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41. 发明授权

US4864029A Isothiazole and Isoxazole derivatives 失效
标题翻译：异噻唑和异恶唑衍生物
公开(公告)号：US4864029A
公开(公告)日：1989-09-05
申请号：US192799
申请日：1988-05-11
申请人： Klaus Jelich , Wilhelm Brandes , Gerd Hanssler , Paul Reinecke
发明人： Klaus Jelich , Wilhelm Brandes , Gerd Hanssler , Paul Reinecke
IPC分类号： A01N43/56 , A01N43/74 , A01N43/80 , A01N43/82 , A01N43/824 , C07D231/46 , C07D231/48 , C07D261/08 , C07D333/28 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , A01N43/56 , A01N43/74 , A01N43/80 , A01N43/82 , C07D231/48 , C07D261/08 , C07D333/28 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Microbicidal substituted pyrazolin-5-ones of the formula ##STR1## in which R.sup.1 and R.sup.2 independently of one another each represent hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, alkyllaminocarbonylalkyl or dialkylaminocarbonylalkyl, or represent in each case optionally substituted oxiranylalkyl, aralkyl, heterocyclyl or aryl andHet represents an optionally substituted heterocyclic radical.Intermediates therefor of the formula ##STR2## in which R is alkyl, are also new.
摘要翻译：其中R1和R2彼此独立地表示氢，烷基，烯基，炔基，氰基烷基，羟基烷基，烷氧基烷基，烷硫基烷基，烷氧基羰基，羟基羰基烷基，烷氧基羰基烷基，氨基羰基烷基，烷基氨基羰基烷基或氨基羰基烷基，二烷基氨基羰基烷基，或在每种情况下表示任选取代的环氧烷基烷基，芳烷基，杂环基或芳基，Het表示任选取代的杂环基。其中R为烷基的式“IMAGE”的中间体也是新的。

42. 发明授权

US08835645B2 Process for preparing cyanimino-1,3-thiazolidines 有权
标题翻译：制备氰氨基-1,3-噻唑烷的方法
公开(公告)号：US08835645B2
公开(公告)日：2014-09-16
申请号：US12677462
申请日：2008-09-02
申请人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
发明人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
IPC分类号： C07D277/06 , C07D277/18
CPC分类号： C07D277/18
摘要： The present invention relates to a process for preparing cyanimino-1,3-thiazolidines, which are important building blocks for the preparation of crop protection active ingredients and pharmaceuticals, by the following scheme: where A is an alkali metal and X represents an acid radical.
摘要翻译：本发明涉及制备氰氨基-1,3-噻唑烷的方法，它们是制备作物保护活性成分和药物的重要结构单元，其方法如下：其中A为碱金属，X为酸基。

43. 发明授权

US06211379B1 Process for preparing heterocyclic compounds 有权
标题翻译：制备杂环化合物的方法
公开(公告)号：US06211379B1
公开(公告)日：2001-04-03
申请号：US09488436
申请日：2000-01-20
申请人： Hermann Seifert , Reinhard Lantzsch , Werner Lindner , Klaus Jelich
发明人： Hermann Seifert , Reinhard Lantzsch , Werner Lindner , Klaus Jelich
IPC分类号： C07D41706
CPC分类号： C07D417/06
摘要： The present application relates to a process for preparing compounds of the formula (I) in which R1, A, X and Z are each as defined in the description by reacting compounds of the formula (II) in which A and X are each as defined in the description with compounds of the formula (III) in which Z, R1 and M1 are each as defined in the description.
摘要翻译：本申请涉及一种制备式（I）化合物的方法，其中R 1，A，X和Z各自如说明书中所定义，通过使式（II）化合物（其中A和X各自如上所定义）在其中Z，R 1和M 1各自如说明书中所定义的式（III）化合物的描述中。

