持带静电的粉末; 第二步，用静电粉末喷涂物体; 第三步骤，将物体加热至约100℃的表面温度，从而通过将物体暴露于红外辐射和加热空气来熔化保留在表面上的粉末; 第四步，其中物体被电磁辐射辐射，用于引发熔化的物料的固化，以在物体表面上回流，物体与被冷却的辐射同时进行。

44. 发明授权

US6002066A H2-M modified transgenic mice 失效
标题翻译： H2-M修饰的转基因小鼠
公开(公告)号：US6002066A
公开(公告)日：1999-12-14
申请号：US780949
申请日：1997-01-10
申请人： Wai-Ping Leung , Lars Karlsson , Lubing Zhou , Per A. Peterson
发明人： Wai-Ping Leung , Lars Karlsson , Lubing Zhou , Per A. Peterson
IPC分类号： A01K67/027 , C07K14/74 , C12N5/10 , C12N15/09 , C12N15/85 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C12N15/8509 , A01K67/0276 , C07K14/70539 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0368 , A01K2267/0381
摘要： A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.
摘要翻译：通过将改变的H2-Ma基因引入宿主小鼠中制备具有H2-Ma基因改变的转基因小鼠。所得转基因小鼠不产生功能性H2-M分子。

45. 发明授权

US5160258A Device at a heat treatment oven 失效
标题翻译：设备在热处理炉
公开(公告)号：US5160258A
公开(公告)日：1992-11-03
申请号：US588347
申请日：1990-09-26
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： F24C3/02 , F24C15/32
CPC分类号： F24C15/322
摘要： A device at a heat treatment oven of the type using a combination of radiation heat and convection heat, and where in connection to the oven chamber are provided means (4, 19) arranged to circulate the oven atmosphere through the oven chamber and a channel (20, 21) situated outside the oven chamber and back to the oven chamber, whereby the device incorporates a gas burner (7) arranged at combustion to emit its flame in a direction, which at least partly touches or coincides with the circulation channel (20, 21) for the oven atmosphere, and where the gas burner (7) is arranged to direct its flame into a vessel (22), provided in the circulation channel (20, 21) for the circulating atmosphere.
摘要翻译：设置在使用辐射热和对流热的组合的类型的热处理炉中的装置，并且其中连接到烘箱室的装置设置成使得烘箱气氛循环通过烤箱室和通道（4,19） 20,21），其位于烤箱室外部并返回到烘箱室，由此该装置包括燃烧器（7），该气体燃烧器（7）布置在燃烧时以沿着与循环通道（20）至少部分接触或重合的方向发射其火焰，21），并且其中气体燃烧器（7）布置成将其火焰引导到设置在用于循环气氛的循环通道（20,21）中的容器（22）中。

46. 发明授权

US09157983B2 Method for real-time, automatic, wideband, high accuracy RF direction finding 有权
标题翻译：实时，自动，宽带，高精度RF方向发现的方法
公开(公告)号：US09157983B2
公开(公告)日：2015-10-13
申请号：US13653476
申请日：2012-10-17
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： G01S5/02 , G01S3/74
CPC分类号： G01S3/74
摘要： This system and method provides a direction finding system that enables modern RF DF systems to analyze short duration signals in the entire instantaneous bandwidth. By providing a method to process wideband data, the invention drastically improves throughput and probability of intercept (POI). The invention is unique in that it does not require separate narrowband channels for analysis, and can simultaneously calculate azimuth and elevation estimates for every frequency in the bandwidth of an incident signal. It is also well-suited for fixed point, FPGA implementations making it a perfect match for modern state-of-the-art processing systems. The system and method capitalizes on the ability of Fourier Frequency Transform operations to accurately resolve incident wave phase at discrete frequencies. The system then uses the phase information from the individual elements in the array to arrive at an emitter azimuth angle. The azimuth angle is nearly simultaneously used in concert with lookup tables of all possible elevation angles to compare the arrival time delay between the array elements to determine emitter elevation angle.
摘要翻译：该系统和方法提供了一种方向发现系统，其使得现代RF DF系统能够在整个瞬时带宽中分析短持续时间信号。通过提供处理宽带数据的方法，本发明大大提高了吞吐量和拦截概率（POI）。本发明是独特的，因为它不需要单独的窄带信道用于分析，并且可以同时计算入射信号带宽中每个频率的方位角和高程估计。它也非常适合固定点，FPGA实现使其成为现代最先进的处理系统的完美匹配。该系统和方法利用傅里叶频率变换操作精确地解决离散频率入射波相位的能力。然后，系统使用来自阵列中的各个元件的相位信息来达到发射器方位角。方位角几乎同时用于所有可能仰角的查找表，以比较阵列元件之间的到达时间延迟，以确定发射器仰角。

