专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20130197009A1 ANTAGONIST FOR MUTANT ANDROGEN RECEPTOR 审中-公开
标题翻译：拮抗剂对突变型受体的拮抗作用
公开(公告)号：US20130197009A1
公开(公告)日：2013-08-01
申请号：US13877358
申请日：2011-10-21
申请人： Yukitaka Ideyama , Sadao Kuromitsu , Takashi Furutani , Masayoshi Takeda , Satoshi Konagai , Tomohiro Yamada , Nobuaki Taniguchi , Yutaka Kondoh , Masaaki Hirano , Kazushi Watanabe , Takashi Sugane , Akio Kakefuda
发明人： Yukitaka Ideyama , Sadao Kuromitsu , Takashi Furutani , Masayoshi Takeda , Satoshi Konagai , Tomohiro Yamada , Nobuaki Taniguchi , Yutaka Kondoh , Masaaki Hirano , Kazushi Watanabe , Takashi Sugane , Akio Kakefuda
IPC分类号： C07D401/02 , C07D401/14 , C07D403/02
CPC分类号： C07D401/02 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/12
摘要： [Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation[Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.
摘要翻译：本发明的目的在于提供一种可用于治疗伴随雄激素受体突变的前列腺癌的新型抗癌药物。本发明人进行了关于雄激素相关疾病的全面研究，雄激素药物变得无效。结果发现，作为本发明的药物组合物的活性成分的化合物在人突变型雄激素受体（AR）中表现出对转录活化的抑制作用，并且在人体中具有优异的抗肿瘤作用前列腺癌的小鼠，从而完成本发明。因此，作为本发明的药物组合物的活性成分的化合物可用于一系列与前列腺癌有关的雄激素受体相关疾病。

42. 发明授权

US08395762B2 Apparatus and method for measuring chromatic dispersion 有权
标题翻译：用于测量色散的装置和方法
公开(公告)号：US08395762B2
公开(公告)日：2013-03-12
申请号：US12647267
申请日：2009-12-24
申请人： Masaaki Hirano , Toshiki Taru
发明人： Masaaki Hirano , Toshiki Taru
IPC分类号： G01N21/00 , H04B10/08 , H04B17/00
CPC分类号： G01M11/338
摘要： Highly accurate measurement of chromatic dispersions of a device under test that is an optical component is enabled with a simple structure comprising: propagating pump light having a wavelength λpump and probe light having a wavelength λprobe through the device; calculating the generation efficiency of the idler light with respect to the wavelength λpump by measuring the power of idler light having a wavelength λidler output from the device according to four-wave mixing generated in the device; seeking the frequency difference or wavelength difference between the pump light and the probe light that makes an extremum of generation efficiency of the idler light; calculating phase mismatch among the pump light wavelength having such frequency difference or wavelength difference, the probe light wavelength, and the idler light wavelength; and on the basis of such calculation results, calculating the chromatic dispersion of the device at the wavelength λpump.
摘要翻译：通过简单的结构实现了作为光学部件的被测器件的色散的高精度测量，包括：通过器件传播具有波长λpump的泵浦光和具有波长λ探针的探测光; 通过根据在装置中产生的四波混频测量从器件输出的具有波长λidler的惰性光的功率来计算相对于波长λpump的惰轮光的发生效率; 寻求激发光的发光效率极值的泵浦光和探测光之间的频差或波长差; 计算具有这样的频率差或波长差的泵浦光波长，探测光波长和惰轮波长的相位失配; 并且基于这样的计算结果，计算波长λpump处的器件的色散。