44. 发明授权

US5936113A Process for making O,S-dimethyl phosphoramidothioate 失效
标题翻译：制备O，S-二甲基氨基硫代磷酸酯的方法
公开(公告)号：US5936113A
公开(公告)日：1999-08-10
申请号：US988303
申请日：1997-12-10
申请人： Vidyantha A. Prasad , Klaus Jelich , Donald K. Smith
发明人： Vidyantha A. Prasad , Klaus Jelich , Donald K. Smith
IPC分类号： C07F9/24
CPC分类号： C07F9/2408
摘要： The present invention provides a method for making O,S-dimethyl phosphoramidothioate. In accordance with that process, a mixture containing O,S-dimethyl phosphoramidothioate is lagered at a temperature of from 35.degree. C. to about 45.degree. C. for from about 3 to about 6 hours.
摘要翻译：本发明提供了制备O，S-二甲基氨基硫代磷酸酯的方法。根据该方法，将含有O，S-二甲基硫代磷酸酯的混合物在35℃至约45℃的温度下放置约3至约6小时。

45. 发明授权

US5856499A Synthesis of 2-(methysulfonyl)-5-(trifluoro-methyl)-,3,4-thiadiazole via oxidation of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole with glacial acetic acid 失效
标题翻译：通过2-（甲硫基）-5-（三氟甲基）-1,3,4-噻二唑与冰醋酸的氧化合成2-（甲磺酰基）-5-（三氟甲基） - ，3,4-噻二唑
公开(公告)号：US5856499A
公开(公告)日：1999-01-05
申请号：US989594
申请日：1997-12-12
申请人： Vidyanatha A. Prasad , Jacqueline M. Applegate , Klaus Jelich , Achim Noack
发明人： Vidyanatha A. Prasad , Jacqueline M. Applegate , Klaus Jelich , Achim Noack
IPC分类号： B01J31/04 , C07B61/00 , C07D285/12 , C07D285/125
CPC分类号： C07D285/125
摘要： The present invention provides a process for making thiadiazole sulfones. The present process is used to make 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole. 2-(Methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole is made using catalytic oxidation in the presence of a suitable oxidizing agent. The catalyst used for the oxidation reaction is glacial acetic acid.
摘要翻译：本发明提供了制备噻二唑砜的方法。本方法用于制备2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑。在合适的氧化剂存在下，使用催化氧化制备2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑。用于氧化反应的催化剂是冰醋酸。

46. 发明授权

US5648495A Process for the preparation of 5-substituted 2-chloropyridines 失效
标题翻译： 5-取代的2-氯吡啶的制备方法
公开(公告)号：US5648495A
公开(公告)日：1997-07-15
申请号：US584867
申请日：1996-01-11
申请人： Klaus Jelich , Hans Lindel , Christoph Mannheims , Reinhard Lantzsch , Walter Merz
发明人： Klaus Jelich , Hans Lindel , Christoph Mannheims , Reinhard Lantzsch , Walter Merz
IPC分类号： C07B37/10 , C07D213/61
CPC分类号： C07D213/61
摘要： The present invention relates to a process for the preparation of 5-substituted 2-chloropyridines of the formula (I) ##STR1## by reaction of acetenamides of the formula (II) ##STR2## with Vilsmeier reagent, which is prepared by reaction of dialkylformamides of the formula (III) ##STR3## with a chlorinating agent, the excess of which is removed from the reaction mixture by distillation or by addition of dialkylformamide after completion of the reaction of the Vilsmeier reagent with the acetenamide of the formula (II), wherein in the formulae (I)-(III):R represents optionally substituted alkyl or aralkyl,R.sup.1 represents C.sub.1 -C.sub.4 -alkyl or aryl-C.sub.1 -C.sub.4 -alkyl,R.sup.2 and R.sup.3 represent straight-chain, branched or cyclic C.sub.4 -C.sub.8 -alkyl.
摘要翻译：本发明涉及通过式（Ⅱ）的乙酰胺与Vilsmeier试剂的反应制备式（Ⅰ）的（I）的5-取代的2-氯吡啶的方法，其中通过式（Ⅲ）的二烷基甲酰胺与氯化剂反应来制备，其中过氯化物通过蒸馏或通过加入二烷基甲酰胺从反应混合物中除去，该反应混合物在Vilsmeier试剂与式（II）的乙酰胺，其中在式（I） - （III）中：R表示任选取代的烷基或芳烷基，R 1表示C 1 -C 4 - 烷基或芳基-C 1 -C 4 - 烷基，R 2和R 3表示直链链，支链或环状C 4 -C 8 - 烷基。