47. 发明申请

US20110010060A1 METHOD AND DEVICE FOR AUTOMATIC OR SEMIAUTOMATIC SELECTION OF A BETTER STARTING GEAR IN A VEHICLE 有权
标题翻译：用于自动或半自动选择车辆中更好的起动齿轮的方法和装置
公开(公告)号：US20110010060A1
公开(公告)日：2011-01-13
申请号：US12919824
申请日：2008-02-28
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： F16H59/68
CPC分类号： F16H61/0213 , B60T7/12 , B60T7/122 , B60T2201/06 , F16H59/66 , F16H2061/023
摘要： Method and a device for automatic selection of a better starting gear in a vehicle, including the steps of engaging a first starting gear, on driver demand controlling propulsion torque as to attempt to achieve a first take off, if the first starting gear is too high interrupting the first take off and automatically braking the vehicle, engaging a second adapted starting gear which is a lower gear compared to the first starting gear, controlling propulsion torque as to attempt to achieve a second vehicle take off, and if the second vehicle take off attempt results in a transmitting of torque to driven wheels of the vehicle being enough as to perform a take off then stop braking the vehicle. An incorrectly selected starting gear can thus be automatically changed. The starting gear change can be performed in an uphill situation.
摘要翻译：一种用于自动选择车辆起动装置的方法和装置，包括如下步骤：如果第一起动档位太高则包括使驾驶员需求控制推进转矩达到首次起飞的步骤中断第一次起飞并自动制动车辆，与第一起动齿轮相比接合作为下齿轮的第二适配起动齿轮，控制推进转矩以试图实现第二车辆起飞，以及如果第二车辆起飞导致对车辆的从动轮的扭矩的传递足以执行起飞，然后停止制动车辆。因此，可能会自动更改错误选择的起动档位。启动变速可以在上坡的情况下进行。

