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    • 42. 发明授权
    • Synthetic elastomeric insoluble cross-linked polypentapeptide
    • 合成弹性不溶性交联多肽
    • US4132746A
    • 1979-01-02
    • US704088
    • 1976-07-09
    • Dan W. UrryKouji Okamoto
    • Dan W. UrryKouji Okamoto
    • A61F2/06A61L27/22C08G69/10
    • A61L27/227A61F2/06C08G69/10
    • An insoluble cross-linked polypentapeptide is totally synthesized by preparing two modified linear polypentapeptides patterned on the polypentapeptide from the pentapeptide (Val.sub.1 -Pro.sub.2 -Gly.sub.3 -Val.sub.4 -Gly.sub.5) one of the repeating peptide sequences contained in tropoelastin, the precursor protein of the core of the elastic fiber of the vascular wall, and by cross-linking the modified polypentapeptides. One of the intermediate polypentapeptides is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one amino function and the other is modified by replacing a portion of at least one of the amino acid residues with the residue of an amino acid having more than one carboxyl function, to provide free amino groups on the one intermediate and free carboxyl groups on the other for interreaction in the presence of a suitable cross-linking agent.The resulting cross-linked insoluble polypentapeptide is elastomeric in nature and capable of calcification by withdrawing calcium ions from a serum medium, thus making it useful as a calcifiable matrix for the formation of an artificial bone structure. The calcifiable material can be treated to make it useful in artificial vascular wall formation.
    • 不溶性交联的多肽通过制备在五肽(Val1-Pro2-Gly3-Val4-Gly5)的多肽上图案化的两种修饰的线性多肽,其是复合蛋白质中的一个重复肽序列,核心的前体蛋白 血管壁的弹性纤维,以及交联改性的多肽。 通过用至少一个氨基酸残基替换一部分氨基酸具有多于一个氨基功能的氨基酸的残基,修饰其中之一,另一个通过将一部分至少一个氨基酸 具有多于一个羧基官能团的氨基酸残基的残基,在一个中间体上提供游离氨基,在另一个中间提供游离羧基,并在合适的交联剂存在下进行相互作用。
    • 44. 发明授权
    • Phase comparator and reproduction signal processor using the same
    • 相位比较器和再现信号处理器使用相同
    • US08188795B2
    • 2012-05-29
    • US12439966
    • 2008-07-08
    • Kouji OkamotoKouhei Nakata
    • Kouji OkamotoKouhei Nakata
    • H03L7/00G11B5/09
    • G11B20/1403G11B20/10009G11B20/10046G11B20/10222G11B20/10425G11B2220/2562
    • In a synchronous reproduction signal processor, when a phase error between reproduction data and a clock is repeatedly detected such that a clock synchronized with a reproduction signal is generated based on the phase error, a filtering process unit (34) performs a filtering process which performs a weighed addition with respect to a phase error series prior to the current time from a phase error calculation unit (33) using, e.g., a FIR filter with a plurality of taps so as to generate a reference value under reduced influence of noise mixed in the phase error series by feedback correction. A cross detection unit (32) detects the timing with which the sampled reproduction data crosses the reference value generated by the filtering process unit (34). This allows effective use of the dynamic range of the feedbacked reference value without limiting it, and simultaneously achieves the enhancement of noise immunity.
    • 在同步再现信号处理器中,当重复检测再现数据和时钟之间的相位误差,从而基于相位误差产生与再现信号同步的时钟时,滤波处理单元(34)执行滤波处理 相对于来自相位误差计算单元(33)的当前时间之前的相位误差系列的加权加法,其使用例如具有多个抽头的FIR滤波器,以便在减少的混合噪声的影响下产生参考值 相位误差系列通过反馈校正。 交叉检测单元(32)检测采样再现数据与由滤波处理单元(34)生成的参考值相交的定时。 这允许有效地使用反馈参考值的动态范围而不限制它,并且同时实现抗噪声的增强。
    • 48. 发明申请
    • Water-Soluble Elastin, Process For Producing Same, And Food And Medicine Containing Same
    • 水溶性弹性蛋白,生产方法,含有相同的食品和药物
    • US20080096812A1
    • 2008-04-24
    • US11666443
    • 2005-10-27
    • Kouji OkamotoHiroshi YamadaIori Maeda
    • Kouji OkamotoHiroshi YamadaIori Maeda
    • A61K38/39C07K14/78C07K1/14A61P9/10A61P7/02A23J1/00
    • C07K14/78A61K38/00
    • A low-molecular-weight water-soluble elastin having a molecular weight of about 10,000 to 30,000 and a high-molecular-weight water-soluble elastin having a molecular weight of about 30,000 to 300,000 are provided, 79% to 84% of the constituent amino acids of the elastin comprising proline, glycine, alanine, and valine, 2% to 3% comprising aspartic acid and glutamic acid, 0.7% to 1.3% comprising lysine, histidine, and arginine, and 0.2% to 0.4% comprising desmosine and isodesmosine. The low-molecular-weight water-soluble elastin that is obtained may be used in a functional food or a medicine. Such a high-purity water-soluble elastin may be produced by obtaining pure insoluble elastin by subjecting animal body tissue to a collagen removal treatment and then fragmenting the insoluble elastin by means of a solubilizing liquid. It may be produced simply, merely by adjusting the concentration of an alkaline solution and the reaction time without recovering insoluble elastin from the animal body tissue.
    • 提供分子量约为10,000至30,000的低分子量水溶性弹性蛋白和分子量为约30,000至300,000的高分子量水溶性弹性蛋白,79%至84%的成分 包含脯氨酸,甘氨酸,丙氨酸和缬氨酸的弹性蛋白的氨基酸,包含天冬氨酸和谷氨酸的2%至3%,包含赖氨酸,组氨酸和精氨酸的0.7%至1.3%的氨基酸,以及包含去肌氨酸和异丝氨酸的0.2%至0.4% 。 获得的低分子量水溶性弹性蛋白可以用于功能性食品或药物中。 这样的高纯度水溶性弹性蛋白可以通过使动物体组织进行胶原去除处理,然后利用增溶液使不溶性弹性蛋白破碎而获得纯不溶性弹性蛋白来制造。 仅通过调节碱性溶液的浓度和反应时间就可以简单地制备,而不从动物体组织中回收不溶性弹性蛋白。
    • 49. 发明授权
    • Wobble signal processing apparatus
    • 摆动信号处理装置
    • US07327658B2
    • 2008-02-05
    • US10722397
    • 2003-11-28
    • Hiroki MouriKouji OkamotoYouichi Ogura
    • Hiroki MouriKouji OkamotoYouichi Ogura
    • G11B7/00
    • G11B7/0053
    • The present invention is made to improve the conventional analog processing that is easily affected by variations in semiconductor processing. This invention provides a wobble signal processing apparatus that can reduce the circuit scale and the power consumption as well as improve the quality of signal processing. The wobble signal processing apparatus of the present invention digitally processes a part that has conventionally been processed by an analog system, and a PRML circuit is further provided to implement error detection, whereby the circuit scale and the power consumption is reduced. This improves the detection of a signal that is inputted to the wobble signal processing apparatus.
    • 本发明是为了改进容易受半导体处理变化影响的常规模拟处理。 本发明提供一种可以减小电路规模和功耗以及提高信号处理质量的摆动信号处理装置。 本发明的摆动信号处理装置对传统上由模拟系统处理的部分进行数字处理,并且进一步提供PRML电路以实现错误检测,由此降低了电路规模和功耗。 这改善了输入到摆动信号处理装置的信号的检测。