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41. 发明授权

US06887371B2 System for automated separation of fluid components 有权
标题翻译：液体组分自动分离系统
公开(公告)号：US06887371B2
公开(公告)日：2005-05-03
申请号：US10396871
申请日：2003-03-25
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： A61M1/36 , B01D17/038 , B04B5/04 , B04B9/10 , B04B11/04 , B04B13/00 , B01D17/12
CPC分类号： B04B13/00 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , B04B5/0442 , B04B9/10 , B04B11/04 , B04B2005/045
摘要： A system for automated operation of a blood separation system controlling the input of blood samples, the separation of blood components, and the discharge of the components. The system includes a blood reservoir and centrifuge for receiving blood samples and separating the blood components. A sensor determines when adequate separation has been achieved and a controller receives signals from the sensor to operate a centrifuge drive assembly to achieve desired separation. Separation may be based on a calibrated rotation time for the centrifuge as measured by a timer. An input pump pumps blood samples to the blood reservoir, and an outlet pump removes separated samples from the blood reservoir. The inlet and outlet pumps are operated by the controller, and the inlet pump may be operated to discharge separated components not collected by the blood separation system, whereby additional sample volume is added for ongoing operation.
摘要翻译：一种用于自动操作血液分离系统的系统，其控制血液样品的输入，血液成分的分离以及组分的排出。该系统包括用于接收血液样品并分离血液成分的血液储存器和离心机。传感器确定何时实现了足够的分离，并且控制器从传感器接收信号以操作离心机驱动组件以实现期望的分离。分离可以基于由定时器测量的离心机的校准旋转时间。输入泵将血液样本泵送到血液储存器，并且出口泵从血液储存器中移除分离的样品。入口和出口泵由控制器操作，并且入口泵可以被操作以排出未被血液分离系统收集的分离的组分，由此添加另外的样品体积用于正在进行的操作。

42. 发明授权

US06764460B2 Extracorporeal blood processing system 有权
标题翻译：体外血液处理系统
公开(公告)号：US06764460B2
公开(公告)日：2004-07-20
申请号：US09911955
申请日：2001-07-24
申请人： Victor D. Dolecek , John J. Kappus , Mark Joseph Brierton
发明人： Victor D. Dolecek , John J. Kappus , Mark Joseph Brierton
IPC分类号： A61M3700
CPC分类号： A61M1/3624 , A61M1/3639 , A61M1/3641 , A61M1/3652 , A61M1/3693 , A61M1/3696 , A61M2205/12 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system including a disposable assembly that has integral fluid passageways. A blood removal conduit and a blood return conduit are interconnected with the integral fluid passageways. A diaphragm is mounted in the disposable assembly and is removably attachable to a sensor via a number of connection devices. In one embodiment, the sensor may include a transducer that is capable of measuring the force exerted on the diaphragm. The corresponding force may be correlated to a pressure of fluid in either the blood removal conduit and/or the blood return conduit.
摘要翻译：一种体外血液处理系统，包括具有整体流体通道的一次性组件。除血管道和血液回流管道与整体流体通道相互连接。隔膜安装在一次性组件中，并通过多个连接装置可移除地附接到传感器。在一个实施例中，传感器可以包括能够测量施加在隔膜上的力的换能器。相应的力可以与除血导管和/或血液返回导管中的流体的压力相关。

43. 发明授权

US06605028B2 Blood centrifuge having integral heating to control cellular component temperature 失效
公开(公告)号：US06605028B2
公开(公告)日：2003-08-12
申请号：US09832516
申请日：2001-04-09
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： B04B1502
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , B04B5/0442 , B04B15/02 , B04B2005/045
摘要： A centrifuge system with a temperature control system for controlling the temperature of fractions removed or output from the centrifuge to a collection chamber. In one embodiment, the centrifuge system provides an integral heater element operable by a temperature controller to control the temperature of the collection chamber or dispenser assembly. A temperature sensor is provided to allow the temperature controller to accurately monitor the temperature of the fraction held in chambers or syringes in the dispenser assembly. In a more particular embodiment, the centrifuge system is utilized to separate and extract platelets from blood samples. The heater element is positioned adjacent collection syringes in the dispenser assembly and selectively operated to maintain the temperature of the platelets in the collection syringes within an activation temperature range to activate the platelets and facilitate creation of autologous platelet gel.

44. 发明授权

US06589155B2 Miniaturized blood centrifuge having side mounted motor with belt drive 失效
公开(公告)号：US06589155B2
公开(公告)日：2003-07-08
申请号：US09833232
申请日：2001-04-09
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： B04B910
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2205/331 , A61M2205/3368 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： A belt-driven blood centrifuge with side-mounted drive motor for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly rotated at an input rotation speed and a rotor assembly rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt, a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell of the drive shaft assembly. A base is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.

45. 发明授权

US5720716A Extracorporeal blood processing methods and apparatus 失效
公开(公告)号：US5720716A
公开(公告)日：1998-02-24
申请号：US504049
申请日：1995-06-07
申请人： Jeffrey J. Blakeslee , Brian M. Holmes , Victor D. Dolecek
发明人： Jeffrey J. Blakeslee , Brian M. Holmes , Victor D. Dolecek
IPC分类号： A61M1/36 , B04B5/04 , B04B9/08 , A61M37/00
CPC分类号： B04B5/0442 , A61M1/3624 , A61M1/3639 , A61M1/3652 , A61M1/3693 , A61M1/3696 , B04B9/08 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

