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41. 发明授权

US08795664B2 Monoclonal antibodies targeting amyloid beta oligomers 有权
标题翻译：针对淀粉样β寡聚体的单克隆抗体
公开(公告)号：US08795664B2
公开(公告)日：2014-08-05
申请号：US13701758
申请日：2011-06-03
申请人： Thomas Bayer , Oliver Wirths , Henrik Martens , Christian Erck
发明人： Thomas Bayer , Oliver Wirths , Henrik Martens , Christian Erck
IPC分类号： A61K39/395 , C07K16/18 , C12N5/20
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/32 , C07K2317/33 , C07K2317/76
摘要： The invention relates to binding molecules capable of specifically recognizing soluble oligomers of N-terminal truncated Aβ starting with pyroglutamate (AβρE), pharmaceutical compositions comprising same, and their respective therapeutic uses. Particularly, the invention relates to an antibody molecule capable of specifically recognizing Aβ oligomers, wherein said antibody binds and/or detects an epitope as bound and/or detected by antibody PG3-38 9D5H6 as deposited under DSM AC-C3056. Further, the invention provides a method of inhibiting the formation or the seeding effect of said AβρE oligomers, and a method for identifying agents useful in the treatment and/or prevention of an amyloid-related disorder as well as methods of diagnosing a subject suspected of suffering from a disease associated with amyloidogenesis and/or amyloid plaque formation and to methods of monitoring the efficacy of a treatment of a disease associated with amyloidogenesis and/or amyloid-plaque formation characterized by the presence of Aβ oligomers in a subject.
摘要翻译：本发明涉及能够特异性识别N-末端截短的A和Bgr的可溶性低聚物的结合分子; 由焦谷氨酸（A＆Bgr; E）开始，包含其的药物组合物及其各自的治疗用途。特别地，本发明涉及能够特异性识别A＆bgr的抗体分子; 寡聚体，其中所述抗体结合和/或检测由DSM AC-C3056沉积的抗体PG3-38 9D5H6结合和/或检测的表位。此外，本发明提供了抑制所述Aβ和β-寡聚体的形成或播种作用的方法，以及用于鉴定可用于治疗和/或预防淀粉样蛋白相关病症的药剂的方法以及诊断方法怀疑患有与淀粉样变性和/或淀粉样蛋白斑形成相关的疾病的受试者以及监测与淀粉样变性和/或淀粉样蛋白斑形成有关的疾病的治疗功效的方法，其特征在于存在Aβ和B淀粉样蛋白。受试者中的寡聚体。

42. 发明授权

US08258926B2 Method for automatically checking in passengers and their luggage 有权
标题翻译：自动检查乘客及其行李的方法
公开(公告)号：US08258926B2
公开(公告)日：2012-09-04
申请号：US12469999
申请日：2009-05-21
申请人： Thomas Bayer , Balthazar-Simon Ten Berge , Wolf-Stephan Wilke
发明人： Thomas Bayer , Balthazar-Simon Ten Berge , Wolf-Stephan Wilke
IPC分类号： H04Q5/22
CPC分类号： G07C9/00111 , B64F1/366 , G06Q10/08 , G06Q50/30
摘要： A method for automatically checking in passengers and their luggage by an electronic input of the passenger data or travel data by the passenger himself into an automatic check-in terminal is provided. In the automatic check-in terminal, possibly following selection of various criteria, the boarding pass and one or more information media for attachment to the luggage are created and output. The information medium created is a luggage tag which is easy to affix to the luggage item and which contains, in machine-readable form, at least all the data and information which are required for a later generation of an internationally standardized, preferably self-adhesive luggage band which is affixed to the luggage item within a conveying and sorting system in addition to the luggage tag.
摘要翻译：提供了一种通过乘客自身的电子输入或乘客自身的旅行数据自动检查乘客及其行李的方法，该自动登机终端。在自动登机终端中，可能在选择各种标准之后，建立并输出登机牌和用于附着到行李的一个或多个信息介质。所创建的信息介质是容易粘贴到行李件的行李标签，并且以机器可读形式包含至少所有数据和信息，这些数据和信息为后来产生国际标准化，优选自粘性所需的所有数据和信息行李带除了行李标签之外，还贴在行李箱内的运输和分拣系统内。