43. 发明申请

US20120189262A1 OPTICAL FIBER PREFORM, OPTICAL FIBER, AND METHOD OF MANUFACTURING OPTICAL FIBER PREFORM 有权
标题翻译：光纤预制件，光纤和制造光纤预制件的方法
公开(公告)号：US20120189262A1
公开(公告)日：2012-07-26
申请号：US13352644
申请日：2012-01-18
申请人： Masaaki HIRANO , Tetsuya Haruna , Yoshiaki Tamura
发明人： Masaaki HIRANO , Tetsuya Haruna , Yoshiaki Tamura
IPC分类号： G02B6/00 , C03C13/04 , C03B37/012
CPC分类号： C03B37/01807 , C03B37/01853 , C03B2201/07 , C03B2201/12 , C03B2201/20 , C03B2201/50 , Y10T428/294
摘要： An optical fiber preform includes a core portion, in which the core portion includes an alkali-metal-doped core glass portion doped with an alkali metal, the maximum concentration of oxygen molecules in the core portion is 30 mol ppb or more, and the average concentration of the alkali metal in the core portion is 5 atomic ppm or more. A method of manufacturing an optical fiber preform includes an alkali-metal-doping step of doping a pipe composed of silica-based glass with an alkali metal, an oxygen-molecule-doping step of doping the glass pipe with oxygen molecules, and a collapsing step of collapsing the glass pipe by heating the glass pipe, in which the optical fiber preform is manufactured.
摘要翻译：光纤预制棒包括芯部，芯部包括掺杂有碱金属的碱金属掺杂的芯玻璃部分，芯部中的氧分子的最大浓度为30mol ppb以上，平均芯部中的碱金属的浓度为5原子ppm以上。制造光纤预制棒的方法包括：碱金属掺杂步骤，用碱金属掺杂由二氧化硅基玻璃构成的管，用氧分子掺杂玻璃管的氧分子掺杂步骤，以及塌陷通过加热其中制造光纤预制棒的玻璃管来塌缩玻璃管的步骤。

44. 发明授权

US07960562B2 Propane-1,3-dione derivative or salt thereof 有权
标题翻译：丙烷-1,3-二酮衍生物或其盐
公开(公告)号：US07960562B2
公开(公告)日：2011-06-14
申请号：US11887384
申请日：2006-03-30
申请人： Masaaki Hirano , Isao Kinoyama , Shunichiro Matsumoto , Eiji Kawaminami , Kei Ohnuki , Hirofumi Yamamoto , Kazuhiko Osoda , Tatsuhisa Takahashi , Takashi Shin , Takanori Koike , Itsuro Shimada , Hiroyuki Hisamichi , Toshiyuki Kusayama
发明人： Masaaki Hirano , Isao Kinoyama , Shunichiro Matsumoto , Eiji Kawaminami , Kei Ohnuki , Hirofumi Yamamoto , Kazuhiko Osoda , Tatsuhisa Takahashi , Takashi Shin , Takanori Koike , Itsuro Shimada , Hiroyuki Hisamichi , Toshiyuki Kusayama
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D235/12 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14
摘要： It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by —SO2—R3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone-dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.
摘要翻译：旨在提供可用作GnRH受体拮抗剂的化合物。本发明人进一步研究了丙烷-1,3-二酮衍生物。结果证实，在具有2-（1,3-二氢-2H-苯并咪唑）的丙烷-1,3-二酮衍生物中具有被-SO 2 -R 3表示的基团取代的苯环或噻吩环的化合物 -2-亚基）具有优异的GnRH受体拮抗作用，完成了本发明。因为本发明的化合物具有强的GnRH受体拮抗作用，因此可用于治疗性激素依赖性疾病，特别是GnRH相关疾病。此外，由于本发明的化合物在人体中具有优异的代谢稳定性，药物相互作用少，因此作为上述疾病的药物具有优选的特性。

45. 发明申请

US20110085768A1 OPTICAL FIBER AND METHOD OF MANUFACTURING OPTICAL FIBER 有权
标题翻译：光纤和制造光纤的方法
公开(公告)号：US20110085768A1
公开(公告)日：2011-04-14
申请号：US12903798
申请日：2010-10-13
申请人： Tetsuya Nakanishi , Masaaki Hirano , Tetsuya Haruna , Maki Ikechi
发明人： Tetsuya Nakanishi , Masaaki Hirano , Tetsuya Haruna , Maki Ikechi
IPC分类号： G02B6/44 , G02B6/02
CPC分类号： C03B37/02727 , C03B2203/19 , C03B2203/222 , G02B6/02 , G02B6/02366 , G02B6/03627 , G02B6/0365 , G02B6/03694
摘要： An optical fiber having excellent strength that can be manufactured at low cost, as well as a method for making such optical fiber, is provided. An optical fiber 1 is a silica-based optical fiber comprising a core 11, an optical cladding 12 surrounding the core 11, and a jacketing region 13 surrounding the optical cladding 12 and having a uniform composition throughout from the internal circumference to the outer circumference. A compressive strained layer having a residual compressive stress is provided at the outermost circumference of the jacketing region 13.
摘要翻译：提供了具有可以低成本制造的优异强度的光纤以及制造这种光纤的方法。光纤1是包括芯11，围绕芯11的光学包层12和围绕光学包层12并且具有从内周到外周均匀组成的护套区域13的二氧化硅基光纤。在护套区域13的最外周设有具有残余压应力的压应变层。