46. 发明授权

US09028388B2 Multi-unit blood processor with volume prediction 有权
标题翻译：多单位血液处理器具有体积预测
公开(公告)号：US09028388B2
公开(公告)日：2015-05-12
申请号：US13102728
申请日：2011-05-06
申请人： Victor D. Dolecek , Darryl Hudock
发明人： Victor D. Dolecek , Darryl Hudock
IPC分类号： B04B5/04 , B04B11/00 , A61M1/36 , B04B13/00
CPC分类号： A61M1/0209 , A61M1/0272 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/3331 , A61M2205/3379 , B01D21/262 , B04B5/02 , B04B5/0428 , B04B5/0442 , B04B7/00 , B04B11/00 , B04B2013/006
摘要： Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
摘要翻译：用于通过从感测到的压力预测复合流体的体积并预测其它分离组分的体积从感测到的其它组分移动到收集袋来预测从复合流体分离的组分的体积的方法和装置。

47. 发明授权

US08840535B2 Multi-unit blood processor with temperature sensing 有权
标题翻译：具有温度感测功能的多单元血液处理器
公开(公告)号：US08840535B2
公开(公告)日：2014-09-23
申请号：US13093999
申请日：2011-04-26
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： B04B13/00 , A61M1/36 , B04B15/02 , B04B5/04 , A61M1/02
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M1/3698 , A61M2205/3306 , A61M2205/3368 , A61M2205/3606 , B04B5/0428 , B04B13/00 , B04B15/00 , B04B15/02
摘要： Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded. If the temperature of any of the units exceeds a pre-determined maximum, portions of the blood separation device may be cooled. A controller may determine which of the units to process first, generally proceeding from the warmest unit to the coolest. The order of unit processing may be changed during processing. The detected temperature may be used to calibrate a pressure sensor used to predict the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.
摘要翻译：用于离心血液成分分离的方法和装置，包括在多个分离单元中的每一个中的温度感测。记录随时间变化的血液单位温度。如果任何单元的温度超过预定的最大值，则可以冷却血液分离装置的部分。控制器可以确定首先处理哪些单元，通常从最暖的单元进行到最冷的单元。处理过程中可能会改变单位处理顺序。检测到的温度可用于校准用于预测从复合流体分离的组分的体积的压力传感器，其通过从感测到的压力预测复合流体的体积并预测其它分离组分的体积与其它组分的感测运动收集袋子。

48. 发明申请

US20090294383A1 Flexible centrifuge bag and methods of use 有权
标题翻译：灵活的离心机袋及使用方法
公开(公告)号：US20090294383A1
公开(公告)日：2009-12-03
申请号：US12454839
申请日：2009-05-21
申请人： Victor D. Dolecek , David Malcolm
发明人： Victor D. Dolecek , David Malcolm
IPC分类号： B01D21/26
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M2202/0423 , B04B2005/045
摘要： A flexible, disposable centrifuge bag for receiving and holding a fluid sample, comprising one or more tubes and upper and lower flexible sheets having doughnut shaped configurations. The upper and lower sheets are superimposed and completely sealed together at their outer perimeters to define an outer perimeter of the centrifuge bag. The inner perimeter of the bag defines a central core. The tubes are sandwiched between the upper and lower sheets and extend from the central core of the centrifuge bag. The upper and lower sheets are sealed together at their inner perimeters such that the tubes are sealed between said upper and lower sheets at the inner perimeter. The bag may be used to harvest platelet rich plasma from whole blood in either a batch method or while simultaneously infusing additional aliquots of whole blood into the bag during centrifugation.
摘要翻译：一种用于接收和保持流体样品的柔性一次性离心机袋，包括一个或多个管和具有环形构型的上下柔性片。上片和下片在其外周叠加并完全密封在一起以限定离心机袋的外周。袋的内周界定中心芯。管夹在上下片之间并从离心机袋的中心芯延伸。上下板在其内周边密封在一起，使得管在内周边处密封在所述上板和下板之间。该袋可以用于以批量方法从全血中收集富含血小板的血浆，或者在离心过程中同时将额外的全血量等分进入袋中。

49. 发明授权

US07252758B2 Centrifuge system utilizing disposable components and automated processing of blood to collect platelet rich plasma 有权
公开(公告)号：US07252758B2
公开(公告)日：2007-08-07
申请号：US11271434
申请日：2005-11-10
申请人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
发明人： Victor D. Dolecek , Gary L. Berg , Kenneth E. Merte , David Malcolm , Kevin D. McIntosh , Vitaly G. Sitko
IPC分类号： C02F1/38
CPC分类号： A61M1/3693 , A61M1/1081 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2205/331 , B04B5/0442 , B04B7/02 , B04B13/00 , A61M2202/0092
摘要： A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

50. 发明授权

US06942880B1 Autologous platelet gel having beneficial geometric shapes and methods of making the same 有权
标题翻译：具有有益的几何形状的自体血小板凝胶及其制造方法
公开(公告)号：US06942880B1
公开(公告)日：2005-09-13
申请号：US09832518
申请日：2001-04-09
申请人： Victor D. Dolecek
发明人： Victor D. Dolecek
IPC分类号： A61L24/00 , A61L26/00 , A61M1/36 , A51K35/14
CPC分类号： A61L26/0057 , A61L24/0005 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2205/331
摘要： The present invention relates to the production of platelet gels formed into beneficial geometric shapes. Specifically the present invention provides a simpler way to introduce platelet gel for specific uses, such as into the cavity of a gum left after a tooth extraction. Molds of predetermined shapes are provided for forming the desired shape.
摘要翻译：本发明涉及形成有益几何形状的血小板凝胶的制备。具体地说，本发明提供了一种简单的方法来引入用于特定用途的血小板凝胶，例如在拔牙后留下的口香糖。提供预定形状的模具以形成所需的形状。

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