47. 发明授权

US5541332A Chloropyridinium chlorides and process for their preparation 失效
标题翻译：氯吡啶鎓氯化物及其制备方法
公开(公告)号：US5541332A
公开(公告)日：1996-07-30
申请号：US368179
申请日：1995-01-04
申请人： Reinhard Lantzsch , Klaus Jelich , Carl Casser , Christoph Mannheims , Knud Lawrenz
发明人： Reinhard Lantzsch , Klaus Jelich , Carl Casser , Christoph Mannheims , Knud Lawrenz
IPC分类号： C07D213/20 , C07D213/61
CPC分类号： C07D213/61
摘要： A process for the preparation of a chloropyridine of the formula ##STR1## which comprises reacting an enamide of the formula ##STR2## with a chlorinating agent in the presence of a di-substituted formamide ##STR3## in which R.sup.4 and R.sup.5 each individually is alkyl or cycloalkyl or together are alkanediyl, at a temperature between about -30.degree. C. and 100.degree. C., thereby to produce a compound of the formula ##STR4## and subjecting said compound to thermal cleavage. Compounds I are novel. Compounds IV are known intermediates for agrochemicals and pharmaceuticals.
摘要翻译：（IV）的氯吡啶的制备方法，其包括在二取代的甲酰胺（III）的存在下使式（I）的酰胺与氯化剂反应，其中R 4和R 5各自独立地是烷基或环烷基或一起是烷二基，在约-30℃至100℃的温度下，从而产生下式化合物（I），并使所述化合物热裂解。化合物I是新的。化合物IV是农药和药物的已知中间体。

48. 发明授权

US5332824A Process for the preparation of 2-amino-5-methyl-pyridine 失效
标题翻译： 2-氨基-5-甲基 - 吡啶的制备方法
公开(公告)号：US5332824A
公开(公告)日：1994-07-26
申请号：US43648
申请日：1993-04-06
申请人： Eric Rivadeneira , Klaus Jelich
发明人： Eric Rivadeneira , Klaus Jelich
IPC分类号： C07D213/73 , C07D213/74 , C07D213/89 , C07D213/18 , C07D213/20
CPC分类号： C07D213/73 , C07D213/74
摘要： The invention relates to a novel process and novel intermediates for the preparation of 2-amino-5-methylpyridine (I) ##STR1## The process is characterized in that in a first step 3-methyl-pyridine 1-oxide of the formula (II) ##STR2## is reacted with a trialkylamine of the general formula (III)R.sub.3 N (III)in whichR represents alkyl,and with an electrophilic compound, in the presence or absence of a diluent, to give the ammonium salt of the general formula (IV) ##STR3## in which R has the abovementioned meaning andZ.sup..crclbar. represents an anion formed from an electrophilic compound, the compound (IV)is, possibly, isolated as a crude intermediate and, possibly, further purified and then in a second step the ammonium salt of the formula (IV) is reacted with hydrogen bromide, in the presence or absence of a diluent, at temperatures between 150.degree. C. and 300.degree. C.The compound (I) is an intermediate for the preparation of agrochemicals, for example of herbicides.
摘要翻译：本发明涉及一种用于制备2-氨基-5-甲基吡啶（I）的新方法和新型中间体（I）。该方法的特征在于在第一步中，将3-甲基 - 吡啶-1-氧化物式（II）与存在或不存在稀释剂的通式（III）的通式（III）R3N（III）的三烷基胺反应，其中R表示烷基，并与亲电子化合物反应，得到通式（IV）的铵盐其中R具有上述含义，Z（ - ）表示由亲电子化合物形成的阴离子，化合物（IV）可能被分离为粗中间体并且可能进一步纯化，然后在第二步中，在存在或不存在稀释剂的情况下，在150℃至300℃的温度下，使式（IV）的铵盐与溴化氢反应。化合物（I）是用于制备农药的中间体，例如除草剂。