46. 发明授权

US07894697B2 Optical fiber, optical transmission line, optical module, and optical transmission system 有权
标题翻译：光纤，光传输线，光模块和光传输系统
公开(公告)号：US07894697B2
公开(公告)日：2011-02-22
申请号：US11976110
申请日：2007-10-22
申请人： Takashi Sasaki , Kazumasa Makihara , Tetsuya Haruna , Masashi Onishi , Masaaki Hirano
发明人： Takashi Sasaki , Kazumasa Makihara , Tetsuya Haruna , Masashi Onishi , Masaaki Hirano
IPC分类号： G02B6/02 , G02B6/036 , G02B6/028 , G02B6/00 , H04J14/02
CPC分类号： G02B6/03644 , C03B2203/22 , C03B2203/29 , C03B2203/36 , G02B6/02261 , G02B6/03627 , G02B6/29377
摘要： The present invention relates to an optical fiber which has a structure for further increasing an FOM (=|dispersion|/loss) and which can be applied to a dispersion compensation module. The optical fiber is mainly composed of silica glass and has a core region including a center of an optical axis, a depressed region surrounding the core region, a ring region surrounding the depressed region, and a cladding region surrounding the ring region and doped with F. As compared with the refractive index of pure silica glass, a relative refractive index difference of the core region is greater than 2% but less than 3%, a relative refractive index difference of the depressed region is −1% or more but −0.5% or less, a relative refractive index difference of the ring region is 0.01% or more but 0.24% or less, and a relative refractive index difference of the cladding region is −0.3% or more but −0.1% or less. The FOM at the wavelength of 1550 nm is 250 ps/nm/dB or more.
摘要翻译：本发明涉及具有进一步增加FOM（= |色散| /损耗）的结构的光纤，并且可以应用于色散补偿模块。该光纤主要由石英玻璃构成，具有包括光轴中心，围绕芯区域的凹陷区域，围绕该凹陷区域的环形区域和围绕该环形区域并且掺杂有F的包层区域的芯区域与纯石英玻璃的折射率相比，芯区域的相对折射率差大于2％但小于3％，凹陷区域的相对折射率差为-1％以上-0.5 ％以下，环区域的相对折射率差为0.01％以上且0.24％以下，包层区域的相对折射率差为-0.3％以上-0.1％以下。 1550nm波长的FOM为250ps / nm / dB以上。

47. 发明授权

US07787730B2 Optical fiber and broadband light source 有权
标题翻译：光纤和宽带光源
公开(公告)号：US07787730B2
公开(公告)日：2010-08-31
申请号：US11922783
申请日：2007-03-12
申请人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
发明人： Masaaki Hirano , Tetsuya Nakanishi , Toshiaki Okuno
IPC分类号： G02B6/02
CPC分类号： G02B6/03627 , G02B6/02028 , G02B6/02242 , G02B6/02257 , G02B6/02271 , G02F1/3532 , G02F2001/3528
摘要： An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area of 12 μm2 or less at the central wavelength, outputs supercontinuum light having a wavelength bandwidth expanded to 1000 nm or more.
摘要翻译：可以产生具有更宽带宽的SC光的光纤和宽带光源。宽带光源1配备有种子光源11和光纤12.种子光源11输出在1500nm至1650nm的波长范围内的中心波长的光。光纤12输出来自种子光源的光输出的结果的超连续光。在中心波长处具有在1300nm至1500nm的波长范围内的零色散波长和12μm2或更小的有效面积的光纤12输出具有扩展至1000nm以上的波长带宽的超连续光。

48. 发明授权

US07486862B2 Optical fiber and manufacturing method thereof 有权
标题翻译：光纤及其制造方法
公开(公告)号：US07486862B2
公开(公告)日：2009-02-03
申请号：US10556946
申请日：2004-05-18
申请人： Yuichi Ohga , Masashi Onishi , Osamu Kasuu , Shuichiro Kato , Toru Adachi , Takashi Sasaki , Masaaki Hirano
发明人： Yuichi Ohga , Masashi Onishi , Osamu Kasuu , Shuichiro Kato , Toru Adachi , Takashi Sasaki , Masaaki Hirano
IPC分类号： G02B6/02 , C03B37/023
CPC分类号： C03B37/01228 , C03B37/01211 , C03B37/01231 , C03B37/01248 , C03B37/02754 , Y02P40/57
摘要： A core rod is inserted into a cladding pipe, moisture in a space between the core rod and the cladding pipe is removed, and an optical fiber is drawn while the space is connected to a dry-gas atmosphere and/or being decompressed and while the core rod and the cladding pipe are being unified with each other. Alternatively, the core rod is inserted into the cladding pipe, and an optical fiber is drawn from one end while moisture on the surface of the core rod and the internal surface of the cladding pipe is being removed. Accordingly, a high quality optical fiber is manufactured with good productivity.
摘要翻译：将芯棒插入包层管中，去除芯棒和包层管之间的空间中的水分，并且在空间连接到干燥气体气氛和/或减压的同时拉出光纤，同时芯棒和包层管彼此统一。或者，将芯棒插入到包层管中，并且从一端抽出光纤，同时除去芯棒的表面和包层管的内表面上的水分。因此，以高生产率制造高品质的光纤。

