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41. 发明授权

US5700286A Polymer film for wrapping a stent structure 失效
标题翻译：用于包裹支架结构的聚合物膜
公开(公告)号：US5700286A
公开(公告)日：1997-12-23
申请号：US701405
申请日：1996-08-22
申请人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
发明人： Joseph M. Tartaglia , Joseph P. Loeffler , Todd H. Turnlund
IPC分类号： A61M31/00 , A61F2/00 , A61F2/82 , A61F2/92 , A61L27/00 , A61L31/00 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/92 , A61F2/915 , A61F2002/075 , A61F2220/005 , A61F2250/0067
摘要： The drug loaded stent includes an expandable stent structural member, and a planar sheet of polymeric material attached to the outside of the expandable stent structural member. The polymeric material is preferably bioabsorbable, and loaded or coated with a therapeutic agent or drug to reduce or prevent restenosis in the vessel being treated. The polymer material can be attached to the metal stent at one or more points, and wrapped in a coil around the stent in an unexpanded state, to uncoil and expand in diameter to substantially match the expanded diameter of the metal stent; or can be wrapped tightly around the stent structural member and attached to itself, to stretch radially when the stent structural member is expanded. In another currently preferred embodiment, a combination of a stent structural member and a polymeric film wrapping can be provided with a coating of lubricious material. The lubricious material can be polyethylene oxide, polyethylene glycol, polyethylene acetate, polyvinyl pyrrolidone, polyvinyl alcohol, polyacrylamide, hydrophilic soft segment urethanes, some natural gums, polyanhydrides or other similar hydrophilic polymers, and combinations thereof. The layer of lubricious material protects the stent from the guide or the body lumen in which the stent is inserted by providing a low friction surface over the stents.
摘要翻译：药物负载支架包括可扩张的支架结构构件和附接到可扩张支架结构构件的外侧的聚合物材料的平面片。聚合物材料优选是生物可吸收的，并且加载或涂覆有治疗剂或药物以减少或预防待治疗血管中的再狭窄。聚合物材料可以以一个或多个点附着到金属支架上，并且以未膨胀的状态包裹在支架周围的线圈中，以直径展开和膨胀以与金属支架的扩张直径基本匹配; 或者可以紧紧地包裹在支架结构构件上并且附接到其自身，以在支架结构构件膨胀时径向拉伸。在另一个目前优选的实施方案中，支架结构构件和聚合物膜包裹物的组合可以提供有润滑材料的涂层。润滑材料可以是聚环氧乙烷，聚乙二醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮，聚乙烯醇，聚丙烯酰胺，亲水性软链段聚氨酯，一些天然树胶，聚酐或其它类似的亲水聚合物，及其组合。光滑材料层通过在支架上提供低摩擦表面来保护支架免于插入支架的引导件或体腔。

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