49. 发明授权

US5233043A 2-alkoxy-5-alkoxymethyl-pyridines and a process for their preparation 失效
标题翻译： 2-烷氧基-5-烷氧基甲基吡啶及其制备方法
公开(公告)号：US5233043A
公开(公告)日：1993-08-03
申请号：US801318
申请日：1991-12-02
申请人： Klaus Jelich
发明人： Klaus Jelich
IPC分类号： C07D213/61 , C07D213/64
CPC分类号： C07D213/64 , C07D213/61
摘要： A process for the preparation of a 2-alkoxy-5-alkoxymethylpyridine derivative of the formula (II) ##STR1## in which R.sup.1 represents alkyl, comprising reacting a 3-dichloromethylpyridine, of the formula III, ##STR2## with an alcohol of the formula R.sup.1 --OH (IV) and with the corresponding alkali metal alkoxide of this alcohol, at a temperature between 0.degree. C. and 150.degree. C.
摘要翻译：一种制备式（II）的2-烷氧基-5-烷氧基甲基吡啶衍生物的方法，其中R 1表示烷基，包括使式III的3-二氯甲基吡啶与式）与式R 1 -OH（IV）的醇和该醇的相应碱金属醇盐在0℃至150℃的温度下反应。

50. 发明授权

US5103011A Preparation of 2-chloro-5- methyl-pyridine 失效
标题翻译： 2-氯-5-甲基 - 吡啶的制备
公开(公告)号：US5103011A
公开(公告)日：1992-04-07
申请号：US644702
申请日：1991-01-23
申请人： Klaus Jelich , Dieter Kaufmann , Bernd Gallenkamp , Reinhard Lantzsch
发明人： Klaus Jelich , Dieter Kaufmann , Bernd Gallenkamp , Reinhard Lantzsch
IPC分类号： C07D213/61
CPC分类号： C07D213/61
摘要： In the preparation of 2-chloro-5-methyl-pyridine of the formula ##STR1## by reacting 3-methyl-pyridine-1-oxide of the formula ##STR2## with a chlorinating agent, the improvement which comprises effecting the reaction in the presence of a chlorinating agent of the formula ##STR3## in which A represents oxygen or the grouping ##STR4## in which R.sup.2 and R.sup.3 individually represent alkyl, cycloalkyl or aryl or together represent alkanediyl or oxaalkanediyl andR.sup.1 represents hydrogen, chlorine, alkyl, cycloalkyl, aryl or the grouping ##STR5## in which R.sup.2 and R.sup.3 have the abovementioned meanings,and where, if R.sup.1 represents aryl, A must represent the grouping ##STR6## in the presence of a basic organic nitrogen compound and in the presence of a diluent at a temperature between about -20.degree. C. and +120.degree. C. The product is known to be useful in the systhesis of pharmaceuticals and insecticides.
摘要翻译：在通式（Ⅰ）的3-甲基 - 吡啶-1-氧化物与氯化剂反应制备式（Ⅰ）的2-氯-5-甲基 - 吡啶时，其改进是包括在其中A表示氧的分子式（III）的氯化剂或其中R 2和R 3各自表示烷基，环烷基或芳基或一起代表烷二基或氧杂烷二基的基团的组合的存在下进行反应，以及 R 1表示氢，氯，烷基，环烷基，芳基或其中R 2和R 3具有上述含义的基团，其中，如果R 1表示芳基，则A在碱性有机物存在下必须代表“IMAGE” 氮化合物和稀释剂存在下，在约-20℃至+ 120℃之间的温度下进行。已知该产物可用于药物和杀虫剂的合成。

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