49. 发明申请

US20080212091A1 Light source unit and spectrum analyzer 审中-公开
标题翻译：光源单元和频谱分析仪
公开(公告)号：US20080212091A1
公开(公告)日：2008-09-04
申请号：US12010212
申请日：2008-01-22
申请人： Masato Tanaka , Tetsuya Nakanishi , Tetsuya Haruna , Masaaki Hirano , Toshiaki Okuno , Takashi Sasaki , Masashi Onishi
发明人： Masato Tanaka , Tetsuya Nakanishi , Tetsuya Haruna , Masaaki Hirano , Toshiaki Okuno , Takashi Sasaki , Masashi Onishi
IPC分类号： G01J3/447 , H01S3/10
CPC分类号： G01J3/10 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/021 , G01J3/0218 , G01J3/0224 , G01J3/0229 , G01J3/0297 , G01J3/06 , G01J3/14 , G01J3/1895 , G01J3/26 , G01J3/433 , G01J2003/065
摘要： A light source unit and a spectrum analyzer are provided in which the influence of interference can be reduced under conditions where light is separated into spectral components. A spectrum analyzer 1 is equipped with a light source unit 2 for irradiating light onto sample A, a detector unit 3 for detecting the light reflected, scattered, or transmitted from the sample A, and a sample stage 4 on which a sample A is placed. A wide band light source 20 generates wide band light P1 such as supercontinuum light (SC light). Also, the light source unit 2 has an interference suppressing means for suppressing the interference of each wavelength component of the wide band light P1.
摘要翻译：提供了一种光源单元和频谱分析仪，其中在将光分离成光谱分量的条件下可以降低干扰的影响。频谱分析仪1具备用于向样品A照射光的光源单元2，检测从样品A反射，散射或透射的光的检测器单元3和放置样品A的样品台4 。宽带光源20产生诸如超连续光（SC light）的宽带光P 1。此外，光源单元2具有用于抑制宽带光P 1的每个波长分量的干扰的干扰抑制装置。

50. 发明授权

US07340137B2 Optical fiber and optical module 有权
标题翻译：光纤和光模块
公开(公告)号：US07340137B2
公开(公告)日：2008-03-04
申请号：US11586004
申请日：2006-10-25
申请人： Takemi Hasegawa , Masaaki Hirano
发明人： Takemi Hasegawa , Masaaki Hirano
IPC分类号： G02B6/02
CPC分类号： G02B6/03694 , G02B6/02028 , G02B6/0281 , H01S3/06716 , H01S3/302
摘要： An optical fiber capable of effectively suppressing stimulated Brillouin scattering, and an optical module including the fiber are provided. The fiber includes a core region, and a cladding region having a refractive index lower than that of the core region and an acoustic velocity higher than that of the core region. An effective area of the fiber is 5λ2 or less at at least one light wavelength λ. The ratio ΔA/ΔO of an acoustic relative refractive index ratio ΔA and an optical relative refractive index ratio ΔO is 25 or more. The optical module includes the optical fiber, a light source that outputs first light having a wavelength λ1, and a multiplexer that receives the first light and second light having a wavelength λ2 and that multiplexes and couples the first light and the second light to the optical fiber.
摘要翻译：提供能够有效地抑制受激布里渊散射的光纤，以及包括该光纤的光学模块。纤维包括芯区域和折射率低于核心区域的折射率的包层区域，并且声速比芯区域高。纤维的有效面积在至少一个光波长λ为5λ2以下。声学相对折射率比ΔA和光学相对折射率ΔA的比值ΔA为25以上。光学模块包括光纤，输出具有波长λ1的第一光的光源，以及接收第一光的多路复用器和具有波长λ2的第二光并且将第一光和第二光复用并耦合到光纤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式