48. 发明申请

US20090243818A1 Method and apparatus for detecting the presence and locations of radio controlled improvised explosive devices in real time 失效
标题翻译：用于实时检测无线电控制的简易爆炸装置的存在和位置的方法和装置
公开(公告)号：US20090243818A1
公开(公告)日：2009-10-01
申请号：US11332801
申请日：2006-01-12
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： B60Q1/00 , H04B1/18 , H04L27/00
CPC分类号： H04K3/92 , H04K3/45 , H04K3/65 , H04K2203/24
摘要： A Method and Apparatus for Detecting the Presence and Locations of Radio Controlled Improvised Explosive Devices in Real Time. The system will clandestinely detect the presence and location of RCIED's along roadways in real time. This “RCIED Street Sweeper” system consequently allows its users to remove the explosive devices, pre-detonate them, or simply avoid the location so that the weapons cannot be used against a convoy or other important target. The system has the abilities (disclosed in U.S. patent application Ser. No. 10/829,858) to conduct fast wideband scanning of the RF spectrum looking for ambient RF signals as well as RCIED leakage signals. Furthermore the system has the ability to correlate the received leakage signals with the ambient RF signal environment, in order to verify authenticity. Still further, the system has the ability to continually mark and record the precise map location where each of those RF spectrum measurements emanated, including the relative distances between them. Still further, the preferred system will calculate adjusted curve profiles given the real time distance data. Fifth, the preferred system needs to have the ability to correlate sets of trend data with the adjusted curve profiles to determine matches. Further yet, the system alerts the vehicle driver to the presence and location of any RCIED that is detected by the system. Finally, the system is capable of being installed in a low profile, clandestine manner on a mobile platform such as a car or truck, so as not to alert insurgents of its existence.
摘要翻译：一种用于实时检测无线电控制的简易爆炸装置的存在和位置的方法和装置。该系统将秘密地检测RCIED在路面上的存在和位置。因此，这个“RCIED街道清扫车”系统允许其用户拆除爆炸装置，预先引爆它们，或者简单地避免位置使武器不能用于对抗车队或其他重要的目标。该系统具有能力（在美国专利申请No.10 / 829,858中公开），以进行RF频谱的快速宽带扫描，寻找环境RF信号以及RCIED泄漏信号。此外，系统具有将接收到的泄漏信号与环境RF信号环境相关联的能力，以便验证真实性。此外，系统具有连续地标记和记录发出这些RF频谱测量中的每一个的精确地图位置的能力，包括它们之间的相对距离。此外，优选的系统将计算给定实时距离数据的经调整的曲线曲线。第五，首选系统需要具有将趋势数据集与调整后的曲线特征相关联以确定匹配的能力。此外，系统向车辆驾驶员警告系统检测到的任何RCIED的存在和位置。最后，该系统能够在移动平台（如汽车或卡车）上以低调，秘密的方式安装，以免警告叛乱分子的存在。

49. 发明申请

US20080269994A1 Selective Anti-Lock Braking System 有权
标题翻译：选择性防抱死制动系统
公开(公告)号：US20080269994A1
公开(公告)日：2008-10-30
申请号：US12066272
申请日：2006-09-08
申请人： Svante Karlsson , Lars Karlsson , Sixten Berglund
发明人： Svante Karlsson , Lars Karlsson , Sixten Berglund
IPC分类号： B60W10/02 , B60W10/18 , B60W30/02
CPC分类号： B60T8/17616 , B60T2201/04 , B60T2260/04 , B60W10/11 , B60W10/184 , B60W30/18118 , B60W2520/26 , B60W2530/10 , B60W2550/142 , B60Y2200/14
摘要： Automatic mechanical transmission system for a vehicle with antilock braking which is configured to selectively decouple the drive train of the vehicle from the wheels of the vehicle. The system includes a first sensor for sensing at least one operational state of the vehicle, a second sensor for sensing a wheel-lock up condition of the vehicle, and a logic control unit. The logic control unit is configured to receive signals from the first and second sensors. When the first sensor communicates a first predetermined operational state of the vehicle and the second sensor communicates a wheel-lockup condition, the logic unit directs disengagement of the drive train from the wheels. Alternatively, when a second predetermined operational state of the vehicle and wheel lock-up condition is communicated, the logic control unit directs engagement of the drive train and the wheels.
摘要翻译：用于具有防抱死制动的车辆的自动机械传动系统，其被配置为选择性地将车辆的传动系与车辆的车轮分离。该系统包括用于感测车辆的至少一个操作状态的第一传感器，用于感测车辆的车轮锁定状态的第二传感器和逻辑控制单元。逻辑控制单元被配置为从第一和第二传感器接收信号。当第一传感器通信车辆的第一预定操作状态并且第二传感器传达车轮锁定状态时，逻辑单元引导传动系与轮的分离。或者，当通信车辆和车轮锁定状态的第二预定操作状态时，逻辑控制单元引导传动系和车轮的接合。

50. 发明授权

US07439335B2 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US07439335B2
公开(公告)日：2008-10-21
申请号：US10822173
申请日：2004-04-08
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N5/00 , C07K14/74
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，以及将正在进行的激活状态转移到Th1或Th2细胞的优选的分化群体中。

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