43. 发明申请

US20110259144A1 GEARING 有权
标题翻译：齿轮
公开(公告)号：US20110259144A1
公开(公告)日：2011-10-27
申请号：US13073572
申请日：2011-03-28
申请人： Frank Michel , Michael Schmidt , Thomas Bayer , Heiko Schreiber , Lars Estermann
发明人： Frank Michel , Michael Schmidt , Thomas Bayer , Heiko Schreiber , Lars Estermann
IPC分类号： F16H35/00
CPC分类号： F16H25/06
摘要： Gearing (1), in particular single-stage gearing having a transmission ratio of greater than 1 to 10, having an internal gear (2) with an internal toothing (5), a first toothed ring with radially movable first teeth (6) for engaging into the internal toothing (5), a second toothed ring with radially movable second teeth (7) for engaging into the internal toothing (5), an inner shaft (21) on which is fastened a first cam disk (16) for the radial drive of the first teeth (6) and a second cam disk (17) for the radial drive of the second teeth (7), and a load dividing device for dividing a torque transmitted via the toothed rings between the toothed rings.
摘要翻译：齿轮（1），特别是具有大于1至10的传动比的单级传动装置，具有带内齿轮（5）的内齿轮（2），具有可径向移动的第一齿（6）的第一齿环，用于接合到所述内齿（5）中的第二齿环，具有用于接合到所述内齿（5）中的径向可移动的第二齿（7）的第二齿环，内轴（21），紧固在所述内齿轮（21）上的第一凸轮盘第一齿（6）的径向驱动和用于第二齿（7）的径向驱动的第二凸轮盘（17），以及负载分配装置，用于分割通过齿环之间的齿环传递的扭矩。

44. 发明申请

US20100130324A1 COAXIAL TRANSMISSION 有权
标题翻译：同轴传输
公开(公告)号：US20100130324A1
公开(公告)日：2010-05-27
申请号：US12597538
申请日：2008-04-14
申请人： Thomas Wilhelm , Michael Schmidt , Thomas Bayer
发明人： Thomas Wilhelm , Michael Schmidt , Thomas Bayer
IPC分类号： F16H37/02 , F16H49/00
CPC分类号： F16H25/06 , Y10T74/19
摘要： A coaxial transmission, especially a hollow shaft drive, comprising a driving element (7) and a driven element (3), a plurality of radially mobile toothed quadrants (5) providing a gear ratio and transmitting a driving torque between the driving element (7) and the driven element (3). An internal gear (1) or especially the housing for receiving the inner gearing of the internal gear (13) are configured as a multipart structure.
摘要翻译：包括驱动元件（7）和从动元件（3）的同轴传动装置，特别是空心轴驱动器，多个径向移动的齿形齿条（5），提供传动比并在驱动元件（7））和从动元件（3）。内部齿轮（1）或特别是用于接收内齿轮（13）的内齿轮的壳体被配置为多部分结构。

45. 发明申请

US20090205451A1 GEARING 有权
标题翻译：齿轮
公开(公告)号：US20090205451A1
公开(公告)日：2009-08-20
申请号：US12439049
申请日：2007-07-27
申请人： Thomas Bayer , Michael Schmidt
发明人： Thomas Bayer , Michael Schmidt
IPC分类号： F16H49/00 , F16H35/00
CPC分类号： F16H49/001 , F16H25/06 , F16H2025/066 , Y10T74/19 , Y10T74/19005 , Y10T74/19219 , Y10T74/19555 , Y10T74/19893
摘要： In a gearing, in particular coaxial gearing, hollow shaft gearing, hypoid gearing, axial gearing or linear gearing, with a driving element (7), an element (3) and an output element (11), a stepping-up and transmission of a driving torque between driving element (7) and output element (11) are to take place via a plurality of movable tooth segments (5).
摘要翻译：在具有驱动元件（7），元件（3）和输出元件（11）的传动装置中，特别是同轴传动装置，空心轴传动装置，准双曲面传动装置，轴向传动装置或线性传动装置，驱动元件（7）和输出元件（11）之间的驱动扭矩将通过多个可动齿段（5）进行。

46. 发明申请

US20090028383A1 Method and Device for Monitoring the Transportation of a Number of Objects 审中-公开
标题翻译：监控一些物体运输的方法和装置
公开(公告)号：US20090028383A1
公开(公告)日：2009-01-29
申请号：US12180876
申请日：2008-07-28
申请人： Thomas Bayer
发明人： Thomas Bayer
IPC分类号： G06K9/00
CPC分类号： G07B17/00435 , G07B17/00467 , G07B17/00661 , G07B2017/00443 , G07B2017/00475 , G07B2017/00709
摘要： The transportation progress of a number of objects that are provided with an identifier of a destination address, in particular mail items, are monitored. Each object passes through a sorting unit at least once. The sorting unit generates an image of the object and identifies the destination address of the object by evaluating the image. Each object is transported to the identified destination address. The sorting unit examines each object passing through the sorting unit within a predefined time period to determine whether or not the object has at least one predefined optically detectable characteristic. To this end the sorting unit evaluates the image of the object generated by the sorting unit. The sorting unit is connected to a database. The sorting unit only stores an image of an object in the database, if the object has the characteristic. The images stored in the database are evaluated according to a predefined evaluation criterion.
摘要翻译：监视提供有目的地地址的标识符，特别是邮件项目的多个对象的传送进度。每个物体至少通过一个分拣单元。分类单元通过评估图像来生成对象的图像并识别对象的目的地址。每个对象被传送到所识别的目的地址。分类单元在预定时间内检查通过分类单元的每个对象，以确定对象是否具有至少一个预定义的可光学检测的特征。为此，排序单元评估由分类单元生成的对象的图像。分拣单元连接到数据库。如果对象具有特征，则分类单元仅将对象的图像存储在数据库中。根据预定义的评估标准来评估存储在数据库中的图像。

47. 发明申请

US20080269640A1 Appliance for Recording Diagnostic Values in the Body 审中-公开
标题翻译：用于记录身体中的诊断值的设备
公开(公告)号：US20080269640A1
公开(公告)日：2008-10-30
申请号：US12093353
申请日：2006-10-26
申请人： Thomas Bayer , Roman Stauch
发明人： Thomas Bayer , Roman Stauch
IPC分类号： A61B5/00
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/14532
摘要： In an appliance for recording diagnostic values in the body, with at least one sensor element that is assigned to a housing, the housing is intended to be able to be implanted with the at least one sensor element.
摘要翻译：在用于在身体中记录诊断值的装置中，至少一个传感器元件被分配给壳体，壳体旨在能够植入至少一个传感器元件。

48. 发明申请

US20070179119A1 Solid and crystalline ibandronate sodium and processes for preparation thereof 有权
标题翻译：固体和结晶伊班膦酸钠及其制备方法
公开(公告)号：US20070179119A1
公开(公告)日：2007-08-02
申请号：US11644568
申请日：2006-12-22
申请人： Revital Lifshitz-Liron , Thomas Bayer , Judith Aronhime , Michael Pinchasov
发明人： Revital Lifshitz-Liron , Thomas Bayer , Judith Aronhime , Michael Pinchasov
IPC分类号： A61K31/66 , C07F9/22 , C07F9/28
CPC分类号： C07F9/3873
摘要： The present invention relates to solid amorphous and crystalline forms of ibandronate sodium.
摘要翻译：本发明涉及伊班膦酸钠的固体无定形和结晶形式。

49. 发明申请

US20070161606A1 Solid and crystalline ibandronic acid 失效
标题翻译：固体和结晶伊班膦酸
公开(公告)号：US20070161606A1
公开(公告)日：2007-07-12
申请号：US11525804
申请日：2006-09-22
申请人： Thomas Bayer , Ben-Zion Dolitzky , Revital Lifshitz-Liron , Inna Perutski , Michael Pinchasov
发明人： Thomas Bayer , Ben-Zion Dolitzky , Revital Lifshitz-Liron , Inna Perutski , Michael Pinchasov
IPC分类号： A61K31/66 , C07F9/22
CPC分类号： C07F9/3873
摘要： Provided are novel crystalline and amorphous forms of ibandronic acid, methods for their preparation, and pharmaceutical compositions containing them. Also provided are methods for purifying and assaying ibandronic acid in any crystalline form (or amorphous).
摘要翻译：提供了新的结晶和无定形形式的伊班膦酸，其制备方法和含有它们的药物组合物。还提供了用于纯化和测定任何结晶形式（或无定形）的伊班膦酸的方法。

50. 发明授权

US07192355B2 Coupling for connecting two components 有权
标题翻译：用于连接两个组件的耦合
公开(公告)号：US07192355B2
公开(公告)日：2007-03-20
申请号：US10474888
申请日：2002-02-08
申请人： Thomas Bayer , Christof Old
发明人： Thomas Bayer , Christof Old
IPC分类号： F16D3/66
CPC分类号： F16D3/72
摘要： A coupling for connecting two components, in particular a clamping collar with a centering hub, whereby, between both components an axially deformable and radially centering element is arranged.
摘要翻译：用于连接两个部件的联接器，特别是具有定心毂的夹紧套环，由此在两个部件之间布置有可轴向变形的和径向对中的元件。

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